Variación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestación

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dc.contributor.advisorLozano Marquez, Harvey
dc.contributor.authorReina Rueda, Karen Johanna
dc.contributor.researchgroupReproducción Animal y Salud de Hatospa
dc.date.accessioned2023-02-01T21:49:21Z
dc.date.available2023-02-01T21:49:21Z
dc.date.issued2022
dc.descriptionilustraciones, graficasspa
dc.description.abstractLa evaluación de la gestación por medio de biomarcadores y ultrasonografía para detectar patologías fetales y placentarias son herramientas importantes para el diagnóstico oportuno de patologías del feto y la placenta. La Alfafetoproteína (AFP) es una glicoproteína producida por el hígado fetal y a través de la placenta llega a sangre periférica de la madre durante la gestación. Este biomarcador ha sido utilizado en medicina humana para detectar patologías fetales y placentarias. Los objetivos del estudio fueron determinar la variación de la concentración de Alfafetoproteína en yeguas de grupo racial criollo colombiano en la Sabana de Bogotá durante el último tercio de la gestación y asociar la variación sérica de Alfafetoproteína con los cambios ultrasonográficos de la placenta y feto, el tipo de parto y la sobrevivencia neonatal. Dentro de los materiales y métodos se utilizó una población de 21 yeguas gestantes a las cuales se les tomaron muestras de sangre de la vena yugular y un examen ultrasonográfico rectal y transabdominal, para evaluar la unión útero placentaria, la frecuencia cardiaca del feto, órbita fetal y el diámetro de la arteria aorta fetal a partir del séptimo mes de gestación hasta el parto. La concentración de Alfafetoproteína fue medida por un ensayo de ELISA para AFP especie: Equus caballus de USBiologycal®. Se analizaron los datos por medio de medidas repetidas en el tiempo, para evaluar los cambios mes a mes. La concentración de Alfafetoproteína presentó un aumento a medida que avanzó la gestación. No se encontraron diferencias estadísticamente significativas en su concentración en los meses de gestación evaluados, como tampoco una relación con los parámetros ultrasonográficos de feto y placenta. Los parámetros de viabilidad, el grosor útero placentario transabdominal y transrectal, el diámetro de la aorta y la órbita fetal aumentan a medida que avanza la gestación, a excepción de la frecuencia cardiaca la cual disminuye con el avance de la gestación. Se encontró un diámetro aórtico menor al reportado en razas de mayor tamaño, no se observó un efecto de la edad, el peso de la yegua, el sexo de la cría y el método de reproducción sobre los parámetros de viabilidad. Esto con el fin de brindar una nueva herramienta para la evaluación de viabilidad fetal y patologías de la placenta en el último tercio de la gestación. Estos parámetros de viabilidad fetal tomados de yeguas con gestaciones normales sirven de guía para evaluar clínicamente el desarrollo de la gestación en yeguas criollas colombianas. (Texto tomado de la fuente)spa
dc.description.abstractThe evaluation of pregnancy through biomarkers and ultrasonography to detect fetal and placental pathologies are important tools for the early diagnosis of fetal and placental pathologies in horses. Alphafetoprotein (AFP) is a glycoprotein produced by the fetal liver and reaches the mother's peripheral blood through the placenta during pregnancy. This biomarker has been used in human medicine to detect fetal and placental pathologies. The objectives of the study are to determine the variation of the concentration of AFP in mares of the Colombian Creole racial group in the Bogota savanna during the last third of gestation and associate the serum variation of AFP with the ultrasound changes of the placenta and fetus, type of delivery and neonatal survival. A population of n=21 pregnant mares was used, from which blood samples were taken from the jugular vein, and a rectal and transabdominal ultrasonographic examination, this was used to evaluate the uteroplacental union, fetal heart rate, fetal orbit, and the diameter of the fetal aortic artery from the seventh month of gestation until delivery; AFP concentration was measured by an ELISA assay for AFP species: Equus caballus from USBiologycal®; the data was analyzed using repeated measures over time to assess month to month changes. Although AFP concentration showed an increase as gestation progressed, no statistically significant differences were found in its concentration in the gestational months evaluated, and there was no relationship with the ultrasonographic parameters of the fetus and placenta. Furthermore, it was found that viability parameters increase as gestation progresses, except for heart rate, which decreases with advancing gestation. An aortic diameter smaller than reported in larger breeds was found. No effect of age, the weight of the mare, the sex of the foal and the method of reproduction was observed. This study seeks to provide a new tool for the evaluation of fetal viability and pathologies of the placenta in the last third of gestation and serve as a guide to clinically evaluate the development of pregnancy in Colombian Creole mareseng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Salud Animal o Magíster en Producción Animalspa
dc.description.methodsestudio prospectivo de investigaciónspa
dc.description.researchareaReproducción animalspa
dc.format.extentxv, 68 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/83231
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicina Veterinaria y de Zootecniaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción Animalspa
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dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
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dc.subject.agrovocDesarrollo embrionariospa
dc.subject.agrovocPeriodo de Gestaciónspa
dc.subject.agrovocEmbriologíaspa
dc.subject.ddc590 - Animales::599 - Mamíferosspa
dc.subject.ddc630 - Agricultura y tecnologías relacionadasspa
dc.subject.lembEtapas del desarrollo animalspa
dc.subject.lembAnimal developmental stageseng
dc.subject.proposalAlfafetoproteínaspa
dc.subject.proposalPlacentaspa
dc.subject.proposalEquinosspa
dc.subject.proposalGestaciónspa
dc.subject.proposalFetospa
dc.subject.proposalAlphafetoproteineng
dc.subject.proposalPlacentaeng
dc.subject.proposalEquineeng
dc.subject.proposalGestationeng
dc.subject.proposalFetuseng
dc.subject.unescoEnfermedad animalspa
dc.subject.unescoAnimal diseaseseng
dc.titleVariación de las concentraciones séricas de alfa-fetoproteína en yeguas criollas colombianas durante el último tercio de la gestaciónspa
dc.title.translatedVariation in serum concentrations of alpha-fetoprotein in criollo mares Colombians during the last third of the gestationeng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.awardtitleDescripción de parámetros biométricos fetales y concentración de alfafetoproteína en yeguas de grupo racial criollo colombiano en el último tercio de la gestaciónspa

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Maestría en Salud y Producción Animal