Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application

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dc.contributor.advisorClavijo Grimaldo, Aleida Dianneyspa
dc.contributor.authorMuñoz González, Ana Maríaspa
dc.contributor.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001661109spa
dc.contributor.orcidhttps://orcid.org/0000-0002-3191-9891spa
dc.contributor.researchgroupBiomecánicaspa
dc.date.accessioned2024-07-04T19:58:01Z
dc.date.available2024-07-04T19:58:01Z
dc.date.issued2024-06-30
dc.descriptionilustraciones, diagramas, fotografíasspa
dc.description.abstractThis thesis explores the design, fabrication, and of polymeric nanofiber scaffolds with electroconductive nanofillers for cardiac tissue engineering, focusing on myocardial tissue repair through differentiated incorporation of graphene and polypyrrole (PPy) into polycaprolactone (PCL) matrices via electrospinning. The work aims to establish fabrication parameters and assess the morphological, mechanical, chemical, electrical and biocompatibility properties of the scaffolds, with the goal of selecting those that offer optimal theorical electromechanical coupling with myocardial tissue. Two strategies are distinguished: one focused on scaffolds doped with graphene, which show improvements in structural uniformity and mechanical properties, and another on scaffolds enriched with PPy, noted for their significant electrical conductivity. Both strategies present specific advantages, such as enhanced hydrophilicity and the promotion of cell adhesion and proliferation, crucial for tissue regeneration. Despite challenges like the uniform dispersion of nanoparticles and matching the mechanical properties to those of native myocardium, the research highlights the potential of in situ polymerization of PPy as a balanced method for achieving scaffolds with optimized electrical properties and biocompatibility.eng
dc.description.abstractEsta tesis explora el diseño, fabricación y análisis de andamios de nanofibras poliméricas con nanorrellenos electroconductivos para la ingeniería de tejidos cardíacos, centrándose en la reparación del tejido miocárdico mediante la incorporación diferenciada de grafeno y polipirrol (PPy) en matrices de policaprolactona (PCL) a través del electrohilado. El trabajo tiene como objetivo establecer parámetros de fabricación y evaluar las propiedades morfológicas, mecánicas, químicas, eléctricas y de biocompatibilidad de los andamios, con el fin de seleccionar aquellos que ofrezcan un acoplamiento electromecánico teórico óptimo con el tejido miocárdico. Se distinguen dos estrategias: una centrada en andamios dopados con grafeno, que muestran mejoras en la uniformidad estructural y propiedades mecánicas, y otra en andamios enriquecidos con PPy, conocidos por su significativa conductividad eléctrica. Ambas estrategias presentan ventajas específicas, como la mejora de la hidrofilicidad y la promoción de la adhesión y proliferación celular, cruciales para la regeneración del tejido. A pesar de desafíos como la dispersión uniforme de nanopartículas y la correspondencia de las propiedades mecánicas con las del miocardio nativo, la investigación resalta el potencial de la polimerización in situ de PPy como un método equilibrado para lograr andamios con propiedades eléctricas y biocompatibilidad optimizadas. (Texto tomado de la fuente).spa
dc.description.degreelevelDoctoradospa
dc.description.degreenameDoctor en Ingenieríaspa
dc.description.researchareaNanomateriales e ingeniería tisularspa
dc.format.extentxv, 201 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86396
dc.language.isoengspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Ingenieríaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ingeniería - Doctorado en Ingeniería - Ciencia y Tecnología de Materialesspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.decsMateriales Biocompatibles/análisisspa
dc.subject.decsBiocompatible Materials/analysiseng
dc.subject.decsIngeniería de Tejidos/métodosspa
dc.subject.decsTissue Engineering/methodseng
dc.subject.decsMiocardio/patologíaspa
dc.subject.decsMyocardium/pathologyeng
dc.subject.proposalElectrospinningeng
dc.subject.proposalNanofillereng
dc.subject.proposalElectroconductiveeng
dc.subject.proposalPolycaprolactoneeng
dc.subject.proposalPolypyrroleeng
dc.subject.proposalGrapheneeng
dc.subject.proposalScaffoldeng
dc.subject.proposalTissue engineeringeng
dc.subject.proposalElectrohiladospa
dc.subject.proposalRelleno conductorspa
dc.subject.proposalNanorellenospa
dc.subject.proposalPolicaprolactonaspa
dc.subject.proposalPolipirrolspa
dc.subject.proposalGrafenospa
dc.subject.proposalAndamiospa
dc.subject.proposalIngeniería de tejidosspa
dc.titleEvaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering applicationeng
dc.title.translatedEvaluación de la adición de nanorrellenos conductores en andamios para aplicaciones de ingeniería de tejidos miocárdicosspa
dc.typeTrabajo de grado - Doctoradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_db06spa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/doctoralThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TDspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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