Asociación del polimorfismo rs4680 del gen COMT y el polimorfismo rs6265 del gen BDNF con el sistema BIS/BAS en población bogotana

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dc.contributor.advisorArboleda Granados, Humbertospa
dc.contributor.advisorRestrepo Castro, Juan Camilospa
dc.contributor.authorDueñas Amaya, Laura Julianaspa
dc.contributor.researchgroupGRUPO DE NEUROCIENCIAS-UNIVERSIDAD NACIONAL DE COLOMBIAspa
dc.date.accessioned2021-01-14T19:26:57Zspa
dc.date.available2021-01-14T19:26:57Zspa
dc.date.issued2020-12-04spa
dc.description.abstractAnxiety disorders are a group of psychological and neurological problems that represent various forms of abnormal or pathological fear and anxiety (Orozco & Baldares, 2012). Even though around 14% of the world population has suffered from an anxiety disorder, their causes are not entirely clear (Bandelow & Michaelis, 2015). The bio-psychological theory of Gray (1987) suggests that there are two systems that govern our personality, the BIS/BAS systems. The behavioral inhibition system (BIS) describes a fearful reacting-style to novelty, and is related to a greater social reticence. Both the COMT and BDNF have been postulated as candidate genes for anxiety disorders. The polymorphisms of greatest interest are the rs4680 of the COMT gene that plays an essential role in the degradation of extracellular dopamine in the prefrontal cortex, and the rs6265 of the BDNF gene that has been related to the activation of the amygdala as well as behaviors associated with anxiety (Johnson, Carver, Joormann & Cuccaro, 2016). The aim of this study was to evaluate the possible relationship between the rs4680 polymorphism of the COMT gene and the rs6265 polymorphism of the BDNF gene with the BIS/BAS system in a sample of the population of the city of Bogotá. According to the results obtained, it is evident that the frequency of the risk allele A of the rs6265 polymorphism of the BDNF gene is greater in the group with BIS sensitivity than in the group with BAS sensitivity, which allows to identify the risk allele A of as a possible predisposition factor for a BIS sensitivity.spa
dc.description.abstractLos trastornos de ansiedad constituyen un grupo de alteraciones psicológicas y neurológicas que representan varias formas de miedo y ansiedad anormales o patológicas (Orozco & Baldares, 2012). Aun cuando alrededor del 33,7% de la población mundial ha sufrido algún trastorno de ansiedad, las causas que desencadenan el mismo no son del todo claras (Bandelow & Michaelis, 2015). La teoría bio-psicológica de Gray (1987) plantea la existencia de dos sistemas que rigen nuestra personalidad, el sistema BIS/BAS. El sistema de inhibición conductual (BIS) describe un estilo temeroso de reaccionar ante la novedad y se encuentra relacionado con una mayor reticencia social. Tanto el gen COMT como el gen BDNF han sido postulados como genes candidatos para los trastornos de ansiedad. Los polimorfismos de mayor interés son el rs4680 del gen COMT que juega un papel esencial en la degradación de dopamina extracelular en la corteza prefrontal, y el rs6265 del gen BDNF que se ha asociado con la activación de la amígdala y con algunos de los comportamientos asociados a la ansiedad (Johnson, Carver, Joormann & Cuccaro, 2016). El objetivo de este estudio fue evaluar la posible relación entre el polimorfismo rs4680 del gen COMT y el polimorfismo rs6265 del gen BDNF con el sistema BIS/BAS en una muestra de población de la ciudad de Bogotá. De acuerdo a los resultados obtenidos, se evidencia que la frecuencia del alelo riesgo del polimorfismo rs6265 del gen BDNF es mayor en el grupo con sensibilidad BIS frente al grupo con sensibilidad BAS por lo que se permite identificar el alelo riesgo A del gen BDNF como un posible factor de predisposición para una sensibilidad BIS.spa
dc.description.additionalLínea de Investigación: Neurodesarrollospa
dc.description.degreelevelMaestríaspa
dc.format.extent101spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationDueñas Amaya, L. J., Arboleda Granados & H., Restrepo Castro, J. C. (2020). Asociación del polimorfismo rs4680 del gen COMT y el polimorfismo rs6265 del gen BDNF con el sistema BIS/BAS en población bogotana.spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/78740
dc.language.isospaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.programBogotá - Medicina - Maestría en Neurocienciasspa
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dc.rightsDerechos reservados - Universidad Nacional de Colombiaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.spaAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc610 - Medicina y saludspa
dc.subject.proposalTrastornos de Ansiedadspa
dc.subject.proposalAnxiety Disorderseng
dc.subject.proposalBIS/BASspa
dc.subject.proposalBIS / BASeng
dc.subject.proposalgen COMTspa
dc.subject.proposalCOMT geneeng
dc.subject.proposalrs4680eng
dc.subject.proposalrs4680spa
dc.subject.proposalBDNF geneeng
dc.subject.proposalgen BDNFspa
dc.subject.proposalrs6265eng
dc.subject.proposalrs6265spa
dc.titleAsociación del polimorfismo rs4680 del gen COMT y el polimorfismo rs6265 del gen BDNF con el sistema BIS/BAS en población bogotanaspa
dc.title.alternativeAssociation of the rs4680 polymorphism of the COMT gene and the rs6265 polymorphism of the BDNF gene with the BIS/BAS system in the population of Bogotaspa
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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