Necesidad de endoscopias terapéuticas en pacientes de cuidados intensivos en una institución colombiana

dc.contributor.advisorOtero Regino, William Alberto
dc.contributor.advisorGomez Zuleta, Martin Alonso
dc.contributor.authorGallego Ospina, Daniel Mauricio
dc.contributor.refereeRuz Morales, Oscar Fernando
dc.contributor.relatedpersonRodriguez Gutierrez, Andres Fernando
dc.date.accessioned2023-01-30T13:48:58Z
dc.date.available2023-01-30T13:48:58Z
dc.date.issued2023-01-28
dc.description.abstractIntroducción: La hemorragia gastrointestinal aguda es frecuente en los pacientes críticamente enfermos internados en UCI, con una incidencia del 5 al 25%, asociándose a un aumento de la morbilidad y mortalidad. Los estudios endoscópicos ayudan al diagnostico, estratificación y manejo de estos pacientes, sin embargo, a pesar de su frecuente realización, pueden ser normales hasta en un tercio de los pacientes con sospecha de sangrado digestivo. Objetivos: Determinar la necesidad de intervención terapéutica endoscópica en pacientes críticamente enfermos internados en UCI con hemorragia gastrointestinal manifiesta, o sospecha de hemorragia gastrointestinal Materiales y métodos: Es un estudio observacional analítico basado en los resultados de procedimientos endoscópicos gastrointestinales y registros médicos de pacientes mayores de 18 años hospitalizados en la unidad de cuidado intensivo del Hospital Universitario Nacional de Colombia, a quienes se les realizo estudios endoscópicos gastrointestinales, Resultados: Se incluyeron 210 EVDA. Los hallazgos fueron los siguientes: Esofagitis erosiva 20,5%, gastritis crónica 83,3%, gastritis erosiva 36,2%, duodenitis erosiva 12,8 y úlcera gástrica Forrest III. El 23,8% requirió endoscópia terapéutica, siendo la hemostasia endoscópica la modalidad mas frecuente 19%. El 21,4 % de los pacientes requirió endoscopia terapéutica principalmente hemostasia 19%, terapia de inyección con adrenalina 8%, ligadura 6,7%, dual 3,3%. Se documento como predictores de endoscopia terapéutica la presencia de trombocitopenia (<150.000) OR 3,3 IC 95% (1,57-6,91) p=0,001 y el antecedente de ulcera gastroduodenal o sangrado gastrointestinal previo OR 3,35 IC 95% (1,37-8,21). (Texto tomado de la fuente)spa
dc.description.abstractIntroduction: Acute gastrointestinal bleeding is frequent in critically ill patients hospitalized in ICU, with an incidence of 5 to 25%, being associated with increased morbidity and mortality. Endoscopic studies help in the diagnosis, stratification and management of these patients, however, despite their frequent performance, they may be normal in up to one third of patients with suspected gastrointestinal bleeding. Objectives: To determine the need for endoscopic therapeutic intervention in critically ill patients admitted to the ICU with overt gastrointestinal bleeding, occult or suspected gastrointestinal bleeding or acute anemia. Materials and methods: This is an analytical observational study based on the results of gastrointestinal endoscopic procedures and medical records of patients over 18 years of age hospitalized in the intensive care unit of the National University Hospital of Colombia, who underwent gastrointestinal endoscopic studies, between April 1, 2016 through April 30, 2022. Results: 210 EVDA were included. The findings were as follows: Erosive esophagitis 20.5%, chronic gastritis 83.3%, erosive gastritis 36.2%, erosive duodenitis 12.8 and Forrest III gastric ulcer. Therapeutic endoscopy was required in 23.8%, with endoscopic hemostasis being the most frequent modality 19%. Therapeutic endoscopy was required in 21.4% of patients, mainly hemostasis 19%, adrenaline injection therapy 8%, ligation 6.7%, dual 3.3%. The presence of thrombocytopenia (<150,000) OR 3.3 95% CI (1.57- 6.91) p=0.001 and a history of previous gastroduodenal ulcer or gastrointestinal bleeding OR 3.35 95% CI (1.37-8.21) wereeng
dc.description.degreelevelEspecialidades Médicasspa
dc.description.degreenameEspecialista en Gastroenterologíaspa
dc.format.extentx, 35 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/83178
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina - Especialidad en Gastroenterologíaspa
dc.relation.references1. Kwack WG. Clinical outcomes of esophagogastroduodenoscopy in critically ill patients using high-dose proton pump inhibitor for suspected bleeding: A retrospective cohort study. Medicine (Baltimore). 2021 Aug 27;100(34):e27028. doi: 10.1097/MD.0000000000027028. PMID: 34449479; PMCID: PMC8389866.spa
dc.relation.references2. Proctor DD. Critical issues in digestive diseases. Clin Chest Med. 2003 Dec;24(4):623-32. doi: 10.1016/s0272-5231(03)00103-5. PMID: 14710694.spa
dc.relation.references3. Skok P, Sinkovič A. Upper gastrointestinal haemorrhage: predictive factors of in-hospital mortality in patients treated in the medical intensive care unit. J Int Med Res. 2011;39(3):1016-27. doi: 10.1177/147323001103900337. PMID: 21819736.spa
dc.relation.references4. Bardou M, Quenot JP, Barkun A. Stress-related mucosal disease in the critically ill patient. Nat Rev Gastroenterol Hepatol. 2015 Feb;12(2):98-107. doi: 10.1038/nrgastro.2014.235. Epub 2015 Jan 6. PMID: 25560847.spa
dc.relation.references5. C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Møller MH; SUP-ICU co-authors. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med. 2015 May;41(5):833-45. doi: 10.1007/s00134-015-3725-1. Epub 2015 Apr 10. PMID: 25860444.spa
dc.relation.references6. Mutlu GM, Mutlu EA, Factor P. GI complications in patients receiving mechanical ventilation. Chest. 2001 Apr;119(4):1222-41. doi: 10.1378/chest.119.4.1222. PMID: 11296191spa
dc.relation.references7. Cook DJ, Griffith LE, Walter SD, Guyatt GH, Meade MO, Heyland DK, Kirby A, Tryba M; Canadian Critical Care Trials Group. The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients. Crit Care. 2001 Dec;5(6):368-75. doi: 10.1186/cc1071. Epub 2001 Oct 5. PMID: 11737927; PMCID: PMC83859.spa
dc.relation.references8. Marker S, Krag M, Møller MH. What's new with stress ulcer prophylaxis in the ICU? Intensive Care Med. 2017 Aug;43(8):1132-1134. doi: 10.1007/s00134-017-4733-0. Epub 2017 Feb 25. PMID: 28238056.spa
dc.relation.references9. Granholm A, Lange T, Anthon C, Marker S, Krag M, Meyhoff T, et al. Timing of onset of gastrointestinal bleeding in the ICU: protocol for a preplanned observational study. Acta Anaesth Scand. 2018. doi: https://doi.org/10.1111/ aas.13144.spa
dc.relation.references10. Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Møller MH; SUP-ICU co-authors. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med. 2015 May;41(5):833-45. doi: 10.1007/s00134-015-3725-1. Epub 2015 Apr 10. PMID: 25860444.spa
dc.relation.references11. Granholm A, Zeng L, Dionne JC, Perner A, Marker S, Krag M, MacLaren R, Ye Z, Møller MH, Alhazzani W; GUIDE Group. Predictors of gastrointestinal bleeding in adult ICU patients: a systematic review and meta-analysis. Intensive Care Med. 2019 Oct;45(10):1347-1359. doi: 10.1007/s00134-019-05751-6. Epub 2019 Sep 5. PMID: 31489445.spa
dc.relation.references12. Granholm A, Krag M, Marker S, Alhazzani W, Perner A, Møller MH. Predictors of gastrointestinal bleeding in adult ICU patients in the SUP-ICU trial. Acta Anaesthesiol Scand. 2021 Jul;65(6):792-800. doi: 10.1111/aas.13805. Epub 2021 Mar 15. PMID: 33635540.spa
dc.relation.references13. Steinberg KP. Stress-related mucosal disease in the critically ill patient: risk factors and strategies to prevent stress-related bleeding in the intensive care unit. Crit Care Med. 2002 Jun;30(6 Suppl):S362-4. doi: 10.1097/00003246-200206001-00005. PMID: 12072662.spa
dc.relation.references14. Siddiqui F, Ahmed M, Abbasi S, Avula A, Siddiqui AH, Philipose J, Khan HM, Khan TMA, Deeb L, Chalhoub M. Gastrointestinal Bleeding in Patients With Acute Respiratory Distress Syndrome: A National Database Analysis. J Clin Med Res. 2019 Jan;11(1):42-48. doi: 10.14740/jocmr3660. Epub 2018 Dec 3. PMID: 30627277; PMCID: PMC6306132.spa
dc.relation.references15. Al Duhailib Z, Dionne JC, Alhazzani W. Management of severe upper gastrointestinal bleeding in the ICU. Curr Opin Crit Care. 2020 Apr;26(2):212-218. doi: 10.1097/MCC.0000000000000699. PMID: 32004196.spa
dc.relation.references16. Church J, Kao J. Bedside colonoscopy in intensive care units: indications, techniques, and outcomes. Surg Endosc. 2014 Sep;28(9):2679-82. doi: 10.1007/s00464-014-3526-6. Epub 2014 Apr 26. PMID: 24771194.spa
dc.relation.references17. Jean-Baptiste S, Messika J, Hajage D, Gaudry S, Barbieri J, Duboc H, Dreyfuss D, Coffin B, Ricard JD. Clinical impact of upper gastrointestinal endoscopy in critically ill patients with suspected bleeding. Ann Intensive Care. 2018 Jul 4;8(1):75. doi: 10.1186/s13613-018-0423-5. PMID: 29974284; PMCID: PMC6031555.spa
dc.relation.references18. Medina Torres, D. E., Otero Regino, W., & Otero Ramos, E. R. (2019). Requerimiento de hemostasia endoscópica en pacientes de una unidad de cuidado intensivo con hemorragia de vías digestivas altas. Revista Colombiana De Gastroenterología, 34(4), 356-363. https://doi.org/10.22516/25007440.362spa
dc.relation.references19. Lin CC, Lee YC, Lee H, Lin JT, Ho WC, Chen TH, Wang HP. Bedside colonoscopy for critically ill patients with acute lower gastrointestinal bleeding. Intensive Care Med. 2005 May;31(5):743-6. doi: 10.1007/s00134-005-2604-6. Epub 2005 Apr 1. PMID: 15803300.spa
dc.relation.references20. Duboc H, Issoufaly T, Soliman H, Sztrymf B, Prat D, Le Meur M, Laissi M, Berquier G, Dreyfuss D, Coffin B, Ricard JD, Messika J. Are bedside colonoscopies performed in intensive care unit really useful? J Crit Care. 2021 Jun;63:56-61. doi: 10.1016/j.jcrc.2021.02.001. Epub 2021 Feb 10. PMID: 33618283.spa
dc.relation.references21. Rodriguez Chamorro MA, Garcia-Jimenez E, Amariles P, Rodri-guez Chamorro A, Faus MJ. [Review of the test used formeasuring therapeutic compliance in clinical practice]. AtenPrimaria. 2008;40:413---8, 13125407 [pii].spa
dc.relation.references22. Kim, J. H., Kim, J. H., Chun, J., Lee, C., Im, J. P., & Kim, J. S. (2018). Early versus late bedside endoscopy for gastrointestinal bleeding in critically ill patients. The Korean journal of internal medicine, 33(2), 304–312. https://doi.org/10.3904/kjim.2016.182spa
dc.relation.references23. Lewis, J. D., Shin, E. J., & Metz, D. C. (2000). Characterization of gastrointestinal bleeding in severely ill hospitalized patients. Critical care medicine, 28(1), 46–50. https://doi.org/10.1097/00003246-200001000-0000spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc610 - Medicina y salud::616 - Enfermedadesspa
dc.subject.otherEstudio Observacionalspa
dc.subject.otherObservational Studyeng
dc.subject.otherHemorragia Gastrointestinalspa
dc.subject.otherTrombocitopeniaeng
dc.subject.otherÚlcera Gástricaspa
dc.subject.otherGastrointestinal Hemorrhageeng
dc.subject.otherThrombocytopeniaeng
dc.subject.otherStomach Ulcereng
dc.subject.proposalEndoscopia terapéuticaspa
dc.subject.proposalUCIspa
dc.subject.proposalSangrado gastrointestinalspa
dc.subject.proposalHemostasia endoscópicaspa
dc.subject.proposalTherapeutic endoscopyeng
dc.subject.proposalICUeng
dc.subject.proposalGastrointestinal bleedingeng
dc.subject.proposalEndoscopic hemostasiseng
dc.titleNecesidad de endoscopias terapéuticas en pacientes de cuidados intensivos en una institución colombianaspa
dc.title.translatedNeed for therapeutic endoscopies in intensive care patients in a Colombian institutioneng
dc.typeTrabajo de grado - Especialidad Médicaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

Archivos

Bloque original

Mostrando 1 - 1 de 1
Cargando...
Miniatura
Nombre:
1032419191.2022.pdf
Tamaño:
778.48 KB
Formato:
Adobe Portable Document Format
Descripción:
Trabajo de grado - Especialista en Gastroenterología

Bloque de licencias

Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
5.74 KB
Formato:
Item-specific license agreed upon to submission
Descripción: