Caracterización electroencefalográfica de la ruta subcortical colículo superior – amígdala, vía tálamo, durante la asociación de estímulos condicionado e incondicionado: Evaluación de la integración sensorial multimodal en colículo superior y amígdala
| dc.contributor.advisor | Múnera Galarza, Alejandro | spa |
| dc.contributor.advisor | Rojas Barreto, Manuel | spa |
| dc.contributor.advisor | Cardenas, Fernando | spa |
| dc.contributor.author | Cárdenas Molano, Melissa Andrea Netsash | spa |
| dc.date.accessioned | 2021-01-15T18:06:28Z | spa |
| dc.date.available | 2021-01-15T18:06:28Z | spa |
| dc.date.issued | 2020-08-11 | spa |
| dc.description.abstract | Superior Colliculus (SC) is a crucial structure for vertebrate survival given its role in organizing behavioral responses to unexpected visual stimuli. SC is anatomically and functionally connected with aversive stimuli processing structures such as the amygdala (AM). However, little is known about their electrophysiological activity in response to paired presentation of visual and somatosensory stimuli in anaesthetized rats. The main purpose of the present study was to compare electrophysiological activity in SC and AM during paired and unpaired presentation of visual and somatosensory stimuli in rats under anesthesia (urethane, 1,5 g/kg) Eight males Wistar rats (380 ± 20gr, with ad libitum access to food and water, 12:12h light-dark cycle and temperature 20±2˚C) were implanted with unilateral recording electrodes in SC and AM and stimulating electrodes at the contralateral whisker pad. Stable components of unpaired visual (light flash) and somatosensory (whisker pad electric shock) stimuli evoked potentials in SC and AM were characterized. Paired presentation of visual and somatosensory stimuli induced significant changes in AM, but no SC visual-evoked potential: 1) increasing of P1N1a peak-to-peak amplitude; and, 2) increasing of absolute spectral power for all frequency band (except theta). A second round of unpaired presentations of visual stimuli induced reversion of the above mentioned changes; in addition, unpairing of visual stimuli induced another significant changes: 1) increased N2 area under the curve in SC; and, 2) diminished P2 area under the curve in AM. Taken together such results indicate that early components of AM evoked potential are sensitive to visual stimuli pairing, while late components of both SC and AM evoked potentials are sensitive to visual stimuli unpairing. | spa |
| dc.description.abstract | El Colículo Superior (CS) tiene gran relevancia para la supervivencia de los vertebrados pues es capaz de desencadenar comportamientos reflejos ante estímulos visuales sorpresivos. Se asocia anatómico-funcionalmente a otras estructuras encargadas del procesamiento emocional de estímulos potencialmente aversivos, como la Amígdala (AM). Sin embargo, a la fecha poco se sabe de la actividad electrofisiológica de dichas estructuras ante la presentación emparejada de estímulos visuales y somatosensoriales en ratas anestesiadas. El objetivo de esta investigación fue comparar la respuesta electrofisiológica en CS y AM frente a la presentación emparejada y no-emparejada de estímulos visuales y somatosensoriales en ratas bajo anestesia (uretano, 1,5 g/kg). Se utilizaron 8 ratas Wistar (380 ± 20gr, con comida y agua ad libitum, ciclo luz-oscuridad de 12:12h y temperatura 20±2˚C) con electrodos de registro unilateralmente implantados en CS y AM y electrodos de estimulación en el parche de vibrisas contralateral. Se caracterizaron los componentes estables de los potenciales provocados en CS y AM por estímulos luminosos (destello de luz) y somatosensoriales (choque eléctrico en las vibrisas) no-emparejados. La presentación emparejada del estímulo visual con el somatosensorial indujo cambios en los potenciales provocados visuales en AM, pero no en CS, con respecto a la presentación no-emparejada: 1) aumento significativo de la amplitud pico a pico del componente P1N1a; y 2) aumento significativo de la potencia espectral absoluta en todas las bandas de frecuencia (a excepción de la banda theta). Al volver a presentar el estímulo visual de forma no-emparejada, los cambios anteriormente citados se revirtieron, llegando al nivel basal; además, esta segunda presentación no-emparejada del estímulo visual, provocó: 1) aumento significativo del área bajo la curva del componente N2 en CS; y 2) disminución significativa del área bajo la curva del componente P2 en AM. Estos resultados indican que los componentes tempranos del potencial provocado en AM son sensibles al emparejamiento del estímulo visual, mientras que los componentes tardíos de los potenciales provocados en CS y AM son sensibles al desemparejamiento del mismo. | spa |
| dc.description.degreelevel | Maestría | spa |
| dc.format.extent | 127 | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.uri | https://repositorio.unal.edu.co/handle/unal/78771 | |
| dc.language.iso | spa | spa |
| dc.publisher.branch | Universidad Nacional de Colombia - Sede Bogotá | spa |
| dc.publisher.program | Bogotá - Medicina - Maestría en Neurociencias | spa |
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| dc.rights | Derechos reservados - Universidad Nacional de Colombia | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.license | Atribución-NoComercial 4.0 Internacional | spa |
| dc.rights.spa | Acceso abierto | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | spa |
| dc.subject.ddc | 610 - Medicina y salud | spa |
| dc.subject.proposal | Rata | spa |
| dc.subject.proposal | Rat | eng |
| dc.subject.proposal | Aprendizaje | spa |
| dc.subject.proposal | Learning | eng |
| dc.subject.proposal | Amígdala | spa |
| dc.subject.proposal | Electrophysiology | eng |
| dc.subject.proposal | Superior colliculus | eng |
| dc.subject.proposal | Colículo superior | spa |
| dc.subject.proposal | Amygdala | eng |
| dc.subject.proposal | Electrofisiología | spa |
| dc.title | Caracterización electroencefalográfica de la ruta subcortical colículo superior – amígdala, vía tálamo, durante la asociación de estímulos condicionado e incondicionado: Evaluación de la integración sensorial multimodal en colículo superior y amígdala | spa |
| dc.type | Trabajo de grado - Maestría | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_bdcc | spa |
| dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/masterThesis | spa |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | spa |
| oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |