Alcance fitoterapéutico de TongXinLuo en el tratamiento de la disfunción endotelial y sus complicaciones, revisión narrativa

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dc.contributor.advisorMockus Sivickas, Ismena Vilte Ona
dc.contributor.advisorPatiño Patiño, Aldo Fernando
dc.contributor.authorSolano Viracachá, Iván Francisco
dc.contributor.educationalvalidatorAmador Foriga, Diana Patricia
dc.coverage.countryColombia
dc.date.accessioned2025-09-08T21:14:41Z
dc.date.available2025-09-08T21:14:41Z
dc.date.issued2025
dc.description.abstractLa disfunción endotelial constituye un mecanismo fisiopatológico central en enfermedades cerebrovasculares y trastornos neurodegenerativos como la demencia vascular (DVa). Aunque existen terapias farmacológicas convencionales, los desafíos en su prevención y tratamiento integral persisten. Desde la Medicina Tradicional China (MTC), se han propuesto alternativas complementarias, destacando el preparado fitoterapéutico TongXinLuo (TXL), cuyos componentes presentan propiedades antiinflamatorias, antioxidantes, antiaterogénicas, hipolipemiantes, antiagregantes plaquetarios y neuroprotectoras. Objetivo: Revisar de forma integradora la evidencia científica sobre TXL en la disfunción endotelial y su potencial en la prevención y tratamiento de la demencia vascular, promoviendo la complementariedad entre la MTC y la medicina occidental. Metodología: Se realizó una revisión narrativa con enfoque integrador, consultando literatura indexada en bases como PubMed, Scopus, EMBASE, LILACS, Web of Science, Chinese Biomedical, Cochrane y VHL, hasta abril de 2025. Se incluyeron estudios clínicos, revisiones sistemáticas, metaanálisis y trabajos experimentales relacionados con TXL, disfunción endotelial y DVa. Resultados: La evidencia sugiere que TXL modula diversas vías implicadas en la disfunción endotelial, incluyendo inflamación, estrés oxidativo y función vascular cerebral. Estudios preclínicos y clínicos reportan beneficios como reducción del volumen de infarto, mejora cognitiva y regulación de biomarcadores. No obstante, las limitaciones metodológicas, especialmente en investigaciones fuera de Asia, dificultan la generalización de sus resultados. Conclusión: TXL representa una opción terapéutica prometedora para la DVa. Se requiere mayor investigación clínica multicéntrica que valide su eficacia y seguridad en contextos occidentales. (Texto tomado de la fuente)spa
dc.description.abstractEndothelial dysfunction is a central pathophysiological mechanism in cerebrovascular diseases and neurodegenerative disorders such as vascular dementia (VaD). Although conventional pharmacological therapies are available, challenges persist in terms of prevention and comprehensive management. Traditional Chinese Medicine (TCM) offers complementary alternatives, including the herbal preparation TongXinLuo (TXL), whose components exhibit anti-inflammatory, antioxidant, anti-atherogenic, hypolipidemic, antiplatelet, and neuroprotective properties. Objective: To conduct an integrative review of the scientific evidence on TXL in relation to endothelial dysfunction and its potential role in the prevention and treatment of vascular dementia, promoting the complementarity between TCM and Western medicine. Methods: A narrative review with an integrative approach was carried out through a search of indexed literature in databases such as PubMed, Scopus, EMBASE, LILACS, Web of Science, Chinese Biomedical, Cochrane and VHL, up to April 2025. Clinical studies, systematic reviews, meta-analyses, and experimental research related to TXL, endothelial dysfunction, and VaD were included. Results: The evidence suggests that TXL modulates multiple pathways involved in endothelial dysfunction, including inflammation, oxidative stress, and cerebral vascular function. Preclinical and clinical studies report benefits such as reduced infarct volume, improved cognition, and biomarker regulation. However, methodological limitations—particularly in studies conducted outside Asia—limit the generalizability of the findings. Conclusion: TXL, shows promise as a therapeutic option for VaD. Further multicenter clinical research is needed to validate its efficacy and safety in Western contexts.eng
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Medicinas Alternativas con Profundización en Medicina Tradicional China y Acupuntura
dc.description.methodsTipo de estudio: Revisión narrativa. Fuentes de información: Bases de datos: PubMed / Medline, Scopus, EMBASE, LILACS, Web of Science Chinese Biomedical, Cochrane Library Database, VHL. Términos de búsqueda: TongXinLuo, TXL, tong‐xin‐luo, demencia vascular, endotelio vascular, células endoteliales, enfermedades cardiovasculares, ictus, enfermedad cerebrovascular, hipercolesterolemia, ateroesclerosis. Estos términos libres se tradujeron a lenguaje controlado utilizando términos MeSH, DeCS y Emtree. Estrategias de búsqueda: Se usaron los operadores booleanos “AND”, “OR” y “NOT”. Se incluyeron todos los estudios encontrados hasta abril de 2025, cuando se inició la extracción y síntesis de la información. Criterios de inclusión: Estudios realizados en humanos y en modelos animales, que destaquen las características, clasificación, efecto, seguridad y uso terapéutico de TongXinLuo en demencia vascular y disfunción endotelial cerebral; Ensayos clínicos, artículos de revisión, revisiones sistemáticas, metaanálisis y reportes de casos. que describan el impacto del uso de TongXinLuo en la función endotelial cerebrovascular; Artículos escritos en inglés y español. Criterios de exclusión: Artículos que se refieran a arterioesclerosis, dislipidemia, sin mención de ECCV; Artículos de otros fármacos o compuestos diferentes a TXL; Cartas al editor; Artículos sin acceso completo.
dc.format.extentix, 82 páginas
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/88657
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
dc.publisher.facultyFacultad de Medicina
dc.publisher.placeBogotá, Colombia
dc.publisher.programBogotá - Medicina - Maestría en Medicina Alternativa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc616.812
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéutica
dc.subject.ddc610 - Medicina y salud::616 - Enfermedades
dc.subject.decsDemencia vascular -- Terapiaspa
dc.subject.decsDementia, vascular -- Therapyeng
dc.subject.decsDemencia vascular -- Tratamiento farmacológicospa
dc.subject.decsDementia, vascular -- Drug therapyeng
dc.subject.decsFitoterapiaspa
dc.subject.decsPhytotherapyeng
dc.subject.decsMedicamentos herbarios chinosspa
dc.subject.decsDrugs, Chinese herbaleng
dc.subject.decsTrastornos cerebrovasculares -- Fisiopatologíaspa
dc.subject.decsCerebrovascular disorders -- Physiopathologyeng
dc.subject.decsFactores de crecimiento endotelial vascularspa
dc.subject.decsVascular endothelial growth factorseng
dc.subject.decsCélulas endotelialesspa
dc.subject.decsEndothelial Cellseng
dc.subject.decsEndotelio vascularspa
dc.subject.decsEndothelium, vasculareng
dc.subject.decsHipercolesterolemiaspa
dc.subject.decsHypercholesterolemiaeng
dc.subject.decsAccidente cerebrovascularspa
dc.subject.decsStrokeeng
dc.subject.decsPlaca ateroscleróticaspa
dc.subject.decsPlaque, atheroscleroticeng
dc.subject.lembMedicina china -- Investigaciones -- Colombiaspa
dc.subject.lembMedicine, Chinese -- Researcheng
dc.subject.proposalTongXinLuochino
dc.subject.proposalTXL
dc.subject.proposalEndotelio vascularspa
dc.subject.proposalCélulas endotelialesspa
dc.subject.proposalIctusspa
dc.subject.proposalEnfermedad cerebrovascularspa
dc.subject.proposalHipercolesterolemiaspa
dc.subject.proposalAteroesclerosisspa
dc.subject.proposalVascular dementiaeng
dc.subject.proposalEndotheliumeng
dc.subject.proposalStrokeeng
dc.subject.proposalCerebrovascular diseaseseng
dc.titleAlcance fitoterapéutico de TongXinLuo en el tratamiento de la disfunción endotelial y sus complicaciones, revisión narrativaspa
dc.title.translatedPhytotherapeutic potential of TongXinLuo in endothelial dysfunction and related complications : a narrative revieweng
dc.typeTrabajo de grado - Maestría
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentBibliotecarios
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentMaestros
dcterms.audience.professionaldevelopmentPúblico general
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2

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