Factibilidad técnica y económica de la producción de galactooligosacáridos (GOS) a partir de lactosuero dulce en la región de Nariño

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dc.contributor.advisorNoriega Valencia, Mario Andres
dc.contributor.advisorSerrato Bermúdez, Juan Carlos
dc.contributor.authorMonrroy Quezada, Oscar Javier
dc.contributor.cvlacMonrroy Quezada, Oscar Javier [0002045781]
dc.contributor.orcidMonrroy Quezada, Oscar Javier [0009000283880471]
dc.contributor.researchgroupGrupo de Investigación en Procesos Químicos y Bioquímicos
dc.coverage.countryColombia
dc.coverage.temporalNariño
dc.date.accessioned2025-11-29T22:21:13Z
dc.date.available2025-11-29T22:21:13Z
dc.date.issued2025
dc.descriptionilustraciones a color, diagramas, mapas, tablasspa
dc.description.abstractEl lactosuero dulce es uno de los subproductos más comunes en la industria láctea mundial y posee componentes de la leche como lactosa, proteínas y minerales. Sin embargo, su aprovechamiento es difícil debido a su alto contenido de agua (>93 %). Entre las principales alternativas de aprovechamiento del lactosuero se ha estudiado la síntesis de galactooligosacáridos (GOS) por transgalactosilación enzimática; pero, este proceso no se ha abordado de forma completa desde la adecuación de la materia prima hasta la obtención de los GOS purificados, y tampoco se reportan evaluaciones técnico – económicas completas. En este sentido, este trabajo realizó la evaluación técnica y económica de la producción de GOS a partir de lactosuero dulce. Inicialmente, se realizó un estudio de mercado enfocado en la obtención de lactosuero dulce en Nariño - Colombia, y el mercado de GOS en el mundo; permitiendo recomendar una escala de producción, y una posible ubicación de la planta. Posteriormente, se propusieron el diagrama de flujos de proceso (PFD), los balances de materia y energía, y la estimación de dimensiones de equipos. Finalmente, con esta información se realizó el cálculo del CAPEX y OPEX, para después hallar el valor de la tasa interna de retorno (TIR) y el valor actual neto (VAN) del proceso. El proceso propuesto permite obtener 3.1 ton/día de GOS con un 58 % de pureza a partir del procesamiento de 100.8 ton/día de lactosuero dulce, requiriendo una inversión de 33.033.295 USD y un OPEX de 19.383.185 USD anual; con una TIR del 16 % y un VAN de 6.069.092 USD (Texto tomado de la fuente).spa
dc.description.abstractSweet whey is one of the most common by-products in the global dairy industry and contains milk components such as lactose, proteins and minerals. However, it is difficult to use due to its high-water content (>93%). Among the main alternatives for the use of whey, the synthesis of galactooligosaccharides (GOS) by enzymatic transgalactosylation has been studied; however, this process has not been fully addressed from the adequacy of the raw material to the obtaining of the purified GOS, and complete technical-economic evaluations are not reported. In this sense, this work carried out the technical and economic evaluation of the production of GOS from sweet whey. Initially, a market study was carried out focused on obtaining sweet whey in Nariño-Colombia, and the GOS market in the world, allowing to recommend a scale of production, and a possible location of the plant. Subsequently, the process flow diagram (PFD), the material and energy balances, and the estimation of equipment dimensions were proposed. Finally, with this information, the CAPEX and OPEX calculation were carried out, and then the value of the internal rate of return (IRR) and the net present value (NPV) of the process were found. The proposed process allows obtaining 3.1 tons/day of GOS with 58% purity from the processing of 100.8 tons/day of sweet whey, requiring an investment of 33.033.295 USD and an OPEX of 19.383.185 USD per year; with an IRR of 16% and a NPV of 6.069.092 USD.eng
dc.description.degreelevelMaestría
dc.description.degreenameMagister en Ingenieria Quimica
dc.description.methodsLa metodología descrita en este apartado se desarrolló con el fin de alcanzar los tres objetivos específicos mencionados en la sección anterior. Para el primer objetivo específico se realizó un análisis de mercado exploratorio, enfocado en las materias primas requeridas para la síntesis de los GOS en la región de Nariño: fuentes de lactosuero dulce, la disponibilidad de las enzimas β-galactosidasa y glucosaoxidasa (Gox), acompañado de un análisis de los productores de GOS a nivel nacional e internacional, sus posibles productos competencia a nivel nacional y latinoamericano, y una revisión del mercado global y nacional de otros productos derivados de la síntesis de GOS tales como la proteína en polvo y el ácido glucónico. Posteriormente, tomando como base el análisis de mercado se determinó la oferta de lactosuero a nivel local y la demanda de GOS a nivel nacional e internacional; con ello se determinó la escala de producción de GOS y la posible ubicación de la planta dentro del departamento de Nariño. Luego, con información previa del grupo de investigación se planteó el diagrama de flujo de proceso y se realizó el modelamiento de este, realizando los balances de materia y energía, y el dimensionamiento de los equipos. Finalmente, para la determinación de la factibilidad económica se realizó la estimación de los costos de inversión y operación, valores a partir de los cuales se calcularon indicadores económicos como la tasa interna de retorno (TIR) y el valor actual neto (VAN), y por último se realizaron análisis de sensibilidad para determinar el efecto de los principales costos operativos en la rentabilidad del proceso.
dc.description.researchareaBiorrefinerias
dc.format.extentxx, 159 páginas
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/89163
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
dc.publisher.facultyFacultad de Ingeniería
dc.publisher.placeBogotá, Colombia
dc.publisher.programBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería Química
dc.relation.referencesAli, E., Orfi, J., AlAnsary, H., Soukane, S., Elcik, H., Alpatova, A., & Ghaffour, N. (2021). Cost analysis of multiple effect evaporation and membrane distillation hybrid desalination system. Desalination, 517, 115258. https://doi.org/10.1016/j.desal.2021.115258
dc.relation.referencesAlibaba. (s/f-a). Galacto-oligosaccharide (GOS) Galactooligosaccharides powder 70% Galactooligosaccharides. Galacto-oligosaccharide (GOS) Galactooligosaccharides powder 70% Galactooligosaccharides. Recuperado el 19 de enero de 2024, de https://www.alibaba.com/product-detail/Galacto-oligosaccharide-GOS-Galactooligosaccharides-powder-70_1600762746204.html
dc.relation.referencesAlibaba. (s/f-b). Gluconato de calcio en polvo blanco de grado alimenticio. Gluconato de calcio en polvo blanco de grado alimenticio. Recuperado el 20 de febrero de 2025, de https://spanish.alibaba.com/product-detail/Best-Price-Food-Grade-White-Powder-1601217110134.html
dc.relation.referencesAlibaba. (s/f-c). Glucose oxidase Sunson. Glucose oxidase Sunson. Recuperado el 15 de marzo de 2025, de https://spanish.alibaba.com/product-detail/Food-grade-glucose-oxidase-enzyme-for-60651972590.html
dc.relation.referencesAlibaba. (s/f-d). Lactase Enzyme Powder. Lactase Enzyme Powder. Recuperado el 19 de febrero de 2025, de https://spanish.alibaba.com/product-detail/lactase-enzyme-powder-for-reducing-added-1600899772195.html
dc.relation.referencesAlibaba. (s/f-e). Supply Food Grade Powder Galacto-oligosaccharides/ Galactooligosaccharide Gos With Competitive Price 57%. Supply Food Grade Powder Galacto-oligosaccharides/ Galactooligosaccharide Gos With Competitive Price 57%. Recuperado el 19 de enero de 2024, de https://www.alibaba.com/product-detail/Supply-Food-Grade-Powder-Galacto-oligosaccharides_1600277440533.html
dc.relation.referencesAmazon. (s/f). Oligomate S-HP 17.6 oz (500 g). Oligomate S-HP 17.6 oz (500 g). Recuperado el 19 de enero de 2024, de https://www.amazon.co.jp/-/en/gp/product/B00VDM3IVM/
dc.relation.referencesAmbrogi, V., Bottacini, F., Cao, L., Kuipers, B., Schoterman, M., & Van Sinderen, D. (2023). Galacto-oligosaccharides as infant prebiotics: Production, application, bioactive activities and future perspectives. Critical Reviews in Food Science and Nutrition, 63(6), 753–766. https://doi.org/10.1080/10408398.2021.1953437
dc.relation.referencesAydiner, C., Sen, U., Topcu, S., Ekinci, D., Altinay, A. D., Koseoglu-Imer, D. Y., & Keskinler, B. (2014). Techno-economic viability of innovative membrane systems in water and mass recovery from dairy wastewater. Journal of Membrane Science, 458, 66–75. https://doi.org/10.1016/j.memsci.2014.01.058
dc.relation.referencesBaldasso, C., Barros, T. C., & Tessaro, I. C. (2011). Concentration and purification of whey proteins by ultrafiltration. Desalination, 278(1–3), 381–386. https://doi.org/10.1016/j.desal.2011.05.055
dc.relation.referencesBBI Solutions. (s/f). GO3B3—Glucose oxidase. GO3B3 - Glucose oxidase. Recuperado el 15 de marzo de 2025, de https://www.bbisolutions.com/en/product/glucose-oxidase3
dc.relation.referencesBedzo, O. K. K., Mandegari, M., & Görgens, J. F. (2020). Techno‐economic analysis of inulooligosaccharides, protein, and biofuel co‐production from Jerusalem artichoke tubers: A biorefinery approach. Biofuels, Bioproducts and Biorefining, 14(4), 776–793. https://doi.org/10.1002/bbb.2105
dc.relation.referencesBest Elite. (s/f). Whey Total 2 Lb Best Elite. Whey Total 2 Lb Best Elite. Recuperado el 3 de febrero de 2025, de https://urma3668752.mercadoshops.com.co/MCO-872572389-100-whey-total-2-libras-best-elite-2lb-2libras-pure-protein-_JM
dc.relation.referencesBiosynth. (s/f). β-Galactosidase. β-Galactosidase. Recuperado el 19 de febrero de 2025, de https://www.biosynth.com/p/FL31718/9031-11-2-v-galactosidase-100kug
dc.relation.referencesBulk Supplements. (s/f). Polvo de gluconato de calcio. Polvo de gluconato de calcio. Recuperado el 20 de febrero de 2025, de https://www.bulksupplements.com/es-co/products/gluconato-de-calcio-en-polvo?country=CO&variant=32133383127151
dc.relation.referencesCañete-Rodríguez, A. M., Santos-Dueñas, I. M., Jiménez-Hornero, J. E., Ehrenreich, A., Liebl, W., & García-García, I. (2016). Gluconic acid: Properties, production methods and applications—An excellent opportunity for agro-industrial by-products and waste bio-valorization. Process Biochemistry, 51(12), 1891–1903. https://doi.org/10.1016/j.procbio.2016.08.028
dc.relation.referencesCarl Roth. (s/f). Glucose oxidase (GOD). Glucose oxidase (GOD). Recuperado el 15 de marzo de 2025, de https://www.carlroth.com/com/en/enzymes/glucose-oxidase-%28god%29/p/6028.1
dc.relation.referencesCastro, G. (2020). Desarrollo de un proceso de producción-separación de galactooligosacáridos mediante un sistema acuoso de dos fases asistido por microondas [Tesis de Doctorado]. Universidad Nacional de Colombia.
dc.relation.referencesCHR HANSEN. (s/f). Ha-Lactase 5200. Ha-Lactase 5200. Recuperado el 2 de febrero de 2025, de https://www.dilaco.com/dinamicos/productos/presentacion/PR_07-450804.pdf
dc.relation.referencesClasado BioSciences. (s/f). Bimuno GOS [Ventas]. Bimuno GOS. Recuperado el 1 de septiembre de 2023, de https://clasado.com/bimuno-gos/
dc.relation.referencesCórdova, A., Astudillo, C., Santibañez, L., Cassano, A., Ruby-Figueroa, R., & Illanes, A. (2017). Purification of galacto-oligosaccharides (GOS) by three-stage serial nanofiltration units under critical transmembrane pressure conditions. Chemical Engineering Research and Design, 117, 488–499. https://doi.org/10.1016/j.cherd.2016.11.006
dc.relation.referencesCreative Enzymes. (s/f). Glucose oxidase (Food Grade). Glucose oxidase (Food Grade). Recuperado el 15 de marzo de 2025, de https://www.creative-enzymes.com/product/glucose-oxidase-food-grade-_3170.html
dc.relation.referencesCuartas-Uribe, B., Alcaina-Miranda, M. I., Soriano-Costa, E., Mendoza-Roca, J. A., Iborra-Clar, M. I., & Lora-García, J. (2009). A study of the separation of lactose from whey ultrafiltration permeate using nanofiltration. Desalination, 241(1–3), 244–255. https://doi.org/10.1016/j.desal.2007.11.086
dc.relation.referencesDANE. (s/f). Encuesta Anual Manufacturera. Encuesta Anual Manufacturera (Históricos). Recuperado el 1 de septiembre de 2023, de https://www.dane.gov.co/index.php/estadisticas-por-tema/industria/encuesta-anual-manufacturera-enam/eam-historicos
dc.relation.referencesDSM. (s/f). Oligosacáridos de la leche materna [Empresarial]. Oligosacáridos de la leche materna. Recuperado el 1 de septiembre de 2023, de https://www.dsm.com/human-nutrition/es_LA/products/hmos.html
dc.relation.referencesEMIS. (s/f). Compañias de productos lácteos [Economica]. Compañias. Recuperado el 1 de septiembre de 2023, de https://www-emis-com.hemeroteca.lasalle.edu.co/php/companies
dc.relation.referencesFAO. (s/f-a). Producción de cultivos y productos de ganadería. Cultivos y productos de ganadeía. Recuperado el 1 de septiembre de 2023, de https://www.fao.org/faostat/es/#data/QCL
dc.relation.referencesFAO. (s/f-b). The Global Dairy Sector: Facts.
dc.relation.referencesFEDEGAN. (s/f). Federación Colombiana de Ganaderos: Fondo Nacional del Ganado—Fondo de Estabilización de Precios [Estatal]. Estadisticas : General. Recuperado el 1 de septiembre de 2023, de https://www.fedegan.org.co/estadisticas/general
dc.relation.referencesFischer, C., & Kleinschmidt, T. (2018). Synthesis of Galactooligosaccharides in Milk and Whey: A Review: Synthesis of galactooligosaccharides…. Comprehensive Reviews in Food Science and Food Safety, 17(3), 678–697. https://doi.org/10.1111/1541-4337.12344
dc.relation.referencesFischer, C., & Kleinschmidt, T. (2019). Effect of glucose depletion during the synthesis of galactooligosaccharides using a trienzymatic system. Enzyme and Microbial Technology, 121, 45–50. https://doi.org/10.1016/j.enzmictec.2018.10.009
dc.relation.referencesFischer Scientific. (s/f-a). Calcium Gluconate, Anhydrous, Powder. Calcium Gluconate, Anhydrous, Powder. Recuperado el 20 de febrero de 2025, de https://www.fishersci.com/shop/products/calcium-gluconate-anhydrous-powder-usp-98-102-spectrum-chemical/18601302
dc.relation.referencesFischer Scientific. (s/f-b). MP BiomedicalsTM glucosa oxidasa. MP BiomedicalsTM glucosa oxidasa. Recuperado el 15 de marzo de 2025, de https://www.fishersci.es/shop/products/mp-biomedicals-glucose-oxidase-4/11481092
dc.relation.referencesFlipkart. (s/f). SHARRETS Calcium Gluconate Powder 500g. SHARRETS Calcium Gluconate Powder 500g. Recuperado el 20 de febrero de 2025, de https://www.flipkart.com/sharrets-calcium-gluconate-powder-500g-versatile-food-additive/p/itm2af8415ae2009?pid=VSLGWQX37GGGH4ZP
dc.relation.referencesFriesland Campina. (s/f). Galacto-oligosaccharides products [Ventas]. Galacto-oligosaccharides products. Recuperado el 1 de septiembre de 2023, de https://www.frieslandcampinaingredients.com/ingredient-group/gos/
dc.relation.referencesGlentham. (s/f). Glucose oxidase. Glucose oxidase. Recuperado el 15 de marzo de 2025, de https://www.glentham.com/en/products/product/GZ1910/
dc.relation.referencesGobernación de Nariño. (2020). Plan de Desarrollo: Mi Nariño, en defensa de lo nuestro 2020-2023.
dc.relation.referencesGoldberg, I., & Rokem, J. S. (2009). Organic and Fatty Acid Production, Microbial.
dc.relation.referencesGómez, J. A., & Sánchez, Ó. J. (2022). Producción de galactooligosacáridos: Alternativa para el aprovechamiento del lactosuero. Una revisión. Ingeniería y Desarrollo, 37(01), 129–158. https://doi.org/10.14482/inde.37.1.637
dc.relation.referencesGosling, A., Stevens, G. W., Barber, A. R., Kentish, S. E., & Gras, S. L. (2010). Recent advances refining galactooligosaccharide production from lactose. Food Chemistry, 121(2), 307–318. https://doi.org/10.1016/j.foodchem.2009.12.063
dc.relation.referencesGrupo RBK. (s/f). Gluconato De Sodio. Gluconato De Sodio. Recuperado el 20 de febrero de 2025, de https://www.cometealgo.com.co/MCO-886185627-gluconato-de-sodio-kg-_JM
dc.relation.referencesGuio, F. (2014). EVALUACIÓN DE LA PRODUCCIÓN DE GALACTOOLIGOSACÁRIDOS A PARTIR DE MATERIAS PRIMAS LÁCTEAS CON β- GALACTOSIDASA INMOVILIZADA [Tesis de Maestría]. Universidad Nacional de Colombia.
dc.relation.referencesHapag-Lloyd. (2016). Colombia—Local Charges/Service Fees. Colombia - Local Charges/Service Fees. https://www.hapag-lloyd.com/content/dam/website/downloads/pdf/Local_charges_Service_fees%20Colombia%20Jun%2010%202016.pdf
dc.relation.referencesHaribabu, M., Dunstan, D. E., Martin, G. J. O., Davidson, M. R., & Harvie, D. J. E. (2020). Simulating the ultrafiltration of whey proteins isolate using a mixture model. Journal of Membrane Science, 613, 118388. https://doi.org/10.1016/j.memsci.2020.118388
dc.relation.referencesIllanes, A. (2016). Lactose. En Lactose-Derived Prebiotics (pp. 1–33). Elsevier. https://doi.org/10.1016/B978-0-12-802724-0.00001-9
dc.relation.referencesIndustry ARC. (s/f). Galacto-Oligosaccharides Market—Forecast(2023—2028) [Economica]. Galacto-Oligosaccharides Market - Forecast(2023 - 2028). Recuperado el 1 de septiembre de 2023, de https://www.industryarc.com/Research/Galacto-oligosaccharide-Market-Research-504955
dc.relation.referencesIndustry ARC. (s/f). Galacto-Oligosaccharides Market—Forecast(2023—2028) [Economica]. Galacto-Oligosaccharides Market - Forecast(2023 - 2028). Recuperado el 1 de septiembre de 2023, de https://www.industryarc.com/Research/Galacto-oligosaccharide-Market-Research-504955
dc.relation.referencesInsight Partners. (2021). South & Central America Prebiotic Ingredients Market.
dc.relation.referencesKaur, R., Panwar, D., & Panesar, P. S. (2020). Biotechnological approach for valorization of whey for value-added products. En Food Industry Wastes (pp. 275–302). Elsevier. https://doi.org/10.1016/B978-0-12-817121-9.00013-9
dc.relation.referencesLa Cerva, M., Gurreri, L., Cipollina, A., Tamburini, A., Ciofalo, M., & Micale, G. (2019). Modelling and cost analysis of hybrid systems for seawater desalination: Electromembrane pre-treatments for Reverse Osmosis. Desalination, 467, 175–195. https://doi.org/10.1016/j.desal.2019.06.010
dc.relation.referencesLamichhane, P., Kelly, A. L., & Sheehan, J. J. (2018). Effect of milk centrifugation and incorporation of high-heat-treated centrifugate on the composition, texture, and ripening characteristics of Maasdam cheese. Journal of Dairy Science, 101(7), 5724–5737. https://doi.org/10.3168/jds.2017-14178
dc.relation.referencesLavelli, V., & Beccalli, M. P. (2022). Cheese whey recycling in the perspective of the circular economy: Modeling processes and the supply chain to design the involvement of the small and medium enterprises. Trends in Food Science & Technology, 126, 86–98. https://doi.org/10.1016/j.tifs.2022.06.013
dc.relation.referencesLegiscomex. (2024). Tarifas de transporte de carga por carretera. Tarifas de transporte de carga por carretera.
dc.relation.referencesLievore, P., Simões, D. R. S., Silva, K. M., Drunkler, N. L., Barana, A. C., Nogueira, A., & Demiate, I. M. (2015). Chemical characterisation and application of acid whey in fermented milk. Journal of Food Science and Technology, 52(4), 2083–2092. https://doi.org/10.1007/s13197-013-1244-z
dc.relation.referencesLima, J. C., Bonfim-Rocha, L., Barão, C. E., Coimbra, J. S. R., & Cardozo-Filho, L. (2021). Techno-Economic assessment of α-Lactalbumin and β-Lactoglobulin fractionation from whey protein isolated solution using supercritical carbon dioxide in a continuous reactor. Journal of the Taiwan Institute of Chemical Engineers, 118, 87–96. https://doi.org/10.1016/j.jtice.2020.12.024
dc.relation.referencesMAERSK. (2023). Bunker Adjustment Factor (BAF). Bunker Adjustment Factor (BAF). https://www.maersk.com/news/articles/2023/12/01/bunker-adjustment-factor
dc.relation.referencesMANN HUMMEL. (s/f). NADIR NP030 P. NADIR NP030 P. https://water-membrane-solutions.mann-hummel.com/content/dam/water-membrane-solutions/download/technical-data-sheets/nadir/nadir-np030-p-flat-sheet-membrane-data-sheet.pdf/_jcr_content/renditions/original./nadir-np030-p-flat-sheet-membrane-data-sheet.pdf
dc.relation.referencesMegazyme. (2025). Beta-galactosidase (Aspergillus Niger). Beta-galactosidase (Aspergillus Niger). https://www.megazyme.com/beta-galactosidase-aspergillus-niger
dc.relation.referencesMercado Libre. (s/f). Gluconato De Sodio 1 Kilo. Gluconato De Sodio 1 Kilo. Recuperado el 20 de febrero de 2025, de https://articulo.mercadolibre.com.co/MCO-587867417-gluconato-de-sodio-1-kilo-_JM
dc.relation.referencesMerkel, A., Voropaeva, D., & Ondrušek, M. (2021). The impact of integrated nanofiltration and electrodialytic processes on the chemical composition of sweet and acid whey streams. Journal of Food Engineering, 298, 110500. https://doi.org/10.1016/j.jfoodeng.2021.110500
dc.relation.referencesMesa Regional de Ganadería Sostenible Nariño. (s/f). Mapa de localización de centros de acopio/transformación de leche en Nariño.
dc.relation.referencesMinj, S., & Anand, S. (2020). Whey Proteins and Its Derivatives: Bioactivity, Functionality, and Current Applications. Dairy, 1(3), 233–258. https://doi.org/10.3390/dairy1030016 Mordor Intelligence. (2024). Global Dairy Protein Market Size and Share Analysis—Growth Trends and Forecasts (2024—2029).
dc.relation.referencesMostafa Imeni, S., Pelaz, L., Corchado-Lopo, C., Maria Busquets, A., Ponsá, S., & Colón, J. (2019). Techno-economic assessment of anaerobic co-digestion of livestock manure and cheese whey (Cow, Goat & Sheep) at small to medium dairy farms. Bioresource Technology, 291, 121872. https://doi.org/10.1016/j.biortech.2019.121872
dc.relation.referencesMueller, I., Seidel-Morgenstern, A., & Hamel, C. (2021). Simulated-moving-bed technology for purification of the prebiotics galacto-oligosaccharides. Separation and Purification Technology, 271, 118829. https://doi.org/10.1016/j.seppur.2021.118829
dc.relation.referencesMuvdi-Nova, C. J., Mora-García, S. A., & Cáceres-Roa, S. A. (2021). Evaluating volume reduction of clarified acid bovine milk whey via falling film vacuum evaporation. Ciencia & Tecnología Agropecuaria, 22(1). https://doi.org/10.21930/rcta.vol22_num1_art:1241
dc.relation.referencesNavarro, R. E. Z. (2021). Plan de ordenamiento productivo: Cadena Lactéa en Colombia.
dc.relation.referencesNFBC. (s/f). King-Prebiotics® Galactooligosaccharides (GOS) [Ventas]. King-Prebiotics® Galactooligosaccharides (GOS). Recuperado el 1 de septiembre de 2023, de https://nfbc-oligo.com/?p=1873&lang=en
dc.relation.referencesNielsen, E. N., Gøtke, M., Cordin, U., Skibsted, L. H., Velizarov, S., Crespo, J. G., & Ahrné, L. M. (2023). Effect of reverse osmosis pre-processing of acid whey and electrodialysis current density on process performance. Food and Bioproducts Processing, 140, 72–83. https://doi.org/10.1016/j.fbp.2023.05.002
dc.relation.referencesNielsen, E. N., Merkel, A., Yazdi, S. R., & Ahrné, L. (2021). The effect of acid whey composition on the removal of calcium and lactate during electrodialysis. International Dairy Journal, 117, 104985. https://doi.org/10.1016/j.idairyj.2021.104985
dc.relation.referencesNissin Sugar CO LTD. (s/f). Cup Oligo / GOS [Ventas]. Cup Oligo / GOS. Recuperado el 1 de septiembre de 2023, de https://www.nissin-sugar.co.jp/english/product/oligo/index.html
dc.relation.referencesNoriega, M. A., Rico-Rodríguez, F., Rosales, J. D., & Serrato-Bermúdez, J. C. (2024). Kinetics of galactooligosaccharides (GOS) production with two β-galactosidases: Metallic ion effect and mathematical model. Chemical Engineering Research and Design, 212, 341–348. https://doi.org/10.1016/j.cherd.2024.11.001
dc.relation.referencesNovozymes. (s/f). Lactozym Pure. Lactozym Pure. Recuperado el 2 de febrero de 2025, de https://tienda.quimtia.com.pe/media/catalog/product/file/Lactozym-Pure-350000766-FT.pdf
dc.relation.referencesNutramerican. (s/f). Bi Pro Classic. Bi Pro Classic. Recuperado el 3 de febrero de 2025, de https://nutramerican.com/producto/biproclassic_chocolate
dc.relation.referencesOliveros, D. (2024). Evaluación de un sistema multienzimático inmovilizado para la producción de galacto-oligosacáridos a partir de lactosuero [Tesis de Maestría]. Universidad Nacional de Colombia.
dc.relation.referencesOlveira, G., & González-Molero, I. (2016). Actualización de probióticos, prebióticos y simbióticos en nutrición clínica. Endocrinología y Nutrición, 63(9), 482–494. https://doi.org/10.1016/j.endonu.2016.07.006
dc.relation.referencesOptimum Nutrition. (s/f). Gold Standard 100% Whey. Gold Standard 100% Whey. Recuperado el 3 de febrero de 2025, de https://www.optimumnutrition.com.co/producto/gold-standard-100-whey/
dc.relation.referencesOutinen, M., Heino, A., & Uusi-Rauva, J. (2010). Pre-treatment methods of Edam cheese milk. Effect on the whey composition. LWT - Food Science and Technology, 43(4), 647–654. https://doi.org/10.1016/j.lwt.2009.12.001
dc.relation.referencesOzel, B., McClements, D. J., Arikan, C., Kaner, O., & Oztop, M. H. (2022). Challenges in dried whey powder production: Quality problems. Food Research International, 160, 111682. https://doi.org/10.1016/j.foodres.2022.111682
dc.relation.referencesPal, P., Kumar, R., & Banerjee, S. (2016). Manufacture of gluconic acid: A review towards process intensification for green production. Chemical Engineering and Processing: Process Intensification, 104, 160–171. https://doi.org/10.1016/j.cep.2016.03.009
dc.relation.referencesPan, K., Song, Q., Wang, L., & Cao, B. (2011). A study of demineralization of whey by nanofiltration membrane. Desalination, 267(2–3), 217–221. https://doi.org/10.1016/j.desal.2010.09.029
dc.relation.referencesPeters, M. S., Timmerhaus, K. D., Carberry, J. J., Fair, J. R., Schowalter, W. P., & Tipell, M. (1991). Plant Design and Economics for Chemical Engineers (Cuarta). McGraw-Hill.
dc.relation.referencesPrabhuzantye, T., Khaire, R. A., & Gogate, P. R. (2019). Enhancing the recovery of whey proteins based on application of ultrasound in ultrafiltration and spray drying. Ultrasonics Sonochemistry, 55, 125–134. https://doi.org/10.1016/j.ultsonch.2019.03.008
dc.relation.referencesProenzimas. (s/f). AMIZYME YLC 50D. AMIZYME YLC 50D. Recuperado el 2 de febrero de 2025, de https://www.proenzimas.com/pdf/Amizyme%20YLC%2050%20D.pdf
dc.relation.referencesPruksasri, S., Nguyen, T.-H., Haltrich, D., & Novalin, S. (2015). Fractionation of a galacto-oligosaccharides solution at low and high temperature using nanofiltration. Separation and Purification Technology, 151, 124–130. https://doi.org/10.1016/j.seppur.2015.07.015
dc.relation.referencesRalex Membranes. (s/f-a). Ralex Membrane AMHPP. Ralex Membrane AMHPP. https://www.mega.cz/files/datasheet/MEGA-RALEX-AMH-PP-en.pdf
dc.relation.referencesRalex Membranes. (s/f-b). Ralex Membrane CMHPES. Ralex Membrane CMHPES. https://www.mega.cz/files/datasheet/MEGA-RALEX-CMH-PES-en.pdf
dc.relation.referencesRaut, S., Jain, S., Dhamole, P., & Agrawal, S. (2022). WPC manufacturing using thermal -polyelectrolyte precipitation: A product quality and techno-economic assessment. Journal of Food Engineering, 315, 110796. https://doi.org/10.1016/j.jfoodeng.2021.110796
dc.relation.referencesReports Insights. (2023). Prebiotics Market Set to Hit USD 10,435.16 Million By 2030. Prebiotics Market Set to Hit USD 10,435.16 Million By 2030. https://www.globenewswire.com/news-release/2023/08/02/2716613/0/en/Prebiotics-Market-Set-to-Hit-USD-10-435-16-Million-By-2030-Says-Reports-Insights.html
dc.relation.referencesResearch Nester. (2021). Global Galacto-Oligosaccharides Market to Grow with a CAGR of 10.15% Throughout 2021-2028 Owing to Rising Demand for Microbiota-Targeted Therapies and Precision Nutrition Products; Market to Cross USD 1,120 Million in 2028 [Economica]. Global Galacto-Oligosaccharides Market to Grow with a CAGR of 10.15% Throughout 2021-2028 Owing to Rising Demand for Microbiota-Targeted Therapies and Precision Nutrition Products; Market to Cross USD 1,120 Million in 2028. https://www.globenewswire.com/news-release/2021/01/21/2162145/0/en/Global-Galacto-Oligosaccharides-Market-to-Grow-with-a-CAGR-of-10-15-Throughout-2021-2028-Owing-to-Rising-Demand-for-Microbiota-Targeted-Therapies-and-Precision-Nutrition-Products-M.html
dc.relation.referencesRico-Rodríguez, F. (2018). Evaluación de un sistema mixto de enzimas para la producción de galactooligosacáridos y ácido glucónico a partir de lactosuero como fuente de lactosa [Tesis de Doctorado]. Universidad Nacional de Colombia.
dc.relation.referencesRico-Rodríguez, F., Noriega, M. A., Lancheros, R., & Serrato-Bermúdez, J. C. (2021). Kinetics of galactooligosaccharide (GOS) production with two β-galactosidases combined: Mathematical model and raw material effects. International Dairy Journal, 118, 105015. https://doi.org/10.1016/j.idairyj.2021.105015
dc.relation.referencesRico-Rodríguez, F., Serrato, J. C., Montilla, A., & Villamiel, M. (2018). Impact of ultrasound on galactooligosaccharides and gluconic acid production throughout a multienzymatic system. Ultrasonics Sonochemistry, 44, 177–183. https://doi.org/10.1016/j.ultsonch.2018.02.022
dc.relation.referencesSantibáñez, L., Córdova, A., Astudillo-Castro, C., & Illanes, A. (2019). Effect of the lactose hydrolysis on galacto-oligosaccharides mixtures subjected to nanofiltration: A detailed fractionation analysis. Separation and Purification Technology, 222, 342–351. https://doi.org/10.1016/j.seppur.2019.04.020
dc.relation.referencesSantibáñez, L., Fernández-Arrojo, L., Guerrero, C., Plou, F. J., & Illanes, A. (2016). Removal of lactose in crude galacto-oligosaccharides by β-galactosidase from Kluyveromyces lactis. Journal of Molecular Catalysis B: Enzymatic, 133, 85–91. https://doi.org/10.1016/j.molcatb.2016.07.014
dc.relation.referencesSantibáñez, L., Guerrero, C., & Illanes, A. (2017). Raw galacto-oligosaccharide purification by consecutive lactose hydrolysis and selective bioconversion. International Dairy Journal, 75, 91–100. https://doi.org/10.1016/j.idairyj.2017.07.008
dc.relation.referencesSaputo Dairy UK. (s/f). Oligosaccharides for Infant Formulas. Oligosaccharides for Infant Formulas. Recuperado el 1 de septiembre de 2023, de https://www.gosguthealth.com/en/infant-nutrition
dc.relation.referencesScott, F., Vera, C., & Conejeros, R. (2016). Technical and Economic Analysis of Industrial Production of Lactose-Derived Prebiotics With Focus on Galacto-Oligosaccharides. En Lactose-Derived Prebiotics (pp. 261–284). Elsevier. https://doi.org/10.1016/B978-0-12-802724-0.00007-X
dc.relation.referencesSeider, W. D. (2016). Product and Process Design Principles. 4.
dc.relation.referencesSemana. (2022, julio). Principales compañias de lácteos en Colombia [Diario]. El escalafón de las empresas lecheras colombianas: ¿está la marca de leche que usted compra? https://www.semana.com/economia/empresas/articulo/el-escalafon-de-las-empresas-lecheras-colombianas-esta-la-marca-de-leche-que-usted-compra/202255/
dc.relation.referencesSen, D., Gosling, A., Stevens, G. W., Bhattacharya, P. K., Barber, A. R., Kentish, S. E., Bhattacharjee, C., & Gras, S. L. (2011). Galactosyl oligosaccharide purification by ethanol precipitation. Food Chemistry, 128(3), 773–777. https://doi.org/10.1016/j.foodchem.2011.03.076
dc.relation.referencesShoprythm. (s/f). MYOC Sodium Gluconate Powder. MYOC Sodium Gluconate Powder. Recuperado el 20 de febrero de 2025, de https://www.shoprythm.com/products/myoc-sodium-gluconate-powder?variant=41578267476102
dc.relation.referencesSigma Aldrich. (s/f-a). Beta-galactosidase from Aspergillus Oryzae. Beta-galactosidase from Aspergillus Oryzae. Recuperado el 2 de febrero de 2025, de https://www.sigmaaldrich.com/specification-sheets/194/640/G5160-BULK________SIGMA____.pdf
dc.relation.referencesSigma Aldrich. (s/f-b). Glucose Oxidase from Aspergillus niger. Glucose Oxidase from Aspergillus niger. Recuperado el 15 de marzo de 2025, de https://www.sigmaaldrich.com/CO/en/product/sigma/g7141
dc.relation.referencesSigma Aldrich. (s/f-c). Sodium gluconate. Sodium gluconate. Recuperado el 20 de febrero de 2025, de https://www.sigmaaldrich.com/CO/en/product/mm/817054
dc.relation.referencesSigma Aldrich. (s/f-d). β-Galactosidase from Kluyveromyces lactis. β-Galactosidase from Kluyveromyces lactis. Recuperado el 19 de febrero de 2025, de https://www.sigmaaldrich.com/CO/en/product/sigma/g3665
dc.relation.referencesSouza, A. F. C. E., Gabardo, S., & Coelho, R. D. J. S. (2022). Galactooligosaccharides: Physiological benefits, production strategies, and industrial application. Journal of Biotechnology, 359, 116–129. https://doi.org/10.1016/j.jbiotec.2022.09.020
dc.relation.referencesSynder Filtration. (s/f-a). NFX (TFC 150—300 Da). NFX (TFC 150 - 300 Da). https://synderfiltration.com/2014/wp-content/uploads/2018/11/NFX-TFC-150-300Da-Sanitary-Specsheet.pdf
dc.relation.referencesSynder Filtration. (s/f-b). ST (PES 10,000 Da). ST (PES 10,000 Da). https://synderfiltration.com/2014/wp-content/uploads/2018/05/ST-PES-10kD-Sanitary-Specsheet.pdf
dc.relation.referencesTaiwan Fructose Co. LTD. (s/f). Oligo-saccharides. Oligo-saccharides. Recuperado el 1 de septiembre de 2023, de http://www.fructose.com.tw/en/Products/3/Oligo-Saccharides
dc.relation.referencesTanguy, G., Beaucher, E., Dolivet, A., Kerjouh, A., Maillard, M.-B., Hamon, P., & Croguennec, T. (2022). Behaviour of minerals during the vacuum concentration of dairy ultrafiltration permeates. International Dairy Journal, 133, 105426. https://doi.org/10.1016/j.idairyj.2022.105426
dc.relation.referencesTarapata, J., Dybowska, B. E., & Zulewska, J. (2022). Evaluation of fouling during ultrafiltration process of acid and sweet whey. Journal of Food Engineering, 328, 111059. https://doi.org/10.1016/j.jfoodeng.2022.111059
dc.relation.referencesTeam Warrior. (s/f). Warrior Whey Protein. Warrior Whey Protein. Recuperado el 3 de febrero de 2025, de https://teamwarrior.com/products/warrior-whey-protein-powder-1kg-strawberry-creme
dc.relation.referencesTechnavio. (2024). Global Organic Whey Protein Market 2024-2028.
dc.relation.referencesTrade Map. (2025). Lista de importaciones y exportaciones por subpartida arancelaria. Lista de importaciones y exportacione. https://www.trademap.org/Country_SelProduct_TS.aspx
dc.relation.referencesUald Lamkaddam, I., Vega, E., Colón, J., Ponsá, S., Llenas, L., & Mora, M. (2023). Progressive freeze concentration of cheese whey for protein and lactose recovery. International Dairy Journal, 139, 105572. https://doi.org/10.1016/j.idairyj.2022.105572
dc.relation.referencesUSP. (2023, mayo 9). Volumen de leche captada por la industria. Volumen de leche captada por la industria. http://uspleche.minagricultura.gov.co/acopio.html
dc.relation.referencesVera, C., Guerrero, C., Aburto, C., Cordova, A., & Illanes, A. (2020). Conventional and non-conventional applications of β-galactosidases. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1868(1), 140271. https://doi.org/10.1016/j.bbapap.2019.140271
dc.relation.referencesWang, G., Wang, H., Chen, Y., Pei, X., Sun, W., Liu, L., Wang, F., Umar Yaqoob, M., Tao, W., Xiao, Z., Jin, Y., Yang, S.-T., Lin, D., & Wang, M. (2021). Optimization and comparison of the production of galactooligosaccharides using free or immobilized Aspergillus oryzae β-galactosidase, followed by purification using silica gel. Food Chemistry, 362, 130195. https://doi.org/10.1016/j.foodchem.2021.130195
dc.relation.referencesWen-qiong, W., Yun-chao, W., Xiao-feng, Z., Rui-xia, G., & Mao-lin, L. (2019). Whey protein membrane processing methods and membrane fouling mechanism analysis. Food Chemistry, 289, 468–481. https://doi.org/10.1016/j.foodchem.2019.03.086
dc.relation.referencesWilliams Zambrano, M. B., & Dueñas Rivadeneira, A. A. (2021). Alternativas para el aprovechamiento del lactosuero: Antecedentes investigativos y usos tradicionales. La Técnica: Revista de las Agrociencias. ISSN 2477-8982, 26, 39. https://doi.org/10.33936/la_tecnica.v0i26.3490
dc.relation.referencesYakult Pharmaceutical Industry. (s/f). Oligomate: Galacto-oligosaccharides [Ventas]. Oligomate : Galacto-oligosaccharides. Recuperado el 1 de septiembre de 2023, de https://www.yakult.co.jp/ypi/en/product/ori.html
dc.relation.referencesYin, H., Bultema, J. B., Dijkhuizen, L., & Van Leeuwen, S. S. (2017). Reaction kinetics and galactooligosaccharide product profiles of the β-galactosidases from Bacillus circulans, Kluyveromyces lactis and Aspergillus oryzae. Food Chemistry, 225, 230–238. https://doi.org/10.1016/j.foodchem.2017.01.030
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc660 - Ingeniería química
dc.subject.ddc640 - Gestión del hogar y vida familiar::641 - Alimentos y bebidas
dc.subject.lembINDUSTRIA LECHERA-INNOVACIONES TECNOLOGICASspa
dc.subject.lembDairying - Technological Innovationseng
dc.subject.lembPRODUCTOS LACTEOSspa
dc.subject.lembDairy productseng
dc.subject.lembLACTOSAspa
dc.subject.lembLactoseeng
dc.subject.lembNUTRICIONspa
dc.subject.lembNutritioneng
dc.subject.lembCONTROL DE PROCESOS QUIMICOSspa
dc.subject.lembChemical process controleng
dc.subject.lembPROCESOS QUIMICOSspa
dc.subject.lembChemical processeseng
dc.subject.lembINGENIERIA QUIMICAspa
dc.subject.lembChemical engineeringeng
dc.subject.proposalGalactooligosacáridos (GOS)spa
dc.subject.proposalFactibilidad técnica y económicaspa
dc.subject.proposalLactosuero dulcespa
dc.subject.proposalTransgalactosilaciónspa
dc.subject.proposalNariño – Colombiaspa
dc.subject.proposalDiseño Básicospa
dc.subject.proposalGalactooligosaccharides (GOS)eng
dc.subject.proposalTechnical and economic feasibilityeng
dc.subject.proposalSweet Wheyeng
dc.subject.proposalTransgalactosylationeng
dc.subject.proposalBasic Designeng
dc.titleFactibilidad técnica y económica de la producción de galactooligosacáridos (GOS) a partir de lactosuero dulce en la región de Nariñospa
dc.title.translatedTechnical and economic feasibility of the production of galactooligosaccharides (GOS) from sweet whey in the Nariño regioneng
dc.typeTrabajo de grado - Maestría
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentDataPaper
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentPúblico general
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
oaire.fundernameColciencias, Universidad Nacional de Colombia

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