Caracterización de los pacientes con Diagnóstico de linfoma B difuso de célula Grande en el Instituto Nacional de Cancerología
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Ospina Idárraga, Juan Alejandro
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Trabajo de grado - Pregrado
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2015
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Los Linfomas B Difusos de Células Grandes (LBDCG) son los linfomas no Hodgkin más frecuentes en adultos, subdividiéndose según variantes morfológicas e inmunofenotipo. Actualmente en Europa y Estados Unidos, se estima una incidencia de Linfomas no Hodgkin entre 15-20 casos/100.000 habitantes, siendo los LBDCG el 31% y el 37% de los tumores derivados de células B a nivel global. A pesar de ser los LBDCG un grupo de enfermedades con gran impacto en tasas de morbilidad y mortalidad, no existen estudios en la población Colombiana que identifiquen las características de esta enfermedad. En el presente estudio describimos de forma sistemática las características clínicas, histopatológicas e inmunofenotípicas de la población con diagnóstico de LBDCG que ha sido diagnosticada y ha recibido tratamiento en el Instituto Nacional de Cancerología de Colombia en el período comprendido entre Enero de 2009 y Diciembre de 2013, con la validación del Índice Pronóstico Internacional.
Abstract. Diffuse Large B Cell Lymphomas (DLBCL) are the most frequent non Hodgkin’s lymphomas in adult population, they are classiffied according morphologic variants and immunophenotype. At present in Europe and United States Non Hodgkin’s lymphoma’s incidence is estimated between 15-20 cases/100.000 population, being DLBCL 31% and 37% of all B-Cell derived tumors worldwide. Even though DLBCL are a group of diseases with great impact in morbidity and mortality rates, there are no publications in Colombian population that allow to identify its caractheristics. In the present study we describe in a systematic way the clinical, histopathological and immunophetotypical features of patients with DLBCL that has been diagnosticated and has recieved treatment in Nacional Cancer Institute of Colombia in the period between January of 2009 and December of 2013, with the validation of International Prognostic Index.
Abstract. Diffuse Large B Cell Lymphomas (DLBCL) are the most frequent non Hodgkin’s lymphomas in adult population, they are classiffied according morphologic variants and immunophenotype. At present in Europe and United States Non Hodgkin’s lymphoma’s incidence is estimated between 15-20 cases/100.000 population, being DLBCL 31% and 37% of all B-Cell derived tumors worldwide. Even though DLBCL are a group of diseases with great impact in morbidity and mortality rates, there are no publications in Colombian population that allow to identify its caractheristics. In the present study we describe in a systematic way the clinical, histopathological and immunophetotypical features of patients with DLBCL that has been diagnosticated and has recieved treatment in Nacional Cancer Institute of Colombia in the period between January of 2009 and December of 2013, with the validation of International Prognostic Index.