Concentración de cortisol en cabello de estudiantes de medicina (Universidad Nacional) y tiempo de transporte al lugar de estudios (2022)

dc.contributor.advisorMockus Sivickas, Ismena Vilte Onaspa
dc.contributor.advisorAranzález Ramírez, Luz Helenaspa
dc.contributor.authorMorales Vargas, Maria Paulaspa
dc.contributor.cvlacMorales Vargas, María Paula [0002285950]spa
dc.contributor.orcidMorales Vargas, María Paula [0009-0003-2941-7213]spa
dc.coverage.cityBogotáspa
dc.coverage.countryColombiaspa
dc.coverage.temporal2022
dc.date.accessioned2025-04-01T20:43:43Z
dc.date.available2025-04-01T20:43:43Z
dc.date.issued2024
dc.descriptionilustraciones, diagramas, tablasspa
dc.description.abstractIntroducción: Se han descrito alteraciones del eje hipotálamo-hipófisis-adrenal en sujetos con tiempo de transporte prolongado al sitio de estudio. Bogotá, una de las ciudades con mayor congestión vehicular en el mundo, presenta largos tiempos de desplazamiento que pueden afectar la calidad de vida y la salud de sus habitantes, incluyendo a los estudiantes universitarios. Se ha identificado que el estrés crónico, mediado por la secreción persistente de cortisol, puede estar influenciado por factores como el tiempo de transporte y el sexo biológico. La medición de cortisol en cabello permite evaluar retrospectivamente la acumulación de esta hormona y su relación con el estrés prolongado. Objetivo: Determinar la relación entre los niveles de cortisol en cabello, un marcador de estrés crónico, y el tiempo dedicado al transporte en estudiantes de medicina de la Universidad Nacional de Colombia. Materiales y métodos: Se realizó un estudio cuasi-experimental, longitudinal, cuantitativo y analítico en una población de 40 hombres y 40 mujeres, estudiantes de Medicina cursando sus asignaturas durante el segundo semestre del año 2023 en el Campus Universitario. Se tomaron muestras de cabello al inicio y final del semestre para evaluar los niveles de cortisol acumulativo. La extracción del cortisol se realizó con metanol y se cuantificó mediante ELISA. Para el análisis inferencial se emplearon pruebas ANOVA, test de Friedman, t-Student y Mann-Whitney. Se realizaron análisis de correlación y un modelo de regresión para evaluar la asociación entre las variables. Resultados: La tendencia observada, aunque no estadísticamente significativa, mostró que a medida que disminuye el tiempo de transporte, la concentración de cortisol en cabello tiende a disminuir. Si bien el tiempo de transporte no constituyó un predictor significativo, el sexo biológico parece influir en los niveles de cortisol, ya que las mujeres presentaron valores más elevados y una mayor variabilidad en comparación con los hombres. Además, se observó una relación entre los niveles de cortisol y la distribución del tejido adiposo, lo que sugiere un posible vínculo entre el estrés crónico y los cambios metabólicos en esta población. Conclusiones: Este es el primer estudio en Colombia que analiza el cortisol en cabello en estudiantes de medicina, destacando la influencia del sexo biológico en la respuesta al estrés crónico. Aunque el tiempo de transporte no fue un predictor significativo, se identificaron tendencias que sugieren su impacto en la regulación del eje hipotálamo hipófisis-adrenal. Adicionalmente, la relación observada entre los niveles de cortisol y el tejido adiposo abre nuevas líneas de investigación sobre los efectos metabólicos del estrés crónico en poblaciones académicas (Texto tomado de la fuente).spa
dc.description.abstractIntroduction: Alterations of the hypothalamic-pituitary-adrenal axis have been described in individuals with prolonged commuting times to their study site. Bogotá, one of the most traffic-congested cities in the world, has lengthy travel times that can affect the quality of life and health of its inhabitants, including university students. Chronic stress, mediated by persistent cortisol secretion, may be influenced by factors such as commuting time and biological sex. The measurement of cortisol in hair allows a retrospective assessment of the accumulation of this hormone and its relationship with prolonged stress. Objective: To determine the relationship between hair cortisol levels, a marker of chronic stress, and the time spent commuting among medical students at the National University of Colombia. Materials and Methods: A quasi-experimental, longitudinal, quantitative, and analytical study was conducted with a population of 40 men and 40 women, all medical students attending courses during the second semester of 2023 at the University Campus. Hair samples were collected at the beginning and end of the semester to evaluate cumulative cortisol levels. Cortisol extraction was performed using methanol, and quantification was done by ELISA. For inferential analysis, ANOVA, Friedman’s test, Student’s t-test, and the Mann-Whitney test were used. Correlation analyses and a regression model were developed to assess the association among variables. Results: The observed trend, although not statistically significant, indicated that as commuting time decreases, hair cortisol concentration tends to decrease as well. While commuting time was not a significant predictor, biological sex appeared to influence cortisol levels, with women exhibiting higher values and greater variability compared to men. Furthermore, a relationship was noted between cortisol levels and adipose tissue distribution, suggesting a potential link between chronic stress and metabolic changes in this population. Conclusions: This is the first study in Colombia to analyze hair cortisol in medical students, highlighting the influence of biological sex on chronic stress response. Although commuting time was not a significant predictor, certain trends suggest its impact on the regulation of the hypothalamic-pituitary-adrenal axis. Additionally, the observed relationship between cortisol levels and adipose tissue opens new lines of research on the metabolic effects of chronic stress in academic populations.eng
dc.description.abstractIntroduction: Des altérations de l’axe hypothalamo-hypophyso-surrénalien ont été décrites chez des sujets ayant un temps de transport prolongé vers leur lieu d’étude. Bogotá, l’une des villes les plus congestionnées au monde, connaît de longs temps de déplacement pouvant affecter la qualité de vie et la santé de ses habitants, y compris des étudiants universitaires. Le stress chronique, médié par une sécrétion persistante de cortisol, peut être influencé par des facteurs tels que la durée du transport et le sexe biologique. La mesure du cortisol dans les cheveux permet d’évaluer rétrospectivement l’accumulation de cette hormone et son lien avec un état de stress prolongé. Objectif: Déterminer la relation entre les niveaux de cortisol dans les cheveux, marqueur de stress chronique, et le temps dédié au transport chez des étudiants en médecine de l’Université nationale de Colombie. Matériels et méthodes: Une étude quasi-expérimentale, longitudinale, quantitative et analytique a été menée auprès de 40 hommes et 40 femmes, étudiants en médecine durant le second semestre 2023 sur le campus universitaire. Des échantillons de cheveux ont été prélevés au début et à la fin du semestre pour évaluer les niveaux de cortisol cumulés. L’extraction du cortisol a été réalisée à l’aide de méthanol et sa quantification effectuée par méthode ELISA. Pour l’analyse inférentielle, des tests ANOVA, de Friedman, t de Student et de Mann-Whitney ont été utilisés. Des analyses de corrélation et un modèle de régression ont également été réalisés pour évaluer l’association entre les variables. Résultats: La tendance observée, quoique non significative sur le plan statistique, a montré qu’à mesure que le temps de transport diminuait, la concentration de cortisol dans les cheveux avait tendance à baisser. Bien que le temps de transport n’ait pas constitué un prédicteur significatif, le sexe biologique semble influencer les niveaux de cortisol, les femmes présentant des valeurs plus élevées et une plus grande variabilité que les hommes. De plus, une relation a été observée entre les niveaux de cortisol et la distribution du tissu adipeux, suggérant un possible lien entre le stress chronique et les modifications métaboliques dans cette population. Conclusions: Il s’agit de la première étude en Colombie à analyser le cortisol dans les cheveux chez des étudiants en médecine, soulignant l’influence du sexe biologique sur la réponse au stress chronique. Bien que le temps de transport n’ait pas été un prédicteur significatif, certaines tendances indiquent son impact potentiel sur la régulation de l’axe hypothalamo-hypophyso-surrénalien. Par ailleurs, le lien observé entre les niveaux de cortisol et le tissu adipeux ouvre de nouvelles pistes de recherche sur les effets métaboliques du stress chronique au sein des populations universitaires.fra
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Fisiologíaspa
dc.description.methodsInvestigación básicaspa
dc.format.extentxii, 82 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/87808
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina - Maestría en Fisiologíaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.subject.ddc610 - Medicina y salud::612 - Fisiología humanaspa
dc.subject.ddc610 - Medicina y salud::616 - Enfermedadesspa
dc.subject.decsHipófisisspa
dc.subject.decsPituitary Glandeng
dc.subject.decsTrastornos por Estrés Postraumáticospa
dc.subject.decsStress Disorders, Post-Traumaticeng
dc.subject.decsAnálisis de Cabellospa
dc.subject.decsHair Analysiseng
dc.subject.proposalCortisolspa
dc.subject.proposalCabellospa
dc.subject.proposalTiempo de transportespa
dc.subject.proposalEstrés crónicospa
dc.subject.proposalEstudiantes de medicinaspa
dc.subject.proposalUniversidad Nacional de Colombiaspa
dc.subject.proposalBogotáspa
dc.subject.proposalCortisoleng
dc.subject.proposalHaireng
dc.subject.proposalCommute timeeng
dc.subject.proposalChronic stresseng
dc.subject.proposalTransportationeng
dc.subject.proposalMedical studentseng
dc.subject.proposalNational University of Colombiaeng
dc.subject.proposalCortisol, cheveuxfra
dc.subject.proposalTemps de transportfra
dc.subject.proposalStress chroniquefra
dc.subject.proposalÉtudiants en médecinefra
dc.subject.proposalUniversité Nationale de Colombiefra
dc.titleConcentración de cortisol en cabello de estudiantes de medicina (Universidad Nacional) y tiempo de transporte al lugar de estudios (2022)spa
dc.title.translatedCortisol concentration in hair of medical students (National University) and commute time to study location (2022)eng
dc.title.translatedConcentration de cortisol dans les cheveux des étudiants en médecine (Université Nationale) et temps de transport vers le lieu d’études (2022)fra
dc.typeTrabajo de grado - Maestríaspa
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