Factores predictores de actividad clínica en paciente con artritis reumatoide temprana en una cohorte colombiana

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Prieto Rayo, Yised Natalia

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Rheumatoid arthritis is a chronic systemic disease, in which early diagnosis is essential in the prevention of unfavorable outcomes. Materials and methods: This project was elaborated from a historic cohort from the Clínica de Artritis Reumatoide, Fundación Santa Fe de Bogotá, selecting patients with an onset of symptoms lesser than 12 moths. We aim to find associated factors with a short term sustained remission defined by DAS28 VSG <2.6, DAS 28 PCR <2.6, SDAI <3.3 CDAI <2.8 in least in two consecutive locations in between the first and last medical visit, time in which the disease was on remission, ≥ 6 months defined as short term sustained remission or ≥ 24 moths defined as long term sustained remission. A univariate analysis was made, along with a multivariate logistic regression analysis to carry out the selection of the variables. Results: 165 patients were included in the study. Short term sustained remission by DAS 28 VSG was achieved in 74%of the patients, DAS 28 PCR in 50% of the patients, long term sustained remission by DAS 28 VSG in 46% of the patients and DAS 28 PCR in 52% of the patients. The predictors of short term sustained remission were Very Early Rheumatoid Arthritis OR 2,69; (OR 2,6 CI 1.26-5.91; P=0.012), alcohol consumption (OR 3,86 CI 0.98- 18.1 P=0.065), DAS 28 VSG_0 (OR 0.41 CI 0.26-0.62 P=<0.001), and family history of AR (OR 0.42 CI 0.17-0.99 P=0.052). The predictors for long term sustained remission were male gender (OR 5.21; CI 1.98-14.9; P=0.001), duration of the symptoms and the onset of FARME (OR 0.81 CI 0.66-0.99; P=0-046).

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