Diseño de un sistema bioadhesivo de clorhexidina empleando pullulan como matriz para uso en mucosa oral
Cargando...
Archivos
Autores
Castro Ruíz, Jean Mario
Director
Tipo de contenido
Document language:
Español
Fecha
Título de la revista
ISSN de la revista
Título del volumen
Documentos PDF
Resumen
Se desarrollaron sistemas poliméricos bioadhesivos del tipo película polimérica y comprimido usando el biopolímero pullulan, como alternativa terapéutica en el transporte de sustancias activas para el tratamiento de la gingivitis y de la enfermedad periodontal. Se realizaron estudios de caracterización in vitro y de mucoadhesión de las formulaciones propuestas. Como fármaco modelo se utilizó digluconato de clorhexidina. En la presente investigación se evaluó la capacidad del polímero pullulan para formar películas y tabletas. A estos sistemas poliméricos se les determinaron propiedades mecánicas, propiedades de transporte, actividad antiséptica, caracterización de las microestructuras obtenidas y se comprobó la liberación del fármaco desde los sistemas estudiados.
Abstract. Bioadhesive polymeric systems type polymeric film and tablet were developed using pullulan biopolymer, as a therapeutic alternative in the transport of active substances in treatment of gingivitis and periodontal disease. Proposal formulations were described by in vitro characterization and mucoadhesion studies. Chlorhexidine digluconate was used as a drug model. In the present research, the ability of pullulan polymer to form films and tablets was evaluated. Mechanical and transport properties, as well as antiseptic activity and microstructures characteristics were determined for these polymeric systems; drug release behavior in the studied systems was also verified.
Abstract. Bioadhesive polymeric systems type polymeric film and tablet were developed using pullulan biopolymer, as a therapeutic alternative in the transport of active substances in treatment of gingivitis and periodontal disease. Proposal formulations were described by in vitro characterization and mucoadhesion studies. Chlorhexidine digluconate was used as a drug model. In the present research, the ability of pullulan polymer to form films and tablets was evaluated. Mechanical and transport properties, as well as antiseptic activity and microstructures characteristics were determined for these polymeric systems; drug release behavior in the studied systems was also verified.