Sensibilidad y especificidad del dímero D en el diagnóstico de enfermedad cerebrovascular de origen isquémico de etiología cardioembólica en menores de 18 años
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Aristizábal Flórez, David
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Trabajo de grado - Pregrado
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EspañolFecha de publicación
2014
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Objetivos: Evaluar la hipótesis que la elevación del dímero D se relaciona con la de enfermedad cerebrovascular de origen isquémico de etiología cardioembólica. Métodos: Se llevó a cabo un estudio retrospectivo, descriptivo de pruebas diagnósticas, para examinar el rendimiento diagnóstico del dímero-D en la diferenciación entre la enfermedad cerebrovascular cardioembólica y no cardioembólica, entre los años 2007 y 2013. Resultados: Dentro de los 21 pacientes incluidos en el estudio, el 52% fueron arteriopatías, 14% cardioembólicos y el 24% sin diagnóstico establecido. La sensibilidad y especificidad del dímero-D para la enfermedad cerebrovascular de origen cardioembólico fue 33.3% (IC 95%: 0-100) y 88.89% (IC 95%: 71,58-100). Conclusiones:Si bien el número de pacientes es inferior a lo estimado para poder establecer resultados confiables, podemos inferir que el dímero D tiene una muy pobre sensibilidad y una aceptable especificidad, que en el caso que este fuera el rendimiento operativo de la prueba, no se recomendaría como prueba de tamizaje para el diagnóstico de ECV de etiología cardioembólica.
Abstract. Objective: To test the hypothesis that the elevation of D-dimer is related to the diagnosis of arterial ischemic stroke of cardioembolicetiology. Methods: To examine the diagnostic value of D-dimer to differentiate stroke etiologies, between cardioembolic and non cardioembolic stroke, we conducted a retrospective, descriptive, diagnostic study, between 2007 and 2013. Results: Of 21 ischemic stroke patients included, 52% were arteriopathies14% cardioembolic and 24% of undetermined origin. The sensitivity and specificity of D-dimer for cardioembolic subtype were 33.3% (95% CI: 0-100) and 88.89% (95% CI: 71,58-100), respectively. Conclusions: The size of population of study is inferior to the number estimated to establish reliable results; however, we can infer that D-dimer has a poor sensitivity and an acceptable specificity, that in case, it was the diagnostic performance of this plasma biomarker, as consequence of the low prevalence of cardioembolic stroke subtype, it should not be used as screening test for the diagnosis of cardioembolic stroke.
Abstract. Objective: To test the hypothesis that the elevation of D-dimer is related to the diagnosis of arterial ischemic stroke of cardioembolicetiology. Methods: To examine the diagnostic value of D-dimer to differentiate stroke etiologies, between cardioembolic and non cardioembolic stroke, we conducted a retrospective, descriptive, diagnostic study, between 2007 and 2013. Results: Of 21 ischemic stroke patients included, 52% were arteriopathies14% cardioembolic and 24% of undetermined origin. The sensitivity and specificity of D-dimer for cardioembolic subtype were 33.3% (95% CI: 0-100) and 88.89% (95% CI: 71,58-100), respectively. Conclusions: The size of population of study is inferior to the number estimated to establish reliable results; however, we can infer that D-dimer has a poor sensitivity and an acceptable specificity, that in case, it was the diagnostic performance of this plasma biomarker, as consequence of the low prevalence of cardioembolic stroke subtype, it should not be used as screening test for the diagnosis of cardioembolic stroke.