“Niveles de IGF-1 y variables hormonales y metabólicas en hombres obesos con sín-drome metabólico comparados con hombres obesos sin síndrome metabólico y hombres sanos con peso normal”
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Bernal Vargas, Mónica Alejandra
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Trabajo de grado - Pregrado
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EspañolFecha de publicación
2018
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El incremento de la prevalencia del SM conduce al aumento de la morbimortalidad relacionada con enfermedad cardiovascular y DM2. Dado que el IGF-1 media las señales en varios tejidos y permite la coordinación del metabolismo de lípidos y carbohidratos, se ha convertido en blanco de estudio para comprender la fisiopatología del síndrome metabólico. Objetivo: Comparar los niveles de IGF-1 en una población de hombres jóvenes obesos y no obesos estableciendo su relación con parámetros clínicos y antropométricos. Métodos: Se llevó a cabo un estudio de corte transversal analítico en una población de hombres entre los 18 y 30 años, 41 no obesos y 39 obesos. Se correlacionaron los niveles de IGF-1 con variables bioquímicas, antropométricas y de composición corporal, realizando un análisis descriptivo y una regresión lineal múltiple para predecir los niveles de IGF1 con las medidas de las características de interés de la población. Resultados: El grupo de obesos se obtuvo una mediana de IGF-1 de 328.9 ng/mL (±281.2-394.4) comparado con el grupo de hombres jóvenes sanos, con una mediana de 379.5 ng/mL (±318.3-436.8), con una diferencia estadísticamente significativa (p=0.02). Las variables que predijeron de manera significativa los niveles de IGF-1 fueron obesidad, el índice de relación cintura cadera y glucemia basal con coeficientes de regresión de -53,7, -615,11 y -2,36, con un valor de p = 0.049, 0.002 y 0.026 respectivamente. Conclusión: Los niveles de IGF-1 son más altos en individuos sanos comparados con individuos obesos. Los valores de glucemia y de índice cintura cadera y la presencia de obesidad, predicen de manera inversa la presencia de niveles bajos de IGF-1.
Abstract: The increasing prevalence of metabolic syndrome has led to an increased morbidity and mortality related to cardiovascular disease and DM2. Since IGF-1 mediates signals in a variety of tissues and allows the coordination of lipid and carbohydrate metabolism, it has become a target for the study of metabolic syndrome pathophysiology. Objective: To compare the levels of IGF-1 in a population of obese and non-obese young men, establishing their relationship with clinical and anthropometric parameters. Methods: An analytical cross-sectional study was carried out in a population of men between 18 and 30 years old, 41 non-obese and 39 obese. The levels of IGF-1 were correlated with biochemical, anthropometric and body composition variables, performing a descriptive analysis and a multiple linear regression to predict the levels of IGF1 with the measurements of the characteristics of interest of the population. Results: The obese group obtained a median of IGF-1 of 328.9 ng / mL (± 281.2-394.4) compared with the group of healthy young men, with a median of 379.5 ng / mL (± 318.3-436.8), with a statistically significant difference (p = 0.02). The variables that significantly predicted IGF-1 levels were obesity, waist-hip ratio and baseline glycemia. Regression coefficients were -53.7, -615.11 and -2.36, with a p-value = 0.049, 0.002 and 0.026 respectively. Conclusion: IGF-1 levels are higher in healthy individuals compared to obese individuals. The values of glycemia and hip-waist index and the presence of obesity, predict inversely the presence of low levels of IGF-1.
Abstract: The increasing prevalence of metabolic syndrome has led to an increased morbidity and mortality related to cardiovascular disease and DM2. Since IGF-1 mediates signals in a variety of tissues and allows the coordination of lipid and carbohydrate metabolism, it has become a target for the study of metabolic syndrome pathophysiology. Objective: To compare the levels of IGF-1 in a population of obese and non-obese young men, establishing their relationship with clinical and anthropometric parameters. Methods: An analytical cross-sectional study was carried out in a population of men between 18 and 30 years old, 41 non-obese and 39 obese. The levels of IGF-1 were correlated with biochemical, anthropometric and body composition variables, performing a descriptive analysis and a multiple linear regression to predict the levels of IGF1 with the measurements of the characteristics of interest of the population. Results: The obese group obtained a median of IGF-1 of 328.9 ng / mL (± 281.2-394.4) compared with the group of healthy young men, with a median of 379.5 ng / mL (± 318.3-436.8), with a statistically significant difference (p = 0.02). The variables that significantly predicted IGF-1 levels were obesity, waist-hip ratio and baseline glycemia. Regression coefficients were -53.7, -615.11 and -2.36, with a p-value = 0.049, 0.002 and 0.026 respectively. Conclusion: IGF-1 levels are higher in healthy individuals compared to obese individuals. The values of glycemia and hip-waist index and the presence of obesity, predict inversely the presence of low levels of IGF-1.