Propiedades biológicas y actividad antioxidante del corozo (Bactris guineensis) del Caribe Colombiano

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dc.contributor.advisorRojano, Benjamín Alberto
dc.contributor.advisorRugeles López, María Teresa
dc.contributor.authorJaimes Gualdrón, Tania Rocío
dc.contributor.orcidJaimes, Tania [0000-0003-3146-1718]spa
dc.contributor.researchgroupAlimentos y Nutraceuticosspa
dc.date.accessioned2024-11-11T17:05:44Z
dc.date.available2024-11-11T17:05:44Z
dc.date.issued2020
dc.descriptionIlustraciones, gráficasspa
dc.description.abstractLas especies reactivas del oxígeno (EROs) pueden causar daño oxidativo a biomoléculas importantes en la célula, por lo que surge la necesidad de consumir antioxidantes exógenos en la dieta de fuentes vegetales, como por ejemplo las antocianinas, las cuales son compuestos con múltiples propiedades biológicas. Así, el propósito de esta investigación fue preparar un extracto de corozo (Bactris guineensis), fruta del Caribe Colombiano, determinar su contenido de metabolitos de interés, entre ellos las antocianinas, y evaluar su actividad antioxidante y antimicrobiana frente a bacterias y virus en modelos in vitro, así como su efecto en la viabilidad de células cancerosas. Para esto se utilizó extracción química para obtener el extracto, métodos colorimétricos y fluorimétricos para determinar el contenido de metabolitos y la actividad antioxidante, y ensayos en cultivos celulares para determinar las propiedades biológicas. El extracto mostró un alto contenido de metabolitos, en especial antocianinas, buena actividad antioxidante, gran inhibición del crecimiento bacteriano (Klebsiella sp. y Staphylococcus sp.) y de infección viral (FLUAV y VIH-1), y finalmente disminuyó la viabilidad de células de cáncer de próstata murino y humano. De esta manera, se logró obtener un extracto promisorio con excelentes propiedades biológicas. (Tomado de la fuente)spa
dc.description.abstractReactive oxygen species (ROS) can cause oxidative damage to important biomolecules in cells, and that is why there is an increasing need to consume exogenous antioxidants in the diet from vegetable sources; for example anthocyanins, which are compounds with multiple biological properties. Therefore, the purpose of this research was to prepare an extract from corozo (Bactris guineensis), fruit from the Colombian Caribbean, determine its content of metabolites of interest, and evaluate its antioxidant and antimicrobial activity against bacteria and virus in vitro models, as well as its effect on cancer cells. To accomplish this objective, chemical extraction was used to obtain the extract, colorimetric and fluorimetric methods to determine metabolite content and antioxidant activity, and cell culture assays to determine biological properties. The extract showed a high metabolite content, especially in anthocyanins, a good antioxidant activity, great inhibition of bacterial (Klebsiella sp. and Staphylococcus sp.) growth and viral (FLUAV and HIV-1) infection, and finally, it decreased the viability of murine and human prostate cancer cells. From all this, we managed to obtain a promising extract with excellent biological properties.eng
dc.description.curricularareaBiotecnología.Sede Medellínspa
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ciencias - Biotecnologíaspa
dc.description.researchareaCiencia de los alimentosspa
dc.description.sponsorshipUniversidad Nacional de Colombia - Sede Medellín Sede de Investigación Universitaria (SIU) - Universidad de Antioquia (UdeA) Istituto di Chimica Biomolecolare - Consiglio Nazionale delle Ricerche (ICV-CNR) en Nápoles, Italiaspa
dc.format.extent82 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/87167
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Medellínspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeMedellín, Colombiaspa
dc.publisher.programMedellín - Ciencias - Maestría en Ciencias - Biotecnologíaspa
dc.relation.indexedLaReferenciaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc540 - Química y ciencias afines::543 - Química analíticaspa
dc.subject.ddc580 - Plantas::582 - Plantas destacadas por características vegetativas y floresspa
dc.subject.ddc660 - Ingeniería química::664 - Tecnología de alimentosspa
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.lembCáncer - Aspectos inmunológicos
dc.subject.lembCáncer - Investigaciones
dc.subject.lembAntioxidantes
dc.subject.proposalfrutaspa
dc.subject.proposalantocianinasspa
dc.subject.proposalantioxidantespa
dc.subject.proposalantimicrobianaspa
dc.subject.proposalvirusspa
dc.subject.proposalbacteriaspa
dc.subject.proposalcáncerspa
dc.subject.proposalfruiteng
dc.subject.proposalanthocyaninseng
dc.subject.proposalantioxidanteng
dc.subject.proposalantimicrobialeng
dc.subject.proposalviruseng
dc.subject.proposalbacteriaeng
dc.subject.proposalcancereng
dc.titlePropiedades biológicas y actividad antioxidante del corozo (Bactris guineensis) del Caribe Colombianospa
dc.title.translatedBiological properties and antioxidant activity of corozo (Bactris guineensis) of the Colombian Caribbeaneng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
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dcterms.audience.professionaldevelopmentMaestrosspa
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oaire.awardtitlePropiedades biológicas y actividad antioxidante del corozo (Bactris guineensis) del Caribe Colombianospa
oaire.fundernameUniversidad Nacional de Colombiaspa

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