Se continuó con el proyecto de trabajo de grado “ENSAYO PATOGENÉSICO SOBRE LOS CÁLICES de Physalis peruviana L.” (Rivera, D., 2009) y en el presente estudio patogenésico homeopático se investigan los probables efectos de sustancias, diluidas y agitadas en forma seriada, preparadas de acuerdo al método homeopático, suministradas a voluntarios relativamente sanos. Se realizó la patogenesia de Physalis peruviana L. 30 CH (Uchuba) mediante un ensayo clínico doble ciego. Participaron cinco mujeres y siete hombres, conformaron dos grupos al azar: control y experimento. La toma del medicamento se suspendió cuando apareció un síntoma y se mantuvo la observación a los experimentadores durante 30 días después de la aparición del primer síntoma. Todos los participantes del grupo experimento presentaron síntomas y cinco participantes del grupo placebo. Las cefaleas, alteraciones del sueño y síntomas digestivos fueron los síntomas más frecuentemente presentados en el grupo experimento. Se observaron diferencias clínicas entre ambos grupos a pesar de la no diferencia estadística en presencia de síntomas mentales, locales y totales. Se encontró asociación entre la toma del medicamento y la presencia de síntomas generales y totales. / Abstract. The degree Project “Pathogenetic Essay about the Calices of Physalis peruviana L” (Rivera, D., 2009) was continued. In this pathogenetic and homeopathic study the side effects of diluted and shaken substances are researched. They were prepared according to the homeopathic method. Those substances were given to patients who are healthy. The pathogenetic of the Physalis Peruviana L. 30 CH (Uchuba) was done throughout a double blind clinical test. Five women and seven men participated in this research, they made two random groups: Control and experiment. They stopped taking the medicine when a symptom appeared; and the observation of the experimenters was continued during thirty days after the first symptoms appeared. All the participants of the experimental group had symptoms and five participants of the placebo group too. The headaches, sleep alterations and digestive symptoms were the most frequent symptoms presented by the experimental group. Clinical differences were observed between the groups in spite of the no-difference in the statistical in the presence of total, local and mental symptoms. There was an association between the taking of the medicine and the general and total symptoms.