Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional
| dc.contributor.advisor | Ruíz Villa, Carlos Alberto | |
| dc.contributor.advisor | Patiño Arcila, Iván David | |
| dc.contributor.author | Vélez Salazar, Fabián Mauricio | |
| dc.contributor.cvlac | https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001521879 | spa |
| dc.contributor.googlescholar | https://scholar.google.com/citations?user=56Sj_tYAAAAJ&hl=es | spa |
| dc.contributor.orcid | Vélez Salazar, Fabián Mauricio [0000-0002-7299-5970] | spa |
| dc.contributor.researchgate | https://www.researchgate.net/profile/Fabian-Velez-Salazar | spa |
| dc.date.accessioned | 2023-05-29T19:47:45Z | |
| dc.date.available | 2023-05-29T19:47:45Z | |
| dc.date.issued | 2022-07 | |
| dc.description | ilustraciones, | spa |
| dc.description.abstract | Los modelos de electroporación y electroquimioterapia son esquemas teóricos que describen procesos electrofisiológicos basados en formulaciones matemáticas que ayudan a comprender y predecir el comportamiento de fenómenos de transporte y dosificación de medicamentos mediante modelado y simulación computacional. En este trabajo se simuló el transporte de masa en tejidos electroporados usando técnicas sin malla mediante un estudio paramétrico de la influencia del voltaje y el espaciamiento entre pulsos en la eficiencia, agresividad y uniformidad del proceso de electroporación analizando el cambio de concentración de medicamentos entre los espacios extracelular e intracelular. Se utilizó el método de Funciones de Base Radial (RBF) para resolver el sistema de ecuaciones diferenciales del fenómeno y se simuló el transporte de fármacos quimioterapéuticos clásicos en tejidos electroporados a través del Método Global MAPS, estudiando la influencia de las dos variables sobre la magnitud y distribución del campo eléctrico, las concentraciones extracelulares e intracelulares y la eficiencia y agresividad del protocolo de electroporación. Los análisis se centran en la comparación de la respuesta de dos medicamentos quimioterapéuticos al cambio de los parámetros de electroporación y la influencia de esta respuesta en la eficiencia y agresividad del tratamiento. Se obtuvo que para ambos medicamentos la agresividad es inversamente proporcional al espaciamiento entre pulsos y directamente proporcional al voltaje. Para el protocolo menos agresivo de ambos medicamentos la eficacia es adecuada para la doxorrubicina y muy baja para el cisplatino. Como conclusión, la agresividad de un protocolo no es necesariamente proporcional a su eficacia; esta relación es determinada por el tipo de medicamento (texto tomado de la fuente) | spa |
| dc.description.abstract | Electroporation and electrochemotherapy models are theoretical schemes that describe electrophysiological processes based on mathematical formulations that help to understand and predict the behavior of drug transport and dosing phenomena through modeling and computational simulation. In this work, mass transport in electroporated tissues was simulated using mesh-free techniques through a parametric study of the influence of voltage and pulse spacing on the efficiency, aggressiveness and uniformity of the electroporation process by analyzing the change in drug concentration between the extracellular and intracellular spaces. The Radial Basis Functions (RBF) method was used to solve the system of differential equations of the phenomenon and the transport of classical chemotherapeutic drugs in electroporated tissues was simulated through the Global MAPS Method, studying the influence of the two variables on the magnitude and distribution of the electric field, the extracellular and intracellular concentrations and the efficiency and aggressiveness of the electroporation protocol. The analyses focus on the comparison of the response of two chemotherapeutic drugs to the change of the electroporation parameters and the influence of this response on the efficiency and aggressiveness of the treatment. It was obtained that for both drugs aggressiveness is inversely proportional to pulse spacing and directly proportional to voltage. For the less aggressive protocol of both drugs the efficacy is adequate for doxorubicin and very low for cisplatin. As a conclusion, the aggressiveness of a protocol is not necessarily proportional to its efficacy; this relationship is determined by the type of drug | eng |
| dc.description.curriculararea | Área Curricular de Ingeniería Administrativa e Ingeniería Industrial | spa |
| dc.description.degreelevel | Doctorado | spa |
| dc.description.degreename | Doctor en Ingeniería | spa |
| dc.description.researcharea | Organizaciones, Gestión Tecnológica y Tic’s | spa |
| dc.format.extent | 206 páginas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.instname | Universidad Nacional de Colombia | spa |
| dc.identifier.reponame | Repositorio Institucional Universidad Nacional de Colombia | spa |
| dc.identifier.repourl | https://repositorio.unal.edu.co/ | spa |
| dc.identifier.uri | https://repositorio.unal.edu.co/handle/unal/83900 | |
| dc.language.iso | spa | spa |
| dc.publisher | Universidad Nacional de Colombia | spa |
| dc.publisher.branch | Universidad Nacional de Colombia - Sede Medellín | spa |
| dc.publisher.faculty | Facultad de Minas | spa |
| dc.publisher.place | Medellín, Colombia | spa |
| dc.publisher.program | Medellín - Minas - Doctorado en Ingeniería - Industria y Organizaciones | spa |
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| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.license | Reconocimiento 4.0 Internacional | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | spa |
| dc.subject.ddc | 000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación | spa |
| dc.subject.ddc | 620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería | spa |
| dc.subject.ddc | 000 - Ciencias de la computación, información y obras generales::006 - Métodos especiales de computación | spa |
| dc.subject.lemb | Electroporación - Modelos matemáticos | |
| dc.subject.proposal | Cáncer | spa |
| dc.subject.proposal | Modelos matemáticos | spa |
| dc.subject.proposal | Simulación biocomputacional | spa |
| dc.subject.proposal | Concentración extra-intracelular | spa |
| dc.subject.proposal | Electroporación | spa |
| dc.subject.proposal | Electroquimioterapia | spa |
| dc.subject.proposal | Cancer | eng |
| dc.subject.proposal | Mathematical models | eng |
| dc.subject.proposal | Biocomputational simulation | eng |
| dc.subject.proposal | Extra-intracellular concentration | eng |
| dc.subject.proposal | Electroporation | eng |
| dc.subject.proposal | Electrochemotherapy | eng |
| dc.subject.wikidata | Electroporación | |
| dc.subject.wikidata | Electroquimioterapia | |
| dc.title | Respuesta del cáncer al tratamiento mediante quimioterapia y terapia electroquímica utilizando modelado y simulación biocomputacional | spa |
| dc.title.translated | Response of cancer to treatment by chemotherapy and electrochemical therapy using biocomputational modeling and simulation | eng |
| dc.type | Trabajo de grado - Doctorado | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_db06 | spa |
| dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/doctoralThesis | spa |
| dc.type.redcol | http://purl.org/redcol/resource_type/TD | spa |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | spa |
| dcterms.audience.professionaldevelopment | Público general | spa |
| oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
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