Contribución a la fitoquímica, a la evaluación de la actividad antioxidante y el posible efecto neuroprotector de la especie Polygala paniculata

Vista sencilla de ítem
dc.contributor.advisorRojas Cardozo, Maritza Adelina
dc.contributor.advisorVasquez Londono, Carlos Alberto
dc.contributor.authorGonzalez Rodriguez, Miguel Oswaldo
dc.date.accessioned2022-08-18T21:46:06Z
dc.date.available2022-08-18T21:46:06Z
dc.date.issued2022-08-17
dc.description
dc.description
dc.descriptionfotografías a color, ilustraciones, gráficas, tablasspa
dc.description.abstractLa herbolaria china ocupa un lugar muy importante dentro de las terapias que conforman la Medicina Tradicional China. En Colombia, por las limitaciones en la consecución de los medicamentos herbales de origen asiático es necesario encontrar especies medicinales similares en nuestra flora. Se escogió la especie Polygala paniculata por su cercanía taxonómica con la especie Polygala tenuifolia de la herbolaria en China, la cual cuenta con estudios previos sobre su efecto neuroprotector, constituyéndose en una especie promisoria para el tratamiento para enfermedades neurodegenerativas, que afectan la salud pública. Se estudió la fitoquímica de las raíces y de las partes aéreas de la especie Polygala paniculata, donde se detectaron metabolitos secundarios como flavonoides, terpenos/esteroides y cumarinas, además se evaluó su capacidad antioxidante y se analizó cualitativa y cuantitativamente la presencia de flavonoides. La comparación con la fitoquímica de Polygala tenuifolia mostró apreciables diferencias. La revisión bibliográfica realizada, vincula algunos flavonoides con el efecto neuroprotector, lo cual permite considerar los resultados preliminares como promisorios sobre el potencial neuroproctector de Polygala paniculata y se requerirá de investigaciones adicionales para su confirmación. (Texto tomado de la fuente)spa
dc.description.abstractContribution to the phytochemistry, the evaluation of the antioxidant activity and the possible neuroprotective effect of the species Polygala paniculata Chinese herbalism occupies a very important place within the therapies that make up Traditional Chinese Medicine. In Colombia, due to the limitations in obtaining herbal medicines of Asian origin, it is necessary to find similar medicinal species in our flora. The Polygala paniculata species was chosen due to its taxonomic closeness to the Polygala tenuifolia species of herbal medicine in China, which has previous studies on its neuroprotective effect, becoming a promising species for the treatment of neurodegenerative diseases that affect public health. The phytochemistry of the roots and aerial parts of the Polygala paniculata species was studied, where secondary metabolites such as flavonoids, terpenes/steroids and coumarins were detected, their antioxidant capacity was also evaluated and the presence of flavonoids was analyzed qualitatively and quantitatively. The comparison with the phytochemistry of Polygala tenuifolia showed appreciable differences. The bibliographic review carried out links some flavonoids with the neuroprotective effect, which allows us to consider the preliminary results as promising on the neuroprotective potential of Polygala paniculata and additional research will be required for confirmation.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Medicina Alternativaspa
dc.description.researchareaAcupuntura y Medicina Tradicional Chinaspa
dc.description.technicalinfoArchivo texto ilustrado a color en formato PDFspa
dc.description.technicalinfoColor illustrated text file in PDF formateng
dc.format.extentxvii, 72 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/81970
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina - Maestría en Medicina Alternativaspa
dc.relation.referencesKlein LC, de Andrade SF, Cechinel Filho V. A pharmacognostic approach to the Polygala genus: phytochemical and pharmacological aspects. Chem Biodivers. 2012 Feb;9(2):181–209.spa
dc.relation.referencesAlzate Guarin F. Redescubriendo a Polygala corifolia (Polygalaceae) después de 170 años de su descripción. Acta biol Colomb. 2016 Aug 30;21(3):645.spa
dc.relation.referencesLacaille-Dubois M-A, Delaude C, Mitaine-Offer A-C. A review on the phytopharmacological studies of the genus Polygala. J Ethnopharmacol. 2020 Mar 1; 249:112417.spa
dc.relation.referencesFarina M, Franco JL, Ribas CM, Meotti FC, Missau FC, Pizzolatti MG, et al. Protective effects of Polygala paniculata extract against methylmercury-induced neurotoxicity in mice. J Pharm Pharmacol. 2005 Nov;57(11):1503–8.spa
dc.relation.referencesConsejo interterritorial del Sistema Nacional de Salud. Estrategia en Enfermedades Neurodegenerativas del Sistema Nacional de Salud. Madrid, España: MINISTERIO DE SANIDAD, SERVICIOS SOCIALES E IGUALDAD; 2016 Apr. Report No.: 680- 16-030–3.spa
dc.relation.referencesTHE PLANT LIST, A working list of the all plant species [Internet]. THE PLANT LIST, A working list of the all plant species. 2012 [cited 2021 May 30]. Available from: http://www.theplantlist.org/tpl1.1/record/kew-2555416spa
dc.relation.referencesUniversidad Nacional de Colombia: [Internet]. [cited 2021 Jun 15]. Available from: http://catalogoplantasdecolombia.unal.edu.co/es/resultados/especie/Polygala%20paniculata/spa
dc.relation.referencesGupta MP, Solís PN, Calderón AI, Guionneau-Sinclair F, Correa M, Galdames C, et al. Medical ethnobotany of the Teribes of Bocas del Toro, Panama. J Ethnopharmacol. 2005 Jan 15;96(3):389–401.spa
dc.relation.referencesNguyen X-M-A, Bun S-S, Ollivier E, Dang T-P-T. Ethnobotanical study of medicinal plants used by K’Ho-Cil people for treatment of diarrhea in Lam Dong Province, Vietnam. J Herb Med. 2020 Feb;19:100320.spa
dc.relation.referencesHermano D. Plantas Utilizadas en los Laboratorios de Farmacia [Internet]. 1960 [cited 2021 Mar 3]. Available from: https://revistas.upb.edu.cospa
dc.relation.referencesFarina M, Aschner M. Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay. Biochim Biophys Acta Gen Subj. 2019 Jan 16;1863(12):129285.spa
dc.relation.referencesFranco JL, Braga HC, Stringari J, Missau FC, Posser T, Mendes BG, et al. Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin. Chem Res Toxicol. 2007 Dec;20(12):1919–26.spa
dc.relation.referencesFacilitated by the Royal Botanic Gardens, Kew. Plants of the World Online [Internet]. About Plants of the World Online. 2019 [cited 2021 Mar 30]. Available from: http://www.plantsoftheworldonline.org/spa
dc.relation.referencesXu SL, Zhu KY, Bi CWC, Yan L, Men SWX, Dong TTX, et al. Flavonoids, derived from traditional Chinese medicines, show roles in the differentiation of neurons: possible targets in developing health food products. Birth Defects Res C Embryo Today. 2013 Dec;99(4):292–9.spa
dc.relation.referencesReynaldo I, Cartaya O. Flavonoides: Características químicas y aplicaciones. Cultivos Tropicales. 2001.spa
dc.relation.referencesForni C, Facchiano F, Bartoli M, Pieretti S, Facchiano A, D’Arcangelo D, et al. Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases. Biomed Res Int. 2019 Apr 7;2019:8748253.spa
dc.relation.referencesUddin MS, Al Mamun A, Kabir MT, Ahmad J, Jeandet P, Sarwar MS, et al. Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration. Eur J Pharmacol. 2020 Nov 5;886:173412.spa
dc.relation.referencesPastore JFB, Abbott JR, Neubig KM, Van Den Berg C, Mota MCDA, Cabral A, et al. Phylogeny and biogeography of Polygala (Polygalaceae). Taxon. 2019 Aug;68(4):673–91.spa
dc.relation.referencesMaher P. The potential of flavonoids for the treatment of neurodegenerative diseases. Int J Mol Sci. 2019 Jun 22;20(12).spa
dc.relation.referencesAbbott R. PHYLOGENY OF THE POLYGALACEAE AND A REVISION OF BADIERA . UNIVERSITY OF FLORIDA; 2009.spa
dc.relation.referencesKubitzki K, editor. Flowering Plants · Eudicots: Berberidopsidales, Buxales, Crossosomatales, Fabales p.p., Geraniales, Gunnerales, Myrtales p.p., Proteales, Saxifragales, Vitales, Zygophyllales, Clusiaceae Alliance, Passifloraceae Alliance, Dilleniaceae, Huaceae, Picramniaceae, Sabiaceae. Berlin, Heidelberg: Springer Berlin Heidelberg; 2007.spa
dc.relation.referencesMartins-Silva C, de Souza Pinho N, Ferreira GG, Aguiar RM, Ferreira TA, Pires RGW, et al. Polygala sabulosa A.W. Bennett extract mitigates motor and cognitive deficits in a mouse model of acute ischemia. Metab Brain Dis. 2021 Mar;36(3):453– 62.spa
dc.relation.referencesFicha de Polygala tenuifolia - Botánica Y Jardines [Internet]. [cited 2022 Jun 13]. Available from: http://www.botanicayjardines.com/polygala-tenuifolia/spa
dc.relation.referencesJiang N, Wei S, Zhang Y, He W, Pei H, Huang H, et al. Protective effects and mechanism of radix polygalae against neurological diseases as well as effective substance. Front Psychiatry. 2021 Dec 17;12:688703.spa
dc.relation.referencesZhao X, Cui Y, Wu P, Zhao P, Zhou Q, Zhang Z, et al. Polygalae Radix: A review of its traditional uses, phytochemistry, pharmacology, toxicology, and pharmacokinetics. Fitoterapia. 2020 Nov;147:104759.spa
dc.relation.referencesBa Y, Wang M, Zhang K, Chen Q, Wang J, Lv H, et al. Intestinal absorption profile of three polygala oligosaccharide esters in polygalae radix and the effects of other components in polygalae radix on their absorption. Evid Based Complement Alternat Med. 2019 Jul 2;2019:1379531.spa
dc.relation.referencesWagner H, Püls S, Barghouti T, Staudinger A, Melchart D. Radix polygalae – yuanzhi. In: Wagner H, Püls S, Barghouti T, Staudinger A, Melchart D, editors. Chromatographic fingerprint analysis of herbal medicines volume V. Cham: Springer International Publishing; 2017. p. 103–15.spa
dc.relation.referencesDeng X, Zhao S, Liu X, Han L, Wang R, Hao H, et al. Polygala tenuifolia: a source for anti-Alzheimer’s disease drugs. Pharm Biol. 2020 Dec;58(1):410–6.spa
dc.relation.referencesLi Z, Liu Y, Wang L, Liu X, Chang Q, Guo Z, et al. Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice. Evid Based Complement Alternat Med. 2014 Mar 12;2014:392324.spa
dc.relation.referencesSun X-L, Ito H, Masuoka T, Kamei C, Hatano T. Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task. Biol Pharm Bull. 2007 Sep;30(9):1727–31.spa
dc.relation.referencesYu L, Sun L, Chen S. Protective effect of senegenin on splenectomy-induced postoperative cognitive dysfunction in elderly rats. Exp Ther Med. 2014 Apr;7(4):821–6.spa
dc.relation.referencesUniversidad Nacional de Colombia. Catálogo de plantas y líquenes de Colombia [Internet]. http://catalogoplantasdecolombia.unal.edu.co/es/resultados/especie/Polygala%20pa niculata/. 2015 [cited 2021 Jun 15]. Available from: http://catalogoplantasdecolombia.unal.edu.cospa
dc.relation.referencesFarina M, Rocha JBT, Aschner M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci. 2011 Oct 10;89(15– 16):555–63.spa
dc.relation.referencesFranco JL, Posser T, Missau F, Pizzolatti MG, Dos Santos ARS, Souza DO, et al. Structure-activity relationship of flavonoids derived from medicinal plants in preventing methylmercury-induced mitochondrial dysfunction. Environ Toxicol Pharmacol. 2010 Nov 1;30(3):272–8.spa
dc.relation.referencesBettio LEB, Machado DG, Cunha MP, Capra JC, Missau FC, Santos ARS, et al. Antidepressant-like effect of extract from Polygala paniculata: involvement of the monoaminergic systems. Pharm Biol. 2011 Dec;49(12):1277–85.spa
dc.relation.referencesNogueira FLP, Fernandes SBO, Reis GM, Matheus ME, Fernandes PD, Lage CLS, et al. Atividade analgésica e antiedematogênica de Polygala paniculata L. (Polygalaceae) selvagem e obtida por micropropagação. Revista Brasileira de Farmacognosia. 2005 Dec;15(4).spa
dc.relation.referencesSimanjuntak HA, Gurning K. UJI AKTIVITAS ANTIBAKTERI DARI SEDIAAN KRIM EKSTRAK ETANOL HERBA TUMBUHAN BALSEM (Polygala paniculata L.) TERHADAP BAKTERI Propionebacterium acnes PENYEBAB JERAWAT. eksakta. 2020 Aug 2;5(2):133.spa
dc.relation.referencesHamburger M, Gupta M, Hostettmann K. Coumarins from Polygala paniculata. Planta Med. 1985 Jun;(3):215–7.spa
dc.relation.referencesPizzolatti MG, Cristiano R, Monache FD, Branco A. Artefatos cumarínicos isolados de Polygala paniculata L. (Polygalaceae). Revista Brasileira de Farmacognosia. 2002;12(1).spa
dc.relation.referencesCristiano R, Pizzolatti MG, Monache FD, Rezende CM, Branco A. Two Xanthones from Polygala paniculata and Confirmation of the 1-Hydroxy- 2,3,5-trimethoxy xanthone at Trace Level by HRGC-MS. Z Naturforsch C. 2003 Aug 1;58(7–8):490– 4.spa
dc.relation.referencesPizzolatti MG, Mendes BG, Soldi C, Carasek E. Analysis of Volatile Compounds Released From Flowers and Roots of Polygala cyparissias and Polygala paniculata by Headspace. 2009 May.spa
dc.relation.referencesVictório CP, Beltrami J, Celso Luiz Salgueiro Lage. Polygala paniculata: a source of methyl salicylate produced through plant tissue culture. 2011 Jun.spa
dc.relation.referencesSingh A, Kukreti R, Saso L, Kukreti S. Oxidative stress: A key modulator in neurodegenerative diseases. Molecules. 2019 Apr 22;24(8).spa
dc.relation.referencesVila M, Przedborski S. Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci. 2003 May;4(5):365–75.spa
dc.relation.referencesFlavonoides [Internet]. [cited 2022 Jun 12]. Available from: https://www.elsevier.es/es-revista-offarm-4-pdf-13028951spa
dc.relation.referencesPino N, Álvarez R, Prado G. Determinación de metabolitos secundarios por cromatografía en capa delgada a especies con uso etnomedicinal como estrategia pedagógica en el aula de clase | . Rev Asoc Col Cienc(Col),. 2017.spa
dc.relation.referencesMarghitas LA. The Development of a Biochemical Profile of Acacia Honey by Identifying Biochemical Determinants of its Quality [Internet]. (8) (PDF) The Development of a Biochemical Profile of Acacia Honey by Identifying Biochemical Determinants of its Quality. 2010 [cited 2022 Jun 12]. Available from: https://www.researchgate.net/publication/235339573_The_Development_of_a_Biochemical_Profile_of_Acacia_Honey_byIdentifying_ Biochemical_Determinants_of_its_Quality.spa
dc.relation.referencesMarina D, Avella G, Alberto C, García O, Cisneros A. Medición de Fenoles y Actividad Antioxidante en Malezas Usadas para Alimentación Animal. undefined. 2008.spa
dc.relation.referencesKuskoski EM, Asuero AG, Troncoso AM, Mancini-Filho J, Fett R. Aplicación de diversos métodos químicos para determinar actividad antioxidante en pulpa de frutos. Ciênc Tecnol Aliment. 2005 Dec;25(4):726–32.spa
dc.relation.referencesSandoval-Avila S, Diaz NF, Gómez-Pinedo U, Canales-Aguirre AA, Gutiérrez Mercado YK, Padilla-Camberos E, et al. Neuroprotective effects of phytochemicals on dopaminergic neuron cultures. Neurologia. 2019 Mar;34(2):114–24.spa
dc.relation.referencesANTIOXIDANTES EN ALIMENTOS Y SALUD - PDF Free Download [Internet]. [cited 2022 Jun 14]. Available from: https://docplayer.es/57194382-Antioxidantes en-alimentos-y-salud.html.spa
dc.relation.referencesBatista ÂG, Ferrari AS, da Cunha DC, da Silva JK, Cazarin CBB, Correa LC, et al. Polyphenols, antioxidants, and antimutagenic effects of Copaifera langsdorffii fruit. Food Chem. 2016 Apr 15;197 Pt B:1153–9.spa
dc.relation.referencesCassidy A, Rimm EB, O’Reilly EJ, Logroscino G, Kay C, Chiuve SE, et al. Dietary flavonoids and risk of stroke in women. Stroke. 2012 Apr;43(4):946–51.spa
dc.relation.referencesSchneider H, Schwiertz A, Collins MD, Blaut M. Anaerobic transformation of quercetin-3-glucoside by bacteria from the human intestinal tract. Arch Microbiol. 1999 Jan;171(2):81–91spa
dc.relation.referencesPark BC, Lee YS, Park H-J, Kwak M-K, Yoo BK, Kim JY, et al. Protective effects of fustin, a flavonoid from Rhus verniciflua Stokes, on 6-hydroxydopamine-induced neuronal cell death. Exp Mol Med. 2007 Jun 30;39(3):316–26.spa
dc.relation.referencesBakoyiannis I, Daskalopoulou A, Pergialiotis V, Perrea D. Phytochemicals and cognitive health: Are flavonoids doing the trick? Biomed Pharmacother. 2019 Jan;109:1488–97.spa
dc.relation.referencesGao X, Cassidy A, Schwarzschild MA, Rimm EB, Ascherio A. Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology. 2012 Apr 10;78(15):1138–45.spa
dc.relation.referencesKim GH, Kim JE, Rhie SJ, Yoon S. The role of oxidative stress in neurodegenerative diseases. Exp Neurobiol. 2015 Dec;24(4):325–40spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-CompartirIgual 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/spa
dc.subject.ddc610 - Medicina y saludspa
dc.subject.ddc580 - Plantasspa
dc.subject.lembBioquímica vegetal
dc.subject.lembPlant biochemistry
dc.subject.proposalPolygala paniculataspa
dc.subject.proposalAntioxidantespa
dc.subject.proposalNeuroprotectorspa
dc.subject.proposalFitoquímicaspa
dc.subject.proposalFlavonoidesspa
dc.subject.proposalNeurodegenerativospa
dc.subject.proposalHerbolaria chinaspa
dc.subject.proposalAntioxidanteng
dc.subject.proposalNeuroprotectiveeng
dc.subject.proposalPhytochemicaleng
dc.subject.proposalFlavonoidseng
dc.subject.proposalNeurodegenerativeeng
dc.subject.proposalChinese herbal medicineeng
dc.titleContribución a la fitoquímica, a la evaluación de la actividad antioxidante y el posible efecto neuroprotector de la especie Polygala paniculataspa
dc.title.translatedContribution to the phytochemistry, the evaluation of the antioxidant activity and the possible neuroprotective effect of the species Polygala paniculataeng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentAdministradoresspa
dcterms.audience.professionaldevelopmentBibliotecariosspa
dcterms.audience.professionaldevelopmentConsejerosspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentGrupos comunitariosspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
dcterms.audience.professionaldevelopmentMedios de comunicaciónspa
dcterms.audience.professionaldevelopmentPadres y familiasspa
dcterms.audience.professionaldevelopmentPersonal de apoyo escolarspa
dcterms.audience.professionaldevelopmentProveedores de ayuda financiera para estudiantesspa
dcterms.audience.professionaldevelopmentPúblico generalspa
dcterms.audience.professionaldevelopmentReceptores de fondos federales y solicitantesspa
dcterms.audience.professionaldevelopmentResponsables políticosspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

Archivos

Bloque original

Mostrando 1 - 1 de 1
Miniatura
Nombre:
19250130.2022.pdf
Tamaño:
2.42 MB
Formato:
Adobe Portable Document Format
Descripción:
Tesis de Maestría en Medicina Alternativa
Descargar

Bloque de licencias

Mostrando 1 - 1 de 1
Miniatura
Nombre:
license.txt
Tamaño:
3.98 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Maestría en Medicina Alternativa