Búsqueda de compuestos con posible actividad inhibitoria de enzimas de interés cosmético a partir de algas del Caribe colombiano

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dc.contributor.advisorCastellanos Hernández, Leonardo
dc.contributor.authorSepúlveda Sánchez, Lady Yohanna
dc.contributor.cvlacrh_0001620161spa
dc.contributor.orcidLady Yohanna Sepulveda Sanchez [0009-0006-9716-7609]spa
dc.contributor.researchgroupGrupo de Investigación: Estudio y Aprovechamiento de Productos Naturales Marinos y Frutas de Colombiaspa
dc.coverage.countryColombia
dc.coverage.regionCaribe
dc.date.accessioned2023-08-31T21:28:49Z
dc.date.available2023-08-31T21:28:49Z
dc.date.issued2022
dc.descriptionilustraciones, diagramasspa
dc.description.abstractLa proliferación de las algas marinas en los arrecifes del Caribe colombiano ha causado una perdida en la biodiversidad de estos ecosistemas. Con el fin de darle un aprovechamiento a esta biomasa, en este documento se investigó su potencial en la producción de cosméticos despigmentantes y antienvejecimiento. Este estudio se compone de cinco capítulos que abarcan aspectos como la revisión bibliográfica, la extracción de compuestos químicos, el análisis mediante Resonancia Magnética Nuclear (RMN) y espectrometría de masas (EM), la evaluación de la actividad inhibitoria enzimática, así como un estudio químico detallado de una de las algas más prometedoras. La revisión bibliográfica se enfoca en los antecedentes de la industria cosmética en Colombia y los avances en formulaciones antienvejecimiento . Además, se profundiza en las características y el potencial de las algas marinas como ingredientes cosméticos. En el segundo capítulo, se exploran diferentes metodologías de extracción de algas pardas y rojas, y se llevó a cabo el perfilado químico de las muestras seleccionadas usando RMN. El tercer capítulo se centra en el análisis de los extractos utilizando espectrometría de masas (LC-MS/MS) con el fin de obtener una visión detallada de su diversidad química, empleando redes moleculares construidas en la plataforma GNPS Global Natural Products Social Molecular Networking. En el cuarto capítulo, se evaluó la actividad antioxidante (DPPH) e inhibitoria de los extractos previamente obtenidos frente a las enzimas tirosinasa, colagenasa y hialuronidasa. Para los extractos más promisorios se evaluó su actividad citotóxica frente a queratinocitos humanos inmortalizados HaCaT y se encontró que Dictyopteris justii, un alga colectada en Providencia, tiene un potencial prometedor para la industria cosmética debido a su actividad inhibidora de las enzimas de interés y su baja toxicidad. Además, se encontró que algunas especies de Sargassum también son candidatas para futuros estudios. Por consiguiente, en el quinto capítulo se realizó el estudio químico de los extractos butanólicos de muestras de D. justii en diferentes locaciones y en diferentes épocas del año en Providencia, encontrando que, sin importar la muestra, la actividad antioxidante y su capacidad de inhibir las enzimas de interés se mantiene, además los compuestos responsables de dicha actividad corresponden a los florotaninos. Como conclusión, se destaca el potencial de estas algas marinas como valiosas materias primas en la industria cosmética, subrayando la importancia de realizar pruebas de seguridad rigurosas antes de su aplicación comercial. Esta tesis integra herramientas de machine learning, metabolómica y análisis multivariado, con el propósito de explorar el potencial de las algas marinas del Caribe colombiano en la industria cosmética. Los resultados destacan el extracto de Dictyopteris justii como un candidato prometedor y resaltan la necesidad de realizar más investigaciones en este campo.(Texto tomado de la fuente)spa
dc.description.abstractThe proliferation of marine algae in the Colombian Caribbean reefs has led to biodiversity loss in these ecosystems. In order to find a use for this biomass, this document explores its potential in the production of depigmenting and anti-aging cosmetics. This study consists of five chapters covering aspects such as literature review, chemical compound extraction, analysis through Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS), evaluation of enzymatic inhibitory activity, as well as a detailed chemical study of one of the most promising algae. The literature review focuses on Colombia's cosmetic industry background and advances in anti-aging formulations. Additionally, it delves into the characteristics and potential of marine algae as cosmetic ingredients. In the second chapter, various methodologies for extracting brown and red algae are explored, and the chemical profiling of selected samples was carried out using NMR. The third chapter analyzes the extracts using mass spectrometry (LC-MS/MS) to obtain a detailed view of their chemical diversity, employing molecular networks built on the GNPS platform Global Natural Products Social Molecular Networking. The fourth chapter evaluated the antioxidant (DPPH) and inhibitory activity of the previously obtained extracts against tyrosinase, collagenase, and hyaluronidase enzymes. For the most promising extracts, their cytotoxic activity against immortalized human keratinocytes (HaCaT) was evaluated, and it was found that Dictyopteris justii, algae collected in Providencia, holds promising potential for the cosmetic industry due to its inhibitory activity on the enzymes of interest and low toxicity. Furthermore, certain species of Sargassum were also identified as candidates for future studies. Consequently, the fifth chapter conducted a chemical study of butanol extracts from samples of D. justii in different locations and times of the year in Providencia. It was found that, regardless of the sample, the antioxidant activity and its ability to inhibit the enzymes of interest remained consistent. Additionally, the compounds responsible for this activity were identified as phlorotannins. In conclusion, the potential of these marine algae as valuable raw materials in the cosmetic industry is emphasized, underscoring the importance of conducting rigorous safety tests before commercial application. This thesis integrates machine learning, metabolomics, and multivariate analysis tools to explore the potential of marine algae from the Colombian Caribbean in the cosmetic industry. The results highlight the extract of Dictyopteris justii as a promising candidate and emphasize the need for further research.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagister en Ciencias - Químicaspa
dc.description.researchareaProductos Naturalesspa
dc.format.extentxxxvi, 309 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/84624
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias - Químicaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseReconocimiento 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/spa
dc.subject.ddc540 - Química y ciencias afinesspa
dc.subject.decsAlgas marinasspa
dc.subject.decsSeaweedeng
dc.subject.lembIndustria de cosméticosspa
dc.subject.lembCosmetics industryeng
dc.subject.proposalProductos Naturales Marinosspa
dc.subject.proposalAlgas Pardasspa
dc.subject.proposalAlgas Rojasspa
dc.subject.proposaltirosinasaspa
dc.subject.proposalcolagenasaspa
dc.subject.proposalHialuronidasaspa
dc.subject.proposalPerfilado metabólicospa
dc.subject.proposalRedes moleculares
dc.titleBúsqueda de compuestos con posible actividad inhibitoria de enzimas de interés cosmético a partir de algas del Caribe colombianospa
dc.title.translatedSearch for compounds with possible inhibitory activity of enzymes of cosmetic interest from seaweed from the Colombian Caribbean.eng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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