Desarrollo de encapsulados a base de aceites esenciales con actividad inhibitoria de la acetilcolinesterasa
| dc.contributor.advisor | Ávila Murillo, Mónica Constanza | |
| dc.contributor.advisor | Castellanos Márquez, Nelson Jair | |
| dc.contributor.author | Bustos Coral, Sebastian | |
| dc.contributor.researchgroup | Grupo de Investigación en Química de Productos Naturales Vegetales Bioactivos (Quipronab) | |
| dc.coverage.country | Colombia | |
| dc.date.accessioned | 2025-09-15T16:17:31Z | |
| dc.date.available | 2025-09-15T16:17:31Z | |
| dc.date.issued | 2025 | |
| dc.description | ilustraciones (principalmente a color), diagramas, fotografías | spa |
| dc.description.abstract | La acetilcolinesterasa es la enzima encargada de la regulación de las conexiones nerviosas en animales, por ello su inhibición es objeto de estudio en diversas aplicaciones. El objetivo de este trabajo fue el estudio de la actividad inhibitoria de la acetilcolinesterasa exhibida por aceites esenciales de cítricos y hierbas aromáticas y la generación de encapsulados de estos. El estudio se dividió en dos partes: el primer capítulo se centró en el análisis del efecto de los cambios en la composición de los aceites sobre su actividad inhibitoria, inicialmente analizando cambios obtenidos como consecuencia del secado de los materiales vegetales y posteriormente estudiando el proceso de autooxidación del aceite esencial de naranja y su incidencia en la actividad inhibitoria de la enzima objeto de estudio. En general, en los estudios de secado no evidenciaron cambios drásticos en la composición de los aceites esenciales, ni en su actividad inhibitoria, mientras que el proceso de autooxidación del aceite esencial de naranja sí permitió aumentar de forma sustancial la actividad inhibitoria del aceite esencial como consecuencia de la producción de compuestos oxigenados. La segunda parte de la investigación, descrita en el capítulo 2, se centró en el estudio de la encapsulación en sílica gel y β-ciclodextrina de los aceites esenciales de naranja oxidado, limón Tahití y menta, seleccionados por sus inhibiciones in vitro en el rango del 65 al 100%. Se observó que en el caso de la sílica gel se obtiene una gran selectividad hacia los compuestos oxigenados de los aceites mientras que la β-ciclodextrina generó una encapsulación menos selectiva pero más eficiente, llegando a obtener eficiencias de encapsulación de entre 73 y 94%. Los análisis de termogravimetría y de cromatografía de gases de espacio de cabeza permitieron evidenciar estabilidad térmica de los encapsulados, mientras que los análisis de espectroscopía infrarroja dieron indicios sobre la interacción de los componentes de los aceites esenciales con los agentes encapsulantes. Los encapsulados preparados mostraron actividad inhibitoria de la acetilcolinesterasa, destacando los encapsulados de aceite esencial de naranja oxidado que mostraron inhibición de hasta el 100 % de la actividad enzimática. (Texto tomado de la fuente) | spa |
| dc.description.abstract | Acetylcholinesterase is the enzyme responsible for regulating nerve connections in animals, making its inhibition a subject of study in various applications. This work aimed to investigate the inhibitory activity of acetylcholinesterase exhibited by essential oils from citrus fruits and aromatic herbs, and to develop encapsulated formulations of these oils. The study was divided into two parts: the first chapter focused on analyzing the effect of changes in the composition of essential oils on their inhibitory activity. This included examining alterations resulting from the drying of plant materials, and subsequently, the process of autoxidation of orange essential oil and its impact on the enzyme's inhibitory activity. In general, the drying studies did not show significant changes in the essential oil composition or their inhibitory activity. However, the autoxidation process of orange essential oil led to a substantial increase in its inhibitory activity due to the formation of oxygenated compounds. The second part of the research, described in Chapter 2, focused on the encapsulation of oxidized orange, Tahiti lime, and mint essential oils using silica gel and β-cyclodextrin, these oils were selected based on their in vitro inhibition values ranging from 65% to 100%. It was observed that silica gel showed high selectivity toward oxygenated compounds in the oils, while β-cyclodextrin yielded a less selective but more efficient encapsulation, achieving efficiencies between 73% and 94%. Thermogravimetric analysis and headspace gas chromatography confirmed the thermal stability of the encapsulated oils, while infrared spectroscopy provided evidence of interactions between essential oil components and the encapsulating agents. The prepared encapsulated products exhibited acetylcholinesterase inhibitory activity, with oxidized orange essential oil encapsulates standing out by achieving up to 100% inhibition of enzymatic activity. | eng |
| dc.description.curriculararea | Química.Sede Bogotá | |
| dc.description.degreelevel | Maestría | |
| dc.description.degreename | Magíster en Ciencias - Química | |
| dc.description.researcharea | Productos Naturales | |
| dc.format.extent | xv, 131 páginas | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.instname | Universidad Nacional de Colombia | spa |
| dc.identifier.reponame | Repositorio Institucional Universidad Nacional de Colombia | spa |
| dc.identifier.repourl | https://repositorio.unal.edu.co/ | spa |
| dc.identifier.uri | https://repositorio.unal.edu.co/handle/unal/88760 | |
| dc.language.iso | spa | |
| dc.publisher | Universidad Nacional de Colombia | |
| dc.publisher.branch | Universidad Nacional de Colombia - Sede Bogotá | |
| dc.publisher.faculty | Facultad de Ciencias | |
| dc.publisher.place | Bogotá, Colombia | |
| dc.publisher.program | Bogotá - Ciencias - Maestría en Ciencias - Química | |
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| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.rights.license | Reconocimiento 4.0 Internacional | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject.bne | Esencias y aceites esenciales -- Composición | spa |
| dc.subject.bne | Essences and essential oils -- Composition | eng |
| dc.subject.bne | Aceites de cítricos | spa |
| dc.subject.bne | Citrus oils | eng |
| dc.subject.bne | Plantas aromáticas | spa |
| dc.subject.bne | Aromatic plants | eng |
| dc.subject.bne | Extractos de plantas | spa |
| dc.subject.bne | Plant extracts | eng |
| dc.subject.ddc | 540 - Química y ciencias afines | |
| dc.subject.ddc | 540 - Química y ciencias afines::547 - Química orgánica | |
| dc.subject.ddc | 660 - Ingeniería química::661 - Tecnología de químicos industriales | |
| dc.subject.decs | Inhibidores de la colinesterasa -- Química | spa |
| dc.subject.decs | Cholinesterase inhibitors -- Chemistry | eng |
| dc.subject.decs | Aceites volátiles -- Farmacología | spa |
| dc.subject.decs | Oils, volatile -- Pharmacology | eng |
| dc.subject.decs | Aceites volátiles -- Química | spa |
| dc.subject.decs | Oils, volatile -- Chemistry | eng |
| dc.subject.decs | Cápsulas -- Farmacología | spa |
| dc.subject.decs | Capsules -- Pharmacology | eng |
| dc.subject.decs | Gel de sílice | spa |
| dc.subject.decs | Silica gel | eng |
| dc.subject.decs | 2-Hidroxipropil-beta-Ciclodextrina | spa |
| dc.subject.decs | 2-Hydroxypropyl-beta-cyclodextrin | eng |
| dc.subject.decs | Ciclodextrinas -- Química | spa |
| dc.subject.decs | Cyclodextrins -- Chemistry | eng |
| dc.subject.other | Composición química | spa |
| dc.subject.other | Chemical composition | eng |
| dc.subject.proposal | Aceites esenciales | spa |
| dc.subject.proposal | Acetilcolinesterasa | spa |
| dc.subject.proposal | Encapsulación | spa |
| dc.subject.proposal | Ciclodextrina | spa |
| dc.subject.proposal | Sílica | spa |
| dc.subject.proposal | Complejos de inclusión | spa |
| dc.subject.proposal | Essential oil | eng |
| dc.subject.proposal | Acetylcholinesterase | eng |
| dc.subject.proposal | Encapsulation | eng |
| dc.subject.proposal | Cyclodextrin | eng |
| dc.subject.proposal | Silica | eng |
| dc.subject.proposal | Inclusion complexes | eng |
| dc.subject.unam | Plantas -- Efectos de los productos químicos | spa |
| dc.subject.unam | Plants -- Effect of chemicals on | eng |
| dc.title | Desarrollo de encapsulados a base de aceites esenciales con actividad inhibitoria de la acetilcolinesterasa | spa |
| dc.title.translated | Development of essential oil-based encapsulates with acetylcholinesterase inhibitory activity | eng |
| dc.type | Trabajo de grado - Maestría | |
| dc.type.coar | http://purl.org/coar/resource_type/c_bdcc | |
| dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa | |
| dc.type.content | Text | |
| dc.type.driver | info:eu-repo/semantics/masterThesis | |
| dc.type.redcol | http://purl.org/redcol/resource_type/TM | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dcterms.audience.professionaldevelopment | Bibliotecarios | |
| dcterms.audience.professionaldevelopment | Estudiantes | |
| dcterms.audience.professionaldevelopment | Investigadores | |
| dcterms.audience.professionaldevelopment | Público general | |
| oaire.accessrights | http://purl.org/coar/access_right/c_abf2 |
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