Evaluación del efecto coadyuvante de 2H-cromen-2-ona para la prevención de convulsiones inducidas experimentalmente en ratones de laboratorio
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Autores
Núñez Medina, Ángela Viviana
Director
Guerrero Pabon, Mario Francisco
Tipo de contenido
Trabajo de grado - Maestría
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EspañolFecha de publicación
2023
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Abstract
Epilepsy is a potentially chronic neurodegenerative disease that affects humans and
animals. The majority of patients require the prescription of antiepileptic drugs (AEDs).
However, around 30% of them do not present complete resolution of their seizures, which
is why they are categorized as refractory patients, that is, individuals who, despite having
a medical regimen, have no control over these. This condition affects their quality of life.
Due to this particularity of pharmacological resistance, the goal of this work was to
evaluate the effect of coumarin (2H-chromen-2-one) as an adjuvant in the prevention of
seizures. In this work, the response of laboratory mice in models of seizure induction
under the effects of antiepileptic drugs such as carbamazepine, valproic acid, and
levetiracetam, the use of coumarin and the combination of drug and coumarin, was
evaluated in stimulation high-intensity electroshock (MES), low-frequency model (6 Hz),
and chemical induction with pentylenetetrazol (PTZ), additionally acute neurotoxicity was
evaluated using the rolling axis test (Rotarod).
From the evaluation of coumarin (2H-chromen-2-one), first of all, in the rolling axis test, it
was found that there was no significant alteration in the motor skills of the individuals.
Regarding the data obtained in the seizure induction trials, it was possible to determine
that the combination of carbamazepine and coumarin had a potential anticonvulsant
effect in the MES model, lower significance was found at the other models concerning the
MES model.
The data provided in the document suggest that the use of coumarin (2H-chromen-2-one)
in combination with first-line prototype drugs in mouse models would exert anticonvulsant
effects and a possible synergistic effect.
Palabras clave
Epilepsia ; cumarina ; pentilentetrazol ; MES ; 6 Hz ; convulsión ; anticonvulsivo ; Epilepsy ; coumarin ; pentylenetetrazole ; seizure ; anticonvulsant
Descripción Física/Lógica/Digital
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