Solubility and solution thermodynamics of acetaminophen in (ethanol + propylene glycol + water) ternary mixtures

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dc.contributor.advisorMartínez Rodríguez, Fleming
dc.contributor.authorRomdhani, Asma
dc.contributor.cvlacRomdhani, Asma [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000117660]spa
dc.contributor.googlescholarRomdhani, Asma [https://scholar.google.com/citations?user=gKs1hk0AAAAJ]spa
dc.contributor.researchgateRomdhani, Asma [https://www.researchgate.net/profile/Asma-Romdhani]spa
dc.contributor.researchgroupGrupo de Investigaciones Farmacéutico-Fisicoquímicasspa
dc.contributor.scopusRomdhani, Asma [https://www-scopus-com.ezproxy.unal.edu.co/authid/detail.uri?origin=resultslist&authorId=54901767600&zone=]spa
dc.date.accessioned2023-01-11T19:53:01Z
dc.date.available2023-01-11T19:53:01Z
dc.date.issued2022-08
dc.descriptionilustraciones, gráficas, tablasspa
dc.description.abstractThe equilibrium solubility of acetaminophen (ACP) was determined at five temperatures from (293.15 to 313.15) K in {ethanol (EtOH) (1) + propylene glycol (PG) (2) + water (3)} ternary mixtures. From the variation of solubility with temperature, the apparent thermodynamic analysis of dissolution was carried out in all the ternary mixtures. Additionally, the thermodynamic quantities of mixing and solvation were also calculated, as well as the apparent specific volume at saturation of ACP. The solubility of ACP expressed in mole fraction (x4) increases with temperature-increasing and also increases with proportion-increasing of EtOH and/or PG. It varies from x4 = 4.56 × 10–3 in the mixture of 0.10-0.10-0.80 (in mass fraction) to x4 = 6.63 × 10–2 in the mixture of 0.80-0.10-0.10 at 298.15 K. The solubility behavior was well correlated using the Jouyban-Acree model obtaining mean percentage deviations (MPD) of 4.0% (N=330).eng
dc.description.abstractSe determinó la solubilidad en equilibrio de acetaminofeno (ACF) a cinco temperaturas desde (293,15 hasta 313,15) K en mezclas ternarias {etanol (EtOH) (1) + propilenglicol (PG) (2) + agua (3)}. A partir de la variación de la solubilidad con la temperatura se realizó el análisis termodinámico aparente de disolución en todas las mezclas ternarias. Adicionalmente se calcularon las cantidades termodinámicas de mezcla y solvatación, así como el volumen específico aparente a saturación de ACF. La solubilidad de ACF expresada en fracción molar (x4) aumenta al incrementar la temperatura y también aumenta con el incremento en las proporciones de EtOH y/o PG. Esta varía desde x4 = 4,56 × 10–3 en la mezcla 0,10-0,10-0,80 (en fracción de masa) hasta x4 = 6,63 × 10–2 en la mezcla 0,80-0,10-0,10 a 298,15 K. El comportamiento de solubilidad se correlacionó adecuadamente mediante el modelo de Jouyban-Acree obteniendo desviaciones porcentuales medias (MPD) del 4,0% (N=330).spa
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ciencias Farmacéuticasspa
dc.description.researchareaFarmacotecniaspa
dc.format.extentxviii, 82 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/82880
dc.language.isoengspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias Farmacéuticasspa
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dc.rightsDerechos reservados al autor, 2022spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseReconocimiento 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/spa
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.otherTermoquímicaspa
dc.subject.otherThermochemistryeng
dc.subject.otherAcetaminophen Assayeng
dc.subject.otherEnsayo de acetaminofénspa
dc.subject.proposalAcetaminopheneng
dc.subject.proposal(Ethanol + propylene glycol + water) mixtureseng
dc.subject.proposalSolubilityeng
dc.subject.proposalJouyban-Acree modeleng
dc.subject.proposalDissolution thermodynamicseng
dc.subject.proposalApparent specific volumeeng
dc.subject.proposalAcetaminofenospa
dc.subject.proposalMezclas (etanol + propilenglicol + agua)spa
dc.subject.proposalSolubilidadspa
dc.subject.proposalModelo de Jouyban-Acreespa
dc.subject.proposalTermodinámica de disoluciónspa
dc.subject.proposalVolumen específico aparentespa
dc.titleSolubility and solution thermodynamics of acetaminophen in (ethanol + propylene glycol + water) ternary mixtureseng
dc.title.translatedSolubilidad y termodinámica de disolución de acetaminofeno en mezclas ternarias (etanol + propilenglicol + agua)spa
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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