Efecto del consumo de bifidobacterias en el peso y grasa corporal de sujetos adultos con sobrepeso y obesidad: revisión sistemática de la literatura

dc.contributor.advisorGonzález Clavijo, Angélica Maríaspa
dc.contributor.authorHamed Riveros, Nicolás Faridspa
dc.date.accessioned2024-03-04T19:09:42Z
dc.date.available2024-03-04T19:09:42Z
dc.date.issued2023-10-23
dc.descriptionilustraciones, diagramasspa
dc.description.abstractEn estudios recientes se ha demostrado que la ingesta de probióticos a través de productos farmacéuticos o alimenticios podría ser una estrategia eficaz en el tratamiento del sobrepeso y la obesidad. Esta revisión sistemática con metaanálisis tuvo como objeto evaluar el impacto de la administración de probióticos del género Bifidobacterium sobre indicadores antropométricos y de composición corporal en personas con sobrepeso y obesidad. Se llevó a cabo una búsqueda sistemática de la literatura de ensayos clínicos aleatorizados en las bases de datos MEDLINE, EMBASE, LILACS y Google Scholar sin restricción de tiempo. Se recuperaron 1527 reportes de estudios de los cuales 11 fueron incluidos para conducir un metaanálisis de efectos aleatorios. La administración de probióticos del género Bifidobacterium resultó en una reducción significativa de la grasa corporal (-0.64 Kg IC 95% = -1.09, -0.18 p = 0.006), porcentaje de grasa corporal (-0.64 % IC 95% = -1.18, -0.11 p = 0.02) y perímetro de cintura (-1.39 cm CI 95% = -1.99, -0.79 p <0.00001), no se encontraron diferencias significativas para el índice de masa corporal, peso corporal ni índice cintura/cadera. En conclusión, esta revisión sistemática resalta el potencial de los probióticos del género Bifidobacterium en el tratamiento del sobrepeso y la obesidad, pero subraya la necesidad de realizar investigaciones adicionales para comprender mejor las interacciones entre cepas y especies, la influencia de las dosis y el vehículo de entrega más efectivo de los probióticos. (Texto tomado de la fuente).spa
dc.description.abstractRecent research has indicated that probiotics found in pharmaceutical or food products may present an effective approach to address overweight and obesity. The purpose of this systematic review, along with an associated meta-analysis, was to evaluate the effects of administering probiotics from the Bifidobacterium genus on anthropometric and body composition parameters in individuals with overweight and obesity. A comprehensive literature search was conducted for randomized clinical trials across MEDLINE, EMBASE, LILACS, and Google Scholar databases, without temporal restrictions. Among the 1,527 identified study reports, 11 were selected for inclusion in a random-effects meta-analysis. The administration of Bifidobacterium genus probiotics led to a statistically significant reduction in body fat (-0.64 kg, 95% CI = -1.09, -0.18, p = 0.006), the percentage of body fat (-0.64%, 95% CI = -1.18, -0.11, p = 0.02), and waist circumference (-1.39 cm, 95% CI = -1.99, -0.79, p <0.00001). However, no significant differences were observed regarding body mass index, body weight, or waist-to-hip ratio. In conclusion, this systematic review underscores the potential of Bifidobacterium genus probiotics in the management of overweight and obesity. It also highlights the necessity for further research to gain a deeper understanding of strain and species interactions, the influence of dosages, and the most efficacious method for delivering probiotics.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Fisiologíaspa
dc.format.extentxiii, 106 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/85765
dc.language.isospaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina - Maestría en Fisiologíaspa
dc.relation.indexedBiremespa
dc.relation.referencesObesity and overweight [Internet]. [citado el 7 de agosto de 2023]. Disponible en: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweightspa
dc.relation.referencesApovian CM. Obesity: definition, comorbidities, causes, and burden. Am J Manag Care. junio de 2016;22(7 Suppl):s176-185.spa
dc.relation.referencesAndolfi C, Fisichella PM. Epidemiology of Obesity and Associated Comorbidities. J Laparoendosc Adv Surg Tech A. agosto de 2018;28(8):919–24.spa
dc.relation.referencesAvgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism. marzo de 2019;92:121–35.spa
dc.relation.referencesZinöcker MK, Lindseth IA. The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic Disease. Nutrients. el 17 de marzo de 2018;10(3):365.spa
dc.relation.referencesAbenavoli L, Scarpellini E, Colica C, Boccuto L, Salehi B, Sharifi-Rad J, et al. Gut Microbiota and Obesity: A Role for Probiotics. Nutrients. el 7 de noviembre de 2019;11(11):E2690.spa
dc.relation.referencesFontané L, Benaiges D, Goday A, Llauradó G, Pedro-Botet J. Influence of the microbiota and probiotics in obesity. Clin E Investig En Arterioscler Publicacion Of Soc Espanola Arterioscler. diciembre de 2018;30(6):271–9.spa
dc.relation.referencesÁlvarez-Arraño V, Martín-Peláez S. Effects of Probiotics and Synbiotics on Weight Loss in Subjects with Overweight or Obesity: A Systematic Review. Nutrients. el 17 de octubre de 2021;13(10):3627.spa
dc.relation.referencesAngelakis E, Armougom F, Million M, Raoult D. The relationship between gut microbiota and weight gain in humans. Future Microbiol. enero de 2012;7(1):91–109.spa
dc.relation.referencesVallianou N, Stratigou T, Christodoulatos GS, Tsigalou C, Dalamaga M. Probiotics, Prebiotics, Synbiotics, Postbiotics, and Obesity: Current Evidence, Controversies, and Perspectives. Curr Obes Rep. el 1 de septiembre de 2020;9(3):179–92.spa
dc.relation.referencesHill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. agosto de 2014;11(8):506–14.spa
dc.relation.referencesOuwehand AC, Invernici MM, Furlaneto FAC, Messora MR. Effectiveness of Multi-strain Versus Single-strain Probiotics: Current Status and Recommendations for the Future. J Clin Gastroenterol. diciembre de 2018;52:S35.spa
dc.relation.referencesUusitupa HM, Rasinkangas P, Lehtinen MJ, Mäkelä SM, Airaksinen K, Anglenius H, et al. Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research. Nutrients. el 25 de marzo de 2020;12(4):892.spa
dc.relation.referencesCochrane Handbook for Systematic Reviews of Interventions [Internet]. [citado el 10 de octubre de 2022]. Disponible en: https://training.cochrane.org/handbook/currentspa
dc.relation.referencesAdak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci. febrero de 2019;76(3):473–93.spa
dc.relation.referencesShapira M. Gut Microbiotas and Host Evolution: Scaling Up Symbiosis. Trends Ecol Evol. el 1 de julio de 2016;31(7):539–49.spa
dc.relation.referencesEl Aidy S, van den Bogert B, Kleerebezem M. The small intestine microbiota, nutritional modulation and relevance for health. Curr Opin Biotechnol. el 1 de abril de 2015;32:14–20.spa
dc.relation.referencesHehemann JH, Correc G, Barbeyron T, Helbert W, Czjzek M, Michel G. Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature. abril de 2010;464(7290):908–12.spa
dc.relation.referencesBarko PC, McMichael MA, Swanson KS, Williams DA. The Gastrointestinal Microbiome: A Review. J Vet Intern Med. enero de 2018;32(1):9–25.spa
dc.relation.referencesHollister EB, Gao C, Versalovic J. Compositional and Functional Features of the Gastrointestinal Microbiome and Their Effects on Human Health. Gastroenterology. el 1 de mayo de 2014;146(6):1449–58.spa
dc.relation.referencesFan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. enero de 2021;19(1):55–71.spa
dc.relation.referencesTurnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. el 21 de diciembre de 2006;444(7122):1027–31.spa
dc.relation.referencesLehnen TE, da Silva MR, Camacho A, Marcadenti A, Lehnen AM. A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism. J Int Soc Sports Nutr. el 20 de octubre de 2015;12(1):36.spa
dc.relation.referencesDabke K, Hendrick G, Devkota S. The gut microbiome and metabolic syndrome. J Clin Invest. 129(10):4050–7.spa
dc.relation.referencesMurphy EF, Cotter PD, Healy S, Marques TM, O’Sullivan O, Fouhy F, et al. Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut. diciembre de 2010;59(12):1635–42.spa
dc.relation.referencesSchwiertz A, Taras D, Schäfer K, Beijer S, Bos NA, Donus C, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obes Silver Spring Md. enero de 2010;18(1):190–5.spa
dc.relation.referencesSc N, Al H, Ma K, Aj S, Sc K. Mechanisms of action of probiotics: recent advances. Inflamm Bowel Dis [Internet]. febrero de 2009 [citado el 16 de octubre de 2023];15(2). Disponible en: https://pubmed.ncbi.nlm.nih.gov/18626975/spa
dc.relation.referencesMohamadzadeh M, Olson S, Kalina WV, Ruthel G, Demmin GL, Warfield KL, et al. Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. Proc Natl Acad Sci U S A. el 22 de febrero de 2005;102(8):2880–5.spa
dc.relation.referencesKawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. el 1 de marzo de 2021;320(3):C375–91.spa
dc.relation.referencesMedina M, Izquierdo E, Ennahar S, Sanz Y. Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol. diciembre de 2007;150(3):531–8.spa
dc.relation.referencesBlum S, Alvarez S, Haller D, Perez P, Schiffrin EJ. Intestinal microflora and the interaction with immunocompetent cells. Antonie Van Leeuwenhoek. 1999;76(1–4):199–205.spa
dc.relation.referencesWieërs G, Belkhir L, Enaud R, Leclercq S, Philippart de Foy JM, Dequenne I, et al. How Probiotics Affect the Microbiota. Front Cell Infect Microbiol. 2019;9:454.spa
dc.relation.referencesKim SK, Guevarra RB, Kim YT, Kwon J, Kim H, Cho JH, et al. Role of Probiotics in Human Gut Microbiome-Associated Diseases. J Microbiol Biotechnol. el 28 de septiembre de 2019;29(9):1335–40.spa
dc.relation.referencesCerdó T, García-Santos JA, G Bermúdez M, Campoy C. The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity. Nutrients. el 15 de marzo de 2019;11(3):635.spa
dc.relation.referencesJones RB, Alderete TL, Martin AA, Geary BA, Hwang DH, Palmer SL, et al. Probiotic supplementation increases obesity with no detectable effects on liver fat or gut microbiota in obese Hispanic adolescents: a 16-week, randomized, placebo-controlled trial. Pediatr Obes. noviembre de 2018;13(11):705–14.spa
dc.relation.referencesChapman CMC, Gibson GR, Rowland I. Health benefits of probiotics: are mixtures more effective than single strains? Eur J Nutr. el 1 de febrero de 2011;50(1):1–17.spa
dc.relation.referencesCrovesy L, Ostrowski M, Ferreira DMTP, Rosado EL, Soares-Mota M. Effect of Lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials. Int J Obes. noviembre de 2017;41(11):1607–14.spa
dc.relation.referencesRussell DA, Ross RP, Fitzgerald GF, Stanton C. Metabolic activities and probiotic potential of bifidobacteria. Int J Food Microbiol. septiembre de 2011;149(1):88–105.spa
dc.relation.referencesTissier H. Recherches sur la flore intestinale des nourrissons: état normal et pathologique. Paris: G. Carré et C. Naud; 1900. 253 p.spa
dc.relation.referencesFelis GE, Dellaglio F. Taxonomy of Lactobacilli and Bifidobacteria. Curr Issues Intest Microbiol. septiembre de 2007;8(2):44–61.spa
dc.relation.referencesC I, Ja S, Hj T. Conjugated linoleic acid. A powerful anticarcinogen from animal fat sources. Cancer [Internet]. el 8 de enero de 1994 [citado el 12 de agosto de 2023];74(3 Suppl). Disponible en: https://pubmed.ncbi.nlm.nih.gov/8039138/spa
dc.relation.referencesPark Y, Storkson JM, Albright KJ, Liu W, Pariza MW. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids. marzo de 1999;34(3):235–41.spa
dc.relation.referencesIbrahim KS, El-Sayed EM. Dietary conjugated linoleic acid and medium-chain triglycerides for obesity management. J Biosci. diciembre de 2021;46(1):12.spa
dc.relation.referencesReardon M, Gobern S, Martinez K, Shen W, Reid T, McIntosh M. Oleic Acid Attenuates trans-10, cis-12 Conjugated Linoleic Acid-Mediated Inflammatory Gene Expression in Human Adipocytes. Lipids. noviembre de 2012;47(11):1043–51.spa
dc.relation.referencesTavares V, Hirata MH, Hirata RDC. [Peroxisome proliferator-activated receptor gamma (PPARgamma): molecular study in glucose homeostasis, lipid metabolism and therapeutic approach]. Arq Bras Endocrinol Metabol. junio de 2007;51(4):526–33.spa
dc.relation.referencesShen W, Chuang CC, Martinez K, Reid T, Brown JM, Xi L, et al. Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice. J Lipid Res. abril de 2013;54(4):909–22.spa
dc.relation.referencesBelury M. Not All trans-Fatty Acids are Alike: What Consumers May Lose When We Oversimplify Nutrition Facts. J Am Diet Assoc. el 1 de noviembre de 2002;102(11):1606–7.spa
dc.relation.referencesHouseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP, Peck LW, Nickel KP, et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun. el 27 de marzo de 1998;244(3):678–82.spa
dc.relation.referencesBelury MA, Mahon A, Banni S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr. enero de 2003;133(1):257S-260S.spa
dc.relation.referencesMei Y, Chen H, Yang B, Zhao J, Zhang H, Chen W. Research progress on conjugated linoleic acid bio-conversion in Bifidobacterium. Int J Food Microbiol. el 16 de mayo de 2022;369:109593.spa
dc.relation.referencesAlvaro E, Andrieux C, Rochet V, Rigottier-Gois L, Lepercq P, Sutren M, et al. Composition and metabolism of the intestinal microbiota in consumers and non-consumers of yogurt. Br J Nutr. enero de 2007;97(1):126–33.spa
dc.relation.referencesSolito A, Bozzi Cionci N, Calgaro M, Caputo M, Vannini L, Hasballa I, et al. Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial. Clin Nutr Edinb Scotl. julio de 2021;40(7):4585–94.spa
dc.relation.referencesKuriyan R. Body composition techniques. Indian J Med Res. noviembre de 2018;148(5):648–58.spa
dc.relation.referencesRayyan – Intelligent Systematic Review - Rayyan [Internet]. [citado el 26 de octubre de 2022]. Disponible en: https://www.rayyan.ai/spa
dc.relation.referencesHaddaway NR, Page MJ, Pritchard CC, McGuinness LA. PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis. Campbell Syst Rev. el 1 de junio de 2022;18(2):e1230.spa
dc.relation.referencesWebPlotDigitizer - Extract data from plots, images, and maps [Internet]. [citado el 31 de agosto de 2023]. Disponible en: https://automeris.io/WebPlotDigitizer/spa
dc.relation.referencesRoB 2: A revised Cochrane risk-of-bias tool for randomized trials | Cochrane Bias [Internet]. [citado el 2 de noviembre de 2022]. Disponible en: https://methods.cochrane.org/bias/resources/rob-2-revised-cochrane-risk-bias-tool-randomized-trialsspa
dc.relation.referencesRevMan [Internet]. [citado el 26 de octubre de 2022]. Disponible en: https://training.cochrane.org/online-learning/core-software/revmanspa
dc.relation.referencesHiggins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Br Med J. 2003;327(7414):557–60.spa
dc.relation.referencesJin ZC, Zhou XH, He J. Statistical methods for dealing with publication bias in meta-analysis. Stat Med. 2015;34(2):343–60.spa
dc.relation.referencesJASP - Free and User-Friendly Statistical Software [Internet]. [citado el 4 de septiembre de 2023]. JASP - A Fresh Way to Do Statistics. Disponible en: https://jasp-stats.org/spa
dc.relation.referencesde Oliveira LC. Influência de Bifidobacterium lactis no peso e composição corporal, glicemia, lipemia e pressão arterial de mulheres com obesidade [PhD Thesis]. UNIVERSIDADE FEDERAL DO RIO DE JANEIRO; 2016.spa
dc.relation.referencesGutiérrez‐Repiso C, Hernández‐García C, García‐Almeida JM, Bellido D, Martín‐Núñez GM, Sánchez‐Alcoholado L, et al. Effect of Synbiotic Supplementation in a Very‐Low‐Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study. Mol Nutr Food Res. octubre de 2019;63(19):1900167.spa
dc.relation.referencesHibberd AA, Yde CC, Ziegler ML, Honoré AH, Saarinen MT, Lahtinen S, et al. Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults. Benef Microbes. el 13 de marzo de 2019;10(2):121–35.spa
dc.relation.referencesMalaguarnera M, Vacante M, Antic T, Giordano M, Chisari G, Acquaviva R, et al. Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis. Dig Dis Sci. febrero de 2012;57(2):545–53.spa
dc.relation.referencesSchellekens H, Torres-Fuentes C, Van De Wouw M, Long-Smith CM, Mitchell A, Strain C, et al. Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human. EBioMedicine. enero de 2021;63:103176.spa
dc.relation.referencesTakahashi S, Anzawa D, Takami K, Ishizuka A, Mawatari T, Kamikado K, et al. Effect of Bifidobacterium animalis ssp. lactis GCL2505 on visceral fat accumulation in healthy Japanese adults: a randomized controlled trial. Biosci Microbiota Food Health. 2016;35(4):163–71.spa
dc.relation.referencesMohammadi-Sartang M, Bellissimo N, Totosy De Zepetnek JO, Brett NR, Mazloomi SM, Fararouie M, et al. The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: A 10-week randomized controlled trial. Nutr Metab Cardiovasc Dis. junio de 2018;28(6):565–74.spa
dc.relation.referencesStenman LK, Lehtinen MJ, Meland N, Christensen JE, Yeung N, Saarinen MT, et al. Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults—Randomized Controlled Trial. EBioMedicine. noviembre de 2016;13:190–200.spa
dc.relation.referencesPedret A, Valls RM, Calderón-Pérez L, Llauradó E, Companys J, Pla-Pagà L, et al. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. Int J Obes. septiembre de 2019;43(9):1863–8.spa
dc.relation.referencesMinami J ichi, Kondo S, Yanagisawa N, Odamaki T, Xiao J zhong, Abe F, et al. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. J Nutr Sci. 2015;4:e17.spa
dc.relation.referencesMinami J, Iwabuchi N, Tanaka M, Yamauchi K, Xiao J zhong, Abe F, et al. Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial. Biosci Microbiota Food Health. 2018;37(3):67–75.spa
dc.relation.referencesViechtbauer W. Conducting Meta-Analyses in R with the metafor Package. J Stat Softw. el 5 de agosto de 2010;36:1–48.spa
dc.relation.referencesBorgeraas H, Johnson LK, Skattebu J, Hertel JK, Hjelmesaeth J. Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials. Obes Rev Off J Int Assoc Study Obes. febrero de 2018;19(2):219–32.spa
dc.relation.referencesBen Othman R, Ben Amor N, Mahjoub F, Berriche O, El Ghali C, Gamoudi A, et al. A clinical trial about effects of prebiotic and probiotic supplementation on weight loss, psychological profile and metabolic parameters in obese subjects. Endocrinol Diabetes Metab. marzo de 2023;6(2):e402.spa
dc.relation.referencesProkopidis K, Giannos P, Kirwan R, Ispoglou T, Galli F, Witard OC, et al. Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta-analysis of randomized controlled trials. J Cachexia Sarcopenia Muscle. febrero de 2023;14(1):30–44.spa
dc.relation.referencesPowell-Wiley TM, Poirier CP, Burke VCLE, Després JP, Gordon-Larsen P, Lavie CJ, et al. Obesity and Cardiovascular Disease. Circulation. el 25 de mayo de 2021;143(21):e984–1010.spa
dc.relation.referencesGreen M, Arora K, Prakash S. Microbial Medicine: Prebiotic and Probiotic Functional Foods to Target Obesity and Metabolic Syndrome. Int J Mol Sci. el 21 de abril de 2020;21(8):2890.spa
dc.relation.referencesT A, A B, T A, H T, H B, A M. Bacterial Probiotics their Importances and Limitations: A Review. J Nutr Health Sci [Internet]. agosto de 2017 [citado el 26 de septiembre de 2023];4(2). Disponible en: http://www.annexpublishers.co/full-text/JNH/4202/Bacterial-Probiotics-their-Importances-and-Limitations-a-Review.phpspa
dc.relation.referencesAli AA, Velasquez MT, Hansen CT, Mohamed AI, Bhathena SJ. Effects of soybean isoflavones, probiotics, and their interactions on lipid metabolism and endocrine system in an animal model of obesity and diabetes. J Nutr Biochem. octubre de 2004;15(10):583–90.spa
dc.relation.referencesKathiriya MR, Vekariya YV, Hati S. Understanding the Probiotic Bacterial Responses Against Various Stresses in Food Matrix and Gastrointestinal Tract: A Review. Probiotics Antimicrob Proteins. agosto de 2023;15(4):1032–48.spa
dc.relation.referencesSanders ME, Marco ML. Food formats for effective delivery of probiotics. Annu Rev Food Sci Technol. 2010;1:65–85.spa
dc.relation.referencesWang J, Zhong Z, Zhang W, Bao Q, Wei A, Meng H, et al. Comparative analysis of the gene expression profile of probiotic Lactobacillus casei Zhang with and without fermented milk as a vehicle during transit in a simulated gastrointestinal tract. Res Microbiol. junio de 2012;163(5):357–65.spa
dc.relation.referencesFredua-Agyeman M, Gaisford S. Comparative survival of commercial probiotic formulations: tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. Benef Microbes. el 1 de enero de 2015;6(1):141–51.spa
dc.relation.referencesFlach J, van der Waal MB, van den Nieuwboer M, Claassen E, Larsen OFA. The underexposed role of food matrices in probiotic products: Reviewing the relationship between carrier matrices and product parameters. Crit Rev Food Sci Nutr. 2018;58(15):2570–84.spa
dc.relation.referencesSperanza B, Campaniello D, Monacis N, Bevilacqua A, Sinigaglia M, Corbo MR. Functional cream cheese supplemented with Bifidobacterium animalis subsp. lactis DSM 10140 and Lactobacillus reuteri DSM 20016 and prebiotics. Food Microbiol. junio de 2018;72:16–22.spa
dc.relation.referencesOliveira RP de S, Perego P, Oliveira MN de, Converti A. Effect of inulin as prebiotic and synbiotic interactions between probiotics to improve fermented milk firmness. J Food Eng. el 1 de noviembre de 2011;107(1):36–40.spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.decsManejo de la Obesidadspa
dc.subject.decsObesity Managementeng
dc.subject.decsProbióticosspa
dc.subject.decsProbioticseng
dc.subject.decsRevisión Sistemáticaspa
dc.subject.decsSystematic Revieweng
dc.subject.proposalBifidobacteriumspa
dc.subject.proposalProbióticosspa
dc.subject.proposalSobrepesospa
dc.subject.proposalObesidadspa
dc.subject.proposalAdiposidadspa
dc.subject.proposalBifidobacteriumeng
dc.subject.proposalProbioticseng
dc.subject.proposalOverweighteng
dc.subject.proposalObesityeng
dc.subject.proposalAdiposityeng
dc.titleEfecto del consumo de bifidobacterias en el peso y grasa corporal de sujetos adultos con sobrepeso y obesidad: revisión sistemática de la literaturaspa
dc.title.translatedEffect of bifidobacterium intake on body weight and body fat in overweight and obese adult subjects: a systematic review and meta-analysiseng
dc.typeTrabajo de grado - Maestríaspa
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Tesis de Maestría en Fisiología

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