Duración del efecto hipotensor de análogos de prostaglandinas, evaluado con prueba de sobrecarga hídrica en pacientes con glaucoma
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Tirado Sandino, Jorge Eduardo
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Trabajo de grado - Pregrado
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EspañolFecha de publicación
2014
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Este ensayo piloto pretende establecer la duración del efecto hipotensor de los análogos de prostaglandinas en monoterapia mediante la Prueba de Sobrecarga Hídrica (PSH) en pacientes con Glaucoma. Para ello, 16 pacientes (31 ojos) con glaucoma primario (de ángulo abierto o cerrado) fueron incluidos y se les realizó PSH antes y durante el tratamiento con análogos de prostaglandinas en esquema de tratamiento diario e interdiario (a las 35 y 44 horas). Veinticuatro ojos (77.42%) recibieron Latanoprost y 7 ojos (22.58%) recibieron Travoprost en esquema de monoterapia de forma aleatoria. Los resultados obtenidos sugieren que con el esquema de tratamiento interdiario, persiste un efecto hipotensor importante, aunque usualmente menor que con el esquema de tratamiento diario. Por otro lado, la diferencia en la presión intraocular (PIO) encontrada entre medidas aisladas y el pico de PIO obtenido con PSH, nos muestra la importancia de encontrar este último para lograr un adecuado manejo del paciente con glaucoma.
Abstract. This pilot study expects to establish the duration of the hypotensive effect of prostaglandin analogues on monotherapy with Water Drinking Test (WDT) in patients with glaucoma. Thirteen patients (thirty one eyes) with primary glaucoma (open and closed angle) were included and we applied the Water Drinking Test (WDT) to them before and during the treatment with prostaglandin analogues daily treatment and alternate day treatment (at 35 hours and 44 hours). Twenty four eyes (77.42%) received Latanoprost and 7 eyes (22.58%) received Travoprost in monotherapy randomized scheme. We found that an important hypotensive effect persisted on those receiving the alternate day treatment, even though it was lower than the effects on daily treatment. On the other hand, the difference between isolated intraocular pressure (IOP) and IOP peak obtained with WDT, highlights the relevance of finding the highest pressure value for achieving a more appropriate glaucoma treatment.
Abstract. This pilot study expects to establish the duration of the hypotensive effect of prostaglandin analogues on monotherapy with Water Drinking Test (WDT) in patients with glaucoma. Thirteen patients (thirty one eyes) with primary glaucoma (open and closed angle) were included and we applied the Water Drinking Test (WDT) to them before and during the treatment with prostaglandin analogues daily treatment and alternate day treatment (at 35 hours and 44 hours). Twenty four eyes (77.42%) received Latanoprost and 7 eyes (22.58%) received Travoprost in monotherapy randomized scheme. We found that an important hypotensive effect persisted on those receiving the alternate day treatment, even though it was lower than the effects on daily treatment. On the other hand, the difference between isolated intraocular pressure (IOP) and IOP peak obtained with WDT, highlights the relevance of finding the highest pressure value for achieving a more appropriate glaucoma treatment.