Variantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemática

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dc.contributor.advisorRey Buitrago, Mauricio
dc.contributor.authorRomero Fonseca, Adriana Zuleny
dc.contributor.researchgroupGenética clínicaspa
dc.date.accessioned2023-04-12T16:20:59Z
dc.date.available2023-04-12T16:20:59Z
dc.date.issued2023-04-11
dc.descriptionilustracionesspa
dc.description.abstractRevisión sistemática de la literatura donde se reporta el resultado de la búsqueda de variantes en genes del Sistema Antígeno Leucocitario Humano y TNF- α asociadas a los fenotipos periodontitis crónica y agresiva, y su posible desequilibrio de ligamiento. La periodontitis es una enfermedad infecciosa que afecta los tejidos de soporte del diente (hueso y encía), dentro de sus presentaciones más comunes se encuentran la periodontitis crónica y la periodontitis agresiva. El TNF-α es una citoquina involucrada en el desarrollo y progresión de la enfermedad periodontal tanto crónica como agresiva; el gen del TNF-α se encuentra dentro de los genes HLA III en el cromosoma 6, dichos genes son heredados en bloque junto con HLA I y HLA II (desequilibrio de ligamiento). Debido a su papel en el desarrollo de la enfermedad periodontal las variantes de TNF-α, HLA I y II pueden llegar a ser indicativos de susceptibilidad a padecer enfermedad periodontal. (Texto tomado de la fuente)spa
dc.description.abstractSystematic review of the literature where the results of the search for variants in genes of the Human Leukocyte Antigen System and TNF-α associated with the chronic and aggressive periodontitis phenotypes, and their possible linkage disequilibrium, are reported. Periodontitis is an infectious disease that affects the supporting tissues of the tooth (bone and gum), among its most common presentations are chronic periodontitis and aggressive periodontitis. TNF-α is a cytokine involved in the development and progression of both chronic and aggressive periodontal disease; the TNF-α gene is found within the HLA III genes on chromosome 6, these genes are inherited en bloc along with HLA I and HLA II (linkage disequilibrium). Due to their role in the development of periodontal disease, TNF-α, HLA I and II variants may become indicative of susceptibility to periodontal disease.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Inmunologíaspa
dc.description.methodsSe realizó una búsqueda de artículos (Pubmed, Wiley online library, Web of science); se tuvo como criterio de inclusión el uso de criterios para el diagnóstico de enfermedad periodontal según la clasificación de 1999 y la determinación y/o análisis de variantes en genes HLA, TNF o en todo el grupo de genes MHC evaluando su asociación con enfermedad periodontal; se excluyeron artículos que no estuviesen escritos en inglés o español, revisiones sistemáticas y/o metaanálisis, estudios en animales, evaluación de periodontitis apical o enfermedad peri-implantar, workshops o abstracts. La determinación del riesgo de sesgo se realizó a través de New Castle Otawa Scale. Para la determinación de la asociación se tomó como variable independiente el polimorfismo estudiado en cada uno de los estudios, la variable dependiente es el estado de salud periodontal. Las medidas de asociación debieron determinarse por pruebas estadísticas validadas para dicho fin (chi cuadrado, prueba de Fisher) y se reconoció entonces el valor p, en adición el valor de OR/RR: mayor a 1 se consideró como una asociación positiva y los valores menores a 1 con asociación negativa. La síntesis de datos se realizó basado en la presentación o no de la variante de TNF-A o de HLA, según esta variante se examinó la relación con los fenotipos de enfermedad periodontal (crónica y agresiva), para el desequilibrio de ligamiento se revisaron las asociaciones múltiples.spa
dc.format.extentxv, 34 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/83699
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.placeBogotá,Colombiaspa
dc.publisher.programBogotá - Medicina - Maestría en Inmunologíaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc610 - Medicina y saludspa
dc.subject.decsPeriodontitis crónicaspa
dc.subject.decsChronic Periodontitiseng
dc.subject.decsControl de infección dentalspa
dc.subject.decsInfection Control, Dentaleng
dc.subject.proposalTNF-α
dc.subject.proposalHLA
dc.subject.proposalPeriodontitis cronicaspa
dc.subject.proposalPeriodontitis agresivaspa
dc.subject.proposalDesequilibrio de ligamientospa
dc.subject.proposalSNV
dc.subject.proposalChronic periodontitiseng
dc.subject.proposalAggressive periodontitiseng
dc.subject.proposalLinkage disequilibrium
dc.titleVariantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemáticaspa
dc.title.translatedGene variants in the Human Leukocyte Antigen (HLA) system and TNF alpha in chronic and aggressive periodontitis phenotypes: a systematic revieweng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
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oaire.awardtitleVariantes génicas en el sistema del Antígeno Leucocitario Humano (HLA) y TNF alfa en fenotipos de periodontitis crónica y agresiva: una revisión sistemáticaspa

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Tesis de Maestría en Inmunología
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Maestría en Inmunología