Identificación de la actividad hipotensora del extracto etanólico de solanum tuberusom en ratas
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Guerrero, Mario
Carrón, Rosalia
Martín, María
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EspañolFecha de publicación
2003
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Se evaluaron los efectos hipotensor y vasodilatador del extracto etanólico de la corteza de Solanum tuberosum en ratas anestesiadas y en anillos vasculares de aorta. La administración del extracto, vía intravenosa (5-15 mg/kg), produjo una disminución de la presión arterial media en función de la dosis, tanto en ratas espontáneamente hipertensas (SHR) como en ratas Wistar. Adicionalmente el extracto provocó una respuesta vasodilatadora (CI50: 3.9E-4 g/ml) en anillos aislados de aorta obtenidos de ratas Wistar, previamente contraidos con KCl 80 mM
Hypotensive and vasorelaxant effects of the ethanolic extract of Solanum tuberosum, in anaesthetized rats and isolated aorta rings were investigated. Intravenous injections of the bark extract (5-15 mg/kg) produced a dose-dependent decreasing in mean arterial pressure and heart rate in spontaneously hypertensive rats (SHR) as well as Wistar rats. Furthermore, the bark extract has produced a vasorelaxant response (in a concentration dependent manner, IC50: 3.9E-4 g/ml), in intact Wistar rat aortic rings, previously contracted by KCl
Hypotensive and vasorelaxant effects of the ethanolic extract of Solanum tuberosum, in anaesthetized rats and isolated aorta rings were investigated. Intravenous injections of the bark extract (5-15 mg/kg) produced a dose-dependent decreasing in mean arterial pressure and heart rate in spontaneously hypertensive rats (SHR) as well as Wistar rats. Furthermore, the bark extract has produced a vasorelaxant response (in a concentration dependent manner, IC50: 3.9E-4 g/ml), in intact Wistar rat aortic rings, previously contracted by KCl