Experiencia con la biopsia de ganglio centinela dinámico en pacientes con cáncer de pene en el Instituto Nacional de Cancerología
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Objetivo: Evaluar la biopsia de ganglio centinela dinámico(BGCD) como método de evaluación ganglionar inguinal para cáncer escamocelular (CEC) de pene en regiones inguinales sin ganglios palpables o con un ganglio palpable y biopsia por aspiración con aguja fina negativa en una única institución. Materiales y Métodos: Se revisó retrospectivamente la historia clínica de los pacientes a quienes se les realizó BGCD desde enero de 2007 a agosto de 2011. Se realizó cálculos estadísticos estándar para establecer el rendimiento de la prueba. Resultados: se realizaron 56 BGCD a 35 pacientes. 12,5% de los ganglios centinela presentaron compromiso metastásico. Dos BGCD resultaron ser falsos negativos en el seguimiento. La sensibilidad fue del 78%, un valor predictivo negativo de 95,9%, tasa de falsos negativos del 22% y 6,7% de complicaciones menores. Conclusiones: La BGCD es un procedimiento adecuado para la estadificación ganglionar de pacientes con CEC de pene, con una baja tasa de complicaciones y puede evitar la linfadenectomía inguinal en la mayoría de los pacientes.
Abstract. Objective: To evaluate the dynamic sentinel lymph‐node biopsy (SLNB) as a staging procedure in groins for squamous cell penile cancer (SCC) with clinically node‐negative and in groins with palpable node with negative fine needle aspiration citology (FNAC) in a single institution. Materials and Methods: We retrospectively reviewed medical records of patients who underwent SLNB from January 2007 to August 2011. Standard statistical calculations were done to establish the performance of the test Results: 56 SLNB were performed in 35 patients. 12.5% of the SNLB were positive for nodal metastasis. Two turned out to be false negatives SLNB at follow‐up. The sensitivity was 78%, negative predictive value 95.9%, false negative rate of 22% and 6.7% minor complications. Conclusions: BGCD is an appropriate procedure for nodal staging of patients with SCC of the penis, with a low rate of complications and inguinal lymphadenectomy can be avoided in most patients.
Abstract. Objective: To evaluate the dynamic sentinel lymph‐node biopsy (SLNB) as a staging procedure in groins for squamous cell penile cancer (SCC) with clinically node‐negative and in groins with palpable node with negative fine needle aspiration citology (FNAC) in a single institution. Materials and Methods: We retrospectively reviewed medical records of patients who underwent SLNB from January 2007 to August 2011. Standard statistical calculations were done to establish the performance of the test Results: 56 SLNB were performed in 35 patients. 12.5% of the SNLB were positive for nodal metastasis. Two turned out to be false negatives SLNB at follow‐up. The sensitivity was 78%, negative predictive value 95.9%, false negative rate of 22% and 6.7% minor complications. Conclusions: BGCD is an appropriate procedure for nodal staging of patients with SCC of the penis, with a low rate of complications and inguinal lymphadenectomy can be avoided in most patients.