Estudio de la actividad de un extracto de cálices de Physalis peruviana sobre estrés oxidativo en roedores con diabetes mellitus tipo II

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dc.contributor.advisorOspina Giraldo, Luis Fernandospa
dc.contributor.advisorModesti Costa, Geisonspa
dc.contributor.authorValderrama Parra, Ivonne Helenaspa
dc.contributor.researchgroupPrincipios Bioactivos en Plantas Medicinalesspa
dc.date.accessioned2024-01-16T00:39:47Z
dc.date.available2024-01-16T00:39:47Z
dc.date.issued2023
dc.descriptionilustraciones, diagramasspa
dc.description.abstractEstudio de la actividad de un extracto de cálices de Physalis peruviana sobre estrés oxidativo en roedores con diabetes mellitus tipo II Se ha demostrado que el estrés oxidativo juega un papel importante en el desarrollo de complicaciones diabéticas, siendo esta enfermedad un trastorno metabólico caracterizado principalmente por obesidad, hiperglucemia, perfil lipídico alterado, estrés oxidativo y compromiso vascular. Physalis peruviana es una planta utilizada en la medicina tradicional colombiana por sus conocidas actividades como regulador de la glucosa. Este estudio tuvo como objetivo evaluar la actividad antidiabética de un extracto estandarizado de P. peruviana y sus fracciones (en Acetato de Etilo, Butanol y Acuosa). Después de diferentes ensayos de detección, se seleccionó la FBuOH (fracción butanólica) por sus efectos promisorios la para pasar a la siguiente etapa del estudio en ensayos crónicos in vivo en dos biomodelos; uno fue un modelo de diabetes inducida por una dieta High Fat Diet/Streptozotocin (HFD/STZ) en ratones CD-1 y el segundo fue el modelo de síndrome metabólico inducido por la administración de fructosa en agua de bebida, en ratones CD- 1. La FBuOH resultó útil para regular la glucosa en sangre, así como el índice de resistencia a la insulina. Además, el perfil lipídico mostró una mejora en comparación con el grupo no tratado y la dosis de 100 mg/kg demostrando mayor protección contra el estrés oxidativo (niveles de catalasa, superóxido dismutasa y malondialdehído). El análisis histopatológico en varios tejidos evidenció preservación de la estructura pancreática, hepática y renal en la mayoría de los animales tratados. La fracción butanólica de Physalis peruviana a 100 mg/kg mostró resultados beneficiosos en cuanto disminuir la hiperglucemia, hiperlipidemia, el estado de estrés oxidativo y el inflamatorio. En experimentos in vivo la fracción butanólica moduló la expresión de citoquinas proinflamatorias IL-6 e TNF- α en hígado de animales con síndrome metabólico, así como en el modelo de células RAW 264.7, demostrando además en este modelo celular protección frente a la formación de nitritos. La fracción butanólica mejoró el estatus diabético por disminución del estrés oxidativo y las complicaciones adyacentes, por lo que podría considerarse beneficioso como coadyuvante en la terapia de la diabetes mellitus. (Texto tomado de la fuente).spa
dc.description.abstractStudy of the activity of an extract of Physalis peruviana calyxes on oxidative stress in rodents with type II diabetes mellitus It has been shown that oxidative stress plays an important role in the development of diabetic complications, being this disease, a metabolic disorder characterized mainly by obesity, hyperglycemia, altered lipid profile, oxidative stress, and vascular compromise. Physalis peruviana is a plant used in traditional Colombian medicine for its known activities as glucose regulation. This study aimed to evaluate the antidiabetic activity of a standardized extract from P. peruviana and its fraction (FAcEt, FBuOH, and H2O). After different detection tests, and checking the promising effects from the fractions, FBuOH (the butanolic fraction) was selected for its promising effects, to continue to the next stage of the study in chronic in vivo in two biomodels; one is a model of diabetes induced by a High Fat Diet/Streptozotocin (HFD/STZ) diet in CD-1 mice and the second was the model of metabolic syndrome induced by the administration of fructose in drinking water, in CD-1 mice. The FBuOH is exhibited to regulate the blood glucose and insulin resistance index. Also, the lipid profile exhibited improvement compared to the non-treated group, and the dose of 100 mg/kg demonstrated major protection against oxidative stress (catalase, superoxide dismutase, and malondialdehyde levels). Histopathological in several tissues evidenced structure preservation of most of the animals treated. The butanol fraction from Physalis peruviana at 100 mg/kg improved hyperglycemia, hyperlipidemia, oxidative stress, and inflammatory outcome. In in vivo experiments, the butanolic fraction modulated the expression of proinflammatory cytokines IL-6 and TNF-α in the liver of animals with metabolic syndrome, as well as in the RAW 264.7 cell model, also demonstrating in this cell model protection against the formation of nitrites. The butanolic fraction improved diabetic status by reducing oxidative stress and related complications, so it could be considered beneficial as an adjuvant in diabetes mellitus therapy. Keywords: Flavonoid, rutin, polyphenols, antioxidant, lipid profile, hyperglycemia, metabolic syndrome, Physalis peruviana.eng
dc.description.degreelevelDoctoradospa
dc.description.degreenameDoctor en Ciencias Farmacéuticasspa
dc.format.extentxviii, 126 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/85315
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Doctorado en Ciencias Farmacéuticasspa
dc.relation.indexedBiremespa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.decsdiabetes mellitus/veterinariaspa
dc.subject.decsDiabetes Mellitus/veterinaryeng
dc.subject.decsdiabetes mellitus/farmacoterapiaspa
dc.subject.decsDiabetes Mellitus/drug therapyeng
dc.subject.decsantioxidantes/síntesis químicaspa
dc.subject.decsAntioxidants/chemical synthesiseng
dc.subject.proposalPhysalis peruvianaspa
dc.subject.proposalPhysalis peruvianaeng
dc.subject.proposalFlavonoidespa
dc.subject.proposalFlavonoideng
dc.subject.proposalLipid profileeng
dc.subject.proposalRutinaspa
dc.subject.proposalRutineng
dc.subject.proposalSíndrome metabólicospa
dc.subject.proposalMetabolic syndromeeng
dc.subject.proposalAntioxidantespa
dc.subject.proposalAnioxidanteng
dc.subject.proposalPerfil lipídicospa
dc.subject.proposalPolifenolesspa
dc.subject.proposalPolyphenolseng
dc.subject.proposalHiperglicemiaspa
dc.subject.proposalHyperglycemiaeng
dc.titleEstudio de la actividad de un extracto de cálices de Physalis peruviana sobre estrés oxidativo en roedores con diabetes mellitus tipo IIspa
dc.title.translatedStudy of the activity of an extract of Physalis peruviana calyxes on oxidative stress in rodents with type II diabetes mellituseng
dc.typeTrabajo de grado - Doctoradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_db06spa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/doctoralThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TDspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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