Estudio de la actividad biológica de alquilglicerol lípidos análogos a compuestos de origen marino contra aislados de origen clínico
| dc.contributor.advisor | Silva Gomez, Edelberto | spa |
| dc.contributor.author | Chaverra Daza, Klauss Estefan | spa |
| dc.contributor.researchgroup | Productos Naturales Vegetales Bioactivos y Quimica EcoIogica | spa |
| dc.date.accessioned | 2020-07-15T22:48:23Z | spa |
| dc.date.available | 2020-07-15T22:48:23Z | spa |
| dc.date.issued | 2020-06-12 | spa |
| dc.description.abstract | In the present study we evaluated the anti-biofilm and anti-quorum sensing activity against 8 clinical isolates and 3 reference strains, using 15 alkylglycerols obtained by chemical synthesis, they are analogous to those present in nature. In the first step, we evaluated the growth inhibitory activity of each alkylglycerol in order to quantify the anti-biofilm activity using 50%, 25% and 12.5% of the MIC concentration through broth microdilution. Using the modified Stepanovic protocol, we obtained biolfilm inhibitions of up 83.9%, which varied according to the alkylglycerol concentration and bacterial genus. The production of violacein of Chromobacterium violaceum ATCC 12472 was used for demonstrating the anti-quourum sensing activity by mean of diffusion on agar and broth microdilution techniques, depending on concentration and technique used; some alkylglycerols led to a lower production of violacein from C. violaceum ATCC 12472. According to these results, alkylglycerols showed different effects depending on their concentration, the microorganism used and the number of chain carbon atoms and their unsaturation’s. | spa |
| dc.description.abstract | En el presente estudio se evaluó la capacidad anti-biofilm y anti-quorum sensing contra 8 aislados clínicos y 3 cepas de referencia, usando 15 alquilglicerol lípidos obtenidos mediante síntesis química, los cuales son análogos a los presentes en la naturaleza. En primer lugar, se evaluó la capacidad inhibitoria de crecimiento de cada compuesto, para luego cuantificar la actividad anti-biofilm usando concentraciones al 50%, 25% y 12.5% de la MIC, mediante la técnica de microdilución en caldo. Utilizando el protocolo de Stepanovic modificado, se obtuvieron inhibiciones de la biopelícula de hasta un 83,9% las cuales variaban de acuerdo a la concentración y al género bacteriano. La producción de violaceína por parte de Chromobacterium violaceum ATCC 12472, fue usada para comprobar la actividad anti-quorum sensing mediante las técnicas de difusión en agar y microdilución en caldo; de acuerdo a la concentración y a la metodología usada, algunos compuestos generaban una disminución en la producción de violaceína por parte de la bacteria. De acuerdo a los resultados de los ensayos presentados en el documento, los alquilglicerol lípidos presentaron diferentes efectos dependientes de la concentración del compuesto, el microorganismo usado y el número de átomos de carbono e insaturaciones de la molécula | spa |
| dc.description.additional | Magíster en Ciencias - Microbiología. Línea de Investigación: Comunicación Bacteriana | spa |
| dc.description.degreelevel | Maestría | spa |
| dc.description.sponsorship | Productos Naturales Vegetales Bioactivos y Química Ecológica | spa |
| dc.format.extent | 113 | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.citation | Chaverra Daza, Klauss (2020). Estudio de la actividad biológica de alquilglicerol lípidos análogos a compuestos de origen marino contra aislados de origen clínico (Universidad Nacional) | spa |
| dc.identifier.uri | https://repositorio.unal.edu.co/handle/unal/77782 | |
| dc.language.iso | spa | spa |
| dc.publisher.branch | Universidad Nacional de Colombia - Sede Bogotá | spa |
| dc.publisher.program | Bogotá - Ciencias - Maestría en Ciencias - Microbiología | spa |
| dc.relation.references | Amara, N., Krom, B. P., Kaufmann, G. F., & Meijler, M. M. (2011). Macromolecular Inhibition of quorum sensing: Enzymes, antibodies, and beyond. Chemical Reviews, 111(1), 195–208. https://doi.org/10.1021/cr100101c | spa |
| dc.relation.references | Balzer, M., Witt, N., Flemming, H. C., & Wingender, J. (2010). Faecal indicator bacteria in river biofilms. Water Science and Technology, 61(5), 1105–1111. https://doi.org/10.2166/wst.2010.022 | spa |
| dc.relation.references | Barnes, A. M. T., Ballering, K. S., & Leibman, R. S. (2012). Enterococcus faecalis produces abundant extracellular structures. MBio, 3(4), 1–9. https://doi.org/10.1128/mBio.00193-12.Editor | spa |
| dc.relation.references | Barragan Avilez, C. M. (2015). Sintesis de Alquilglicerolípidos y determinación de su actividad antifouling (Universidad Nacional de Colombia). Retrieved from http://www.bdigital.unal.edu.co/48913/ | spa |
| dc.relation.references | Barriuso, J., Hogan, D. A., Keshavarz, T., & Martínez, M. J. (2018). Role of quorum sensing and chemical communication in fungal biotechnology and pathogenesis. FEMS Microbiology Reviews, 42(5), 627–638. https://doi.org/10.1093/femsre/fuy022 | spa |
| dc.relation.references | Bassler, W.-L. N. and B. L. (2015). Bacterial Quorum-Sensing Network Architectures. Annu. Rev. Genet, 197–222. https://doi.org/10.1146/annurev-genet-102108-134304.Bacterial | spa |
| dc.relation.references | Becker, S., Soares, C., & Porto, L. M. (2009). Computational analysis suggests that virulence of Chromobacterium violaceum might be linked to biofilm formation and poly-NAG biosynthesis. Genetics and Molecular Biology, 32(3), 640–644. https://doi.org/10.1590/S1415-47572009000300031 | spa |
| dc.relation.references | Bilings, N., Birjiniuk, A., Samad, T. S., Doyle, P. S., & Ribbeck, K. (2016). Material properties of biofilms – key methods for understanding permeability and mechanics. Rep Prog Phys, 78(3), 33. https://doi.org/10.1088/0034-4885/78/3/036601.Material | spa |
| dc.relation.references | Blackledge, M. S., Worthington, R. J., & Melander, C. (2013). Biologically inspired strategies for combating bacterial biofilms. Current Opinion in Pharmacology, 13(5), 699–706. https://doi.org/10.1016/j.coph.2013.07.004 | spa |
| dc.relation.references | Blunt, J. W., Copp, B. R., Keyzers, R. A., Munro, M. H. G., & Prinsep, M. R. (2017). Marine natural products. Nat. Prod. Rep., 34(3), 235–294. https://doi.org/10.1039/C6NP00124F | spa |
| dc.relation.references | Bohlmann, M. K. (2007). Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Human Reproduction Br J Haematol, 22(132), 366–368. https://doi.org/10.1093/humrep/del349 | spa |
| dc.relation.references | Braverman, N. E., Raymond, G. V, Rizzo, W. B., Moser, A. B., Mark, E., Stone, E. M., … Angeles, L. (2017). Peroxisome biogenesis disorders in the Zellweger spectrum: An overveiw of current diagnosis, clinical manifestations, and treatment guidelines. Mol Genet Metab, 117(3), 313–321. https://doi.org/10.1016/j.ymgme.2015.12.009. | spa |
| dc.relation.references | Brissette, J. L., Cabacungan, E. A., & Pieringer, A. (1986). Studies on the Antibacterial Activity of Dodecylglycerol. The Journal of Biological Chemestry, 261(14), 6338–6345. | spa |
| dc.relation.references | Ch’ng, J. H., Chong, K. K. L., Lam, L. N., Wong, J. J., & Kline, K. A. (2019). Biofilm-associated infection by enterococci. Nature Reviews Microbiology, 17(2), 82–94. https://doi.org/10.1038/s41579-018-0107-z | spa |
| dc.relation.references | Chadha, T. (2014). Bacterial Biofilms: Survival Mechanisms and Antibiotic Resistance. Journal of Bacteriology & Parasitology, 05(03), 5–8. https://doi.org/10.4172/2155-9597.1000190 | spa |
| dc.relation.references | Chan, K. G., Liu, Y. C., & Chang, C. Y. (2015). Inhibiting N-acyl-homoserine lactone synthesis and quenching Pseudomonas quinolone quorum sensing to attenuate virulence. Frontiers in Microbiology, 6(OCT), 1–7. https://doi.org/10.3389/fmicb.2015.01173 | spa |
| dc.relation.references | Christensen, Gordon, E. a. (1985). Adherence of Coagulase-Negative Staphylococci to Plastic Tissue Culture Plates: a Quantitative Model for the Adherence of Staphylococci to Medical Device. Journal of Clinical Microbiology, 22(6), 996–1006. Retrieved from papers2://publication/uuid/E1D7238D-250A-4E23-AB70-BBB6A42974D4 | spa |
| dc.relation.references | Clara Barragán A et.al. (2018). Inhibition of quorum sensing by compounds from two Eunicea species and synthetic saturated alkylglycerols. VITAE, 25, 92–103. Retrieved from http://dx.doi.org/10.17533/udea.vitae.v25n2a05 | spa |
| dc.relation.references | Da Silva, T. F., Eira, J., Lopes, A. T., Malheiro, A. R., Sousa, V., Luoma, A., … Brites, P. (2014). Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination. Journal of Clinical Investigation, 124(6), 2560–2570. https://doi.org/10.1172/JCI72063 | spa |
| dc.relation.references | Dean, J. M., & Lodhi, I. J. (2018). Structural and functional roles of ether lipids. Protein and Cell, 9(2), 196–206. https://doi.org/10.1007/s13238-017-0423-5 | spa |
| dc.relation.references | Devescovi, G., Kojic, M., Covaceuszach, S., Cámara, M., Williams, P., Bertani, I., … Venturi, V. (2017). Negative regulation of violacein biosynthesis in Chromobacterium violaceum. Frontiers in Microbiology, 8, 1–11. https://doi.org/10.3389/fmicb.2017.00349 | spa |
| dc.relation.references | Dobretsov, S., Teplitski, M., Bayer, M., Gunasekera, S., Proksch, P., & Paul, V. J. (2011). Inhibition of marine biofouling by bacterial quorum sensing inhibitors. Biofouling, 27(8), 893–905. https://doi.org/10.1080/08927014.2011.609616 | spa |
| dc.relation.references | Even-Tov, E., Omer Bendori, S., Valastyan, J., Ke, X., Pollak, S., Bareia, T., … Eldar, A. (2016). Social Evolution Selects for Redundancy in Bacterial Quorum Sensing. PLoS Biology, 14(2), 1–18. https://doi.org/10.1371/journal.pbio.1002386 | spa |
| dc.relation.references | Fernandez, D. (2017). Estudio de la Actividad Antibiofilm de Alquilgliceroles Análogos a Compuestos de Origen Marino (Universidad Nacional de Colombia). Retrieved from http://bdigital.unal.edu.co/64616/ Consultado 22-Oct-18 | spa |
| dc.relation.references | Gjermansen, M., Nilsson, M., Yang, L., & Tolker-Nielsen, T. (2010). Characterization of starvation-induced dispersion in Pseudomonas putida biofilms: genetic elements and molecular mechanisms. Molecular Microbiology, 75(4), 815–826. https://doi.org/10.1111/j.1365-2958.2009.06793.x | spa |
| dc.relation.references | Grandclément, C., Tannières, M., Moréra, S., Dessaux, Y., & Faure, D. (2015). Quorum quenching: Role in nature and applied developments. FEMS Microbiology Reviews, 40(1), 86–116. https://doi.org/10.1093/femsre/fuv038 | spa |
| dc.relation.references | Hobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015). Giving structure to the biofilm matrix: An overview of individual strategies and emerging common themes. FEMS Microbiology Reviews, 39(5), 649–669. https://doi.org/10.1093/femsre/fuv015 | spa |
| dc.relation.references | Hoshino, T. (2011). Violacein and related tryptophan metabolites produced by Chromobacterium violaceum: Biosynthetic mechanism and pathway for construction of violacein core. Applied Microbiology and Biotechnology, 91(6), 1463–1475. https://doi.org/10.1007/s00253-011-3468-z | spa |
| dc.relation.references | Huseby, M. J., Kruse, A. C., Digre, J., Kohler, P. L., Vocke, J. A., Mann, E. E., … Earhart, C. A. (2010). Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms. Proceedings of the National Academy of Sciences of the United States of America, 107(32), 14407–14412. https://doi.org/10.1073/pnas.0911032107 | spa |
| dc.relation.references | Johnson, J. G., & Clegg, S. (2010). Role of MrkJ, a phosphodiesterase, in type 3 fimbrial xpression and Biofilm formation in Klebsiella pneumoniae. Journal of Bacteriology, 192(15), 3944–3950. https://doi.org/10.1128/JB.00304-10 | spa |
| dc.relation.references | Kamaeva, A. A., Vasilchenko, A. S., & Deryabin, D. G. (2014). Atomic force microscopy reveals a morphological differentiation of Chromobacterium violaceum cells associated with biofilm development and directed by N-hexanoyl-L-homoserine lactone. PLoS ONE, 9(8). https://doi.org/10.1371/journal.pone.0103741 | spa |
| dc.relation.references | Kendall, M. M., & Sperandio, V. (2007). Quorum sensing by enteric pathogens. Current Opinion in Gastroenterology, 23(1), 10–15. https://doi.org/10.1097/MOG.0b013e3280118289 | spa |
| dc.relation.references | Kossei S. Edlbacher. (1915). Beiträge zur chemischen Kenntnis der Mineralkörper. Z. Physiol. Chem, 3, 194–198. | spa |
| dc.relation.references | Kothari, V., Sharma, S., & Padia, D. (2017). Recent research advances on Chromobacterium violaceum. Asian Pacific Journal of Tropical Medicine, 10(8), 744–752. https://doi.org/10.1016/j.apjtm.2017.07.022 | spa |
| dc.relation.references | Kumon, H., Tomochika, K. I., Matunaga, T., Ohmori, H., & Ogawa, M. (1994). A Sandwich Cup Method for the Penetration Assay of Antimicrobial Agents through Pseudomonas Exopolysaccharides. Microbiology and Immunology, 38(8), 615–619. https://doi.org/10.1111/j.1348-0421.1994.tb01831.x | spa |
| dc.relation.references | Kurihara, H., Goto, Y., Aida, M., Hosokawa, M., & Takahashi, K. (2017). Antibacterial Activity against Cariogenic Bacteria and Inhibition of Insoluble Glucan Production by Free Fatty Acids Obtained from Dried Gloiopeltis furcata. Fisheries Science, 65(1), 129–132. https://doi.org/10.2331/fishsci.65.129 | spa |
| dc.relation.references | Kweon, J. H. yan. (2014). Quorum quenching mediated approaches for control of membrane biofouling. International Journal of Biological Sciences, 10(5), 550–565. https://doi.org/10.7150/ijbs.9028 | spa |
| dc.relation.references | Lade, H., Paul, D., & Kweon, J. H. (2014). N -Acyl Homoserine Lactone-Mediated Quorum Sensing with Special Reference to Use of Quorum Quenching Bacteria in Membrane Biofouling Control. BioMed Research International, 2014, 1–25. https://doi.org/10.1155/2014/162584 | spa |
| dc.relation.references | LaSarre, B., & Federle, M. J. (2013). Exploiting Quorum Sensing To Confuse Bacterial Pathogens. Microbiology and Molecular Biology Reviews, 77(1), 73–111. https://doi.org/10.1128/MMBR.00046-12 | spa |
| dc.relation.references | Lebeaux, D., Ghigo, J.-M., & Beloin, C. (2014). Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics. Microbiology and Molecular Biology Reviews, 78(3), 510–543. https://doi.org/10.1128/MMBR.00013-14 | spa |
| dc.relation.references | Lee, J., Wu, J., Deng, Y., Wang, J., Wang, C., Wang, J., … Zhang, L. H. (2013). A cell-cell communication signal integrates quorum sensing and stress response. Nature Chemical Biology, 9(5), 339–343. https://doi.org/10.1038/nchembio.1225 | spa |
| dc.relation.references | Li, J., Wang, W., Xu, S. X., Magarvey, N. A., & McCormick, J. K. (2011). Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci. Proceedings of the National Academy of Sciences of the United States of America, 108(8), 3360–3365. https://doi.org/10.1073/pnas.1017431108 | spa |
| dc.relation.references | Lister, J. L., & Horswill, A. R. (2014). Staphylococcus aureus biofilms: recent developments in biofilm dispersal. Frontiers in Cellular and Infection Microbiology, 4(December), 1–9. https://doi.org/10.3389/fcimb.2014.00178 | spa |
| dc.relation.references | Liu, Z., Wang, W., Zhu, Y., Gong, Q., Yu, W., & Lu, X. (2013). Antibiotics at subinhibitory concentrations improve the quorum sensing behavior of Chromobacterium violaceum. FEMS Microbiology Letters, 341(1), 37–44. https://doi.org/10.1111/1574-6968.12086 | spa |
| dc.relation.references | Lupp, C., & Ruby, E. G. (2005). Vibrio fischeri Uses Two Quorum-Sensing Systems for the Regulation of Early and Late Colonization Factors. 187(11), 3620–3629. https://doi.org/10.1128/JB.187.11.3620 | spa |
| dc.relation.references | Madhani, H. D. (2011). Quorum sensing in fungi: Q&A. PLoS Pathogens, 7(10), 10–12. https://doi.org/10.1371/journal.ppat.1002301 | spa |
| dc.relation.references | Magnusson, C. D., & Haraldsson, G. G. (2011). Ether lipids. Chemistry and Physics of Lipids, 164(5), 315–340. https://doi.org/10.1016/j.chemphyslip.2011.04.010 | spa |
| dc.relation.references | Mann, E. E., & Wozniak, D. (2012). Pseudomonas biofilm matrix composition and niche biology. Physiology and Behavior, 36(4), 893–916. https://doi.org/10.1111/j.1574-6976.2011.00322.x. | spa |
| dc.relation.references | Mathesius, U., Mulders, S., Gao, M., Teplitski, M., Caetano-Anollés, G., Rolfe, B. G., & Bauer, W. D. (2003). Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals. Proceedings of the National Academy of Sciences of the United States of America, 100(3), 1444–1449. https://doi.org/10.1073/pnas.262672599 | spa |
| dc.relation.references | Mcclean, K. H., Winson, M. K., Fish, L., Taylor, A., Chhabra, S. R., Camara, M., … Williams, P. (1997). Quorum sensing and Chromobacterium violaceum : exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones. Microbiology, 143(January 1998), 3703-37 1 1. https://doi.org/10.1099/00221287-143-12-3703 | spa |
| dc.relation.references | Meibom, K. L., & et.al. (2005). Chitin induces natural competence in Vibrio cholerae. Science, 310(5755), 1824–1827. https://doi.org/10.1126/science.1120096 | spa |
| dc.relation.references | Mielich-Süss, B., & Lopez, D. (2015). Molecular mechanisms involved in Bacillus subtilis biofilm formation. Environmental Microbiology, 17(3), 555–565. https://doi.org/10.1111/1462-2920.12527 | spa |
| dc.relation.references | Migiyama, Y., Kaneko, Y., Yanagihara, K., Morohoshi, T., Morinaga, Y., Nakamura, S., … Kohnob, S. (2013). Efficacy of AiiM, an N-acylhomoserine lactonase, against Pseudomonas aeruginosa in a mouse model of acute pneumonia. Antimicrobial Agents and Chemotherapy, 57(8), 3653–3658. https://doi.org/10.1128/AAC.00456-13 | spa |
| dc.relation.references | Mony, B. M., MacGregor, P., Ivens, A., Rojas, F., Cowton, A., Young, J., Matthews, K. (2014). Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei. Nature, 505(7485), 681–685. https://doi.org/10.1038/nature12864 | spa |
| dc.relation.references | Morohoshi, T., Fukamachi, K., Kato, M., Kato, N., & Ikeda, T. (2010). Regulation of the Violacein Biosynthetic Gene Cluster by Acylhomoserine Lactone-Mediated Quorum Sensing in Chromobacterium violaceum ATCC 12472. Bioscience, Biotechnology, and Biochemistry, 74(10), 2116–2119. https://doi.org/10.1271/bbb.100385 | spa |
| dc.relation.references | Mulcahy, H., Charron-Mazenod, L., & Lewenza, S. (2010). Pseudomonas aeruginosa produces an extracellular deoxyribonuclease that is required for utilization of DNA as a nutrient source. Environmental Microbiology, 12(6), 1621–1629. https://doi.org/10.1111/j.1462-2920.2010.02208.x | spa |
| dc.relation.references | Nakatsuji, T., Kao, M. C., Fang, J. Y., Zouboulis, C. C., Zhang, L., Gallo, R. L., & Huang, C. M. (2009). Antimicrobial property of lauric acid against Propionibacterium acnes: Its therapeutic potential for inflammatory acne vulgaris. Journal of Investigative Dermatology, 129(10), 2480–2488. https://doi.org/10.1038/jid.2009.93 | spa |
| dc.relation.references | OMS. (2018). Resistencia a los antibióticos (En linea). Retrieved from http://www.who.int/es/news-room/fact-sheets/detail/resistencia-a-los-antibióticos Consultado 22-Octubre-2018 | spa |
| dc.relation.references | Ortega, C. B. N. (2006). QUÓRUM-SENSIG EN Bradyrhizobium japonicum: IDENTIFICACIÓN DE GENES IMPLICADOS Y DETECCIÓN Y PURIFICACIÓN DE AUTOINDUCTORES (En linea) (Universidad de Granada). Retrieved from https://dialnet.unirioja.es/servlet/tesis?codigo=72701. Consultado 22-Octubre-2018 | spa |
| dc.relation.references | Papaioannou, E., Wahjudi, M., Nadal-Jimenez, P., Koch, G., Setroikromo, R., & Quax, W. J. (2009). Quorum-quenching acylase reduces the virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans infection model. Antimicrobial Agents and Chemotherapy, 53(11), 4891–4897. https://doi.org/10.1128/AAC.00380-09 | spa |
| dc.relation.references | Papenfort, K., & Bassler, B. L. (2016). Quorum sensing signal-response systems in Gram-negative bacteria. Nature Reviews Microbiology, 14(9), 576–588. https://doi.org/10.1038/nrmicro.2016.89 | spa |
| dc.relation.references | Park, J., Jagasia, R., Kaufmann, G. F., Mathison, J. C., Ruiz, D. I., Moss, J. A., Janda, K. D. (2007). Infection Control by Antibody Disruption of Bacterial Quorum Sensing Signaling. Chemistry and Biology, 14(10), 1119–1127. https://doi.org/10.1016/j.chembiol.2007.08.013 | spa |
| dc.relation.references | Parkins, M. D., Ceri, H., & Storey, D. G. (2001). Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation. Molecular Microbiology, 40(5), 1215–1226. https://doi.org/10.1046/j.1365-2958.2001.02469.x | spa |
| dc.relation.references | Pereira, C. S., Thompson, J. A., & Xavier, K. B. (2013). AI-2-mediated signalling in bacteria. FEMS Microbiology Reviews, 37(2), 156–181. https://doi.org/10.1111/j.1574-6976.2012.00345.x | spa |
| dc.relation.references | Pompilio, A., De Nicola, S., Crocetta, V., Guarnieri, S., Savini, V., Carretto, E., & Di Bonaventura, G. (2015). New insights in Staphylococcus pseudintermedius pathogenicity: Antibiotic-resistant biofilm formation by a human wound-associated strain. BMC Microbiology, 15(1), 1–14. https://doi.org/10.1186/s12866-015-0449-x | spa |
| dc.relation.references | Pratt, L. A., & Kolter, R. (1998). Genetic analysis of Escherichia coli biofilm formation : roles of flagella , motility , chemotaxis and type I pili. Molecular Microbiology, 30, 285–293. | spa |
| dc.relation.references | Rasamiravaka, T., Labtani, Q., Duez, P., & El Jaziri, M. (2015). The formation of biofilms by Pseudomonas aeruginosa: A review of the natural and synthetic compounds interfering with control mechanisms. BioMed Research International, 2015. https://doi.org/10.1155/2015/759348 | spa |
| dc.relation.references | Rasmussen, Thomas B., & Givskov, M. (2006). Quorum-sensing inhibitors as anti-pathogenic drugs. International Journal of Medical Microbiology, 296(2–3), 149–161. https://doi.org/10.1016/j.ijmm.2006.02.005 | spa |
| dc.relation.references | Rasmussen, Thomas Bovbjerg, Skindersoe, M. E., Bjarnsholt, T., Phipps, R. K., Christensen, K. B., Jensen, P. O., … Givskov, M. (2005). Identity and effects of quorum-sensing inhibitors produced by Penicillium species. Microbiology, 151(5), 1325–1340. https://doi.org/10.1099/mic.0.27715-0 | spa |
| dc.relation.references | Reuter, K., Steinbach, A., & Helms, V. (2016). Interfering with Bacterial Quorum Sensing. Perspectives in Medicinal Chemistry, 8, 1–15. https://doi.org/10.4137/PMc.s13209 | spa |
| dc.relation.references | Riedel, K., Hentzer, M., Geisenberger, O., Huber, B., Steidle, A., Wu, H., … Eberl, L. (2001). N-Acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms. Microbiology, 147, 3249–3262. https://doi.org/10.1099/00221287-147-12-3249 | spa |
| dc.relation.references | Roy, R., Tiwari, M., Donelli, G., & Tiwari, V. (2018). Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action. Virulence, 9, 522–554. https://doi.org/10.1080/21505594.2017.1313372 | spa |
| dc.relation.references | Satpathy, S., Sen, S. K., Pattanaik, S., & Raut, S. (2016). Review on bacterial biofilm: An universal cause of contamination. Biocatalysis and Agricultural Biotechnology, 7, 56–66. https://doi.org/10.1016/j.bcab.2016.05.002 | spa |
| dc.relation.references | Saville, R. M., Rakshe, S., Haagensen, J. A. J., Shukla, S., & Spormann, A. M. (2011). Energy-dependent stability of Shewanella oneidensis MR-1 biofilms. Journal of Bacteriology, 193(13), 3257–3264. https://doi.org/10.1128/JB.00251-11 | spa |
| dc.relation.references | Scutera, S., Zucca, M., & Savoia, D. (2014). Novel approaches for the design and discovery of quorum-sensing inhibitors. Expert Opinion on Drug Discovery, 9(4), 353–366. https://doi.org/10.1517/17460441.2014.894974 | spa |
| dc.relation.references | Slipski, C. J., Zhanel, G. G., & Bay, D. C. (2018). Biocide Selective TolC-Independent Efflux Pumps in Enterobacteriaceae. Journal of Membrane Biology, 251(1), 15–33. https://doi.org/10.1007/s00232-017-9992-8 | spa |
| dc.relation.references | Song, D., Meng, J., Cheng, J., Fan, Z., Chen, P., Ruan, H., … Shi, Y. (2019). Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution. Nature Microbiology, 4(1), 97–111. https://doi.org/10.1038/s41564-018-0290-8 | spa |
| dc.relation.references | Stelitano, V., Giardina, G., Paiardini, A., Castiglione, N., Cutruzzolà, F., & Rinaldo, S. (2013). C-di-GMP Hydrolysis by Pseudomonas aeruginosa HD-GYP Phosphodiesterases: Analysis of the Reaction Mechanism and Novel Roles for pGpG. PLoS ONE, 8(9), 1–13. https://doi.org/10.1371/journal.pone.0074920 | spa |
| dc.relation.references | Stepanović et.al. (2000). A modified microtiter-plate test for quantification of staphylococcal biofilm formation. Journal of Microbiological Methods, 40(2), 175–179. https://doi.org/10.1016/S0167-7012(00)00122-6 | spa |
| dc.relation.references | Steven J. Projan, E. a. (1994). Glycerol monolaurate inhibits the production of β-lactamase, toxic shock syndrome toxin-1, and other staphylococcal exoproteins by interfering with signal transduction. Journal of Bacteriology, 176(14), 4204–4209. https://doi.org/10.1128/jb.176.14.4204-4209.1994 | spa |
| dc.relation.references | Stoll, L. L., Figard, P. H., Yerram, N. R., Yorek, M. A., & Spector, A. A. (1989). 1-O-alkyl-2-acetyl-sn-glycerol: a platelet-activating factor metabolite with biological activity in vascular smooth muscle cells. Cell Regulation, 1(1), 13–25. | spa |
| dc.relation.references | Sugimoto, S., Iwamoto, T., Takada, K., Okuda, K. I., Tajima, A., Iwase, T., & Mizunoe, Y. (2013). Staphylococcus epidermidis Esp degrades specific proteins associated with staphylococcus aureus biofilm formation and host-pathogen interaction. Journal of Bacteriology, 195(8), 1645–1655. https://doi.org/10.1128/JB.01672-12 | spa |
| dc.relation.references | Taylor, J. R. (1997). Introduction To Error Analysis: The Study of Uncertainties in Physical Measurements. University Science Books. | spa |
| dc.relation.references | Thoendel, M. (2012). Peptide signaling in the Staphylococci. Chem Rev., 111(1), 117–151. https://doi.org/10.1021/cr100370n.Peptide | spa |
| dc.relation.references | Tomasz, A., & Hotchkiss, R. D. (1964). Regulation of the Transformability of Pneumococcal Cultures By Macromolecular Cell Products. Proceedings of the National Academy of Sciences, 51(3), 480–487. https://doi.org/10.1073/pnas.51.3.480 | spa |
| dc.relation.references | Truchado, P., López-Gálvez, F., Gil, M. I., Tomás-Barberán, F. A., & Allende, A. (2009). Quorum sensing inhibitory and antimicrobial activities of honeys and the relationship with individual phenolics. Food Chemistry, 115(4), 1337–1344. https://doi.org/10.1016/j.foodchem.2009.01.065 | spa |
| dc.relation.references | Urbanczyk, H., Ast, J. C., Higgins, M. J., Carson, J., & Dunlap, P. V. (2007). Reclassification of Vibrio fischeri, Vibrio logei, Vibrio salmonicida and Vibrio wodanis as Aliivibrio fischeri gen. nov., comb. nov., Aliivibrio logei comb. nov., Aliivibrio salmonicida comb. nov. and Aliivibrio wodanis comb. nov. International Journal of Systematic and Evolutionary Microbiology, 57(12), 2823–2829. https://doi.org/10.1099/ijs.0.65081-0 | spa |
| dc.relation.references | Vadakkan, K., Choudhury, A. A., Gunasekaran, R., Hemapriya, J., & Vijayanand, S. (2018). Quorum sensing intervened bacterial signaling: Pursuit of its cognizance and repression. Journal of Genetic Engineering and Biotechnology, 16(2), 239–252. https://doi.org/10.1016/j.jgeb.2018.07.001 | spa |
| dc.relation.references | Van Houdt, R., & Michiels, C. W. (2005). Role of bacterial cell surface structures in Escherichia coli biofilm formation. Research in Microbiology, 156(5–6), 626–633. https://doi.org/10.1016/j.resmic.2005.02.005 | spa |
| dc.relation.references | Vasavi, H. S., Arun, A. B., & Rekha, P. D. (2013). Inhibition of quorum sensing in Chromobacterium violaceum by Syzygium cumini L. and Pimenta dioica L. Asian Pacific Journal of Tropical Biomedicine, 3(12), 954–959. https://doi.org/10.1016/S2221-1691(13)60185-9 | spa |
| dc.relation.references | Ved, H. S., Gustow, E., & Pieringer, A. (1984). The Involvement of the Proteinase of Streptococcus fuecium ATCC 9790 in the Stimulation of Its Autolysin Activity by Dodecylglycerol. The Journal of Biological Chemestry, 259(13), 8122–8124. | spa |
| dc.relation.references | Vlad, D. C., Dumitrascu, V., Cornianu, M., Voia, S. O., & Verdes, D. (2013). Functional and morphological alteration in deoxinivalenol ( DON ) induced liver and kidney injuries. 18(6), 8863–8872. | spa |
| dc.relation.references | Walters, M., & Sperandio, V. (2006). Autoinducer 3 and epinephrine signaling in the kinetics of locus of enterocyte effacement gene expression in enterohemorrhagic Escherichia coli. Infection and Immunity, 74(10), 5445–5455. https://doi.org/10.1128/IAI.00099-06 | spa |
| dc.relation.references | Wang, B., & Muir, T. W. (2016). Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles. Cell Chemical Biology, 23(2), 214–224. https://doi.org/10.1016/j.chembiol.2016.01.004 | spa |
| dc.relation.references | Wilkinson, A., Danino, V., Wisniewski-Dyé, F., Lithgow, J. K., & Downie, J. A. (2002). N-acyl-homoserine lactone inhibition of rhizobial growth is mediated by two quorum-sensing genes that regulate plasmid transfer. Journal of Bacteriology, 184(16), 4510–4519. https://doi.org/10.1128/JB.184.16.4510-4519.2002 | spa |
| dc.relation.references | Winzer, K., Hardie, K. R., Burgess, N., Doherty, N., Kirke, D., Holden, M. T. G., … Williams, P. (2002). LuxS : its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)- furanone. Microbiology, 148(2002), 909–922. https://doi.org/10.1099/00221287-148-4-909 | spa |
| dc.relation.references | Won, S. R., Hong, M. J., Kim, Y. M., Li, C. Y., Kim, J. W., & Rhee, H. I. (2007). Oleic acid: An efficient inhibitor of glucosyltransferase. FEBS Letters, 581(25), 4999–5002. https://doi.org/10.1016/j.febslet.2007.09.045 | spa |
| dc.relation.references | Wood, P. L., Mankidy, R., Ritchie, S., Heath, D., Wood, J. A., Flax, J., & Goodenowe, D. B. (2010). Circulating plasmalogen levels and Alzheimer Disease Assessment Scale-Cognitive scores in Alzheimer patients. Journal of Psychiatry and Neuroscience, 35(1), 59–62. https://doi.org/10.1503/jpn.090059 | spa |
| dc.relation.references | Yoon, B. K., Jackman, J. A., Valle-González, E. R., & Cho, N. J. (2018). Antibacterial free fatty acids and monoglycerides: Biological activities, experimental testing, and therapeutic applications. International Journal of Molecular Sciences, 19(4). https://doi.org/10.3390/ijms19041114 | spa |
| dc.rights | Derechos reservados - Universidad Nacional de Colombia | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.license | Atribución-NoComercial-SinDerivadas 4.0 Internacional | spa |
| dc.rights.spa | Acceso abierto | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | spa |
| dc.subject.ddc | 570 - Biología | spa |
| dc.subject.ddc | 540 - Química y ciencias afines | spa |
| dc.subject.proposal | Inhibición | spa |
| dc.subject.proposal | Inhibition | eng |
| dc.subject.proposal | Concentración | spa |
| dc.subject.proposal | Concentration | eng |
| dc.subject.proposal | Alkylglycerols | eng |
| dc.subject.proposal | Alquilglicerol lípidos | spa |
| dc.subject.proposal | Strains | eng |
| dc.subject.proposal | Cepas | spa |
| dc.subject.proposal | Aislados clínicos | spa |
| dc.subject.proposal | Clinical isolates | eng |
| dc.title | Estudio de la actividad biológica de alquilglicerol lípidos análogos a compuestos de origen marino contra aislados de origen clínico | spa |
| dc.type | Trabajo de grado - Maestría | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_bdcc | spa |
| dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/masterThesis | spa |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | spa |
| oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |