Estudio computacional de ligandos quelantes de cobre coordinados por N, O y P con potencial aplicación en la enfermedad de Alzheimer

dc.contributor.advisorAlí Torres, Jorge Isaac
dc.contributor.advisorFlores Gaspar, Areli
dc.contributor.authorPuentes Díaz, Nicolás Daniel
dc.contributor.orcid0000-0002-4638-229Xspa
dc.contributor.researchgroupQuímica Cuántica y Computacionalspa
dc.date.accessioned2023-06-01T16:11:49Z
dc.date.available2023-06-01T16:11:49Z
dc.date.issued2023
dc.descriptionilustraciones, graficasspa
dc.description.abstractLa Organización Mundial de la Salud estima que hay cerca de 50 millones de personas que padecen demencia en el mundo, casos de los cuales del 60% al 70% se trata de la enfermedad de Alzheimer (EA). Entre las características más importantes de su patología se encuentra la agregación de péptidos ß-amiloide (Aβ) a nivel cerebral, la desregulación de iones metálicos y el estrés oxidativo. Particularmente, ha sido demostrado que los complejos formados por el Aβ y el cobre extraneuronal son capaces de catalizar la producción de especies reactivas de oxígeno que pueden desencadenar la muerte neuronal. En este trabajo se estudió la potencial aplicación de 109 ligandos quelantes de cobre como posibles agentes multifuncionales en el marco de la EA, distribuidos en tres conjuntos de estructuras diversas: ligandos con átomos donadores de N, O y S, ligandos tipo pinza y ligandos tipo salen. La evaluación de su potencial farmacológico se realizó empleando herramientas bioinformáticas y de estructura electrónica siguiendo cuatro criterios clave: el cumplimiento de las reglas de cinco de Lipinski, la permeación de la barrera hematoencefálica, el potencial estándar de reducción y las afinidades por los iones de cobre. Como resultado se redujo el conjunto inicial de 109 candidatos identificando 8 ligandos como prometedores agentes antioxidantes y 8 ligandos como prometedores agentes redistribuidores en el marco de la EA. Adicionalmente, se propone un mecanismo multifuncional novedoso denominado mecanismo supresor para el cual se identificaron 3 candidatos prometedores. De esta forma, se proponen en total 19 moléculas para dar el paso a una caracterización farmacológica en el marco de la EA de manera experimental. (Texto tomado de la fuente)spa
dc.description.abstractThe World Health Organization estimates that about 50 million people suffer from dementia worldwide, cases of which 60% to 70% are due to Alzheimer’s disease (AD). Among the most important characteristics of its pathology are the β-amyloid peptide (Aβ) aggregation in the brain, the metallic ion dysregulation, and oxidative stress. In particular, it has been shown that the complexes formed by Aβ and extraneuronal copper are capable of catalyzing the production of reactive oxygen species that can lead to neuronal death. In this work, the potential application of 109 copper chelating ligands as multifunctional agents in the framework of AD was studied, distributed in three sets of diverse structures: ligands with N, O and S donor atoms, pincer-type ligands, and salen-type ligands. Its pharmacological potential evaluation was carried out using bioinformatic and electronic structure tools following four key criteria: compliance with Lipinski’s rules of five, blood-brain barrier permeation, standard reduction potential, and affinities towards copper ions. As a result, the initial set of 109 candidates was narrowed down, identifying 8 ligands as promising antioxidant agents and 8 ligands as promising distributor agents in AD’s framework. Additionally, a novel multifunctional mechanism called suppressor mechanism is proposed for which 3 promising candidates were identified. In this way, a total of 19 molecules are proposed to initiate their experimental pharmacological characterization in AD’s framework.eng
dc.description.degreelevelMaestríaspa
dc.format.extentxii, 163 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/83945
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias - Químicaspa
dc.relation.referencesCipriani, G.; Dolciotti, C.; Picchi, L. y Bonuccelli, U. Neurological Sciences 2011, 32, 275-279spa
dc.relation.referencesHaynes, S. y Feinleib, M., Second Conference on the Epidemiology of Aging : proceedings of the second conference, March 28-29, 1977, National Institutes of Health, Bethesda, Md. U.S Department of Health y Human Services: 1980spa
dc.relation.referencesWorld Health Organization Dementia https://www.who.int/es/news-room/factsheets/ detail/dementiaspa
dc.relation.referencesAzheimer’s Association Alzheimer’s & Dementia 2022, 18, 700-789spa
dc.relation.referencesWang, L.; Yin, Y.-L.; Liu, X.-Z.; Shen, P.; Zheng, Y.-G.; Lan, X.-R.; Lu, C.-B. y Wang, J.-Z. Translational Neurodegeneration 2020, 9, 10spa
dc.relation.referencesCummings, J. L.; Morstorf, T. y Zhong, K. Alzheimer’s Research & Therapy 2014, 6, 37spa
dc.relation.referencesRamesh, M. y Govindaraju, T. Chemical Science 2022, 13, 13657-13689spa
dc.relation.referencesKim, A.; Lim, S. y Kim, Y. International Journal of Molecular Sciences 2018, 19, 128spa
dc.relation.referencesDi Natale, G.; Sabatino, G.; Sciacca, M. F. M.; Tosto, R.; Milardi, D. y Pappalardo, G. Molecules 2022, 27, 5066spa
dc.relation.referencesSelkoe, D. J. Nature 2003, 426, 900-4spa
dc.relation.referencesRauk, A. Chemical Society Reviews 2009, 38, 2698-2715spa
dc.relation.referencesWilquet, V. y Strooper, B. D. Current Opinion in Neurobiology 2004, 14, 582-588spa
dc.relation.referencesSelkoe, D. J. Science 2002, 298, 789-791spa
dc.relation.referencesBishop, G. M. y Robinson, S. R. Drugs & Aging 2004, 21, 621-630spa
dc.relation.referencesAlí-Torres, J.; Mirats, A.; Maréchal, J.-D.; Rodríguez-Santiago, L. y Sodupe, M. The Journal of Physical Chemistry B 2014, 118, 4840-4850spa
dc.relation.referencesWhite, A. R.; Reyes, R.; Mercer, J. F.; Camakaris, J.; Zheng, H.; Bush, A. I.; Multhaup, G.; Beyreuther, K.; Masters, C. L. y Cappai, R. Brain Research 1999, 842, 439-444spa
dc.relation.referencesRajasekhar, K.; Chakrabarti, M. y Govindaraju, T. Chemical Communications 2015, 51, 13434-13450spa
dc.relation.referencesPanza, F.; Lozupone, M.; Logroscino, G. e Imbimbo, B. P. Nature Reviews Neurology 2019, 15, 73-88spa
dc.relation.referencesPanza, F.; Lozupone, M.; Seripa, D. e Imbimbo, B. P. Annals of Neurology 2019, 85, 303-315spa
dc.relation.referencesLoureiro, J. C.; Pais, M. V.; Stella, F.; Radanovic, M.; Teixeira, A. L.; Forlenza, O. V. y de Souza, L. C. Current Opinion in Psychiatry 2020, 33, 284-291spa
dc.relation.referencesDavis, D. G.; Schmitt, F. A.; Wekstein, D. R. y Markesbery, W. R. Journal of Neuropathology and Experimental Neurology 1999, 58, 376-388spa
dc.relation.referencesNeve, R. L. y Robakis, N. K. Trends in Neurosciences 1998, 21, 15-19spa
dc.relation.referencesYang, S.; Landau, S. y Jagust, W. Lifelong brain-stimulating habits linked to lower Alzheimer’s protein levels https://news.berkeley.edu/2012/01/23/engagedbrain- amyloid-alzheimers/spa
dc.relation.referencesSalim, S. Journal of Pharmacology and Experimental Therapeutics 2017, 360, 201-205spa
dc.relation.referencesCampian, J. L.; Qian, M.; Gao, X. y Eaton, J. W. Journal of Biological Chemistry 2004, 279, 46580-46587spa
dc.relation.referencesTurrens, J. F. The Journal of Physiology 2003, 552, 335-344spa
dc.relation.referencesBrand, M. D. Free Radical Biology and Medicine 2016, 100, 14-31spa
dc.relation.referencesZhou, X.; Zhuang, Z.; Wang, W.; He, L.; Wu, H.; Cao, Y.; Pan, F.; Zhao, J.; Hu, Z.; Sekhar, C. y Guo, Z. Cellular Signalling 2016, 28, 1163-1171spa
dc.relation.referencesSharma, P.; Jha, A. B.; Dubey, R. S. y Pessarakli, M. Journal of Botany 2012, 2012, 1-26spa
dc.relation.referencesDietz, K.-J.; Baier, M. y Krämer, U. en Heavy Metal Stress in Plants; Springer Berlin Heidelberg: Berlin, Heidelberg, 1999, págs. 73-97spa
dc.relation.referencesHeld, P. BioTek Instruments 2021, 1-14spa
dc.relation.referencesJomova, K. y Valko, M. Toxicology 2011, 283, 65-87spa
dc.relation.referencesHippeli, S. y Elstner, E. F. FEBS Letters 1999, 443, 1-7spa
dc.relation.referencesJomova, K.; Baros, S. y Valko, M. Transition Metal Chemistry 2012, 37, 127-134spa
dc.relation.referencesKehrer, J. P. Toxicology 2000, 149, 43-50spa
dc.relation.referencesChevion, M.; Berenshtein, E. y Zhu, B.-Z. en Reactive Oxygen Species in Biological Systems; Kluwer Academic Publishers: Boston, 2006, p´ags. 103-131spa
dc.relation.referencesProusek, J. Pure and Applied Chemistry 2007, 79, 2325-2338spa
dc.relation.referencesLiochev, S. I. y Fridovich, I. Redox Report 2002, 7, 55-57spa
dc.relation.referencesShen, J.; Griffiths, P. T.; Campbell, S. J.; Utinger, B.; Kalberer, M. y Paulson, S. E. Scientific Reports 2021, 11, 7417spa
dc.relation.referencesDikalov, S. I.; Vitek, M. P. y Mason, R. P. Free Radical Biology and Medicine 2004, 36, 340-347spa
dc.relation.referencesNúñez, M. T. e Hidalgo, C. Frontiers in Neuroscience 2019, 13, DOI: 10.3389/ fnins.2019.00048spa
dc.relation.referencesGoldstein, J. C.; Waterhouse, N. J.; Juin, P.; Evan, G. I. y Green, D. R. Nature Cell Biology 2000, 2, 156-162spa
dc.relation.referencesMirats, A.; Alí-Torres, J.; Rodríguez-Santiago, L.; Sodupe, M. y La Penna, G. Physical Chemistry Chemical Physics 2015, 17, 27270-27274spa
dc.relation.referencesMirats, A.; Alí-Torres, J.; Rodríguez-Santiago, L. y Sodupe, M. Theoretical Chemistry Accounts 2016, 135, 75.spa
dc.relation.referencesEn Principles of Biochemistry, 6.a ed.; W. H. Freeman & Company: 2009; cap. 13, pág. 531spa
dc.relation.referencesNguyen, M.; Huang, M.; Liu, Y.; Meunier, B. y Robert, A. Comptes Rendus Chimie 2017, 20, 987-989spa
dc.relation.referencesRai, R. K.; Chalana, A.; Karri, R.; Das, R.; Kumar, B. y Roy, G. Inorganic Chemistry 2019, 58, 6628-6638spa
dc.relation.referencesGuo, Q.; Sopher, B. L.; Furukawa, K.; Pham, D. G.; Robinson, N.; Martin, G. M. y Mattson, M. P. The Journal of Neuroscience 1997, 17, 4212-4222spa
dc.relation.referencesMarques, C. A.; Keil, U.; Bonert, A.; Steiner, B.; Haass, C.; Müller, W. E. y Eckert, A. Journal of Biological Chemistry 2003, 278, 28294-28302spa
dc.relation.referencesEckert, A.; Steiner, B.; Marques, C.; Leutz, S.; Romig, H.; Haass, C. y M¨uller, W. E. Journal of Neuroscience Research 2001, 64, 183-192spa
dc.relation.referencesSmith, M. A.; Hirai, K.; Hsiao, K.; Pappolla, M. A.; Harris, P. L. R.; Siedlak, S. L.; Tabaton, M. y Perry, G. Journal of Neurochemistry 2002, 70, 2212-2215spa
dc.relation.referencesLaFontaine, M. A.; Mattson, M. P. y Butterfield, D. A. Neurochemical Research 2002, 27, 417-421spa
dc.relation.referencesSchuessel, K.; Frey, C.; Jourdan, C.; Keil, U.;Weber, C. C.; M¨uller-Spahn, F.; M¨uller, W. E. y Eckert, A. Free Radical Biology and Medicine 2006, 40, 850-862spa
dc.relation.referencesBogdanovic, N.; Zilmer, M.; Zilmer, K.; Rehema, A. y Karelson, E. Dementia and Geriatric Cognitive Disorders 2001, 12, 364-370spa
dc.relation.referencesLeibson, C. L.; Rocca, W. A.; Hanson, V. A.; Cha, R.; Kokmen, E.; O’Brien, P. C. y Palumbo, P. J. American Journal of Epidemiology 1997, 145, 301-308spa
dc.relation.referencesGuo, Z. et al. Neurology 2000, 54, 1316-1323spa
dc.relation.referencesKivipelto, M.; Helkala, E.-L.; Laakso, M. P.; H¨anninen, T.; Hallikainen, M.; Alhainen, K.; Iivonen, S.; Mannermaa, A.; Tuomilehto, J.; Nissinen, A. y Soininen, H. Annals of Internal Medicine 2002, 137, 149spa
dc.relation.referencesHonig, L. S.; Tang, M.-X.; Albert, S.; Costa, R.; Luchsinger, J.; Manly, M.; Stern, Y. y Mayeux, R. Archives of Neurology 2004, 61, 368spa
dc.relation.referencesFoley, D. J. y White, L. R. JAMA 2002, 287, 3261spa
dc.relation.referencesMorris, M. C.; Evans, D. A.; Bienias, J. L.; Tangney, C. C.; Bennett, D. A.; Wilson, R. S.; Aggarwal, N. y Schneider, J. Archives of Neurology 2003, 60, 940spa
dc.relation.referencesTruelsen, T.; Thudium, D. y Gronbaek, M. Neurology 2002, 59, 1313-1319spa
dc.relation.referencesSung, S.; Yao, Y.; Uryu, K.; Yang, H.; Lee, V. M.; Trojanowski, J. Q. y Pratic`o, D. The FASEB Journal 2004, 18, 323-325spa
dc.relation.referencesNunomura, A.; Perry, G.; Aliev, G.; Hirai, K.; Takeda, A.; Balraj, E. K.; Jones, P. K.; Ghanbari, H.; Wataya, T.; Shimohama, S.; Chiba, S.; Atwood, C. S.; Petersen, R. B. y Smith, M. A. Journal of Neuropathology & Experimental Neurology 2001, 60, 759-767spa
dc.relation.referencesAbe, T.; Tohgi, H.; Isobe, C.; Murata, T. y Sato, C. Journal of Neuroscience Research 2002, 70, 447-450spa
dc.relation.referencesNunomura, A.; Perry, G.; Pappolla, M. A.; Wade, R.; Hirai, K.; Chiba, S. y Smith, M. A. The Journal of Neuroscience 1999, 19, 1959-1964spa
dc.relation.referencesNunomura, A.; Chiba, S.; Lippa, C. F.; Cras, P.; Kalaria, R. N.; Takeda, A.; Honda, K.; Smith, M. A. y Perry, G. Neurobiology of Disease 2004, 17, 108-113spa
dc.relation.referencesDrake, J.; Link, C. D. y Butterfield, D. A. Neurobiology of aging 2003, 24, 415-20spa
dc.relation.referencesKontush, A.; Berndt, C.;Weber, W.; Akopyan, V.; Arlt, S.; Schippling, S. y Beisiegel, U. Free Radical Biology and Medicine 2001, 30, 119-128spa
dc.relation.referencesZou, K.; Gong, J.-S.; Yanagisawa, K. y Michikawa, M. The Journal of Neuroscience 2002, 22, 4833-4841spa
dc.relation.referencesSmith, M. A.; Nunomura, A.; Zhu, X.; Takeda, A. y Perry, G. Antioxidants & Redox Signaling 2000, 2, 413-420spa
dc.relation.referencesGIACOBINI, E. Annals of the New York Academy of Sciences 2006, 920, 321-327spa
dc.relation.referencesParsons, C. G.; St¨offler, A. y Danysz, W. Neuropharmacology 2007, 53, 699-723spa
dc.relation.referencesAdlard, P. A. y Bush, A. I. Journal of Alzheimer’s Disease 2018, 62, ed. por Perry, G.; Avila, J.; Tabaton, M. y Zhu, X., 1369-1379spa
dc.relation.referencesMezzaroba, L.; Alfieri, D. F.; Colado Sim˜ao, A. N. y Vissoci Reiche, E. M. NeuroToxicology 2019, 74, 230-241spa
dc.relation.referencesBush, A. I. y Curtain, C. C. European Biophysics Journal 2008, 37, 241-245spa
dc.relation.referencesBush, A. I. Journal of Alzheimer’s Disease 2008, 15, ed. por Chohan, M. O., 223-240spa
dc.relation.referencesLovell, M.; Robertson, J.; Teesdale, W.; Campbell, J. y Markesbery, W. Journal of the Neurological Sciences 1998, 158, 47-52spa
dc.relation.referencesDel Barrio, M.; Borghesani, V.; Hureau, C. y Faller, P. en Biometals in Neurodegenerative Diseases, 1.a ed.; Elsevier: 2017; cap. 14, p´ags. 265-281spa
dc.relation.referencesHung, Y. H.; Bush, A. I. y Cherny, R. A. JBIC Journal of Biological Inorganic Chemistry 2010, 15, 61-76spa
dc.relation.referencesValko, M.; Morris, H. y Cronin, M. Current Medicinal Chemistry 2005, 12, 1161-1208spa
dc.relation.referencesBost, M.; Houdart, S.; Oberli, M.; Kalonji, E.; Huneau, J.-F. y Margaritis, I. Journal of Trace Elements in Medicine and Biology 2016, 35, 107-115spa
dc.relation.referencesDavies, K. M.; Hare, D. J.; Cottam, V.; Chen, N.; Hilgers, L.; Halliday, G.; Mercer, J. F. B. y Double, K. L. Metallomics 2013, 5, 43-51spa
dc.relation.referencesXiao, T.; Ackerman, C. M.; Carroll, E. C.; Jia, S.; Hoagland, A.; Chan, J.; Thai, B.; Liu, C. S.; Isacoff, E. Y. y Chang, C. J. Nature Chemical Biology 2018, 14, 655-663spa
dc.relation.referencesRae, T. D.; Schmidt, P. J.; Pufahl, R. A.; Culotta, V. C. y V. O’Halloran, T. Science 1999, 284, 805-808spa
dc.relation.referencesLanza, V.; Travaglia, A.; Malgieri, G.; Fattorusso, R.; Grasso, G.; Di Natale, G.; Zito, V.; Arena, G.; Milardi, D. y Rizzarelli, E. Chemistry - A European Journal 2016, 22, 17767-17775spa
dc.relation.referencesSpeisky, H.; Gómez, M.; Carrasco-Pozo, C.; Pastene, E.; Lopez-Alarcón, C. y Olea- Azar, C. Bioorganic & Medicinal Chemistry 2008, 16, 6568-6574spa
dc.relation.referencesSpeisky, H.; Gómez, M.; Burgos-Bravo, F.; Lopez-Alarcón, C.; Jullian, C.; Olea-Azar, C. y Aliaga, M. E. Bioorganic & Medicinal Chemistry 2009, 17, 1803-1810spa
dc.relation.referencesMatheou, C. J.; Younan, N. D. y Viles, J. H. Biochemical Journal 2015, 466, 233-242spa
dc.relation.referencesSparks, D. L. y Schreurs, B. G. Proceedings of the National Academy of Sciences 2003, 100, 11065-11069spa
dc.relation.referencesXu, J.; Church, S. J.; Patassini, S.; Begley, P.; Waldvogel, H. J.; Curtis, M. A.; Faull, R. L. M.; Unwin, R. D. y Cooper, G. J. S. Metallomics 2017, 9, 1106-1119.spa
dc.relation.referencesKaden, D.; Bush, A. I.; Danzeisen, R.; Bayer, T. A. y Multhaup, G. International Journal of Alzheimer’s Disease 2011, 2011, 1-5spa
dc.relation.referencesBellingham, S. A.; Lahiri, D. K.; Maloney, B.; La Fontaine, S.; Multhaup, G. y Camakaris, J. Journal of Biological Chemistry 2004, 279, 20378-20386spa
dc.relation.referencesCater, M. A.; McInnes, K. T.; Li, Q.-X.; Volitakis, I.; La Fontaine, S.; Mercer, J. F. B. y Bush, A. I. Biochemical Journal 2008, 412, 141-152spa
dc.relation.referencesRaffa, D. F.; G´omez-Balderas, R.; Brunelle, P.; Rickard, G. A. y Rauk, A. JBIC Journal of Biological Inorganic Chemistry 2005, 10, 887-902spa
dc.relation.referencesRickard, G. A.; Gomez-Balderas, R.; Brunelle, P.; Raffa, D. F. y Rauk, A. The Journal of Physical Chemistry A 2005, 109, 8361-8370spa
dc.relation.referencesStrodel, B. y Coskuner-Weber, O. Journal of Chemical Information and Modeling 2019, 59, 1782-1805spa
dc.relation.referencesDrew, S. C. y Barnham, K. J. Accounts of Chemical Research 2011, 44, 1146-1155spa
dc.relation.referencesAtrián-Blasco, E.; Gonzalez, P.; Santoro, A.; Alies, B.; Faller, P. y Hureau, C. Coordination Chemistry Reviews 2018, 371, 38-55spa
dc.relation.referencesHewitt, N. y Rauk, A. The Journal of Physical Chemistry B 2009, 113, 1202-1209spa
dc.relation.referencesKong, X.; Zhao, Z.; Lei, X.; Zhang, B.; Dai, D. y Jiang, L. The Journal of Physical Chemistry A 2015, 119, 3528-3534spa
dc.relation.referencesArrigoni, F.; Di Carlo, C.; Rovetta, A.; De Gioia, L.; Zampella, G. y Bertini, L. European Journal of Inorganic Chemistry 2022, 2022, DOI: 10.1002/ejic.202200245spa
dc.relation.referencesAlí-Torres, J.; Mirats, A.; Maréchal, J.-D.; Rodríguez-Santiago, L. y Sodupe, M. AIP Advances 2015, 5, 092402spa
dc.relation.referencesRaffa, D. F. y Rauk, A. The journal of physical chemistry. B 2007, 111, 3789-99spa
dc.relation.referencesFurlan, S.; Hureau, C.; Faller, P. y La Penna, G. The Journal of Physical Chemistry B 2010, 114, 15119-15133spa
dc.relation.referencesAlí-Torres, J.; Maréchal, J.-D.; Rodríguez-Santiago, L. y Sodupe, M. Journal of the American Chemical Society 2011, 133, 15008-15014spa
dc.relation.referencesReybier, K.; Ayala, S.; Alies, B.; Rodrigues, J. V.; Bustos Rodriguez, S.; La Penna, G.; Collin, F.; Gomes, C. M.; Hureau, C. y Faller, P. Angewandte Chemie 2016, 128, 1097-1101spa
dc.relation.referencesCheng, Z. y Li, Y. Chemical Reviews 2007, 107, 2165-2165spa
dc.relation.referencesRao, R. y Georgieff, M. K. Seminars in Fetal and Neonatal Medicine 2007, 12, 54-63spa
dc.relation.referencesChristy, A. L.; Manjrekar, P. A.; Babu, R. P.; Hegde, A. y Rukmini, M. S. Iranian biomedical journal 2014, 18, 88-93spa
dc.relation.referencesLevi, S. y Finazzi, D. Frontiers in Pharmacology 2014, 5, 1-21spa
dc.relation.referencesWang, X.; Zhang, J.; Zhou, L.; Xu, B.; Ren, X.; He, K.; Nie, L.; Li, X.; Liu, J.; Yang, X. y Yuan, J. Food and Chemical Toxicology 2019, 130, 242-252spa
dc.relation.referencesSchrag, M.; Mueller, C.; Oyoyo, U.; Smith, M. A. y Kirsch, W. M. Progress in Neurobiology 2011, 94, 296-306spa
dc.relation.referencesAkatsu, H.; Hori, A.; Yamamoto, T.; Yoshida, M.; Mimuro, M.; Hashizume, Y.; Tooyama, I. y Yezdimer, E. M. BioMetals 2012, 25, 337-350spa
dc.relation.referencesWong, B. X.; Tsatsanis, A.; Lim, L. Q.; Adlard, P. A.; Bush, A. I. y Duce, J. A. PLoS ONE 2014, 9, ed. por Lakshmana, M. K., e114174spa
dc.relation.referencesBelaidi, A. A.; Gunn, A. P.; Wong, B. X.; Ayton, S.; Appukuttan, A. T.; Roberts, B. R.; Duce, J. A. y Bush, A. I. Neurotherapeutics 2018, 15, 1055-1062spa
dc.relation.referencesRaha, A. A.; Vaishnav, R. A.; Friedland, R. P.; Bomford, A. y Raha-Chowdhury, R. Acta Neuropathologica Communications 2013, 1, 55spa
dc.relation.referencesGanz, T. Blood 2003, 102, 783-788spa
dc.relation.referencesKemna, E. H.; Tjalsma, H.; Willems, H. L. y Swinkels, D. W. Haematologica 2008, 93, 90-97spa
dc.relation.referencesBanerjee, P.; Sahoo, A.; Anand, S.; Ganguly, A.; Righi, G.; Bovicelli, P.; Saso, L. y Chakrabarti, S. NeuroMolecular Medicine 2014, 16, 787-798spa
dc.relation.referencesSilvestri, L. y Camaschella, C. Journal of Cellular and Molecular Medicine 2008, 12, 1548-1550spa
dc.relation.referencesLiu, B.; Moloney, A.; Meehan, S.; Morris, K.; Thomas, S. E.; Serpell, L. C.; Hider, R.; Marciniak, S. J.; Lomas, D. A. y Crowther, D. C. Journal of Biological Chemistry 2011, 286, 4248-4256spa
dc.relation.referencesScott, L. E. y Orvig, C. Chemical Reviews 2009, 109, 4885-4910spa
dc.relation.referencesAlí-Torres, J.; Rodríguez-Santiago, L.; Sodupe, M. y Rauk, A. The Journal of Physical Chemistry A 2011, 115, 12523-12530spa
dc.relation.referencesOrjuela, A. L.; Núñez-Zarur, F. y Alí-Torres, J. RSC Advances 2022, 12, 24077-24087spa
dc.relation.referencesRogers, J. T.; Venkataramani, V.; Washburn, C.; Liu, Y.; Tummala, V.; Jiang, H.; Smith, A. y Cahill, C. M. Journal of Neurochemistry 2016, 138, 479-494spa
dc.relation.referencesRajendran, R.; Minqin, R.; Ynsa, M. D.; Casadesus, G.; Smith, M. A.; Perry, G.; Halliwell, B. y Watt, F. Biochemical and Biophysical Research Communications 2009, 382, 91-95spa
dc.relation.referencesGuo, C.; Wang, P.; Zhong, M.-L.; Wang, T.; Huang, X.-S.; Li, J.-Y. y Wang, Z.-Y. Neurochemistry International 2013, 62, 165-172spa
dc.relation.referencesGumpelmayer, M.; Nguyen, M.; Moln´ar, G.; Bousseksou, A.; Meunier, B. y Robert, A. Angewandte Chemie International Edition 2018, 57, 14758-14763spa
dc.relation.referencesKepp, K. P. Chemical Reviews 2012, 112, 5193-5239spa
dc.relation.referencesMiura, T.; Suzuki, K. y Takeuchi, H. Journal of Molecular Structure 2001, 598, 79-84spa
dc.relation.referencesExley, C. y Mold, M. J. Journal of Trace Elements in Medicine and Biology 2015, 30, 90-95spa
dc.relation.referencesKrewski, D.; Yokel, R. A.; Nieboer, E.; Borchelt, D.; Cohen, J.; Harry, J.; Kacew, S.; Lindsay, J.; Mahfouz, A. M. y Rondeau, V. Journal of Toxicology and Environmental Health, Part B 2007, 10, 1-269spa
dc.relation.referencesKLATZO, I.; WISNIEWSKI, H. y STREICHER, E. Journal of Neuropathology and Experimental Neurology 1965, 24, 187-199spa
dc.relation.referencesSchreeder, M. T.; Favero, M. S.; Hughes, J. R.; Petersen, N. J.; Bennett, P. H. y Maynard, J. E. Journal of Chronic Diseases 1983, 36, 581-593spa
dc.relation.referencesMcDermott, J. R.; Smith, A. I.; Iqbal, K. y Wisniewski, M.D., H. M. Neurology 1979, 29, 809-809spa
dc.relation.referencesReusche, E.; Koch, V.; Lindner, B.; Harrison, A. P. y Friedrich, H. J. Acta Neuropathologica 2001, 101, 211-216spa
dc.relation.referencesMunoz, D. G. Archives of Neurology 1998, 55, 737spa
dc.relation.referencesFukuzumi, S.; Ohtsu, H.; Ohkubo, K.; Itoh, S. e Imahori, H. Coordination Chemistry Reviews 2002, 226, 71-80spa
dc.relation.referencesMujika, J. I.; Rodr´ıguez-Guerra Pedregal, J.; Lopez, X.; Ugalde, J. M.; Rodr´ıguez- Santiago, L.; Sodupe, M. y Mar´echal, J.-D. Chemical Science 2017, 8, 5041-5049spa
dc.relation.referencesRuip´erez, F.; Mujika, J.; Ugalde, J.; Exley, C. y Lopez, X. Journal of Inorganic Biochemistry 2012, 117, 118-123spa
dc.relation.referencesAnzellotti, A. I. y Farrell, N. P. Chemical Society Reviews 2008, 37, 1629spa
dc.relation.referencesTønder, N.; Johansen, F.; Frederickson, C.; Zimmer, J. y Diemer, N. Neuroscience Letters 1990, 109, 247-252spa
dc.relation.referencesAdlard, P. A.; Parncutt, J. M.; Finkelstein, D. I. y Bush, A. I. Journal of Neuroscience 2010, 30, 1631-1636spa
dc.relation.referencesLyubartseva, G.; Smith, J. L.; Markesbery, W. R. y Lovell, M. A. Brain Pathology 2010, 20, 343-350spa
dc.relation.referencesBosomworth, H. J.; Adlard, P. A.; Ford, D. y Valentine, R. A. PLoS ONE 2013, 8, ed. por Skoulakis, E. M. C., e65475spa
dc.relation.referencesZhao, L.; Liu, Q.; Ma, S.; Zhang, Y. y Liang, P. Annals of clinical and laboratory science 2018, 48, 446-452spa
dc.relation.referencesYin, H. Z.; Sensi, S. L.; Ogoshi, F. y Weiss, J. H. The Journal of Neuroscience 2002, 22, 1273-1279spa
dc.relation.referencesKumar, V.; Singh, D.; Singh, B. K.; Singh, S.; Mittra, N.; Jha, R. R.; Patel, D. K. y Singh, C. Molecular and Cellular Biochemistry 2018, 444, 149-160spa
dc.relation.referencesFrazzini, V.; Granzotto, A.; Bomba, M.; Massetti, N.; Castelli, V.; D’Aurora, M.; Punzi, M.; Iorio, M.; Mosca, A.; Delli Pizzi, S.; Gatta, V.; Cimini, A. y Sensi, S. L. Scientific Reports 2018, 8, 9768spa
dc.relation.referencesBush, A.; Pettingell, W.; Multhaup, G.; d Paradis, M.; Vonsattel, J.; Gusella, J.; Beyreuther, K.; Masters, C. y Tanzi, R. Science 1994, 265, 1464-1467spa
dc.relation.referencesHoke, D. E.; Tan, J.-L.; Ilaya, N. T.; Culvenor, J. G.; Smith, S. J.; White, A. R.; Masters, C. L. y Evin, G. M. FEBS Journal 2005, 272, 5544-5557spa
dc.relation.referencesCormick, G. y Beliz´an, J. M. Nutrients 2019, 11, 1606spa
dc.relation.referencesSudhof, T. C. Cold Spring Harbor Perspectives in Biology 2012, 4, a011353-a011353spa
dc.relation.referencesDolphin, A. C. y Lee, A. Nature Reviews Neuroscience 2020, 21, 213-229spa
dc.relation.referencesKhachaturian, Z. S. Alzheimer’s & Dementia 2017, 13, 178spa
dc.relation.referencesWang, Y.; Shi, Y. y Wei, H. Journal of Alzheimer’s Disease & Parkinsonism 2017, 7, 374spa
dc.relation.referencesKuchibhotla, K. V.; Goldman, S. T.; Lattarulo, C. R.; Wu, H.-Y.; Hyman, B. T. y Bacskai, B. J. Neuron 2008, 59, 214-225spa
dc.relation.referencesSciacca, M. F. M.; Monaco, I.; La Rosa, C. y Milardi, D. Chemical Communications 2018, 54, 3629-3631spa
dc.relation.referencesDemuro, A.; Mina, E.; Kayed, R.; Milton, S. C.; Parker, I. y Glabe, C. G. Journal of Biological Chemistry 2005, 280, 17294-17300spa
dc.relation.referencesAyton, S.; Lei, P. y Bush, A. I. Free Radical Biology and Medicine 2013, 62, 76-89spa
dc.relation.referencesBortolato, M.; Chen, K. y Shih, J. C. Advanced Drug Delivery Reviews 2008, 60, 1527-1533spa
dc.relation.referencesZhang, H.-Y. FEBS Letters 2005, 579, 5260-5264spa
dc.relation.referencesSampietro, A.; Pérez-Areales, F. J.; Martínez, P.; Arce, E. M.; Galdeano, C. y Muñoz- Torrero, D. Pharmaceuticals 2022, 15, 545spa
dc.relation.referencesFan, J. y de Lannoy, I. A. Biochemical Pharmacology 2014, 87, 93-120spa
dc.relation.referencesPardridge, W. M. Alzheimer’s & Dementia 2009, 5, 427-432spa
dc.relation.referencesLipinski, C. A.; Lombardo, F.; Dominy, B. W. y Feeney, P. J. Advanced Drug Delivery Reviews 2001, 46, 3-26spa
dc.relation.referencesRodríguez-Rodríguez, C.; Rimola, A.; Alí-Torres, J.; Sodupe, M. y González-Duarte, P. Journal of Computer-Aided Molecular Design 2011, 25, 21-30spa
dc.relation.referencesClark, D. E. Journal of Pharmaceutical Sciences 1999, 88, 815-821spa
dc.relation.referencesStorr, T. Canadian Journal of Chemistry 2021, 99, 1-9spa
dc.relation.referencesSantos, M. A.; Chand, K. y Chaves, S. Coordination Chemistry Reviews 2016, 327- 328, 287-303spa
dc.relation.referencesBolognesi, M. L.; Bartolini, M.; Tarozzi, A.; Morroni, F.; Lizzi, F.; Milelli, A.; Minarini, A.; Rosini, M.; Hrelia, P.; Andrisano, V. y Melchiorre, C. Bioorganic & Medicinal Chemistry Letters 2011, 21, 2655-2658spa
dc.relation.referencesRosini, M.; Simoni, E.; Bartolini, M.; Tarozzi, A.; Matera, R.; Milelli, A.; Hrelia, P.; Andrisano, V.; Bolognesi, M. L. y Melchiorre, C. European Journal of Medicinal Chemistry 2011, 46, 5435-5442spa
dc.relation.referencesCavalli, A.; Bolognesi, M. L.; Capsoni, S.; Andrisano, V.; Bartolini, M.; Margotti, E.; Cattaneo, A.; Recanatini, M. y Melchiorre, C. Angewandte Chemie International Edition 2007, 46, 3689-3692spa
dc.relation.referencesRodríguez-Rodríguez, C.; Telpoukhovskaia, M. y Orvig, C. Coordination Chemistry Reviews 2012, 256, 2308-2332spa
dc.relation.referencesRimola, A.; Alí-Torres, J.; Rodríguez-Rodríguez, C.; Poater, J.; Matito, E.; Solà, M. y Sodupe, M. The Journal of Physical Chemistry A 2011, 115, 12659-12666spa
dc.relation.referencesGyurcsik, B. y Nagy, L. Coordination Chemistry Reviews 2000, 203, 81-149spa
dc.relation.referencesLiu, G.; Men, P.; Kudo, W.; Perry, G. y Smith, M. A. Neuroscience Letters 2009, 455, 187-190.spa
dc.relation.referencesHureau, C.; Sasaki, I.; Gras, E. y Faller, P. ChemBioChem 2010, 11, 950-953spa
dc.relation.referencesPithadia, A. S.; Kochi, A.; Soper, M. T.; Beck, M. W.; Liu, Y.; Lee, S.; DeToma, A. S.; Ruotolo, B. T. y Lim, M. H. Inorganic Chemistry 2012, 51, 12959-12967spa
dc.relation.referencesSegal, M. B. y Zlokovic, B. V., The Blood-Brain Barrier, Amino Acids and Peptides; Springer Netherlands: Dordrecht, 1989spa
dc.relation.referencesSelvaraj, C.; Chandra, I. y Singh, S. K. Molecular Diversity 2022, 26, 1893-1913spa
dc.relation.referencesRodríguez-Rodríguez, C.; Sánchez de Groot, N.; Rimola, A.; Álvarez-Larena, Á.; Lloveras, V.; Vidal-Gancedo, J.; Ventura, S.; Vendrell, J.; Sodupe, M. y González- Duarte, P. Journal of the American Chemical Society 2009, 131, 1436-1451spa
dc.relation.referencesDrew, S. C. Frontiers in Neuroscience 2017, 11, DOI: 10.3389/fnins.2017.00317spa
dc.relation.referencesSquitti, R.; Salustri, C.; Rongioletti, M. y Siotto, M. Frontiers in Neurology 2017, 8, 10-13spa
dc.relation.referencesBush, A. I. y Tanzi, R. E. Neurotherapeutics 2008, 5, 421-432spa
dc.relation.referencesRitchie, C. W. et al. Archives of Neurology 2003, 60, 1685spa
dc.relation.referencesCaballero, A. B.; Iranzo, O.; Hautier, A.; Sabaté, R. y Gamez, P. Inorganic Chemistry 2020, 59, 837-846spa
dc.relation.referencesFerrada, E.; Arancibia, V.; Loeb, B.; Norambuena, E.; Olea-Azar, C. y Huidobro- Toro, J. P. NeuroToxicology 2007, 28, 445-449spa
dc.relation.referencesKung, H. F.; Lee, C.-W.; Zhuang, Z.-P.; Kung, M.-P.; Hou, C. y Plössl, K. Journal of the American Chemical Society 2001, 123, 12740-12741spa
dc.relation.referencesPriyadarsini, K.; Maity, D. K.; Naik, G.; Kumar, M.; Unnikrishnan, M.; Satav, J. y Mohan, H. Free Radical Biology and Medicine 2003, 35, 475-484spa
dc.relation.referencesWanninger, S.; Lorenz, V.; Subhan, A. y Edelmann, F. T. Chemical Society Reviews 2015, 44, 4986-5002spa
dc.relation.referencesPatil, P.; Thakur, A.; Sharma, A. y Flora, S. J. S. Drug Development Research 2020, 81, 165-183spa
dc.relation.referencesChaparro, D.; Flores-Gaspar, A. y Alí-Torres, J. Journal of Alzheimer’s Disease 2021, 82, ed. por Rao, K. J.; Britton, G. B.; Rocha Arrieta, L. L.; Garcia-Cairasco, N.; Lazarowski, A.; Palacios, A.; Espuny, A. C. y Maccioni, R. B., S179-S193.spa
dc.relation.referencesChaparro, D. y Alí-Torres, J. Journal of Molecular Modeling 2017, 23, 283spa
dc.relation.referencesClarke, E. T. y Martell, A. E. Inorganica Chimica Acta 1992, 191, 57-63spa
dc.relation.referencesPrasanthi, J. R.; Schrag, M.; Dasari, B.; Marwarha, G.; Dickson, A.; Kirsch, W. M. y Ghribi, O. Journal of Alzheimer’s Disease 2012, 30, 167-182spa
dc.relation.referencesAsmari, M.; Michalcov´a, L.; Alhazmi, H. A.; Glatz, Z. y El Deeb, S. Microchemical Journal 2018, 137, 98-104spa
dc.relation.referencesAyton, S.; Woodward, M.; Ellis, K. A.; Lim, Y. Y.; Maruff, P. T.; Desmond, P. M.; Salvado, O.; Fazlollahi, A.; Rowe, C. C.; Churilov, L. y Bush, A. I. Alzheimer’s & Dementia 2020, 16, 44107spa
dc.relation.referencesHershko, C.; Konijn, A. M. y Link, G. British Journal of Haematology 1998, 101, 399-406spa
dc.relation.referencesKaviani, S.; Izadyar, M. y Housaindokht, M. R. Computational Biology and Chemistry 2020, 86, 107267spa
dc.relation.referencesBortolami, M.; Pandolfi, F.; De Vita, D.; Carafa, C.; Messore, A.; Di Santo, R.; Feroci, M.; Costi, R.; Chiarotto, I.; Bagetta, D.; Alcaro, S.; Colone, M.; Stringaro, A. y Scipione, L. European Journal of Medicinal Chemistry 2020, 198, 112350spa
dc.relation.referencesHider, R. C.; Bittel, D. y Andrews, G. K. Biochemical Pharmacology 1999, 57, 1031-1035spa
dc.relation.referencesCohen, A. R.; Galanello, R.; Piga, A.; De Sanctis, V. y Tricta, F. Blood 2003, 102, 1583-1587spa
dc.relation.referencesGalanello, R. Therapeutics and clinical risk management 2007, 3, 795-805spa
dc.relation.referencesNurchi, V. M.; Crisponi, G.; Pivetta, T.; Donatoni, M. y Remelli, M. Journal of Inorganic Biochemistry 2008, 102, 684-692spa
dc.relation.referencesVelasco-Sánchez, D.; Aracil, A.; Montero, R.; Mas, A.; Jiménez, L.; O’Callaghan, M.; Tondo, M.; Capdevila, A.; Blanch, J.; Artuch, R. y Pineda, M. The Cerebellum 2011, 10, 1-8spa
dc.relation.referencesSilva, T. y Machado, S. Qu´ımica Nova 2019, 42, 885-890spa
dc.relation.referencesGrossi, C.; Francese, S.; Casini, A.; Rosi, M. C.; Luccarini, I.; Fiorentini, A.; Gabbiani, C.; Messori, L.; Moneti, G. y Casamenti, F. Journal of Alzheimer’s Disease 2009, 17, 423-440spa
dc.relation.referencesCahoon, L. Nature Medicine 2009, 15, 356-359spa
dc.relation.referencesCherny, R. A. et al. Neuron 2001, 30, 665-676spa
dc.relation.referencesDi Vaira, M.; Bazzicalupi, C.; Orioli, P.; Messori, L.; Bruni, B. y Zatta, P. Inorganic Chemistry 2004, 43, 3795-3797spa
dc.relation.referencesTreiber, C.; Simons, A.; Strauss, M.; Hafner, M.; Cappai, R.; Bayer, T. A. y Multhaup, G. Journal of Biological Chemistry 2004, 279, 51958-51964spa
dc.relation.referencesMeade, T. W. Journal of Epidemiology & Community Health 1975, 29, 157-169spa
dc.relation.referencesMAO, X. y SCHIMMER, A. Toxicology Letters 2008, 182, 1-6spa
dc.relation.referencesRodríguez-Santiago, L.; Alí-Torres, J.; Vidossich, P. y Sodupe, M. Physical Chemistry Chemical Physics 2015, 17, 13582-13589.spa
dc.relation.referencesAdlard, P. A. et al. Neuron 2008, 59, 43-55spa
dc.relation.referencesLannfelt, L.; Blennow, K.; Zetterberg, H.; Batsman, S.; Ames, D.; Harrison, J.; Masters, C. L.; Targum, S.; Bush, A. I.; Murdoch, R.; Wilson, J. y Ritchie, C. W. The Lancet Neurology 2008, 7, 779-786spa
dc.relation.referencesFaux, N. G. et al. Journal of Alzheimer’s Disease 2010, 20, 509-516spa
dc.relation.referencesOliveri, V. y Vecchio, G. European Journal of Medicinal Chemistry 2016, 120, 252-274spa
dc.relation.referencesSummers, K. L.; Roseman, G. P.; Sopasis, G. J.; Millhauser, G. L.; Harris, H. H.; Pickering, I. J. y George, G. N. Inorganic Chemistry 2020, 59, 17519-17534spa
dc.relation.referencesRyan, T. M. et al. Journal of Neuroscience 2015, 35, 2871-2884spa
dc.relation.referencesDe Freitas, L. V.; da Silva, C. C.; Ellena, J.; Costa, L. A. S. y Rey, N. A. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2013, 116, 41-48spa
dc.relation.referencesHauser-Davis, R. A.; de Freitas, L. V.; Cukierman, D. S.; Cruz, W. S.; Miotto, M. C.; Landeira-Fernandez, J.; Valiente-Gabioud, A. A.; Fern´andez, C. O. y Rey, N. A. Metallomics 2015, 7, 743-747spa
dc.relation.referencesCukierman, D. S. et al. Journal of Inorganic Biochemistry 2017, 170, 160-168spa
dc.relation.referencesDe Falco, A.; Kincheski, G. C.; Atri´an-Blasco, E.; Hureau, C.; Ferreira, S. T. y Rey, N. A. Behavioural Pharmacology 2020, 31, 738-747spa
dc.relation.referencesYang, X.; Cai, P.; Liu, Q.; Wu, J.; Yin, Y.; Wang, X. y Kong, L. Bioorganic & Medicinal Chemistry 2018, 26, 3191-3201spa
dc.relation.referencesChoi, J.-S.; Braymer, J. J.; Nanga, R. P. R.; Ramamoorthy, A. y Lim, M. H. Proceedings of the National Academy of Sciences 2010, 107, 21990-21995spa
dc.relation.referencesLee, S.; Zheng, X.; Krishnamoorthy, J.; Savelieff, M. G.; Park, H. M.; Brender, J. R.; Kim, J. H.; Derrick, J. S.; Kochi, A.; Lee, H. J.; Kim, C.; Ramamoorthy, A.; Bowers, M. T. y Lim, M. H. Journal of the American Chemical Society 2014, 136, 299-310spa
dc.relation.referencesLakey-Beitia, J.; Gonz´alez, Y.; Doens, D.; Stephens, D. E.; Santamar´ıa, R.; Murillo, E.; Guti´errez, M.; Fern´andez, P. L.; Rao, K.; Larionov, O. V. y Durant-Archibold, A. A. Journal of Alzheimer’s Disease 2017, 60, S59-S68spa
dc.relation.referencesOrjuela, A.; Lakey-Beitia, J.; Mojica-Flores, R.; Hegde, M. L.; Lans, I.; Alí-Torres, J. y Rao, K. Journal of Alzheimer’s Disease 2021, 82, ed. por Rao, K. J.; Britton, G. B.; Rocha Arrieta, L. L.; Garcia-Cairasco, N.; Lazarowski, A.; Palacios, A.; Espuny, A. C. y Maccioni, R. B., S321-S333spa
dc.relation.referencesZhao, X.-Z.; Jiang, T.; Wang, L.; Yang, H.; Zhang, S. y Zhou, P. Journal of Molecular Structure 2010, 984, 316-325spa
dc.relation.referencesVajragupta, O. Free Radical Biology and Medicine 2003, 35, 1632-1644spa
dc.relation.referencesSumanont, Y.; Murakami, Y.; Tohda, M.; Vajragupta, O.; Watanabe, H. y Matsumoto, K. Biological and Pharmaceutical Bulletin 2007, 30, 1732-1739spa
dc.relation.referencesBelda, R.; Blasco, S.; Verdejo, B.; Jiménez, H. R.; Doménech-Carbó, A.; Soriano, C.; Latorre, J.; Terencio, C. y García-Espa˜na, E. Dalton Transactions 2013, 42, 11194spa
dc.relation.referencesLim, G. P.; Chu, T.; Yang, F.; Beech, W.; Frautschy, S. A. y Cole, G. M. The Journal of Neuroscience 2001, 21, 8370-8377.spa
dc.relation.referencesTang, M. y Taghibiglou, C. Journal of Alzheimer’s Disease 2017, 58, ed. por Liu, J., 1003-1016spa
dc.relation.referencesVoulgaropoulou, S.; van Amelsvoort, T.; Prickaerts, J. y Vingerhoets, C. Brain Research 2019, 1725, 146476spa
dc.relation.referencesPradhan, K.; Das, G.; Kar, C.; Mukherjee, N.; Khan, J.; Mahata, T.; Barman, S. y Ghosh, S. ACS Omega 2020, 5, 18958-18967spa
dc.relation.referencesYang, X.; Qiang, X.; Li, Y.; Luo, L.; Xu, R.; Zheng, Y.; Cao, Z.; Tan, Z. y Deng, Y. Bioorganic Chemistry 2017, 71, 305-314spa
dc.relation.referencesIraji, A.; Firuzi, O.; Khoshneviszadeh, M.; Tavakkoli, M.; Mahdavi, M.; Nadri, H.; Edraki, N. y Miri, R. European Journal of Medicinal Chemistry 2017, 141, 690-702spa
dc.relation.referencesKochi, A.; Eckroat, T. J.; Green, K. D.; Mayhoub, A. S.; Lim, M. H. y Garneau- Tsodikova, S. Chemical Science 2013, 4, 4137spa
dc.relation.referencesHiremathad, A.; Keri, R. S.; Esteves, A. R.; Cardoso, S. M.; Chaves, S. y Santos, M. A. European Journal of Medicinal Chemistry 2018, 148, 255-267spa
dc.relation.referencesChaves, S.; Hiremathad, A.; Tom´as, D.; Keri, R. S.; Piemontese, L. y Santos, M. A. New Journal of Chemistry 2018, 42, 16503-16515spa
dc.relation.referencesSilva, T.; Mohamed, T.; Shakeri, A.; Rao, P. P.; Soares da Silva, P.; Remi˜ao, F. y Borges, F. European Journal of Medicinal Chemistry 2019, 167, 146-152spa
dc.relation.referencesVopson, M. M. AIP Advances 2021, 11, 105317spa
dc.relation.referencesFan, H.; Wang, B.; Zhang, Y.; Zhu, Y.; Song, B.; Xu, H.; Zhai, Y.; Qiao, M. y Sun, F. Nature Communications 2021, 12, 7257spa
dc.relation.referencesZangwill, A. Archive for History of Exact Sciences 2013, 67, 331-348spa
dc.relation.referencesFrisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V. y Petersson, G. A. Gaussian 16, Wallingford CT, 2016spa
dc.relation.referencesEsmieu, C.; Guettas, D.; Conte-Daban, A.; Sabater, L.; Faller, P. y Hureau, C. Inorganic Chemistry 2019, 58, 13509-13527spa
dc.relation.referencesBauer, G. y Hu, X. Inorganic Chemistry Frontiers 2016, 3, 741-765spa
dc.relation.referencesKalaiarasi, G.; Mohankumar, A.; Dharani, S.; Dallemer, F.; Sundararaj, P. y Prabhakaran, R. European Journal of Inorganic Chemistry 2021, 2021, 1383-1396spa
dc.relation.referencesValdés, H.; Rufino-Felipe, E. y Morales-Morales, D. Journal of Organometallic Chemistry 2019, 898, 120864spa
dc.relation.referencesAsay, M. y Morales-Morales, D. Dalton Transactions 2015, 44, 17432-17447spa
dc.relation.referencesValdés, H.; García-Eleno, M. A.; Canseco-Gonzalez, D. y Morales-Morales, D. Chem- CatChem 2018, 10, 3136-3172spa
dc.relation.referencesGonzález-Sebastián, L. y Morales-Morales, D. Journal of Organometallic Chemistry 2019, 893, 39-51spa
dc.relation.referencesErxleben, A. Inorganica Chimica Acta 2018, 472, 40-57spa
dc.relation.referencesShimazaki, Y. en Electrochemistry, Khalid, M., ed.; InTech: 2013; cap. 3, pág. 13spa
dc.relation.referencesBratislava University Molinspiration Cheminformatics free web services, 2020spa
dc.relation.referencesErtl, P.; Rohde, B. y Selzer, P. Journal of Medicinal Chemistry 2000, 43, 3714-3717spa
dc.relation.referencesZhao, Y. y Truhlar, D. G. Theoretical Chemistry Accounts 2008, 120, 215-241spa
dc.relation.referencesSugar, J. y Musgrove, A. Journal of Physical and Chemical Reference Data 1990, 19, 527-616spa
dc.relation.referencesWeser, U. Angewandte Chemie 1984, 96, 452-453spa
dc.relation.referencesMunakata, M. y Endicott, J. F. Inorganic Chemistry 1984, 23, 3693-3698spa
dc.relation.referencesTabbì, G.; Giuffrida, A. y Bonomo, R. P. Journal of Inorganic Biochemistry 2013, 128, 137-145spa
dc.relation.referencesDonnelly, P. S.; Caragounis, A.; Du, T.; Laughton, K. M.; Volitakis, I.; Cherny, R. A.; Sharples, R. A.; Hill, A. F.; Li, Q.-X.; Masters, C. L.; Barnham, K. J. y White, A. R. Journal of Biological Chemistry 2008, 283, 4568-4577spa
dc.relation.referencesAmbundo, E. A.; Yu, Q.; Ochrymowycz, L. A. y Rorabacher, D. B. Inorganic Chemistry 2003, 42, 5267-5273spa
dc.relation.referencesReed, J. J. Journal of Research of the National Institute of Standards and Technology 2020, 125, 407spa
dc.relation.referencesKelly, C. P.; Cramer, C. J. y Truhlar, D. G. The Journal of Physical Chemistry B 2006, 110, 16066-16081spa
dc.relation.referencesAbraham, M. H.; Takács-Novák, K. y Mitchell, R. C. Journal of Pharmaceutical Sciences 1997, 86, 310-315spa
dc.relation.referencesXiao, Z. y Wedd, A. G. Natural Product Reports 2010, 27, 768spa
dc.relation.referencesSchaumburg, H. y Herskovitz, S. Neurology 2008, 71, 622-623spa
dc.relation.referencesHimes, R. A.; Park, G. Y.; Barry, A. N.; Blackburn, N. J. y Karlin, K. D. Journal of the American Chemical Society 2007, 129, 5352-5353spa
dc.relation.referencesSanyal, I.; Strange, R. W.; Blackburn, N. J. y Karlin, K. D. Journal of the American Chemical Society 1991, 113, 4692-4693spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.proposalEnfermedad de Alzheimerspa
dc.subject.proposalIones de cobrespa
dc.subject.proposalEstrés oxidativospa
dc.subject.proposalAgentes multifuncionalesspa
dc.subject.proposalTeoría del funcional de la densidadspa
dc.subject.proposalAlzheimer’s diseaseeng
dc.subject.proposalCopper ionseng
dc.subject.proposalOxidative stresseng
dc.subject.proposalMultifunctional agentseng
dc.subject.proposalDensity functional theoryeng
dc.subject.wikidatachelationeng
dc.subject.wikidataAgente quelantespa
dc.titleEstudio computacional de ligandos quelantes de cobre coordinados por N, O y P con potencial aplicación en la enfermedad de Alzheimerspa
dc.title.translatedComputational study of copper chelating ligands coordinated by N, O and P with potential application in Alzheimer’s diseaseeng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

Archivos

Bloque original

Mostrando 1 - 1 de 1
Cargando...
Miniatura
Nombre:
1032489455.2023.pdf
Tamaño:
8.87 MB
Formato:
Adobe Portable Document Format
Descripción:
Tesis de Maestría en Ciencias - Química

Bloque de licencias

Mostrando 1 - 1 de 1
Cargando...
Miniatura
Nombre:
license.txt
Tamaño:
5.74 KB
Formato:
Item-specific license agreed upon to submission
Descripción: