Viscosidad cinemática de mezclas ternarias formadas por agua, alcohol, propilenoglicol y glicerin formal a 25.0 °c
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Arias, Lina
Díaz, Andrea
Martinez, Fleming
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EspañolFecha de publicación
2004
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Como una contribución a la generación, organización y sistematización de datos relacionados con las características de mezclas líquidas ternarias de uso farmacéutico, que sirvan de soporte básico en la formulación de formas farmacéuticas líquidas y que sean útiles para la elección cada vez más racional de sistemas solventes, en este trabajo se presenta la viscosidad cinemática de los sistemas agua-alcohol-propilenoglicol, agua-alcohol-glicerin formal, agua-propilenoglicol-glicerin formal y alcohol-propilenoglicol-glicerin formal estudiada a 25.0 °C. Los resultados obtenidos se presentan de forma de tablas y de coordenadas cartesianas y triangulares, encontrando grandes desviaciones al comportamiento aditivo-logarítmico en casi todos los casos estudiados.
As a contribution in generate and compiling information about the physical behavior of several ternary liquid mixtures used as vehicles in the design of liquid pharmaceutical dosage forms, the kinematic viscosity was determined at 25.0 °C for cosolvent mixtures obtained by mixing purified water, alcohol, propylene glycol, and glycerin formal, that is, solvents commonly used in parenteral medications. The results are presented as tables and Cartesian and triangular graphics. High deviations respect to logarithmic-additive behavior were found in almost the totality of cases studied
As a contribution in generate and compiling information about the physical behavior of several ternary liquid mixtures used as vehicles in the design of liquid pharmaceutical dosage forms, the kinematic viscosity was determined at 25.0 °C for cosolvent mixtures obtained by mixing purified water, alcohol, propylene glycol, and glycerin formal, that is, solvents commonly used in parenteral medications. The results are presented as tables and Cartesian and triangular graphics. High deviations respect to logarithmic-additive behavior were found in almost the totality of cases studied