Recuento De Células Endoteliales En Población Mayor De 50 Años Con Catarata Senil
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Autores
Vargas Riveros, Laura Catalina
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Alzate, Juan Pablo (Thesis advisor)
Tipo de contenido
Trabajo de grado - Pregrado
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EspañolFecha de publicación
2018-01-25
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Objetivo: Describir los hallazgos de microscopía especular endotelial en población colombiana mayor de 50 años que será llevada a cirugía de extracción de catarata en una institución de cirugía ocular de Bogotá, Colombia, y compararla con lo reportado en la literatura de otros países. Método: mediante estudio observacional y descriptivo de corte transversal se analizaron 205 ojos en estudio prequirúrgico de catarata senil de voluntarios mayores de 50 años, sin antecedentes de patología ocular con examen clínico oftalmológico en lámpara de hendidura y realización de microscopía especular. Se obtuvieron datos promedios de la densidad celular (DC), área celular promedio (AC), coeficiente de variación (CV%) y hexagonalidad (H%). Se realizó una revisión bibliográfica de estudios similares bajo los criterios de búsqueda de microscopía especular y población sana. Resultados: edad promedio 73.7 años, entre 50 y 91 años. Sus promedios de DC(DS), AC(DS), CV%(DS) y H%(DS) fueron 2338 (316) cél/mm2, 436 (67)m², 33 (6.28) % y 66 (5) %, respectivamente. En test de Pearson de edad vs DC se observó una correlación débil de -0.15 (P 0.002). Se encontró una diferencia estadísticamente significativa en: CV% (P 0.003) para el rango de 80 a 89 años en el análisis por décadas, y en el análisis de varianza ANOVA de la densidad celular promedio frente a la mayoría de países evaluados, exceptuando India, Tailandia y Brasil. Conclusiones: La información genera acerca del comportamiento endotelial corneal en Colombia, fue similar a lo reportado en la literatura; encontrando conteos celulares levemente inferiores y menor pleomorfismo celular.
Abstract: Objective: To describe the corneal endothelial cell density and morphology in Colombian patients older than 50 years in pre-cataract surgery evaluation in an ocular health institution in Bogotá, Colombia and compare it with similar studies developed in other countries. Method: observational and descriptive cross-sectional study. Ophthalmological clinical examination in a slit lamp and specular microscopy to 205 eyes in a pre-surgical study of senile cataract of volunteers over 50 years of age, with no history of ocular pathology were analyzed. Mean data of cell density (MCD), mean cell area (CA), coefficient of variation (VC%) and hexagonality (H%) were obtained. A bibliographic review of similar studies was carried out under the search criteria of specular microscopy and healthy population. Results: The mean age was 73.7 years; between 50 and 91 years old. Their MCD (SD), CA (SD), CV% (SD) and H% (SD) were 2338 (316) cél/mm2 , 436 (67) m², 33 (6.28) % and 66 (5) %, respectively. In Pearson test of age vs DC a weak correlation of -0.15 was observed (P 0.002). A statistically significant difference was found in: CV% (P 0.003) for the range of 80 to 89 years in the analysis by decades, and in the analysis of variance ANOVA of the average cell density compared to most countries evaluated, except India, Thailand and Brazil. Conclusion: The information obtained about the corneal endothelial behavior in Colombia was similar to that reported in the literature; finding slightly lower cell counts and lower cellular pleomorphism.
Abstract: Objective: To describe the corneal endothelial cell density and morphology in Colombian patients older than 50 years in pre-cataract surgery evaluation in an ocular health institution in Bogotá, Colombia and compare it with similar studies developed in other countries. Method: observational and descriptive cross-sectional study. Ophthalmological clinical examination in a slit lamp and specular microscopy to 205 eyes in a pre-surgical study of senile cataract of volunteers over 50 years of age, with no history of ocular pathology were analyzed. Mean data of cell density (MCD), mean cell area (CA), coefficient of variation (VC%) and hexagonality (H%) were obtained. A bibliographic review of similar studies was carried out under the search criteria of specular microscopy and healthy population. Results: The mean age was 73.7 years; between 50 and 91 years old. Their MCD (SD), CA (SD), CV% (SD) and H% (SD) were 2338 (316) cél/mm2 , 436 (67) m², 33 (6.28) % and 66 (5) %, respectively. In Pearson test of age vs DC a weak correlation of -0.15 was observed (P 0.002). A statistically significant difference was found in: CV% (P 0.003) for the range of 80 to 89 years in the analysis by decades, and in the analysis of variance ANOVA of the average cell density compared to most countries evaluated, except India, Thailand and Brazil. Conclusion: The information obtained about the corneal endothelial behavior in Colombia was similar to that reported in the literature; finding slightly lower cell counts and lower cellular pleomorphism.