Una descripción matemática del recambio evolutivo de los ARNt en el género Drosophila
Autores
Romero Marroquín, Liliana Constanza
Director
Bermúdez Santana, Clara Isabel
Díaz Morales, Hernando
Tipo de contenido
Trabajo de grado - Maestría
Idioma del documento
EspañolFecha de publicación
2014
Título de la revista
ISSN de la revista
Título del volumen
Documentos PDF
Resumen
En este trabajo se consideran los genomas secuenciados de 12 especies del género Drosophila. A cada genoma le es asociado un vector de 22 componentes; 21 de éstas corresponden al número de genes ARNt funcionales, clasificados según el aminoácido que su molécula transcrita es capaz de transportar, la componente restante corresponde al número de pseudogenes ARNt. Considerando los criterios de conservación en sintenia y similitud entre cadenas, la cual es estudiada usando la distancia de Hamming, se establece que cada pareja de vectores está relacionada mediante una transformación afín. Las entradas de las matrices de dichas transformaciones afines representan las tasas de ganancia de genes o pseudogenes ARNt entre los genomas. Adicionalmente, se estudia la correlación entre la distancia de mutación genómica de dos especies y las tasas encontradas (Texto tomado de la fuente).
In this document, we consider the sequenced genomes of 12 species in the genus Drosophila. Each genome is associated with a vector. These vectors have 22 components; 21 of them correspond to the number of functional tRNA genes classified according to the unique type of amino acid that is carried by their transcribed molecules, the remaining component correspond to the number of tRNA pseudogenes. Taking into account the syntenic conservation criteria and the similarity between strings, that has been studied using the Hamming distance, we stablish that each pair of vectors is related by an affine transformation. The matrices entries of those affine transformations represent rates of tRNA gene or pseudogene gain between a pair of genomes. Furthermore, we study the correlation between the genome mutation distances and the obtained rates.
In this document, we consider the sequenced genomes of 12 species in the genus Drosophila. Each genome is associated with a vector. These vectors have 22 components; 21 of them correspond to the number of functional tRNA genes classified according to the unique type of amino acid that is carried by their transcribed molecules, the remaining component correspond to the number of tRNA pseudogenes. Taking into account the syntenic conservation criteria and the similarity between strings, that has been studied using the Hamming distance, we stablish that each pair of vectors is related by an affine transformation. The matrices entries of those affine transformations represent rates of tRNA gene or pseudogene gain between a pair of genomes. Furthermore, we study the correlation between the genome mutation distances and the obtained rates.