Participación de las proyecciones comisurales en los potenciales provocados en la corteza motora primaria de las vibrisas por estimulación somatosensorial

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dc.contributor.advisorMúnera Galarza, Francisco Alejandrospa
dc.contributor.authorMartínez Porras, Alejandra Lucíaspa
dc.contributor.researchgatehttps://www.researchgate.net/profile/Alejandra_Lucia_Martinez_Porrasspa
dc.date.accessioned2024-05-29T23:05:17Z
dc.date.available2024-05-29T23:05:17Z
dc.date.issued2024-05-11
dc.descriptionilustraciones, diagramasspa
dc.description.abstractEstudiar la integración de la información sensorial y motora es fundamental para comprender cómo logramos coordinar y planear nuestros movimientos con exactitud y ejecutarlos acorde a lo que percibimos del mundo exterior y de nuestro propio cuerpo. Debido a la complejidad de los circuitos involucrados y lo invasivo que puede ser estudiarlos en humanos, el uso de modelos animales resulta fundamental. Un sistema sensoriomotor ampliamente utilizado es el las vibrisas en roedores, debido a las facilidades que brinda para estudiar la integración de información sensorial y motora, la plasticidad sináptica dependiente de experiencia e inducida experimentalmente y el aprendizaje motor. Este sistema es de suma importancia ecológica para los roedores y está formado por estructuras subcorticales y corticales ampliamente interconectadas. Las proyecciones comisurales de la corteza motora primaria de las vibrisas (vM1) a la corteza homotópica contralateral son fundamentales para la sincronización bilateral del batido de las vibrisas. Sin embargo, no hay estudios previos sobre la participación de las conexiones comisurales en el procesamiento somatosensorial en vM1. Por esto, en esta tesis se estudió la participación de las conexiones comisurales en los potenciales provocados en vM1 por estimulación eléctrica del parche de vibrisas; para ello, se compararon las respuestas provocadas en vM1i y vM1d por estimulación en el parche de vibrisas izquierdo (WPi) antes y después de inactivar transitoriamente vM1i mediante una inyección de lidocaína al 2\% (LIDO2) o al 5\% (LIDO5). La lidocaína inyectada en vM1i afectó de manera concentración-dependiente el funcionamiento de vM1 ipsilateral y contralateral. Con LIDO2 disminuyó la respuesta cortical ipsilateral hasta los 20 minutos y aumentó de forma sostenida hasta los 140 min en la contralateral; con LIDO5 disminuyó la respuesta en vM1i de forma sostenida hasta los 140 minutos, mientras que en vM1d aumentó inicialmente y luego disminuyó entre los 80 y 140 minutos. En términos de la respuesta al segundo de un par de pulsos: 1) con IIE de 50 ms, LIDO5 desfacilitó la respuesta en vM1i y vM1d, mientras que LIDO2 solo la desfacilitó inicialmente en vM1d; 2) con IIE de 200 ms, LIDO2 desfacilitó de forma continua la respuesta en vM1i, pero sólo transitoriamente en vM1d; y, 3) con IIE de 400 ms, LIDO2 desfacilitó tardíamente la respuesta en ambas cortezas. Las inyecciones de LIDO2 y LIDO5 en vM1i afectaron la actividad neuronal oscilatoria en ambas cortezas, alterando la potencia espectral y la organización temporal en distintas bandas de frecuencia, tanto en la actividad espontánea como en la provocada por estimulación en el parche de vibrisas izquierdo. En conclusión, la inyección intracortical de lidocaína modifica la actividad del circuito no sólo en la corteza inyectada, sino también en la contralateral; este efecto varía en función de la dosis indicando que la interacción comisural en vM1 tiene un carácter dual, inhibidor y excitador, con capacidad para modular el procesamiento sensorial en el circuito de vM1. Además, las modificaciones dependientes de la dosis en la potencia espectral y la organización temporal de la actividad oscilatoria en diferentes bandas de frecuencia sugieren que tales oscilaciones dependen de diferentes poblaciones de interneuronas inhibidoras con diferentes sensibilidades ante la lidocaína. (Texto tomado de la fuente).spa
dc.description.abstractStudying the integration of sensory and motor information is essential to understanding how we coordinate and plan our movements accurately and execute them according to what we perceive from the outside world and our own body. Due to the complexity of the circuits involved and the invasiveness of studying them in humans, the use of animal models is crucial. A widely used sensorimotor system is the whisker system in rodents, which offers advantages for studying the integration of sensory and motor information, experience-dependent and experimentally induced synaptic plasticity, and motor learning. This system is of significant ecological importance for rodents and is composed of extensively interconnected subcortical and cortical structures. Commissural projections from the primary motor cortex of the whiskers (vM1) to the contralateral homotopic cortex are fundamental for the bilateral synchronization of whisker movements. However, there are no previous studies on the role of commissural connections in somatosensory processing in vM1. Therefore, this thesis studied the role of commissural connections in the potentials evoked in vM1 by electrical stimulation of the whisker pad. The evoked responses in ipsilateral (vM1i) and contralateral (vM1d) vM1 by stimulation of the left whisker pad (WPi) were compared before and after transiently inactivating vM1i with a 2 % (LIDO2) or 5 % (LIDO5) lidocaine injection. Lidocaine injected into vM1i affected the functioning of both ipsilateral and contralateral vM1 in a concentration-dependent manner. With LIDO2, the ipsilateral cortical response decreased up to 20 minutes and then increased steadily up to 140 minutes in the contralateral cortex; with LIDO5, the response in vM1i decreased consistently up to 140 minutes, while in vM1d it initially increased and then decreased between 80 and 140 minutes. Regarding the response to the second of a pair of pulses, with an inter-interval of 50 ms, LIDO5 decreased the facilitation of the response in vM1i and vM1d, while LIDO2 only initially decreased the facilitation in vM1d. With an inter-interval of 200 ms, LIDO2 continuously decreased the facilitation in vM1i, but only transiently in vM1d. With an inter-interval of 400 ms, LIDO2 decreased the facilitation in both cortices at a later time. LIDO2 and LIDO5 injections in vM1i affected neuronal oscillatory activity in both cortices, altering the spectral power and temporal organization in different frequency bands, in both spontaneous and whisker pad stimulation-induced activity. In conclusion, intracortical lidocaine injection modifies circuit activity not only in the injected cortex but also in the contralateral cortex; this effect varies depending on the dose, indicating that commissural interaction in vM1 has a dual inhibitory and excitatory nature, with the ability to modulate sensory processing in the vM1 circuit. Additionally, dose-dependent modifications in spectral power and the temporal organization of oscillatory activity in different frequency bands suggest that such oscillations depend on different populations of inhibitory interneurons with varying sensitivities to lidocaine.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Neurocienciasspa
dc.description.researchareaNeurofisiología comportamentalspa
dc.format.extent123 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86185
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina - Maestría en Neurocienciasspa
dc.relation.indexedBiremespa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
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dc.subject.ddc570 - Biología::571 - Fisiología y temas relacionadosspa
dc.subject.decsVibrisas/fisiologíaspa
dc.subject.decsVibrissae/physiologyeng
dc.subject.decsCorteza Motoraspa
dc.subject.decsMotor Cortexeng
dc.subject.decsLidocaínaspa
dc.subject.decsLidocaineeng
dc.subject.proposalIntegración sensoriomotoraspa
dc.subject.proposalVibrisas en roedoresspa
dc.subject.proposalCorteza motora primariaspa
dc.subject.proposalConexiones interhemisféricasspa
dc.subject.proposalSensorimotor integrationeng
dc.subject.proposalWhiskers in rodentseng
dc.subject.proposalPrimary motor cortexeng
dc.subject.proposalInterhemispheric connectionseng
dc.titleParticipación de las proyecciones comisurales en los potenciales provocados en la corteza motora primaria de las vibrisas por estimulación somatosensorialspa
dc.title.translatedParticipation of commissural projections in the evoked potentials in the primary motor cortex of the vibrissae by somatosensory stimulationeng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
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dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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