Efecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 días

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dc.contributor.advisorCasas Bedoya, Gloria Amparospa
dc.contributor.advisorGalvis Mogollón, José Daríospa
dc.contributor.authorGonzález Castiblanco, Johana Katerinespa
dc.date.accessioned2024-02-09T20:10:44Z
dc.date.available2024-02-09T20:10:44Z
dc.date.issued2023
dc.descriptionilustraciones a color, diagramasspa
dc.description.abstractLos antibióticos promotores de crecimiento (APC) han sido usados por años para mejorar los parámetros productivos y la salud intestinal en los animales, sin embargo, su uso desmedido ha contribuido al aumento de la resistencia antimicrobiana tanto en animales como en humanos, siendo un problema relevante de salud pública. En consecuencia, se ha impulsado tendencia de buscar nuevas alternativas como las tributirinas o butirinas esterificadas que alcanzan a tener un mayor efecto en la parte distal del intestino, mejorando los parámetros productivos y la salud intestinal de lechones destetos. El objetivo del proyecto fue evaluar el efecto de la inclusión de una butirina esterificada como alternativa a los antibióticos promotores de crecimiento en lechones destetos, en algunos parámetros productivos y de salud intestinal. En este estudio se seleccionaron 96 lechones de 21 días de edad y fueron asignados a tres tratamientos: un control negativo (CN) sin APC, ácidos orgánicos u óxido de zinc, un control positivo (CP), en el que se incluyó un antibiótico promotor de crecimiento (avilamicina 0,3kg/Ton) y el tratamiento de evaluación que consistió en adicionar una butirina esterificada (2kg/Ton) (CN+B), al control negativo. Los lechones fueron alimentados por 14 días. No se observaron diferencias estadísticamente significativas entre los tratamientos en los parámetros productivos. Sin embargo, el score de consistencia de las heces en los lechones tratados con butirinas esterificadas fue menor que en CP o el CN (p<0.05). El uso de butirinas esterificadas incrementó (p<0.05) la altura de la vellosidad en yeyuno e íleon, así como la relación altura de la vellosidad: profundidad de la cripta en íleon. Así mismo, la expresión de TNF-α en yeyuno fue mayor, mientras que la expresión de IL-6 disminuyó en íleon (p<0.05) en lechones alimentados con dietas suplementadas con butirinas. Se concluyó que las butirinas esterificadas pueden mejorar la función intestinal por su efecto en la morfología intestinal y la consistencia fecal. (Texto tomado de la fuente)spa
dc.description.abstractAntibiotic growth promoters have been used for years to improve growth performance and gut health, however, their excessive use has contributed to the increase in antimicrobial resistance in animals and humans, being a problem relevant to health. Consequently, there has been a tendency to look for new alternatives such as tributyrin or esterified butyrin that have a greater effect on the distal part of the intestine, improving the growth performance and gut health of weaned piglets. The objective of the project was to evaluate the effect of the inclusion of esterified butyrate as an alternative to antibiotic growth promoters in weaned piglets on some growth performance and gut health parameters. In this study, 96 piglets of 21 days of age were selected and allowed three treatments: a negative control (NC) without APC, organic acid, or zinc oxide, a positive control (PC), in which an antibiotic growth promoter was included (avilamycin 0.3kg/Ton), and the evaluation treatment which consisted of adding an esterified butyrate (2kg/Ton) (NC+B), to the negative control. The piglets were fed for 14 days. No statistically significant differences were observed between treatments in growth performance. However, the fecal consistency score in piglets treated with esterified butyrates was lower than in PC or NC (p<0.05). The use of esterified butyrines increased (p<0.05) the height of the villus in the jejunum and ileum, as well as the ratio of villus height: to crypt depth of the ileum. Likewise, the expression of TNF-α in the jejunum was higher, while the expression of IL-6 decreased in the ileum. Overall, esterified butyrates can improve intestinal function due to their effect on intestinal morphology and fecal consistency.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Salud Animal o Magíster en Producción Animalspa
dc.description.researchareaNutrición Animalspa
dc.format.extent106 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/85679
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicina Veterinaria y de Zootecniaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción Animalspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.ddc630 - Agricultura y tecnologías relacionadas::636 - Producción animalspa
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.decsSulfato de Butirosinaspa
dc.subject.decsButirosin Sulfateeng
dc.subject.decsAntibacterianosspa
dc.subject.decsAnti-Bacterial agentseng
dc.subject.decsBiomarcadores farmacológicosspa
dc.subject.decsBiomarkers, pharmacologicaleng
dc.subject.lembProducción animalspa
dc.subject.lembAnimal husbandryeng
dc.subject.lembLechones lactantes - Saludspa
dc.subject.lembBaby pigs - Healtheng
dc.subject.lembEtapas del desarrollo animalspa
dc.subject.lembAnimal developmental stageseng
dc.subject.proposalAntibióticos promotores de crecimientospa
dc.subject.proposalButirinasspa
dc.subject.proposalBiomarcadoresspa
dc.subject.proposalCitoquinasspa
dc.subject.proposalEscherichia colispa
dc.subject.proposalVellosidadspa
dc.subject.proposalLechones destetosspa
dc.subject.proposalGrowth promoting antibioticseng
dc.subject.proposalTributyrineng
dc.subject.proposalBiomarkerseng
dc.subject.proposalCytokineseng
dc.subject.proposalEscherichia colieng
dc.subject.proposalVilluseng
dc.subject.proposalWeaned pigseng
dc.titleEfecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 díasspa
dc.title.translatedEffect of replacing antibiotic growth promoters with tributyrin in pre-starter diets on growth performance and some intestinal health parameters of weaned pigletseng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.awardtitleEfecto del reemplazo de antibióticos promotores de crecimiento por una butirina esterificada en dietas de preiniciación en el rendimiento productivo y algunos parámetros de salud intestinal de lechones destetados a 21 díasspa

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