Efecto de la Simvastatina sobre las vías de señalización PI3K, MAPK y Rho GTPasa en osteosarcoma
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Las estatinas son una familia de medicamentos usados actualmente en el control de enfermedades asociadas con problemas de colesterol, aunque se les han asociados diferentes efectos pleiotropicos dentro de los cuales toma relevancia su efecto anti-tumoral. Se evidenció un efecto diferencial dosis dependiente de la simvastatina sobre la viabilidad, migración, adhesión e invasión celular entre el modelo de osteosarcoma y una línea no tumoral de osteoblastos, la cual presentó una mayor tolerancia al medicamento sugiriendo su potencial uso terapéutico en el control del cáncer.
Abstract. Statins are a family of medications currently used on the control of diseases associated with cholesterol problems, although they have been associated different pleiotropic effects within which takes relevance its effect anti-tumor. A differential dose-dependent effect in cell viability, migration, adhesion and invasion was observed in response to simvastatin in osteosarcoma cells compared to non tumoral osteoblasts. On the other hand, non-tumor cell line taking a greater tolerance to the drug indicating their use in the beneficial of cancer control.
Abstract. Statins are a family of medications currently used on the control of diseases associated with cholesterol problems, although they have been associated different pleiotropic effects within which takes relevance its effect anti-tumor. A differential dose-dependent effect in cell viability, migration, adhesion and invasion was observed in response to simvastatin in osteosarcoma cells compared to non tumoral osteoblasts. On the other hand, non-tumor cell line taking a greater tolerance to the drug indicating their use in the beneficial of cancer control.