Functional gene expression analysis in canine transmissible cancer and its relationship with biological behavior

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dc.contributor.advisorOsorio Zambrano, William Frendspa
dc.contributor.advisorMontoya Flórez, Luis Mauriciospa
dc.contributor.authorLópez Valbuena, Fabián Danilospa
dc.contributor.researchgroupGrupo de Investigación en Patología Veterinariaspa
dc.date.accessioned2025-09-19T13:28:51Z
dc.date.available2025-09-19T13:28:51Z
dc.date.issued2025-09-18
dc.descriptionilustraciones, diagramasspa
dc.description.abstractCanine Transmissible Venereal Tumor (CTVT) is a clonally transmissible neoplasm characterized by cytomorphological heterogeneity and variable responses to chemotherapy. This preliminary study used RNA-Seq data from 10 CTVT samples to explore transcriptomic differences among cytomorphological subtypes (plasmacytoid, lymphocytoid, and mixed) and among different chemotherapy responses (complete response, partial response, and resistance), through differential gene expression analysis, functional enrichment, and gene co-expression network analyses. Following a literature review, experimental findings are presented in two chapters: The first chapter explores gene expression patterns linked to cytomorphological subtypes, revealing that variations in antigen presentation and immune evasion pathways may underlie the distinct biological behaviors observed across these subtypes. The second chapter examines transcriptomic differences related to chemotherapy outcomes, identifying distinct molecular landscapes related with immune activation and mitochondrial apoptosis regulators. These findings provide initial insights into potential mechanisms driving tumor progression and chemoresistance in CTVT, suggesting candidate biomarkers and therapeutic targets. However, validation in larger cohorts and additional functional studies are required to substantiate these associations and elucidate their clinical significance.eng
dc.description.abstractEl tumor venéreo transmisible canino (CTVT, por sus siglas en inglés) es una neoplasia de transmisión clonal, caracterizada por marcada heterogeneidad citomorfológica y respuesta variable a la quimioterapia. En este estudio preliminar se utilizaron datos de RNA-Seq de 10 muestras de CTVT para explorar las diferencias transcriptómicas entre distintos subtipos citomorfológicos (plasmocitoide, linfocitoide y mixto) y entre diferentes respuestas a la quimioterapia con vincristina (respuesta completa, respuesta parcial y resistencia), mediante análisis de expresión génica diferencial, enriquecimiento funcional y redes de coexpresión génica. Tras una revisión de literatura exhaustiva, los hallazgos experimentales se presentan en dos capítulos. El primer capítulo analiza los patrones de expresión génica asociados a los subtipos citomorfológicos, evidenciando que variaciones en vías de presentación de antígenos y evasión inmune podrían sustentar los comportamientos biológicos distintivos observados entre ellos. El segundo capítulo examina las diferencias transcriptómicas relacionadas con respuesta a la quimioterapia, identificando perfiles moleculares diferenciados asociados con activación inmune y regulación de apoptosis mitocondrial. Estos resultados ofrecen una visión preliminar de posibles mecanismos que impulsan la progresión tumoral y la quimiorresistencia en CTVT, y sugieren potenciales biomarcadores y nuevos blancos terapéuticos. No obstante, se requiere la validación de estos hallazgos en cohortes más amplias y mediante estudios funcionales adicionales para confirmar las asociaciones observadas y esclarecer su relevancia clínica. (Texto tomado de la fuente).spa
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Salud y Producción Animalspa
dc.description.methodsThis preliminary study used RNA-Seq data from 10 CTVT samples to explore transcriptomic differences among cytomorphological subtypes (plasmacytoid, lymphocytoid, and mixed) and among different chemotherapy responses (complete response, partial response, and resistance), through differential gene expression analysis, functional enrichment, and gene co-expression network analyses.eng
dc.description.researchareaPatología veterinariaspa
dc.format.extentxiv, 128 páginasspa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/88921
dc.language.isoeng
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.departmentDepartamento de Salud Animalspa
dc.publisher.facultyFacultad de Medicina Veterinaria y de Zootecniaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción Animalspa
dc.relation.indexedBiremespa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc570 - Biología::576 - Genética y evoluciónspa
dc.subject.decsPerfilación de la Expresión Génicaspa
dc.subject.decsGene Expression Profilingeng
dc.subject.decsNeoplasiasspa
dc.subject.decsNeoplasmseng
dc.subject.proposalCanine transmissible venereal tumoreng
dc.subject.proposalDifferential gene expressioneng
dc.subject.proposalFunctional enrichmenteng
dc.subject.proposalGene co-expressioneng
dc.subject.proposalCytomorphologyeng
dc.subject.proposalChemoresistanceeng
dc.subject.proposalVincristineeng
dc.subject.proposalTumor venéreo transmisible caninospa
dc.subject.proposalExpresión génica diferencialspa
dc.subject.proposalEnriquecimiento funcionalspa
dc.subject.proposalCoexpresión génicaspa
dc.subject.proposalCitomorfologíaspa
dc.subject.proposalQuimiorresistenciaspa
dc.subject.wikidataquimiorresistenciaspa
dc.subject.wikidatachemoresistanceeng
dc.titleFunctional gene expression analysis in canine transmissible cancer and its relationship with biological behavioreng
dc.title.translatedAnálisis funcional de expresión génica en cáncer transmisible canino y su relación con el comportamiento biológicospa
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2

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