Efectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotina

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dc.contributor.advisorLamprea Rodríguez, Marisol
dc.contributor.advisorCortés-Patiño, Diana
dc.contributor.authorBallesteros-Acosta, Hans
dc.contributor.cvlacBallesteros-Acosta, Hans [0001711713#]spa
dc.contributor.orcidBallesteros-Acosta, Hans [0000000303879084]spa
dc.contributor.researchgateBallesteros-Acosta, Hans [Hans-Ballesteros-Acosta]spa
dc.contributor.researchgroupNeurociencia Básica y Cognoscitivaspa
dc.date.accessioned2023-07-25T17:39:09Z
dc.date.available2023-07-25T17:39:09Z
dc.date.issued2023
dc.descriptionilustraciones, fotografías, diagramasspa
dc.description.abstractLa interacción social resulta fundamental para el apropiado desarrollo del sistema nervioso y la adquisición de habilidades de supervivencia. Se ha demostrado que impedir las interacciones sociales durante la adolescencia aumenta los efectos de las drogas psicoactivas; sin embargo, existen pocos reportes sobre el impacto del aislamiento social sobre los efectos de la nicotina. El presente estudio evaluó los efectos del aislamiento social durante la adolescencia sobre (1) la acumulación del factor de transcripción ΔFosB en la corteza prelímbica, el núcleo accumbens y el núcleo paraventricular del tálamo, (2) la sensibilización a los efectos locomotores de la nicotina tras su administración repetida y (3) la preferencia condicionada de lugar inducida por diferentes dosis de nicotina (0,1 o 0,3 mg/kg). Los resultados indican que los animales aislados acumulan menos ΔFosB en las estructuras del circuito de recompensa evaluadas. El aislamiento no afectó los procesos de sensibilización locomotora inducida por dosis bajas de nicotina, pero sí se observó un efecto sobre la inducción de una mayor preferencia por lugares asociados con la nicotina. Dicho cambio se mantuvo por más de cuatro sesiones de extinción, únicamente para la dosis más baja. No se observaron incrementos significativos durante el restablecimiento de la asociación para ninguna de las dosis. Los resultados sugieren que el aislamiento social durante la adolescencia no afecta los procesos subyacentes a la expresión de la sensibilización locomotora, pero aumenta la sensibilidad de los animales a los efectos asociativos de la nicotina, incrementando el valor de incentivo de los contextos asociados con la misma. Este efecto podría estar mediado por reducciones en la acumulación de ΔFosB en las estructuras del circuito de recompensa. (Texto tomado de la fuente)spa
dc.description.abstractSocial interaction is essential for the proper development of the nervous system and the acquisition of survival skills. Preventing social interactions during adolescence has been shown to increase the effects of psychoactive drugs; however, there are few reports on the impact of social isolation on the effects of nicotine. The present study evaluated the effects of social isolation during adolescence on (1) the accumulation of the transcription factor ΔFosB in the prelimbic cortex, nucleus accumbens, and paraventricular nucleus of the thalamus, (2) sensitization to the locomotor effects of nicotine after repeated administration, and (3) conditioned place preference induced by different doses of nicotine (0.1 or 0.3 mg/kg). The results indicate that isolated animals accumulated less ΔFosB in the reward circuit structures evaluated. Isolation did not affect locomotor sensitization processes induced by low doses of nicotine but an effect on the induction of increased preference for nicotine-associated locations was observed. Such a change was maintained for more than four extinction sessions, only for the lowest dose. No significant increases were observed during reinstatement of the association for any of the doses. The results suggest that social isolation during adolescence does not affect the processes underlying the expression of locomotor sensitization but increases the sensitivity of animals to the associative effects of nicotine, increasing the incentive value of nicotine-associated contexts. This effect could be mediated by reductions in the accumulation of ΔFosB in reward circuit structures.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMaestría en Psicologíaspa
dc.format.extent104 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/84265
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Ciencias Humanasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias Humanas - Maestría en Psicologíaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.ddc150 - Psicología::156 - Psicología comparadaspa
dc.subject.decsPsicología del Adolescentespa
dc.subject.decsPsychology, Adolescenteng
dc.subject.decsConducta del Adolescentespa
dc.subject.decsAdolescent Behavioreng
dc.subject.proposalAdolescenciaspa
dc.subject.proposalAislamiento socialspa
dc.subject.proposalNicotinaspa
dc.subject.proposalΔFosBspa
dc.subject.proposalSensibilización locomotoraspa
dc.subject.proposalPreferencia condicionada de lugarspa
dc.subject.proposalAdolescenceeng
dc.subject.proposalSocial isolationeng
dc.subject.proposalNicotineeng
dc.subject.proposalΔFosBeng
dc.subject.proposalLocomotor sensitizationeng
dc.subject.proposalConditioned place preferenceeng
dc.titleEfectos del aislamiento social sobre la inducción de procesos de plasticidad y en el aprendizaje de estímulos contextuales asociados a la nicotinaspa
dc.title.translatedEffects of social isolation on the induction of plasticity processes and the learning of nicotine-associated contextual stimulieng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.awardtitleConvocatoria pacto para la generación de nuevo conocimiento a través de proyectos de investigación científica en ciencias médicas y de la salud 2019 Proyecto Código 67701spa
oaire.fundernameMincienciasspa

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