Impacto de la optimización del tratamiento en pacientes con enfermedad por reflujo gastroesofágico que tienen falta de respuesta clínica al IBP. Fase 1
| dc.contributor.advisor | Otero Regino, William Alberto | spa |
| dc.contributor.author | Lozano Martínez, Janer Nelson | spa |
| dc.date.accessioned | 2020-08-24T21:54:30Z | spa |
| dc.date.available | 2020-08-24T21:54:30Z | spa |
| dc.date.issued | 2020-06-01 | spa |
| dc.description.abstract | Introduction: Gastroesophageal reflux disease (GERD) affects one in eight people in Colombia. Its characteristic symptoms are heartburn and regurgitation. The cornerstone of treatment is proton pump inhibitors (PPIs) with a clinical response of 58%-80%. In non-responders 75%-90% have a superimposed functional disorder and could be treated by adding visceral neuromodulators such as amitriptyline. Objective: To evaluate the impact of optimizing treatment in patients with GERD when there is no response to esomeprazole (ESO). Materials and methods: Prospective study in patients with no clinical response (> 2 episodes of reflux/week) treated with ESO half an hour before meals and simultaneously recommendations for weight loss if BMI> 25, stop smoking, stress control and finally increased the dose of ESO to 40 mg on an empty stomach and before dinner. When all the above was done and symptoms persisted, amitriptyline 12.5 mg was added overnight. Every 12 weeks the response was evaluated. Results: 149 patients were included. Optimizing treatment, 111 patients had a clinical response without using amitriptyline (74.5%; 95% CI 67.2%-81.4%). In 22 amitriptyline was added (14.8%), responding 15 patients, 68.2% (95% CI 47.04%-89.32%). A relationship was found between PPI compliance and clinical response (p <0.0001). Conclusion: In patients with GERD and non-response to PPI (ESO), sequential optimization achieved cumulative improvement in symptom control in 86% (95% CI 78.6% -90.4%) of patients, avoiding costly esophageal studies. Key Words: Optimize treatment, PPI, neuromodulator, compliance, clinical response. | spa |
| dc.description.abstract | Introducción: La Enfermedad por reflujo gastroesofágico (ERGE) afecta en Colombia a una de cada ocho personas. Sus síntomas característicos son pirosis y regurgitación. La piedra angular del tratamiento son los inhibidores de bomba de protones (IBP) con respuesta clínica en 58%-80%. En quienes no responden 75%-90% tienen un trastorno funcional superpuesto y se podrían tratar adicionando neuromoduladores viscerales como la amitriptilina. Objetivo: Evaluar el impacto que tiene optimizar el tratamiento en pacientes con ERGE cuando no hay respuesta a esomeprazol (ESO). Materiales y métodos: Estudio prospectivo en pacientes sin respuesta clínica (>2 episodios de reflujo/semana) tratados con ESO media hora antes de las comidas y simultáneamente recomendaciones para bajar de peso si el IMC>25, dejar de fumar, control del estrés y finalmente aumentado la dosis de ESO a 40 mg en ayunas y antes de cena. Cuando se cumplió todo lo anterior y persistían los síntomas, se adicionó amitriptilina 12,5 mg por la noche. Cada 12 semanas se evaluaba la respuesta. Resultados: Se incluyeron 149 pacientes. Optimizando el tratamiento, 111 pacientes tuvieron respuesta clínica sin utilizar amitriptilina (74,5%; IC95% 67,2%-81,4%). En 22 se adicionó amitriptilina (14.8%), respondiendo 15 pacientes, 68.2% (IC95% 47,04%-89,32%). Se encontró relación entre cumplimiento del tratamiento con IBP y la respuesta clínica (p<0.0001). Conclusión: En pacientes con ERGE y falta de respuesta al IBP (ESO), la optimización secuencial logró mejoría acumulativa en el control de los síntomas del 86% (IC95% 78,6%-90,4%) de los pacientes evitando estudios esofágicos costosos. Palabras Clave: Optimización, IBP, neuromodulador, cumplimiento, respuesta clínica. | spa |
| dc.description.degreelevel | Especialidades Médicas | spa |
| dc.format.extent | 103 | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.uri | https://repositorio.unal.edu.co/handle/unal/78202 | |
| dc.language.iso | spa | spa |
| dc.publisher.branch | Universidad Nacional de Colombia - Sede Bogotá | spa |
| dc.publisher.program | Bogotá - Medicina - Especialidad en Gastroenterología | spa |
| dc.relation.references | Vakil N, Van Zanten S V., Kahrilas P, Dent J, Jones R, Bianchi LK, et al. The Montreal definition and classification of gastroesophageal reflux disease: A global evidence-based consensus. Am J Gastroenterol. 2006;101(8):1900–20. | spa |
| dc.relation.references | El-Serag HB, Sweet S, Winchester CC, et al. Update of the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 2014;63(6):871-80. | spa |
| dc.relation.references | Páramo-hernández DB, Albis R, Galiano MT, Molano B De, Rincón R, Pineda-ovalle LF, et al. Prevalence of Gastro-Esophageal Reflux Symptoms and Associated Factors : A Population Survey in the Principal Citie. Rev Colomb Gastroenterol. 2016;31(4):5–12. | spa |
| dc.relation.references | Shaheen NJ, Hansen RA, Morgan DR, et al. The burden of gastrointestinal and liver diseases, 2006. Am J Gastroenterol 2006;101(9):2128–2138. | spa |
| dc.relation.references | Chuang TW Chen SC, Chen KT. Current Status of gastroesophageal reflux disease: diagnosis and treatment. Acta Gastroenterol Belg 2017;80(3):396-404. | spa |
| dc.relation.references | Alzubaidi M, Gabbard S. GERD: Diagnosing and treating the burn. Cleve Clin J Med 2015;82(10):685-692. | spa |
| dc.relation.references | Kahrilas PJ, Shaheen NJ, Vaezi MF, et al. American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease. Gastroenterology 2008;135(4):1383–1391. | spa |
| dc.relation.references | Gyawali P, Kahrilas P, Savarino E et al. Modern diagnosis of GERD: the Lyon Consensus. Gut. 2018; 67(7):1351–1362. | spa |
| dc.relation.references | Aziz Q, Fass R, Gyawali CP, Miwa H, Pandolfino JE, Zerbib F. Esophageal disorders. Gastroenterology 2016; 150 (6):1368-79. | spa |
| dc.relation.references | Li MJ, Li Q, Sun M, Liu LQ. Comparative effectiveness and acceptability of the FDA-licensed proton pump inhibitors for erosive esophagitis: A PRISMA-compliant network meta-analysis. Medicine (Baltimore). 2017;96(39): e8120. | spa |
| dc.relation.references | Scott LJ, Dunn CJ, Mallarkey G, Sharpe M. Esomeprazole. A review of its use in the management of acidrelated disorders in the US. Drugs 2002;62(7):1091-118. | spa |
| dc.relation.references | Schwab M, Klotz U, Hofmann U, Schaeffeler E, Leodolter A, Malfertheiner P, Treiber G. Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical pharmacokinetic data. Clin Pharmacol Ther. 2005;78(6):627-34. | spa |
| dc.relation.references | Hillman L, Yadlapati R, Thuluvath AJ, Berendsen MA, Pandolfino JE. A review of medical therapy for proton pump inhibitor nonresponsive gastroesophageal reflux disease. Dis Esophagus. 2017;30(9):1-15. | spa |
| dc.relation.references | Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 2013;108(3):308-28. | spa |
| dc.relation.references | Ness-Jensen E, Lindam A, Lagergren J, Hveem K. Weight loss and reduction in gastroesophageal reflux. A prospective population-based cohort study: the HUNT study. Am J Gastroenterol. 2013;108(3):376-82. | spa |
| dc.relation.references | Hallan A, Bomme M, Hveem K, Møller-Hansen J, Ness-Jensen E. Risk factors on the development of new-onset gastroesophageal reflux symptoms. A population-based prospective cohort study: the HUNT study. Am J Gastroenterol. 2015; 110(3):393-400. | spa |
| dc.relation.references | Ness-Jensen E, Lindam A, Lagergren J, Hveem K. Tobacco smoking cessation and improved gastroesophageal reflux: a prospective population-based cohort study: the HUNT study. Am J Gastroenterol. 2014;109(2):171-7. | spa |
| dc.relation.references | Song Eu, Jung HK, Jung JM. The association between reflux esophagitis and psychosocial stress. Dig Dis Sci. 2013; 58(2): 471–477. | spa |
| dc.relation.references | Fujiwara Y, Machida A, Watanabe Y, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T. Association between dinner-to-bed time and gastro-esophageal reflux disease. Am J Gastroenterol. 2005;100(12):2633-6. | spa |
| dc.relation.references | Kahrilas PJ; Boeckxstaens G, Smout A. Management of the patient with incomplete response to PPI therapy. Best Pract Res Clin Gastroenterol. 2013; 27(3): 401–414. | spa |
| dc.relation.references | Richter J. How to manage refractory GERD. Nat Clin Pract Gastroenterol Hepatol. 2007;4(12):658-64. | spa |
| dc.relation.references | Ahlawat SK, Mohi-Ud-Din R, Williams DC, Maher KA, Benjamin SB. A prospective study of gastric acid analysis and esophageal acid exposure in pa¬tients with gastroesophageal reflux refractory to medical therapy. Dig Dis Sci. 2005;50(11):2019-24. | spa |
| dc.relation.references | Chiba N, De Gara CJ, Wilkinson JM, Hunt RH. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology. 1997;112(6):1798–1810. | spa |
| dc.relation.references | Fass R, Shapiro M, Dekel R, Sewell J. Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease – where next? Aliment Pharmacol Ther. 2005;22(2):79–94. | spa |
| dc.relation.references | Dickman R, Boaz M, Aizic S, Beniashvili Z, Fass Ronnie, Niv Yaron. Comparison of clinical characteristics of patients with gastroesophageal reflux disease who failed proton pump inhibitor therapy versus those who fully responded. J Neurogastroenterol Motil. 2011; 17(4):387-394 | spa |
| dc.relation.references | Van Soest EM, Siersema PD, Dieleman JP, Sturkenboom MC, Kuipers EJ. Persistence and adherence to proton pump inhibitors in daily clinical practice. Aliment Pharmacol Ther. 2006;24(2):377–385. | spa |
| dc.relation.references | Johnson DA, Lauritsen K, Junghard O, Levine D. Evaluation of symptoms is an unreliable predictor of relapse of erosive esophagitis in patients receiving maintenance PPI therapy. Gastroenterology.2003;124(4 Suppl 1): A540.12. | spa |
| dc.relation.references | Fass R, Thomas S, Traxler B, Sostek M. Patient reported outcome of heartburn improvement: doubling the proton pump inhibitor (PPI) dose in patient who failed standard dose PPI vs. switching to a different PPI. Gastroenterology. 2004;146: A37. | spa |
| dc.relation.references | Hungin AP, Rubin G, O’Flanagan H. Factors influencing compliance in long-term proton pump inhibitor therapy in general practice. Br J Gen Pract. 1999;49(443):463–464. | spa |
| dc.relation.references | Gunaratnam NT, Jesup TP, Inadomi J, et al. Suboptimal proton pump inhibitor dosin is prevalent in patiens whih poorly controlled gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2006;23(10):1473-7. | spa |
| dc.relation.references | Chey WD, Inadomi JM, Booher AM, Sharma VK, Fendrick AM, Howden CW. Primary-care physicians’ perceptions and practices on the management of GERD: results of a national survey. Am J Gastroenterol. 2005;100(6):1237–1242. | spa |
| dc.relation.references | Abdallah J, George N, Yamasaki T, Ganocy S, Fass R. Most Patients with Gastroesophageal Reflux Disease Who Failed Proton Pump Inhibitor Therapy Also Have Functional Esophageal Disorders. Clinical Gastroenterology and Hepatology 2019;17(6):1073–1080. | spa |
| dc.relation.references | Gyawali CP, Fass R. Management of gastroesophageal reflux disease. Gastroenterology 2018;154 (2):302-18. | spa |
| dc.relation.references | Roman S, Keefer L, Imam H, Korrapati P, Mogni B, Eident K, et al. Majority of symptoms in esophageal reflux PPI non-responders are not related to reflux. Neurogastroenterol Motil 2015;27(11):1557-74. | spa |
| dc.relation.references | Weijenborg PW, de Schepper HS, Smout AJ, Bredenoord AJ. Effects of antidepressants in patients with functional esophageal disorders or gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol. 2015;13(2):251-259.e1. | spa |
| dc.relation.references | Hungin APS, Molloy-Bland M, Scarpignato C. Revisiting Montreal: New Insights into Symptoms and Their Causes, and Implications for the Future of GERD. Am J Gastroenterol. 2019; 114 (3):414-421. | spa |
| dc.relation.references | Limsrivilai J, Charatcharoenwitthaya P, Pausawasdi N, et al. Imipramine for treatment of esophageal hypersensitivity and functional heartburn: a randomized placebo-controlled trial. Am J Gastroenterol. 2016;111(2):217–24. | spa |
| dc.relation.references | Ostovaneh MR, Saeidi B, Hajifathalian K, Farrokhi-Khajeh-Pasha Y, Fotouhi A, Mirbagheri SS, et al. Comparing omeprazole with fluoxetine for treatment of patients with heartburn and normal endoscopy who failed once daily proton pump inhibitors: Double-blind placebo-controlled trial. Neurogastroenterol Motil. 2014;26(5):670–8. | spa |
| dc.relation.references | Viazis N, Keyoglou A, Kanellopoulos AK, Karamanolis G, Vlachogiannakos J, Triantafyllou K, et al. Selective serotonin reuptake inhibitors for the treatment of hypersensitive esophagus: A randomized, double-blind, placebo-controlled study. Am J Gastroenterol. 2012;107(11):1662–7. | spa |
| dc.relation.references | Broekaert D, Fischler B, Sifrim D, Janssens J, Tack J. Influence of citalopram, a selective serotonin reuptake inhibitor, on oesophageal hypersensitivity: A double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2006;23(3):365–70. | spa |
| dc.relation.references | Yadlapati R, Vaezi MF, Vela MF, Spechler SJ, Shaheen NJ Richter J, et al. Management options for patients with GERD and persistent symptoms on proton pump inhibithors: Recommendations from an expert Panel. Am J Gastroenterol 2018:113(7): 980-986. | spa |
| dc.relation.references | Yadlapati R, De lay K. Proton pump inhibitor-refractory gastroesophageal reflux disease. Med Clin N A, 2019;103 (1): 15-27. | spa |
| dc.relation.references | Santa María M, Jaramillo M, Otero W. Validación del cuestionario de reflujo gastroesofágico GERDQ en una población colombiana. Rev Col Gastroenterol 2013;28(3):199-206. | spa |
| dc.relation.references | Jones OJ, J Dent, N Vakil, K Halling, B Wernersson, T Lind. Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal refl ux disease in primary care. Aliment Pharmacol Therapy 2009;30(10):1030-8. | spa |
| dc.relation.references | Dent J, Vakil N, Jones R, et al. Validation of the reflux disease questionnaire for the diagnosis of gastroesophageal reflux disease in primary care. Gut 2007; 56(Suppl 111): 328. Abs OP-G-328. | spa |
| dc.relation.references | Prakash Gyawali C, Kahrilas P, Savarino E et al. Modern diagnosis of GERD: the Lyon Consensus. Gut. 2018; 67(7):1351–1362. | spa |
| dc.relation.references | Fass R, Ofman JJ, Sampliner RE, et al. The omeprazole test is as sensitive as 24-h oesophageal pH monitoring in diagnosing gastro-oesophageal reflux disease in symptomatic patients with erosive oesophagitis. Aliment Pharmacol Ther 2000;14(4):389–396. | spa |
| dc.relation.references | Roman S, Gyawali CP, Savarino E, Yadlapati R, Zerbib F, Wu J, et al. Ambulatory reflux monitoring for diagnosis of gastroesophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group. Neurogastroenterol Motil. 2017;29(10):1-15. | spa |
| dc.relation.references | Ness-Jensen, Hveem K, El-serag H, Lagergren J. Lifestyle intervention in gastroesophageal reflux disease. Clin Gastroentrol Hepatol. 2016. 14(2):175-182. | spa |
| dc.relation.references | Castillo R, Otero W TA. Impacto de las medidas generales en el tratamiento del reflujo gastroesofágico: una revisión basada en la evidencia. Rev Col Gastroenterol. 2015;30(4):431–6. | spa |
| dc.relation.references | Weijenborg PW, Cremonini F, Smout AJ, et al. PPI therapy is equally effective in well-defined non-erosive reflux disease and in reflux esophagitis: a meta-analysis. Neurogastroenterol Motil 2012;24(8):747–757. | spa |
| dc.relation.references | Hussain ZH, Henderson E, Maradey-Romerao C, George N, Fass R, Lacy BE. The proton pump inhibitor non respornder: a clinical conundrum. Clin Transl Gastroenterol. 2015;6(8): e106. | spa |
| dc.relation.references | Fass R. Therapeutic options for refractory gastroesophageal reflux disease. J Gastroenterol Hepatol. 2012; 27 Suppl 3:3-7. | spa |
| dc.relation.references | Dal-Paz K, Moraes-Filho JP, Navarro-Rodriguez T, Eisig JN, Barbuti R, Quigley EM. Low levels of adherence with proton pump inhibitor therapy contribute to therapeutic failure in gastroesophageal reflux disease. Dis Esophagus. 2012;25(2):107-13. | spa |
| dc.relation.references | Barrison AF, Jarboe LA, Weinberg BM, Nimmagadda K, Sullivan LM, Wolfe MM. Patterns of proton pump inhibitor use in clinical practice. Am J Med. 2001;111(6):469-73. | spa |
| dc.relation.references | Gyawali CP, Fass R. Management of Gastroesophageal Reflux Disease. Gastroenterology 2018;154(2):302–318. | spa |
| dc.relation.references | Frazzoni M, Conigliaro R, Mirante VG, Melotti G. The added value of quantitative analysis of on-therapy impedance-pH parameters in distinguishing refractory non-erosive reflux disease from functional heartburn. Neurogastroenterol Motil. 2012;24(2):141–146, e87. | spa |
| dc.relation.references | Kunsch S, Neesse A, Linhart T, Nell C, Gress TM, Ellenrieder V. Prospective evaluation of duodenogastroesophageal reflux in gastroesophageal reflux disease patients refractory to proton pump inhibitor therapy. Digestion. 2012;86(4):315–322. | spa |
| dc.relation.references | Yamashita H, Ashida K, Fukuchi T, et al. Combined pH-impedance monitoring and high-resolution manometry of Japanese patients treated with proton-pump inhibitors for persistent symptoms of non-erosive reflux disease. J Smooth Muscle Res. 2012;48(5–6):125–135. | spa |
| dc.relation.references | Scarpellini E, Ang D, Pauwels A, De Santis A, Vanuytsel T, Tack J. Management of refractory typical GERD symptoms. Nat Rev Gastroenterol Hepatol. 2016;13(5):281–294. | spa |
| dc.relation.references | Bautista JM, Wong WM, Pulliam G, Esquivel RF, Fass R. The value of ambulatory 24 hr esophageal pH monitoring in clinical practice in patients who were re¬ferred with persistent gastroesophageal reflux disease (GERD)-related symptoms while on standard dose anti-reflux medications. Dig Dis Sci. 2005;50(10):1909-15. | spa |
| dc.relation.references | Charbel S, Khandwala F, Vaezi MF. The role of esophageal pH monitoring in symptomatic patients on PPI therapy. Am J Gastroenterol.2005;100(2):283-289. | spa |
| dc.relation.references | Karamanolis G, Vanuytsel T, Sifrim D, Bisschops R, Arts J, Caenepeel P, et al. Yield of 24-hour esophageal pH and bilitec monitoring in patients with persisting symptoms on PPI therapy. Dig Dis Sci. 2008;53(9):2387-93. | spa |
| dc.relation.references | Ribolsi M, Cicala M, Zentilin P, Neri M, Mauro A, Efthymakis K, et al. Prevalence and clinical characteristics of refractoriness to optimal proton pump inhibitor therapy in non‐erosive reflux disease. Aliment Pharmacol Ther. 2018; 40(10):1074-1081. | spa |
| dc.relation.references | Azzam RS. Are the persistent symptoms to proton pump inhibitor therapy due to refractory gastroesophageal reflux disease or to other disorders? Arq Gastroenterol, 2018: 55 (Supl 1): 85-91. | spa |
| dc.relation.references | Knowles CH, Aziz Q. Visceral hypersensitivity in non-erosive reflux disease. Gut. 2008;57(5):674–83. | spa |
| dc.relation.references | Emerenziani S, Sifrim D, Habib FI, et al. Presence of gas in the refluxate enhances reflux perception in non-erosive patients with physiological acid exposure of the oesophagus. Gut. 2008;57(4):443–7. | spa |
| dc.relation.references | Miwa H, Kondo T, Oshima T, et al. Esophageal sensation and esophageal hypersensitivity – overview from bench to bedside. J Neurogastroenterol Motil. 2010;16(4):353–62. | spa |
| dc.relation.references | Drewes AM, Schipper KP, Dimcevski G, et al. Multi-modal induction and assessment of allodynia and hyperalgesia in the human oesophagus. Eur J Pain. 2003;7(6):539–49. | spa |
| dc.relation.references | Hobson AR, Khan RW, Sarkar S, et al. Development of esophageal hypersensitivity following experimental duodenal acidification. Am J Gastroenterol. 2004;99(5):813–20. | spa |
| dc.relation.references | Sarkar S, Aziz Q, Woolf CJ, et al. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet. 2000;356(9236):1154-1159. | spa |
| dc.relation.references | Gerson LB, Kahrilas PJ, Fass R. Insights into gastroesophageal reflux disease-associated dyspeptic symptoms. Clin Gastroenterol Hepatol. 2011; 9:824-33. | spa |
| dc.relation.references | Kahrilas PJ, Jonsson A, Denison H, et al. Concomitant symptoms itemized in the Reflux Disease Questionnaire are associated with attenuated heartburn response to acid suppression. Am J Gastroenterol. 2012;107(9):1354–60. | spa |
| dc.relation.references | Xiong N, DuaN Y, Wei J, Mewes R, Leonhart R. Antidepressants vs. Placebo for the Treatment of Functional Gastrointestinal Disorders in Adults: A Systematic Review and Meta-Analysis. Frontiers in Pshychiatry 2018; 9: 659. | spa |
| dc.relation.references | Woo et al. Low dose amitriptyline combined with proton pump inhibidor for functional chest pain. W J Gastroenterol 2013; 19(30): 4958-4965. | spa |
| dc.relation.references | You LQ, Liu J, Jia L, Jiang SM, Wang GQ, Effect of low-dose amitriptyline on globus pharyngeus and it side effects W J Gastroenterol 2013; 19(42):7455-7460. | spa |
| dc.relation.references | Yadlapati R, Hungness ES, Pandolfino JE. Complications of Antireflux Surgery. Am J Gastroenterol. 2018;113(8):1137-1147. | spa |
| dc.relation.references | Jobe BA, Richter JE, Hoppo T, et al. Preoperative diagnostic workup before antirefux surgery: an evidence and experience-based consensus of the Esophageal Diagnostic Advisory Panel. J Am Coll Surg. 2013;217(4): 586–97. | spa |
| dc.relation.references | Fernando HC. Endoscopic fundoplication: patient selection and technique. J Vis Surg. 2017;3:121. | spa |
| dc.relation.references | Moore M, Afaneh C, Benhuri D, et al. Gastroesophageal refux disease: a review of surgical decision making. World J Gastrointest Surg. 2016;8(1): 77–83. | spa |
| dc.relation.references | Rantanen TK, Salo JA, Sipponen JT. Fatal and life-threatening complications in antirefux surgery: analysis of 5,502 operations. Br J Surg. 1999;86(12):1573–77. | spa |
| dc.relation.references | Maret-Ouda J, Wahlin K, El-Serag HB, et al. Association between laparoscopic antirefux surgery and recurrence of gastroesophageal reflux. JAMA. 2017;318(10):939–46. | spa |
| dc.relation.references | Wo JM, Trus TL, Richardson WS, et al. Evaluation and management of postfundoplication dysphagia. Am J Gastroenterol. 1996;91(11):2318–22. | spa |
| dc.relation.references | Rouphael C, Padival R, Sanaka MR, Thota PN. Endoscopic Treatments of GERD. Curr Treat Options Gastroenterol. 2018;16(1):58-71. | spa |
| dc.relation.references | ASGE Technology Committee, Thosani N, Goodman A, Manfredi M, Navaneethan U, Parsi MA, et al. Endoscopic anti-reflux devices [with videos]. Gastrointest Endosc. 2017;86(6):931–48. | spa |
| dc.relation.references | Lipka S, Kumar A, Richter JE. No evidence for efficacy of radiofrequency ablation for treatment of gastroesophageal reflux disease: a systematic review and metaanalysis. Clin Gastroenterol Hepatol. 2015;13(6):1058– 67. | spa |
| dc.relation.references | Pearl J, Pauli E, Dunkin B, Stefanidis D. SAGES endoluminal treatments for GERD. Surg Endosc. 2017;3(10):3783–90. | spa |
| dc.relation.references | Ware JE, Sherboune CD. The MOS 36-item short-form health survey (SF-36) (I). Conceptual framework and ítem selection. Med Care. 1992;30(6):473-83. | spa |
| dc.relation.references | Xiao-Li, GuanHuiWang. International J Nursing Sciences. Quality of life scales for patients with gastroesophageal reflux disease: A literatures review. 2015;2(1):110-114. | spa |
| dc.relation.references | Manterola C, Urrutia S, Otzen Tamara. Calidad de vida relacionada con salud. Instrumentos de medición para valoración de resultados en cirugía digestiva alta. Rev Chil Cir 2014 jun: 66 (3): 274-282. | spa |
| dc.relation.references | Velanovich V, S.R. Vallance, J.R. Gusz, F.V.Tapia, M.A. Harkabus. Quality of life scale for gastroesophageal reflux disease. J Am Coll Surg 1996;18(3):217-224. | spa |
| dc.relation.references | Chan Y, Ching JY, Cheung CM, Tsoi KK, Polder-Verkiel S, Pang SH. Development and validation of a disease-specific quality of life questionnaire for gastro-oesophageal reflux disease: the GERD-QOL questionnaire Aliment Pharmacol Ther, 2010(3);31:452-460. | spa |
| dc.relation.references | Raymond JM, Gywali CP, Bechade D, Smith D, Mathiex H, Poynard T et al. Assesment of quality of life of patients with gastroesophageal reflux. Elaboration and validation of a specific questionnaire. Gastroenterol Clin Biol 1999(1):32-39. | spa |
| dc.relation.references | Holtmann G, Chassany O, Devault KR, Schmitt H, Gebauer U, Doer fler H, et al. International validation of a health-related quality of life questionnaire in patients with erosive gastro-oesophagela reflux disease. Aliment Pharmacol Ther. 2009; 29(6):615-625. | spa |
| dc.relation.references | Zeman Z, Rozxa S, Tihanyi T, Tarko E. Psychometric documentation of a quality of life questionnaire for patients undergoing antireflux surtery (QOLARS). Surg Endosc 2005; 19(2):257-261. | spa |
| dc.relation.references | Wiklund IK, Junghard O, Grace E, Talley NJ, Kamm M, Veldhuyzen van Zanten S, et al. Quality of life in reflux and dyspepsia patients. Psychometric documentation of a new disease-specific questionnaire (QOLRAD). Eur J Surg Suppl 1998;(583):41-49. | spa |
| dc.relation.references | Eggleston A, Farup C, Meier R. The domestic/international gastroenterology surveillance study (DIGEST): design, subjects and methods. Scand J Gastroenterol Supp 1999: 231:9-14. | spa |
| dc.relation.references | Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36) (I). Conceptual framework and ítem selection. Med Care. 1992;30(6):473-83. | spa |
| dc.relation.references | Maleki I, Masoudzadeh A, Khalilian A, Elnaz Daheshpour E. Gastroenterol Hepatol Bed Bench. Quality of life in patients with gastroesophageal reflux disease in an Iranian population. 2013 Spring;6(2):96-100. | spa |
| dc.relation.references | Alonso J, Prieto L, Anto JM. La versión española del SF-36 Health Survey (Cuestionario de Salud SF-36): un instrumento para la medida de los resultados clínicos. Med Clin (Barc). 1995;104(20):771-6. | spa |
| dc.relation.references | Lugo L, García H, Gómez C. Confiabilidad del cuestionario de calidad de vida en salud sf-36 en Medellín, Colombia. Rev Fac Nac Salud Pública. 2006;24(2): 37-50. | spa |
| dc.relation.references | https://www.optum.com/solutions/life-sciences/answer-research/patient-insights/sf-health-surveys/sf-36v2-health-survey.html (Acceso el 09 de junio de 2019). | spa |
| dc.relation.references | Gomez E, Gonzalez R, Alvarado M, Avila R, Prieto A, Valbuena T, et al. Eosinophilic esophagitis: review and update. Front Med (Lausanne). 2018; 5:247. | spa |
| dc.relation.references | US Food and Drugs: Citalopram (marketed as Celexa) Information. 07/09/2015. Último acceso en: 20/07/2019. Disponible en: https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/citalopram-marketed-celexa-information. | spa |
| dc.relation.references | Faruqui AA. Gastroesophageal Reflux Disease Associated with Anxiety: Efficacy and Safety of Fixed Dose Combination of Amitriptyline and Pantoprazole. Gastroenterology Res. 2017; 10(5): 301-304. | spa |
| dc.relation.references | Fass R, Murthy U, Hayden CW, et al. Omeprazole 40 mg once a day is equally effective as lansoprazole 30 mg twice a day in symptom control of patients with gastro-oesophageal reflux disease (GERD) who are resistant to conventional-dose lansoprazole therapy-a prospective, randomized, multi-centre study. Aliment Pharmacol Ther. 2000;14(12):1595‐1603. | spa |
| dc.relation.references | Ates F, Vaezi MF. New Approaches to Management of PPI-Refractory Gastroesophageal Reflux Disease. Curr Treat Options Gastroenterol. 2014;12(1):18‐33. | spa |
| dc.relation.references | Vaezi MF, Fass R, Vakil N, et al. IW-3718 Reduces Heartburn Severity in Patients with Refractory Gastroesophageal Reflux Disease in a Randomized Trial. Gastroenterology 2020;158(8):2093–2103. | spa |
| dc.relation.references | Gadacz T, Zuidema G. Bile acid composition in patients with and without symptoms of postoperative reflux gastritis. Am J Surg 1978;135(1):48–52. | spa |
| dc.relation.references | Fass OZ, Fass R. Overlap Between GERD and Functional Esophageal Disorders-a Pivotal Mechanism for Treatment Failure. Curr Treat Options Gastroenterol. 2019;17(1):161‐164. | spa |
| dc.relation.references | Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, et al. Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. N Engl J Med. 2019;381(16):1513-1523. | spa |
| dc.relation.references | Trudgill NJ, Sifrim D, Sweis R, et al. British Society of Gastroenterology guidelines for oesophageal manometry and oesophageal reflux monitoring. Gut. 2019;68(10):1731‐1750. | spa |
| dc.relation.references | Savarino E, Bredenoord AJ, Fox M, et al. Expert consensus document: Advances in the physiological assessment and diagnosis of GERD. Nat Rev Gastroenterol Hepatol. 2017;14(11):665‐676. | spa |
| dc.relation.references | Katzka DA John E. Pandolfino JE, Kahrilas PJ. Phenotypes of Gastroesophageal Reflux Disease: Where Rome, Lyon, and Montreal Meet. Clinical Gastroenterology and Hepatology. 2020;18(4):767-776. | spa |
| dc.rights | Derechos reservados - Universidad Nacional de Colombia | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.license | Atribución-NoComercial-SinDerivadas 4.0 Internacional | spa |
| dc.rights.spa | Acceso abierto | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | spa |
| dc.subject.ddc | 610 - Medicina y salud | spa |
| dc.subject.ddc | 616 - Enfermedades | spa |
| dc.subject.ddc | 611 - Anatomía humana, citología, histología | spa |
| dc.subject.proposal | optimize treatment | eng |
| dc.subject.proposal | optimización | spa |
| dc.subject.proposal | gastroesophageal reflux disease | eng |
| dc.subject.proposal | enfermedad por reflujo gastroesofágico | spa |
| dc.subject.proposal | inhibidor de bomba de protones IBP | spa |
| dc.subject.proposal | proton pump inhibitor PPI | eng |
| dc.subject.proposal | compliance | eng |
| dc.subject.proposal | cumplimiento | spa |
| dc.subject.proposal | neuromodulador | spa |
| dc.subject.proposal | neuromodulator | eng |
| dc.subject.proposal | clinical response | eng |
| dc.subject.proposal | respuesta clínica | spa |
| dc.title | Impacto de la optimización del tratamiento en pacientes con enfermedad por reflujo gastroesofágico que tienen falta de respuesta clínica al IBP. Fase 1 | spa |
| dc.type | Trabajo de grado - Especialidad Médica | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_bdcc | spa |
| dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/masterThesis | spa |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | spa |
| oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |