Contribución al desarrollo de un sistema autoemulsificable para aplicación tópica de floretina

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dc.contributor.advisorArgón Novoa, Diana Marcelaspa
dc.contributor.authorRodríguez Martínez, Ingrid Andreaspa
dc.contributor.researchgroupSistemas de Liberación Controlada de Moléculas Biológicamente Activasspa
dc.date.accessioned2025-09-12T16:46:08Z
dc.date.available2025-09-12T16:46:08Z
dc.date.issued2025-09-04
dc.descriptionilustraciones, diagramas, fotografíasspa
dc.description.abstractLa floretina es un flavonoide que ha sido asociado con actividad antiinflamatoria y antimicrobiana característica de etapas iniciales en el acné. Sin embargo, se encuentran desafíos asociados a problemas de solubilidad y estabilidad de la molécula, son áreas abiertas a la investigación y profundización que pueden contribuir a mejorar el desempeño de la floretina en su aplicación en el campo tópico. Bajo este contexto, se plantea la hipótesis de que el desarrollo de un sistema de administración tópica tipo sistema de administración de fármacos autoemulsificables (SEDDS) con floretina como ingrediente activo permitirá mejorar la solubilidad y estabilidad de este compuesto. Con el propósito de desarrollar y profundizar en este problema de investigación, en el presente trabajo se condujeron estudios de comprobación y determinación cualitativa y cuantitativa de la actividad de la floretina frente a Staphylococcus epidermidis y Cutinobacterium acnes, dos bacterias gran positivas que son referentes en procesos de disbiosis en cuadros de acné. Así mismo, se conducen ensayos de preformulación y formulación enfocados al desarrollo y caracterización de un sistema autoemulsificable portador de floretina, con el objetivo de contribuir a desarrollar un vehículo que mejora la solubilidad y estabilidad de la molécula para favorecer su actividad frente a las bacterias de referencia. Bajo este escenario, se llevaron a cabo pruebas de desafío en celdas de Franz utilizando piel porcina orientadas a conocer el comportamiento del sistema sobre esta matriz, identificando la retención de la formulación en la epidermis y una acumulación cuantificable de la floretina en el estrato corneo. (Texto tomado de la fuente).spa
dc.description.abstractPhloretin is a flavonoid that has been associated with anti-inflammatory and antimicrobial activity, in early stages of acne. However, challenges related to the molecule's solubility and stability has been described as open areas for further research and development to enhance phloretin’s performance in topical applications. This framework conducts the hypothesis to develop a topical delivery system based on a self-emulsifying drug delivery system (SEDDS). Therefore, phloretin incorporation as the active ingredient in these systems, could enhance the solubility and stability properties. To research the understanding of this scientific inquiry, qualitative studies were conducted to assess the activity of phloretin against Staphylococcus epidermidis and Cutibacterium acnes. Both are a gram-positive bacterias commonly associated with dysbiosis in acne-related conditions. Likewise, the development and characterization of a self-emulsifying drug delivery system (SEDDS) with phloretin focused on the preformulation and formulation studies, was carried out. This fact supports the design of a delivery vehicle that improves the molecule's solubility and stability and improves its activity against the reference bacteria. In this scenario, challenge tests were carried out in Franz cells using porcine skin. The tests promote the understanding of the system's behavior on this matrix. The formulation retention in the epidermis was identified, and a quantifiable accumulation of phloretin in the stratum corneum was also verified.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en ciancias Farmacéuticasspa
dc.description.researchareaTecnología farmacéuticaspa
dc.format.extent151 páginasspa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/88741
dc.language.isospa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias Farmacéuticasspa
dc.relation.indexedBiremespa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.proposalAcnéspa
dc.subject.proposalFloretinaspa
dc.subject.proposalSEDDSspa
dc.subject.proposalS. epidermidisspa
dc.subject.proposalC. acnesspa
dc.subject.proposalAcneeng
dc.subject.proposalPhloterineng
dc.subject.proposalSelf-emulsifying drug delivery systemeng
dc.subject.proposalS. epidermidiseng
dc.subject.proposalC. acneseng
dc.subject.unescoTratamiento médicospa
dc.subject.unescoMedical treatmenteng
dc.subject.unescoFarmacologíaspa
dc.subject.unescoPharmacologyeng
dc.subject.unescoEnfermedad de la pielspa
dc.subject.unescoSkin diseaseseng
dc.titleContribución al desarrollo de un sistema autoemulsificable para aplicación tópica de floretinaspa
dc.title.translatedContribution to the development of a self-emulsifying system for the topical application of phloretineng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
oaire.awardtitleBALCAR-Q: Bioprospección y Química de Algas del Caribespa
oaire.fundernameMinCienciasspa

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