Efecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosa

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dc.contributor.advisorPatiño Ladino, Oscar Javier
dc.contributor.advisorPabón Baquero, Ludy Cristina
dc.contributor.authorHernández Moreno, Lida Vanessa
dc.contributor.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000013937spa
dc.contributor.orcid0000-0001-5427-4398spa
dc.contributor.researchgroupGrupo de Investigación en Química de Productos Naturales Vegetales Bioactivos (Quipronab)spa
dc.date.accessioned2023-05-25T18:48:27Z
dc.date.available2023-05-25T18:48:27Z
dc.date.issued2022-10-07
dc.descriptionilustraciones, graficasspa
dc.description.abstractPseudomonas aeruginosa es una bacteria oportunista catalogada como de prioridad critica por la OMS y está asociada a una amplia gama de infecciones principalmente en las unidades de cuidados intensivos (UCI). La patogenicidad de esta bacteria está regulada principalmente por el sistema de comunicación denominado Quorum Sensing (QS) que le permite controlar sus factores de virulencia. Este sistema ha sido relacionado con la resistencia a los antibióticos y por ende se ha planteado su inhibición a partir de sustancias provenientes de plantas como una estrategia para el control de microorganismos resistentes. Las plantas del género Piper se han caracterizado por tener propiedades antibacterianas, antifúngicas, insecticidas, antioxidantes y citotóxicas, sin embargo, son pocos los estudios enfocados a la inhibición del QS. Por lo tanto, en el presente estudio se determinó el potencial de las sustancias provenientes de especies del género Piper como inhibidores del QS de P. aeruginosa. La metodología que se llevó a cabo comprendió la identificación de algunas especies pertenecientes al género Piper con potencial de inhibición de QS y la formación de biopelícula. Posteriormente se realizó el estudio fitoquímico sobre una de las especies con mayor potencial de inhibición de QS (P. pertomentellum) para aislar e identificar algunos constituyentes químicos bioactivos. Finalmente, se determinó la acción de constituyentes químicos presentes en especies del género Piper sobre la formación de biopelículas y la producción de algunos factores de virulencia (elastasas, proteasas y piocianina) asociados al QS de P. aeruginosa. Los resultados obtenidos permitieron identificar especies pertenecientes al género Piper con potencial de inhibición de QS, destacándose P. asperiusculum, P. cumanense, P. pertomentellum, P. bogotense, P. sucrense y P. grande por presentar porcentajes de producción menores o igual al 50% en los ensayos de formación de biopelícula o producción de violaceína. El estudio fitoquímico realizado sobre la parte aérea de P. pertomentellum permitió aislar e identificar una nueva piperamida (etiltembamida (C1)), junto con cuatro amidas conocidas (tembamida (C2), cefaradiona B (C3), benzamida (C4) y tembamida (C5)). Los compuestos identificados se reportan por primera vez para la especie y sus estructuras están de acuerdo con la quimiotaxonomía del género Piper. Por último, en este estudio se destaca el potencial inhibitorio de los factores de virulencia y en la formación de biopelícula de los compuestos con potencial multidiana que correspondieron a amidas (C9 y C10), hidroquinonas (C8, C18 y C19) y derivados de ácido benzoico (C16). presentes en especies del género Piper. Adicionalmente, con los resultados obtenidos se establecieron algunas relaciones de estructura-actividad preliminar sobre los compuestos más activos. Esta investigación contribuye a la búsqueda de inhibidores de origen natural que pueden servir como alternativa de control del QS en P. aeruginosa para reducir la resistencia bacteriana, mediante la caracterización del potencial inhibitorio de sustancias provenientes de algunas especies del género Piper. (Texto tomado de la fuente)spa
dc.description.abstractPseudomonas aeruginosa is an opportunistic bacterium classified as a critical priority by the WHO and is associated with a wide range of infections mainly in intensive care units (ICU). The pathogenicity of this bacterium is mainly regulated by a communication system called Quorum Sensing (QS) that allows it to control its virulence factors. This system has been related to antibiotic resistance and therefore its inhibition by plant-derived substances has been proposed as a strategy for the control of resistant microorganisms. Plants of the genus Piper have been characterized for having antibacterial, antifungal, insecticidal, antioxidant and cytotoxic properties, however, few studies have focused on the inhibition of the QS. Therefore, in the present study, the potential of substances from Piper species as QS inhibitors of P. aeruginosa was determined. The methodology carried out involved the identification of some species belonging to the genus Piper with potential for QS inhibition and biofilm formation. Subsequently, a phytochemical study was carried out on one of the species with the greatest potential for QS inhibition (P. pertomentellum) to isolate and identify some bioactive chemical constituents. Finally, the action of chemical constituents presents in Piper species on biofilm formation and the production of some virulence factors (elastases, proteases and pyocyanin) associated with QS of P. aeruginosa was determined. The results obtained allowed the identification of species belonging to the genus Piper with QS inhibition potential, with P. asperiusculum, P. cumanense, P. pertomentellum, P. bogotense, P. sucrense and P. grande standing out for presenting production percentages of less than or equal to 50% in the biofilm formation or violacein production assays. The phytochemical study carried out on the aerial part of P. pertomentellum allowed the isolation and identification of a new piperamide (ethyltembamide (C1)), together with four known amides (tembamide (C2), cefaradione B (C3), benzamide (C4) and tembamide (C5)). The identified compounds are reported for the first time for the species and their structures are in agreement with the chemotaxonomy of the genus Piper. Finally, this study highlights the inhibitory potential on virulence factors and biofilm formation of compounds with multidiana potential that corresponded to amides (C9 and C10), hydroquinones (C8, C18 and C19) and benzoic acid derivatives (C16). present in species of the genus Piper. Additionally, with the results obtained, some preliminary structure-activity relationships on the most active compounds were established. This research contributes to the search for inhibitors of natural origin that can serve as an alternative for the control of QS in P. aeruginosa to reduce bacterial resistance, through the characterization of the inhibitory potential of substances from some species of the Piper genus.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagister en Ciencias Farmacéuticasspa
dc.description.researchareaQuímica de Productos Naturalesspa
dc.description.sponsorshipMinicienciasspa
dc.description.sponsorshipUniversidad de La Sallespa
dc.description.sponsorshipUniversidad Nacional de Colombiaspa
dc.description.sponsorshipMinisterio de Medio Ambiente y Desarrollo Sosteniblespa
dc.format.extent167 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/83870
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias Farmacéuticasspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseReconocimiento 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/spa
dc.subject.ddc540 - Química y ciencias afines::547 - Química orgánicaspa
dc.subject.decsPseudomonas aeruginosa
dc.subject.proposalPiper pertomentellumspa
dc.subject.proposalPiperamidasspa
dc.subject.proposalPseudomonas aeruginosaspa
dc.subject.proposalQuorum Sensingspa
dc.subject.proposalPiperspa
dc.subject.proposalFactores de virulenciaspa
dc.subject.proposalPiper pertomentellumeng
dc.subject.proposalPiperamideseng
dc.subject.proposalPseudomonas aeruginosaeng
dc.subject.proposalQuorum Sensingeng
dc.subject.proposalPipereng
dc.subject.proposalvirulence factorseng
dc.titleEfecto inhibitorio de sustancias provenientes de especies del género Piper sobre Quorum Sensing de Pseudomonas aeruginosaspa
dc.title.translatedInhibitory effect of substances from Piper species on Quorum Sensing of Pseudomonas aeruginosaeng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
dcterms.audience.professionaldevelopmentMedios de comunicaciónspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.fundernameMincienciasspa

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