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Síntesis verde y uso de c-tetra(aril)calix[4]resorcinarenos en la fisisorción de un monolito con base en estireno y evaluación en la microextracción por sorción en disco rotatorio (rdse) de norepinefrina

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dc.contributor.advisorMaldonado Villamil, Mauriciospa
dc.contributor.advisorCastillo Aguirre, Alver Alexspa
dc.contributor.authorMatiz Rodríguez, Carlos Andrésspa
dc.contributor.researchgroupAplicaciones Analíticas de Compuestos Orgánicos (Aaco)spa
dc.date.accessioned2023-08-10T02:00:41Z
dc.date.available2023-08-10T02:00:41Z
dc.date.issued2023-08-07
dc.descriptionilustracionesspa
dc.description.abstractEn este trabajo de investigación se implementó la síntesis verde de C-tetra(p hidroxifenil)calix[4]resorcinareno, C-tetra(p-bromofenil)calix[4]resorcinareno y C-tetra(p metoxifenil)calix[4]resorcinareno obteniendo cambios interesantes e inesperados en las proporciones conformacionales de cada uno de ellos. Contrastando y evaluando estos resultados con la metodología convencional. Así mismo se efectuaron análisis de interacción Host-Guest con norepinefrina (NE) y los mencionados calix[4]resorcinarenos por medio de RMN 1H, destacando así el C-tetra(p-metoxifenil)calix[4]resorcinareno como el compuesto con la mejor interacción con el analito de interés. Por otro lado, se efectuó la síntesis de poli(estireno-co-divinilbenceno) mediante polimerización mediada por radicales libres. Posteriormente esta matriz polimérica se empleó en el proceso de fisisorción, con cada uno de los calix[4]resorcinarenos mencionados. Finalmente, la fase sorbente obtenida se implementó en el diseño, cribado y optimización del método de microextracción por sorción en disco rotatorio de NE, obteniendo porcentajes de recuperación próximos a 50%, lo cual deja entrever que dicho método proporciona recuperaciones promisorias. (Texto tomado de la fuente).spa
dc.description.abstractIn this research work we implemented the green synthesis of C-tetra(phydroxyphenyl)calix[4]resorcinarene, C-tetra(p-bromophenyl)calix[4]resorcinarene and Ctetra(p-methoxyphenyl)calix[4]resorcinarene obtaining interesting and unexpected changes in the conformational ratios of each of them. Contrasting and evaluating these results with the conventional methodology. Host-Guest interaction analysis with norepinephrine (NE) and the mentioned calix[4]resorcinarenes was also carried out by means of 1H NMR, highlighting C-tetra(p-methoxyphenyl)calix[4]resorcinarene as the compound with the best interaction with the analyte of interest. On the other hand, the synthesis of poly(styrene-co-divinylbenzene) was carried out by free radical-mediated polymerization. Subsequently, this polymeric matrix was used in the physisorption process, with each of the mentioned calix[4]resorcinarenes. Finally, the sorbent phase obtained was implemented in the design, screening and optimization of the NE rotating disk sorption microextraction method, obtaining recovery percentages close to 50%, which suggests that this method provides promising recoveries.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ciencias - Químicaspa
dc.description.researchareaSíntesis en química orgánicaspa
dc.format.extentxviii, 132 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/84519
dc.language.isospaspa
dc.publisherUnviersidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias - Químicaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc540 - Química y ciencias afines::542 - Técnicas, procedimientos, aparatos, equipos, materialesspa
dc.subject.proposalSíntesis solvent free de calix[4]resorcinarenosspa
dc.subject.proposalCopolímeros de estireno-divinilbencenospa
dc.subject.proposalFisisorciónspa
dc.subject.proposalExtracción por sorción disco rotatorio (RDSE)spa
dc.subject.proposalSistemas huésped-hospederospa
dc.subject.proposalSolvent free synthesis of calix[4]resorcinareneseng
dc.subject.proposalStyrene-divinylbenzene copolymerseng
dc.subject.proposalPhysisorptioneng
dc.subject.proposalRotary disk sorption extraction (RDSE)eng
dc.subject.proposalHost-Gest systemseng
dc.subject.unescoQuímica experimentalspa
dc.subject.unescoExperimental chemistryeng
dc.subject.unescoAnálisis químicospa
dc.subject.unescoChemical analysiseng
dc.subject.unescoInvestigación químicaspa
dc.subject.unescoChemical researcheng
dc.titleSíntesis verde y uso de c-tetra(aril)calix[4]resorcinarenos en la fisisorción de un monolito con base en estireno y evaluación en la microextracción por sorción en disco rotatorio (rdse) de norepinefrinaspa
dc.title.translatedGreen synthesis and use of c-tetra(aryl)calix[4]resorcinarenes in the physisorption of a styrene-based monolith and evaluation in rotating disk sorption microextraction (RDSE) of norepinephrineeng
dc.typeTrabajo de grado - Maestríaspa
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dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
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dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
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