Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia

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dc.contributor.advisorRamírez Nieto, Gloria Consuelospa
dc.contributor.advisorRincón Monroy, Maria Antoniaspa
dc.contributor.authorOspina Jimenez, Andres Felipespa
dc.contributor.cvlacAndres Felipe Ospina [0001884053]spa
dc.contributor.orcid0000-0003-2836-7923spa
dc.contributor.researchgroupMicrobiología y Epidemiologíaspa
dc.coverage.countryColombiaspa
dc.coverage.tgnhttp://vocab.getty.edu/page/tgn/1000050
dc.date.accessioned2024-07-02T20:47:06Z
dc.date.available2024-07-02T20:47:06Z
dc.date.issued2024
dc.descriptionilustraciones, diagramasspa
dc.description.abstractEl Virus de Influenza A (VIA) en cerdos ocasiona infección respiratoria y se asocia al Complejo Respiratorio Porcino, generando impacto económico y sanitario. En Colombia, la limitada información sobre el VIA en cerdos ha llevado al uso de cepas de referencia internacional en pruebas de diagnóstico serológico. La representatividad de dichas cepas en el contexto colombiano es incierta, lo que afecta la precisión del diagnóstico nacional. Por lo tanto, el objetivo del presente estudio fue caracterizar molecular y antigénicamente VIA porcinos presentes en el país, elegir cepas representativas y verificar su utilidad como antígenos en pruebas serológicas. A través de aproximaciones basadas en secuencia y diversas metodologías moleculares, se caracterizaron 38 VIA provenientes de ocho regiones del país, detectados entre 2008 – 2021. Se eligieron siete candidatos virales, los cuales fueron evaluados mediante pruebas de Inhibición de Hemaglutinación (HI). Los resultados obtenidos muestran que en el país existe diversidad filogenética, lo que se evidencia por la identificación del subtipo H1N1 (clados 1A.3.3.2 y 1A.1) y con el reporte por primera vez de virus de los subtipos H1N2 y H3N2. Adicionalmente, se encontraron cinco clústeres antigénicos en el VIA H1 y se reconoció el H3 como una nueva variante genética y antigénica. Los siete candidatos elegidos permitieron una mejor detección de anticuerpos con respecto a las cepas de referencia utilizadas hasta el momento en el país, mostrando buena repetibilidad en la ejecución de la prueba de HI. A través de asociaciones estadísticas se logró reducir el número de candidatos propuestos a cuatro, los cuales pueden ser potencialmente usados como antígenos de referencia en las pruebas serológicas para VIA en cerdos en el país. (Texto tomado de la fuente).spa
dc.description.abstractInfluenza A Virus (IAV) in pigs causes respiratory infections and is associated to the Porcine Respiratory Disease Complex, accounting for economical loses and sanitary issues. In Colombia, knowledge about swine IAV is scarce. This has led to the implementation of international reference strains for serological assays. Representativity of these strains in the Colombian context is unknown affecting the national diagnostic capacity. Therefore, this study aimed the molecular and antigenic characterization of swine IAV in the county, the selection of representative strains, and the assessment of their value as antigens for serological assays. 38 IAV from eight regions of the country detected between 2008 – 2021 were characterized through sequence-based approaches. Seven candidates were selected for serological evaluation using the Hemagglutination Assay (HI). The results showed that there is a significant phylogenetic diversity in the country. This is supported by the recognition of the H1N1 subtype (clades: 1A.3.3.2 and 1A.1) and the identification for the first time of the H1N2 and H3N2 virus subtypes. Five antigenic clusters were recognized in the IAV H1 subtype as well as one in the H3 subtype representing a novel genetic and phylogenetic variant. The seven selected candidates allowed a higher antibody detection than the reference strains used until now in the country and they exhibited good repeatability among performs of the HI assay. Based on statistical associations the number of proposed candidates could be reduced to four. These candidates can potentially be included in serological assays in the country.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Salud Animal o Magíster en Producción Animalspa
dc.description.notesTexto en inglés y españolspa
dc.description.researchareaMicrobiología e inmunologíaspa
dc.format.extentxviii, 189 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86351
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicina Veterinaria y de Zootecniaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción Animalspa
dc.relation.indexedAgrosaviaspa
dc.relation.indexedAgrovocspa
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dc.relation.referencesGoto, Y., Fukunari, K., Tada, S., Ichimura, S., Chiba, Y., & Suzuki, T. (2023). A multiplex real-time RT-PCR system to simultaneously diagnose 16 pathogens associated with swine respiratory disease. Journal of Applied Microbiology, 134(11), 1–14. https://doi.org/10.1093/JAMBIO/LXAD263spa
dc.relation.referencesGong, X., Hu, M., Chen, W., Yang, H., Wang, B., Yue, J., Jin, Y., Liang, L., & Ren, H. (2021). Reassortment Network of Influenza A Virus. Frontiers in Microbiology, 12, 793500. https://doi.org/10.3389/FMICB.2021.793500/BIBTEXspa
dc.relation.referencesGibbs, A. J., Armstrong, J. S., & Downie, J. C. (2009). From where did the 2009 “swine-origin” influenza A virus (H1N1) emerge? Virology Journal, 6(1), 1–11. https://doi.org/10.1186/1743-422X-6-207spa
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dc.relation.referencesGe, J., Lin, X., Guo, J., Liu, L., Li, Z., Lan, Y., Liu, L., Guo, J., Lu, J., Huang, W., Xin, L., Wang, D., Qin, K., Xu, C., & Zhou, J. (2022). The Antibody Response Against Neuraminidase in Human Influenza A (H3N2) Virus Infections During 2018/2019 Flu Season: Focusing on the Epitopes of 329-N-Glycosylation and E344 in N2. Frontiers in Microbiology, 13, 590. https://doi.org/10.3389/FMICB.2022.845088/BIBTEXspa
dc.relation.referencesGauger, P. C., & Vincent, A. L. (2020b). Serum Virus Neutralization Assay for Detection and Quantitation of Serum Neutralizing Antibodies to Influenza A Virus in Swine. In Animal Influenza Virus: Methods in Molecular Biology (pp. 321–333). https://doi.org/10.1007/978-1-0716-0346-8_23spa
dc.relation.referencesGauger, P. C., & Vincent, A. L. (2020a). Enzyme-Linked Immunosorbent Assay for Detection of Serum or Mucosal Isotype-Specific IgG and IgA Whole-Virus Antibody to Influenza A Virus in Swine. In Animal Influenza Virus: Methods in Molecular Biology (pp. 311–320). https://doi.org/10.1007/978-1-0716-0346-8_22spa
dc.relation.referencesGarten, W., Braden, C., Arendt, A., Peitsch, C., Baron, J., Lu, Y., Pawletko, K., Hardes, K., Steinmetzer, T., & Böttcher-Friebertshäuser, E. (2015). Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics. European Journal of Cell Biology, 94(7–9), 375–383. https://doi.org/10.1016/J.EJCB.2015.05.013spa
dc.relation.referencesGao, J., Couzens, L., & Eichelberger, M. C. (2016). Measuring Influenza Neuraminidase Inhibition Antibody Titers by Enzyme-linked Lectin Assay. Journal of Visualized Experiments : JoVE, 2016(115), 54573. https://doi.org/10.3791/54573spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.agrovocVirus de la influenza porcinaspa
dc.subject.agrovocSwine influenzaviruseng
dc.subject.ddc630 - Agricultura y tecnologías relacionadas::632 - Lesiones, enfermedades, plagas vegetalesspa
dc.subject.decsVirus/clasificaciónspa
dc.subject.decsVirus/classificationeng
dc.subject.decsAntígenos/análisisspa
dc.subject.decsAntigens/analysiseng
dc.subject.proposalInfluenzavirusspa
dc.subject.proposalAntigenicidadspa
dc.subject.proposalBioinformáticaspa
dc.subject.proposalInfluenza porcinaspa
dc.subject.proposalCartografia antigénicaspa
dc.subject.proposalSwine Influenzaeng
dc.subject.proposalAntigenic characterizationeng
dc.subject.proposalAntigenic clustereng
dc.subject.proposalBioinformaticseng
dc.titleEvaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
dc.title.translatedAntigenic analysis of field viruses as candidates for the update of serological diagnosis of Influenza in swine in Colombiaeng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.fundernamePorkcolombiaspa

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