Passiflora ligularis Juss. (granadilla): estudios químicos y farmacológicos de una planta con potencial terapéutico

Vista sencilla de ítem
dc.contributor.authorOspina Giraldo, Luis Fernando
dc.contributor.authorCastellanos Hernández, Leonardo
dc.contributor.authorRamos Rodríguez, Freddy Alejandro
dc.contributor.authorModesti Costa, Geison
dc.contributor.authorMena Barreto Silva, Fátima Reina
dc.contributor.authorLópez Vallejo, Fabián
dc.contributor.authorMonzón Daza, Gabriel
dc.contributor.authorMeneses Macías, Carolina
dc.contributor.authorRey Padilla, Diana Patricia
dc.contributor.authorCardona Paredes, María Isabel
dc.contributor.authorEcheverry González, Sandra Milena
dc.contributor.authorSepúlveda, Paula Michelle
dc.contributor.authorGómez Devia, Laura
dc.contributor.editorAragón Novoa, Diana Marcela
dc.coverage.countryColombia
dc.date.accessioned2022-09-15T04:42:53Z
dc.date.available2022-09-15T04:42:53Z
dc.date.issued2021-08
dc.descriptionilustracionesspa
dc.description.abstractEl presente libro es fruto de la investigación interdis- ciplinaria entorno a las hojas de Passiflora ligularis (granadilla) con fines medicinales, entre los grupos de investigación Principios Bioactivos de Plantas Medicinales del Departamento de Farmacia de la Universidad Nacional de Colombia, Estudio y Aprovechamiento de Productos Naturales Marinos y Frutas de Colombia del Departamento de Química de la Universidad Nacional de Colombia y el Grupo de Investigación en Fitoquímica de la Pontificia Universidad Javeriana, con apoyo del Ministerio de Ciencia, Tecnología e Innovación de Colombia. A lo largo de estas páginas, se resumen algunos de los resultados y avances más destacados de estos grupos de investigación en cuanto a la caracterización química de las hojas de esta especie dando énfasis a los flavonoides y saponinas, al estudio in silico, in vitro e in vivo de su actividad farmacológica, principalmente como hipoglicemiante y antinflamatorio, al desarrollo de metodologías analíticas precisas, exactas y reproducibles que permitan la completa caracterización del extracto optimizado obtenido como un ingrediente activo promisorio para el desarrollo de productos fitoterapéuticos, etapa actualmente en progreso. Se pretende que esta publicación permita la divulgación técnica y científica de los resultados de varios años de estudio con el fin de dar valor agregado a los cultivos de Passiflora ligularis, una planta de gran interés comercial debido a sus frutos y cuyas hojas en la actualidad son simplemente un subproducto de su cosecha, desconociendo el potencial terapéutico de las mismas y la posibilidad de convertirse en un materia prima para la obtención de productos fitoterapéuticos estables, seguros y eficaces. (texto tomado de la fuente)spa
dc.description.editionPrimera ediciónspa
dc.description.tableofcontentsPresentación -- Capítulo 1. Estudio in silico y evaluación in vitro de la actividad inhibitoria de flavonoides y saponinas identificados en hojas de Passiflora ligularis Juss. sobre las enzimas α-amilasa y α-glucosidasa -- Capítulo 2. Evaluación de la actividad antiinflamatoria del extracto acuoso, la fracción butanólica y compuestos identificados en las hojas de Passiflora ligularis Juss. -- Capítulo 3. Efecto del extracto acuoso de hojas de Passiflora ligularis Juss. y de sus metabolitos mayoritarios sobre la homeostasis de glucosa -- Capítulo 4. Metodologías analíticas para el estudio y cuantificación de flavonoides en extractos de hojas de Passiflora ligularis Juss. -- Capítulo 5. Estandarización del extracto de hojas de Passiflora ligularis Juss. (granadilla)spa
dc.format.extent150 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.eisbn9789587946437spa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.isbn9789587946420spa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/82289
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombia. Facultad de Ciencias. Departamento de Farmaciaspa
dc.publisher.departmentSede Bogotáspa
dc.publisher.placeBogotáspa
dc.relation.referencesAbad-Zapatero C, Metz JT. Ligand efficiency indices as guideposts for drug discovery. Drug Discov Today. 2005; 10(7): 464-9.spa
dc.relation.referencesAgencia Europea de Medicamentos. Points to consider on the biopharma- ceutical characterisation of herbal medicinal products; 2003.spa
dc.relation.referencesAgyemang K, Han L, Liu E, Zhang Y, Wang T, Gao X. Recent advances in Astragalus membranaceus anti-diabetic research: Pharmacological effects of its phytochemical constituents. Evid Based Complement Altern Med. 2013; 2013: 654643.spa
dc.relation.referencesAhmed N. Advanced Glycation endproducts—role in pathology of diabetic complications. Diabetes Res Clin Pract. 2005; 67(1): 3-21.spa
dc.relation.referencesAjila CM, Brar SK, Verma M, Tyagi RD, Godbout S, Valéro JR. extraction and analysis of polyphenols: Recent Trends. Crit Rev Biotechnol. 2011; 31(3): 227-49.spa
dc.relation.referencesAlarcón-Aguilara FJ, Román-Ramos R, Pérez-Gutiérrez S, Aguilar-Contreras A, Contreras-Weber CC, Flores-Sáenz JL. Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethnopharmacol. 1998; 61(2): 101-10. 52. Cazarolli LH, Zanatta L, Alberton EH, Figueiredo MS, Folador P, Damazio RG et al. Flavonoids: Cellular and Molecular mechanism of action in glucose homeostasis. Mini Rev Med Chem. 2008; 8(10): 1032-8.spa
dc.relation.referencesÁlvarez-Diduk R, Ramírez-Silva MT, Galano A, Merkoçi A. Deprotonation mechanism and acidity constants in aqueous solution of flavonols: A combined experimental and theoretical study. J Phys Chem B. 2013; 117(41): 12347-59. 28. Musialik M, Kuzmicz R, Pawlowski TS, Litwinienko G. Acidity of hydroxyl groups: An overlooked influence on antiradical properties of flavonoids. J Org Chem. 2009; 74(7): 2699-709.spa
dc.relation.referencesAmerican Diabetes Association. Diagnosis and classification of autoimmune diabetes mellitus. Diabetes Care. 2014; 37 (Supplement 1): S81-S90.spa
dc.relation.referencesAndersen OM, Markham KR. Flavonoids: Chemistry, biochemistry and applications. Boca Raton: CRC Press, 2005.spa
dc.relation.referencesAnusooriya P, Malarvizhi D, Gopalakrishnan VK, Devaki K. Antioxidant and antidiabetic effect of aqueous fruit extract of Passiflora ligularis Juss. on streptozotocin induced diabetic rats. Int Sch Res Not. 2014; 2014: 1-10.spa
dc.relation.referencesAragón-Novoa D. Evaluación de la actividad antiinflamatoria de extractos acuosos de especies de Passiflora en el modelo de edema auricular inducido por TPA. En: Primer Congreso Internacional de Productos Fitofarmacéuticos; 2013 oct. 10-2; Centro de Convenciones Cafam, Bogotá.spa
dc.relation.referencesArkhammar P, Juntti-Berggren L, Larsson O, Welsh M, Nånberg E, Sjöholm A et al. Protein kinase C modulates the insulin secretory process by maintaining a proper function of the beta-cell voltage-activated Ca2+ channels. J Biol Chem. 1994; 269(4): 2743-9.spa
dc.relation.referencesAyinampudi SR, Domala R, Merugu R, Bathula S, Janaswamy MR. New icetexane diterpenes with intestinal α-glucosidase inhibitory and free-radical scavenging activity isolated from Premna tomentosa roots. Fitoterapia. 2012; 83: 88-92.spa
dc.relation.referencesBallard CR, Roberto M, Junior M. Health benefits of flavonoids. En: Segura-Campos M, editora. Bioactive compounds. Cambridge: Woodhead Publishing; 2018. pp. 185-201.spa
dc.relation.referencesBardy G, Virsolvy A, Quignard JF, Ravier MA, Bertrand G, Dalle S et al. Quercetin induces insulin secretion by direct activation of L-Type calcium channels in pancreatic beta cells. Br J Pharmacol. 2013; 169(5): 1102-13.spa
dc.relation.referencesBelfiore A, Malaguarnera R, Vella V, Lawrence MC, Sciacca L, Frasca F et al. Insulin receptor isoforms in physiology and disease: An updated view. Endocr Rev. 2017; 38(5): 379-431.spa
dc.relation.referencesBenincáa J, Montanhera A, Zucolotto S, Schenkel E, Fröde T. Evaluation of the anti-inflammatory efficacy of Passiflora edulis. Food Chem. 2007; 104(3): 1097-105.spa
dc.relation.referencesBerman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H et al. The Protein Data Bank. Nucleic Acids Res. 2000; 28: 235-42.spa
dc.relation.referencesCazarolli LH, Folador P, Moresco HH, Brighente IM, Pizzolatti MG, Silva FR. Mechanism of action of the stimulatory effect of apigenin-6-C-(2”-O-α- l-rhamnopyranosyl)-β-L-fucopyranoside on 14C-glucose uptake. Chem Biol Interact. 2009; 179(2-3): 407-12.spa
dc.relation.referencesCazarolli LH, Folador P, Pizzolatti MG, Silva FR. Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscle. Biochimie. 2009; 91(7): 843-9.spa
dc.relation.referencesCazarolli LH, Pereira DF, Kappel VD, Folador P, Figueiredo M dos S, Pizzolatti MG et al. Insulin signaling: A potential signaling pathway for the stimulatory effect of kaempferitrin on glucose uptake in skeletal muscle. Eur J Pharmacol. 2013; 712(1-3): 1-7.spa
dc.relation.referencesCazarolli LH, Zanatta L, Alberton EH, Figueiredo MS, Folador P, Dama- zio RG. Flavonoids: cellular and molecular mechanism of action in glucose homeostasis. Mini Rev Med Chem. 2008; 8(10): 1032-8. 11. Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop. Biomed. 2012; 2(4): 320-30.spa
dc.relation.referencesChemat F, Rombaut N, Sicaire AG, Meullemiestre A, Fabiano-Tixier AS, Abert-Vian M. Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A review. Ultrason Sonochem. 2017; 34: 540-60.spa
dc.relation.referencesChinchansure AA, Korwar AM, Kulkarni MJ, Joshi SP. recent development of plant products with anti-glycation activity: A review. R Soc Chem. 2015; 5: 31113-38.spa
dc.relation.referencesChoi J, Kang HJ, Kim SZ, Kwon TO, Jeong SI, Jang SI. Antioxidant effect of astragalin isolated from the leaves of Morus alba L. against free radical-induced oxidative hemolysis of human red blood cells. Arch Pharm Res. 2013; 36(7): 912-7.spa
dc.relation.referencesKe M, Hu XQ, Ouyang J, Dai B, Xu Y. The effect of astragalin on the VEGF production of cultured Müller cells under high glucose conditions. Biomed Mater Eng. 2012; 22(1-3): 113-9.spa
dc.relation.referencesCosta GM, Cárdenas PA, Gazola AC, Aragón-Novoa D, Castellanos-Her- nández L, Reginatto FH et al. Isolation of C-glycosylflavonoids with α-gluco- sidase inhibitory activity from Passiflora bogotensis Benth by gradient high-speed counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2015; 990: 104-10.spa
dc.relation.referencesCosta GM, Gazola AC, Zucolotto SM, Castellanos L, Ramos FA, Reginatto FH et al. Chemical profiles of traditional preparations of four South American Passiflora species by chromatographic and capillary electrophoretic techniques. Rev Bras Farmacogn. 2016; 26(4): 451-8.spa
dc.relation.referencesCuyckens F, Claeys M. Mass spectrometry in the structural analysis of flavonoids. J Mass Spectrom. 2004; 39(1): 1-15.spa
dc.relation.referencesDa Silva Morrone M, De Assis AM, Da Rocha RF, Gasparotto J, Gazola AC, Costa GM et al. Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models. Food Chem Toxicol. 2013; 60: 45-51.spa
dc.relation.referencesDe Young L, Kheifets J, Ballaron S, Young, J. Edema and cell inliltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents. Agents Actions. 1989; 26(3-4): 335-41.spa
dc.relation.referencesDerbré S, Gatto J, Pelleray A, Coulon L, Séraphin D, Richomme P. Auto- mating a 96-well microtiter plate assay for identification of AGEs inhibitors or inducers: Application to the screening of a small natural compounds library. Anal Bioanal Chem. 2010; 398(4): 1747-58.spa
dc.relation.referencesDerosa G, Maffioli P. α-Glucosidase inhibitors and their use in clinical practice. Arch Med Sci. 2012; 8: 899-906.spa
dc.relation.referencesDhawan K, Dhawan S, Sharma A. Passiflora: A review update. J Ethnophar- macol. 2004; 94(1): 1-23.spa
dc.relation.referencesDíaz-Casasola L, Luna-Pichardo D. Productos finales de glicación avanzada en la enfermedad cardiovascular como complicación de la diabetes. Med e Investig. 2016; 4(1): 52-7.spa
dc.relation.referencesDu Y, Wei T. Inputs and outputs of insulin receptor. Protein Cell. 2014; 5(3): 203-13.spa
dc.relation.referencesEmara S, Mohamed KM, Masujima T, Yamasaki K. Separation of naturally occurring triterpenoidal saponins by capillary zone electrophoresis. Biomed Chromatogr. 2001; 15(4): 252-6.spa
dc.relation.referencesEvans F, Taylor S. (1983). Pro-inflammatory, tumour-promoting and anti-tumour diterpenes of the plant families Euphorbiaceae and Thymelaeaceae. Fortschr Chem Org Naturst. 1983; 44: 1-99.spa
dc.relation.referencesFitzgerald M, Heinrich M, Booker A. Medicinal plant analysis: A historical and regional discussion of emergent complex techniques. Front Pharmacol. 2020; 10: 1480.spa
dc.relation.referencesFrederico MJS, Castro AJG, Pinto VAM, Ramos CDF, Monteiro FBF, Mascarello A et al. Mechanism of action of camphoryl-benzene sulfonamide derivative on glucose uptake in adipose tissue. J Cell Biochem. 2018; 119(6): 4408-19.spa
dc.relation.referencesGhorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017; 96: 305-31spa
dc.relation.referencesGil-Chávez G, Villa JA, Ayala-Zavala JF, Basilio-Heredia J, Sepulveda D, Yahia EM et al. Technologies for extraction and production of bioactive compounds to be used as nutraceuticals and food ingredients: An overview. Compr Rev Food Sci Food Saf. 2013; 12 (1): 5-23.spa
dc.relation.referencesGilles C, Astier J-P, Marchis-Mouren G, Cambillau C, Payan F. Crystal structure of pig pancreatic a-amylase isoenzyme II, in complex with the car- bohydrate inhibitor acarbose. Eur J Biochem. 1996; 238: 561-9.spa
dc.relation.referencesGiner-Larza E, Máñez S, Giner-Pons R, Recio C, Ríos J. On the anti-inflam- matory and anti-phospholipase A(2) activity of extracts from lanostane-rich species. J Ethnopharmacology. 2000; 73: 61-9.spa
dc.relation.referencesGloster TM, Davies GJ. Glycosidase inhibition: Assessing mimicry of the transition state. Org Biomol Chem. 2010; 8: 305-20.spa
dc.relation.referencesGomes Castro AJ, Cazarolli LH, Bretanha LC, Sulis PM, Rey Padilla DP, Aragón Novoa DM. The potent insulin secretagogue effect of betulinic acid is mediated by potassium and chloride channels. Arch Biochem Biophys. 2018; 648: 20-6.spa
dc.relation.referencesGómez H, González K, Medina J. Actividad antiinflamatoria de productos naturales. Bol Latinoam Caribe Plantas Med Aromat. 2011; 10(3): 182-217. 9. Carvajal-de Pabón L, Turbay S, Álvarez L, Rodríguez A, Alvarez J, Bonilla K et al. Relación entre los usos populares de la granadilla (Passiflora ligularis Juss.) y su composición fitoquímica. Biotecnol Sector Agropecuario Agroind. 2014; 12(2): 185-96.spa
dc.relation.referencesGraham N, Jiang CC, Li XZ, Jiang JQ, Ma J. The influence of pH on the degradation of phenol and chlorophenols by potassium ferrate. Chemosphere. 2004; 56(10): 949-56.spa
dc.relation.referencesGupta RK, Kumar D, Chaudhary AK, Maithani M, Singh R. Antidiabetic activity of Passiflora incarnata Linn. in streptozotocin-induced diabetes in mice. J Ethnopharmacol. 2012; 139(3): 801-6.spa
dc.relation.referencesHagenacker T, Hillebrand I, Büsselberg D, Schäfers M. Myricetin reduces voltage activated potassium channel currents in DRG neurons by a P38 depen- dent mechanism. Brain Res Bull. 2010; 83(5): 292-6.spa
dc.relation.referencesHansawasdi C, Kawabata J, Kasai T. Alpha-amylase inhibitors from roselle (Hibiscus sabdariffa Linn.) tea. Biosci Biotechnol Biochem. 2000; 64: 1041-3. 16. Rey DP, Ospina LF, Aragón-Novoa D. Inhibitory effects of an extract of fruits of Physalis peruviana on some intestinal carbohydrases. Rev Colomb Cienc Quím Farm. 2015; 44: 72-89.spa
dc.relation.referencesHong HC, Li SL, Zhang XQ, Ye WC, Zhang QW. Flavonoids with α-gluco- sidase inhibitory activities and their contents in the leaves of Morus atropurpurea. Chin Med. 2013; 8(1): 19.spa
dc.relation.referencesHuang W, Xue A, Niu H, Jia Z, Wang J. Optimised ultrasonic-assisted extraction of flavonoids from folium eucommiae and evaluation of antioxidant activity in multi-test systems in vitro. Food Chem. 2009; 114(3): 1147-54.spa
dc.relation.referencesHughes E, Lee AK, Tse A. Dominant role of sarcoendoplasmic reticulum Ca2+-ATPase pump in Ca2+ homeostasis and exocytosis in rat pancreatic β-cells. Endocrinology. 2006; 147(3): 1396-407.spa
dc.relation.referencesHussain T, Tan B, Murtaza G, Liu G, Rahu N, Saleem Kalhoro M et al. Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy. Pharmacol Res. 2020; 152: 104629.spa
dc.relation.referencesICH. International Conference on Harmonization. Stability testing of new drug substances and products. 2003. pp 1-20.spa
dc.relation.referencesICH. Validation of analytical procedures: Text and methodology Q2(R1). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, Ginebra. 2005.spa
dc.relation.referencesJayachandran M, Zhang T, Ganesan K, Xu B, Chung SSM. Isoquercetin ameliorates hyperglycemia and regulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2018; 829: 112-20.spa
dc.relation.referencesJiang TF, Li Y, Shi YP. Determination of six major flavonoid glycosides in Saussurea mongolica by capillary electrophoresis. Planta Med. 2004; 70(3): 284-7. 21. Johnson RT, Lunte CE. A capillary electrophoresis electrospray ioniza- tion-mass spectrometry method using a borate background electrolyte for the fingerprinting analysis of flavonoids in Ginkgo biloba herbal supplements. Anal Methods. 2016; 16(8): 3325-32.spa
dc.relation.referencesJin Y, Zhang W, Meng Q, Li D, Garg S, Teng L et al. forced degradation of flavonol glycosides extraced from Ginkgo biloba. Chem Res Chinese Univ. 2013; 29(4): 667-70.spa
dc.relation.referencesKang J-H, Sung M-K, Kawada T, Yoo H, Kim Y-K, Kim J-S et al. Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages. Cancer Lett. 2005; 230(2): 219-27.spa
dc.relation.referencesKappel VD, Frederico MJS, Postal BG, Mendes CP, Cazarolli LH, Silva FR. The role of calcium in intracellular pathways of rutin in rat pancreatic islets: Potential insulin secretagogue effect. Eur J Pharmacol. 2013; 702(1-3): 264-8. 23. Fang P, Yu M, Min W, Wan D, Han S, Shan Y et al. Effect of baicalin on GLUT4 expression and glucose uptake in myotubes of rats. Life Sci. 2018; 196: 156-61.spa
dc.relation.referencesKappel VD, Pereira DF, Cazarolli LH, Guesser SM, da Silva CH, Schenkel EP. Short and long-term effects of Baccharis articulata on glucose homeostasis. Molecules. 2012; 17(6): 6754-68.spa
dc.relation.referencesKappel VD, Zanatta L, Postal BG, Silva FR. Rutin potentiates calcium uptake via voltage-dependent calcium channel associated with stimulation of glucose uptake in skeletal muscle. Arch Biochem Biophys. 2013; 532(2): 55-60.spa
dc.relation.referencesKim MS, Kim SH. Inhibitory effect of astragalin on expression of lipopoly- saccharide-induced inflammatory mediators through NF- κB in macrophages. Arch Pharm Res. 2011; 34(12): 2101-7.spa
dc.relation.referencesKittl M, Beyreis M, Tumurkhuu M, Fürst J, Helm K, Pitschmann A et al. Quercetin stimulates insulin secretion and reduces the viability of rat INS-1 beta-cells. Cell Physiol Biochem. 2016; 39(1): 278-93.spa
dc.relation.referencesKleywegt GJ, Jones TA. Model building and refinement practice. Methods Enzymol. 1997; 277: 208-30.spa
dc.relation.referencesKumar Pasupulati A, Chitra PS, Reddy GB. Advanced glycation end pro- ducts mediated cellular and molecular events in the pathology of diabetic nephropathy. Biomol Concepts 2016; 7(5-6): 293-309.spa
dc.relation.referencesLapornik B, Prosek M, Golc A. Comparison of extracts prepared from plant by-products using different solvents and extraction time. J Food Eng. 2005; 71: 214-22.spa
dc.relation.referencesLavilla I, Bendicho C. Fundamentals of ultrasound-assisted extraction. En: Domínguez H, González M, editoras. Water extraction of bioactive compounds: From plants to drug development. Elsevier; 2017. pp. 291-316.spa
dc.relation.referencesLee MH, Lin CC. Comparison of techniques for extraction of isoflavones from the root of Radix Puerariae: Ultrasonic and pressurized solvent extractions. Food Chem. 2007; 105(1): 223-8.spa
dc.relation.referencesLehoczki G, Kandra L, Gyémánt G. The use of starch azure for measure- ment of alpha-amylase activity. Carbohydr Polym. 2018; 183: 263-6.spa
dc.relation.referencesLin G, Li R. Chapter 10 - Natural products targeting inflammation processes and multiple mediators. En: Mandal SC, Mandal V, Konishi T. Natural products and drug discovery: An integrated approach. Ámsterdam: Elsevier, 2018. pp. 277-308.spa
dc.relation.referencesLiu Y, Chen HB, Zhao YY, Wang B, Zhang QY, Zhang L et al. Quantification and stability studies on the flavonoids of Radix hedysari. J Agric Food Chem. 2006; 54(18): 6634-9.spa
dc.relation.referencesLlanos P, Contreras-Ferrat A, Georgiev T, Osorio-Fuentealba C, Espinosa A, Hidalgo J et al. The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice. Am J Physiol Endocrinol Metab. 2015; 308(4): E294-E305. 19. Sweeney G, Somwar R, Ramlal T, Volchuk A, Ueyama A, Klip A. An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes. J Biol Chem. 1999; 274(15): 10071-8.spa
dc.relation.referencesManrique K. Caracterización de flavonoides C-glicosidados en el extracto acuoso de hojas de Passiflora ligularis (granadilla) [tesis de pregrado]. [Bogotá] Universidad Nacional de Colombia; 2012.spa
dc.relation.referencesMarchart E, Krenn L, Kopp B. Quantification of the flavonoid glycosides in Passiflora incarnata by capillary electrophoresis. Planta Med. 2003; 69(5): 452-6. 23. Wu T, Guan Y, Ye J. Determination of flavonoids and ascorbic acid in grapefruit peel and juice by capillary electrophoresis with electrochemical detection. Food Chem. 2007; 100(4): 1573-9.spa
dc.relation.referencesMatsuda H, Wang T, Managi H, Yoshikawa M. Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities. Bioorganic Med Chem. 2003; 11(24): 5317-23.spa
dc.relation.referencesMcGhie TK, Markham KR. Separation of flavonols by capillary electro- phoresis: The effect of structure on electrophoretic mobility. Phytochem Anal. 1994; 5(3): 121-6.spa
dc.relation.referencesMd Yusof AH, Abd Gani SS, Zaidan UH, Halmi MIE, Zainudin BH. Optimization of an ultrasound-assisted extraction condition for flavonoid compounds from Cocoa shells (Theobroma cacao) using response surface metho- dology. Molecules. 2019; 24(4): 1-16.spa
dc.relation.referencesMedina-Franco JL. Advances in computational approaches for drug discovery based on natural products. Rev Latinoam Quim. 2013; 41: 95-110.spa
dc.relation.referencesMendes CP, Postal BG, Oliveira GTC, Castro AJG, Frederico MJS, Moraes ALL et al. Insulin stimulus-secretion coupling is triggered by a novel thiazo- lidinedione/sulfonylurea hybrid in rat pancreatic islets. J Cell Physiol. 2018; 234(1): 509-20.spa
dc.relation.referencesMeneses-Macías C. Saponinas y flavonoides de Passiflora ligularis y evalua- ción de su actividad antiinflamatoria [tesis de maestría]. [Bogotá] Universidad Nacional de Colombia; 2016. 122 p.spa
dc.relation.referencesMeneses-Macías C. Saponinas y flavonoides de Passiflora ligularis y evalua- ción de su actividad antiinflamatoria [tesis de maestría]. [Bogotá] Universidad Nacional de Colombia; 2016. 122 p.spa
dc.relation.referencesMiddleton E, Kandaswami C, Theoharides TC. The effects of plant flavo- noids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000, 52(4): 673-751.spa
dc.relation.referencesMohan S, Nandhakumar L. Role of various flavonoids: Hypotheses on novel approach to treat diabetes. J Med Hypotheses Ideas. 2014; 8(1): 1-6.spa
dc.relation.referencesMontanher A, Zucolotto S, Schenkel E, Fröde T. Evidence of anti-inflam- matory effects of Passiflora edulis in an inflammation model. J Ethnopharmacol. 2007; 109(2): 281-8.spa
dc.relation.referencesMonzón-Daza G, Meneses-Macías C, Forero AM, Rodríguez J, Aragón-Novoa M, Jiménez C et al. Identification of α-amylase and α-glucosidase inhibitors and ligularoside A, a new triterpenoid saponin from Passiflora ligularis Juss. (Sweet Granadilla) leaves, by a nuclear magnetic resonance-based metabolomic study. J Agric Food Chem. 2021; 69(9), 2919-31.spa
dc.relation.referencesMoreno A. Estudios químicos de saponinas presentes en el extracto acuoso de las hojas de Passiflora ligularis (granadilla) [tesis de pregrado]. [Bogotá] Uni- versidad Nacional de Colombia; 2013.spa
dc.relation.referencesMorris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem. 2009; 30: 2785-91.spa
dc.relation.referencesNicolle E, Souard F, Faure P, Boumendjel A. Flavonoids as promising lead compounds in type 2 diabetes mellitus: Molecules of interest and structure activity relationship. Curr Med Chem. 2011; 18(17): 2661-72.spa
dc.relation.referencesOcampo J, Arias JC. Colecta e identificación de genotipos élite de granadilla (Passiflora ligularis Juss.) en Colombia. Rev Colomb Cien Hortíc. 2015; 9(1): 9-23. 5. Lopez G. Estudio fitoquímico y evaluación de la actividad biológica de algunas especies de Passiflora [tesis de maestría]. [Bogotá] Universidad Nacional de Colombia; 2011.spa
dc.relation.referencesOcampo-Pérez J, Coppens-d’Eeckenbrugge G, Restrepo M, Jarvis A, Salazar M, Caetano C. Diversity of Colombian Passifloraceae: Biogeography and an updated list for conservation. Biota Colomb. 2007; 8: 1-45.spa
dc.relation.referencesOng ES. Extraction methods and chemical standardization of botanicals and herbal preparations. J Chromatogr B Anal Technol Biomed Life Sci. 2004; 812: 23-33.spa
dc.relation.referencesOrganización Mundial de la Salud. Estrategia de la OMS sobre medicina tradicional 2014-2023. Ginebra: Organización Mundial de la Salud; 2013. pp 1-72. 3. Leong F, Hua X, Wang M, Chen T, Song Y, Tu P et al. Quality standard of traditional Chinese medicines: Comparison between European Pharmacopoeia and Chinese Pharmacopoeia and recent advances. Chin Med. 2020; 15: 76. 4. Singla R, Jaitak V. Recent advances in plant metabolites analysis, isolation, and characterization. En: Yadav SK, Kumar V, Singh SP, editores. Recent trends and techniques in plant metabolic engineering. Singapur: Springer Nature Singapore; 2018. pp. 75-115.spa
dc.relation.referencesOrganización Mundial de la Salud. Guidelines for the assessment of herbal medicines. Ginebra: Organización Mundial de la Salud; 1996.spa
dc.relation.referencesOrganización Mundial de la Salud. Quality assurance of pharmaceuticals: A compendium of guidelines and related materials. Vol. 2. Good manufacturing practices and inspection. Ginebra: Organización Mundial de la Salud; 1996. 5. Sharapin N. Fundamentos de tecnología de productos fitoterapéuticos. Bogotá: Convenio Andrés Bello; 2000.spa
dc.relation.referencesOrganización Mundial de la Salud. Quality control methods for herbal materials. Ginebra: Organización Mundial de la Salud; 2011.spa
dc.relation.referencesOrganización Mundial de la Salud. WHO Expert Committee on Specifications for Pharmaceutical Preparations. Ginebra: Organización Mundial de la Salud; 2018. Annex 1: Guidelines on Good Herbal Processing Practices for Herbal Medicines; pp. 81-152.spa
dc.relation.referencesOspina LF, Olarte J, Calle J, Pinzón R. Comprobacion de la actividad hipo- glicemiante y captadora de radicales libres oxigenados de los principios activos de Curatella americana L. Rev Colomb Cienc Quím Farm. 1995; 24(1): 6-11.spa
dc.relation.referencesPaini M, Casazza AA, Aliakbarian B, Perego P, Binello A, Cravotto G. Influence of ethanol/water ratio in ultrasound and high-pressure/high-tem- perature phenolic compound extraction from agri-food waste. Int J Food Sci Technol. 2016; 51(2): 349-58.spa
dc.relation.referencesPark JE, Park JY, Seo Y, Han JS. A new chromanone isolated from Portulaca oleracea L. increases glucose uptake by stimulating GLUT4 translocation to the plasma membrane in 3T3-L1 adipocytes. Int J Biol Macromol. 2019; 123: 26-34. 25. Riaz A, Rasul A, Hussain G, Zahoor MK, Jabeen F, Subhani Z et al. Astra- galin: A bioactive phytochemical with potential therapeutic activities. Adv Pharmacol Sci. 2018; 2018: 9794625.spa
dc.relation.referencesPeng S, Zou L, Zhou W, Liu W, Liu C, McClements D. J. Encapsulation of lipophilic polyphenols into nanoliposomes using pH-driven method: Advantages and disadvantages. J Agric Food Chem. 2019; 67(26): 7506-11.spa
dc.relation.referencesPereira MG, Hamerski F, Andrade EF, Scheer Ade P, Corazza ML. Assess- ment of subcritical propane, ultrasound-assisted and soxhlet extraction of oil from Sweet Passion Fruit (Passiflora alata Curtis) seeds. J Supercrit Fluids. 2017; 128: 338-48.spa
dc.relation.referencesPlaza M, Pozzo T, Liu J, Gulshan KZ, Turner C, Karlsson EN. substituent effects on in vitro antioxidizing properties, stability, and solubility in flavonoids. J Agric Food Chem. 2014; 62: 3321-33.spa
dc.relation.referencesProença C, Freitas M, Ribeiro D, Oliveira EFT, Sousa JLC, Tomé SM et al. α-Glucosidase inhibition by flavonoids: An in vitro and in silico structure-activity relationship study. J Enzyme Inhib Med Chem. 2017; 32(1): 1216-28.spa
dc.relation.referencesQian M, Haser R, Buisson G, Duée E, Payan F. The active center of a mammalian alpha-amylase: Structure of the complex of a pancreatic alpha- amylase with a carbohydrate inhibitor refined to 2.2-A resolution. Biochemistry. 1994; 33(20): 6284-94.spa
dc.relation.referencesQian M, Nahoum V, Bonicel J, Bischoff H, Henrissat B, Payan F. Enzy- me-catalyzed condensation reaction in a mammalian α-amylase: High-resolution structural analysis of an enzyme-inhibitor complex. Biochemistry. 2001; 40: 7700-9.spa
dc.relation.referencesQian M, Spinelli S, Driguez H, Payan F. Structure of a pancreatic alpha- amylase bound to a substrate analogue at 2.03 A resolution. Protein Sci. 1997; 6(11): 2285-96.spa
dc.relation.referencesRen L, Qin X, Cao X, Wang L, Bai F, Bai G et al. Structural insight into substrate specificity of human intestinal maltase-glucoamylase. Protein Cell. 2011; 2(10): 827-36.spa
dc.relation.referencesRey D, Fernandes TA, Sulis PM, Gonçalves R, Sepúlveda M, Frederico MJ et al. Cellular target of isoquercetin from Passiflora ligularis Juss. for glucose uptake in rat soleus muscle. Chem Biol Interact. 2020; 330: 109198.spa
dc.relation.referencesRey D, Miranda Sulis P, Alves Fernandes T, Gonçalves R, Silva Frederico MJ, Costa GM. Astragalin augments Basal calcium influx and insulin secretion in rat pancreatic islets. Cell Calcium. 2019; 80: 56-62.spa
dc.relation.referencesRey D, Sulis P, Fernandes T, Gonçalves R, Frederico MJ, Costa GM. Astra- galin augments basal calcium influx and insulin secretion in rat pancreatic islets. Cell Calcium. 2019; 80: 56-62.spa
dc.relation.referencesRorsman P, Braun M, Zhang Q. Regulation of calcium in pancreatic α- and β-cells in health and disease. Cell Calcium. 2012; 51(3-4): 300-8.spa
dc.relation.referencesRotta EM, Rodrigues CA, Jardim IC, Maldaner L, Visentainer JV. Determi- nation of phenolic compounds and antioxidant activity in passion fruit pulp (Passiflora spp.) using a modified QuEChERS method and UHPLC-MS/MS. LWT. 2019, 100: 397-403.spa
dc.relation.referencesRudnicki M, de Oliveira MR, Veiga Pereira T da; Reginatto FH, Dal-Pizzol F, Fonseca Moreira JC. Antioxidant and antiglycation properties of Passiflora alata and Passiflora edulis extracts. Food Chem. 2007; 100(2): 719-24.spa
dc.relation.referencesRuggiero-Lopez D, Lecomte M, Moinet G, Patereau G, Lagarde M, Wier- nsperger N. Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of advanced glycation end product formation. Biochem Pharmacol. 1999; 58(11): 1765-73.spa
dc.relation.referencesSaad AH, Bushra HM. Flavonoids as alternatives in treatment of type 2 diabetes mellitus. Acad J Med Plants. 2013; 1(2): 31-36.spa
dc.relation.referencesSadowska-Bartosz I, Galiniak S, Bartosz G. Kinetics of glycoxidation of bovine serum albumin by glucose, fructose and ribose and its prevention by food components. Molecules. 2014; 19(11): 18828-49.spa
dc.relation.referencesSaeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019; 157: 107843.spa
dc.relation.referencesSafdar MN, Kausar T, Nadeem M. Comparison of ultrasound and mace- ration techniques for the extraction of polyphenols from the Mango peel. J Food Process Preserv. 2017; 41(4).spa
dc.relation.referencesSahoo N, Manchikanti P, Dey S. Herbal drugs: Standards and regulation. Fitoterapia. 2010; 81(6): 462-71.spa
dc.relation.referencesSantangelo C, Vari R, Scazzocchio B, Di Benedetto R, Filesi C, Masella R. Polyphenols, intracellular signalling and inflammation. Ann Ist Super Sanita. 2011; 43(4): 394-405.spa
dc.relation.referencesSato N, Li W, Tsubaki M, Higai K, Takemoto M, Sasaki T et al. Flavonoid Glycosides from Japanese Camellia Oil Cakes and Their Inhibitory Activity against Advanced Glycation End-Products Formation. J. Funct. Foods 2017, 35, 159-165.spa
dc.relation.referencesSchrödinger Release 2018-4. Maestro, Schrödinger. Nueva York, EE. UU. 2018.spa
dc.relation.referencesSchuit FC, Huypens P, Heimberg H, Pipeleers DG. Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes. 2001; 50(1): 1-11.spa
dc.relation.referencesSchuur B, de Haan AB, Kaspereit M, Leeman M. Chiral separations. En: Moo-Young M, editor. Comprehensive biotechnology. 2.a ed. Burlington: Elsevier-Academic Press; 2018. Vol. 2, pp. 737-51.spa
dc.relation.referencesSepúlveda P, Costa GM, Aragón-Novoa D, Ramos F, Castellanos L. Analysis of vitexin in aqueous extracts and commercial products of Andean Passiflora species by UHPLC-DAD. J Appl Pharm Sci. 2018; 8(9): 081-6.spa
dc.relation.referencesSepúlveda P, Echeverrry S, Costa G, Aragón-Novoa M. Passiflora ligularis leaf ultrasound-assisted extraction in the optimization of flavonoid content and enhancement of hypoglycemic activity. J Appl Pharm Sci. 2020; 10(8): 86-94. 10. Costa GM, Gazola AC, Madóglio FA, Zucolotto SM, Reginatto FH, Castellanos L et al. Vitexin derivatives as chemical markers in the differentiation of the closely related species Passiflora alata Curtis and Passiflora quadrangularis Linn. J Liq Chromatogr Relat Technol. 2013; 36: 1697-707.spa
dc.relation.referencesSéro L, Sanguinet L, Blanchard P, Dang BT, Morel S, Richomme P et al. Tuning a 96-well microtiter plate fluorescence-based assay to identify AGE inhibitors in crude plant extracts. Molecules. 2013; 18: 14320-39.spa
dc.relation.referencesSim L, Quezada-Calvillo R, Sterchi EE, Nichols BL, Rose DR. Human intestinal maltase-glucoamylase: Crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity. J Mol Biol. 2008; 375: 782-92.spa
dc.relation.referencesSingh S, Bakshi M. Guidance on Conduct of Stress Tests to Determine Inherent Stability of Drugs. Pharm Technol 2000, 1-14.spa
dc.relation.referencesSingh VP, Bali A, Singh N, Jaggi AS. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol. 2014; 18(1): 1-14.spa
dc.relation.referencesSoares L, Farias M. Qualidade de insumos farmacêuticos ativos de origem natural. En: Simões CM et al. Farmacognosia: Do producto natural ao medi- camento. Porto Alegre: Artmed; 2017. pp 83-128.spa
dc.relation.referencesSudasinghe HP, Peiris DC. Hypoglycemic and hypolipidemic activity of aqueous leaf extract of Passiflora suberosa L. Peer J. 2018; 6(2): e4389.spa
dc.relation.referencesSuntornsuk L. Capillary electrophoresis for pharmaceutical analysis: A survey on recent applications. J Chromatogr Sci. 2007; 45(9): 559-77.spa
dc.relation.referencesSuntornsuk L. Capillary electrophoresis of phytochemical substances. J Pharm Biomed Anal. 2002; 27(5): 679-98.spa
dc.relation.referencesTadera KT, Minami YM, Takamatsu KT, Matsuoka TM. Inhibition of α-glu- cosidase and α-amylase by flavonoids. Nutr Sci Vitaminol. 2006; 52: 149-53. 5. Dhawan K, Dhawan S, Sharma A. Passiflora: A review update. J Ethnophar- macol. 2004; 94: 1-23.spa
dc.relation.referencesToma M, Vinatoru M, Mason TJ. Ultrasonically assisted extraction of bioactive principles from plants and their constituents. En: Mason TJ, editor. Advances in Sonochemistry. Londres: JAI Press; 1999. Vol. 5, pp. 209-47. 20. Mason TJ, Riera E, Vercet A, Lopez-Buesa P. Application of ultrasound. En: Sun DW, editor. Emerging technologies for food processing: An overview. Londres: Elsevier; 2005. pp. 323-51.spa
dc.relation.referencesTomaz I, Maslov L, Stupic D, Preiner D, Ašperger D, Karoglan Kontic J. Multi-response optimisation of ultrasound-assisted extraction for recovery of flavonoids from red grape skins using response surface methodology. Phytochem Anal. 2016; 27(1): 13-22.spa
dc.relation.referencesTremblay F, Dubois M-J. Marette A. Regulation of GLUT4 traffic and function by insulin and contraction in skeletal muscle. Front Biosci, 2003; 8(12): 1072-84.spa
dc.relation.referencesTrott O, Olson A. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading. J Comput Chem. 2010; 31: 455-61.spa
dc.relation.referencesTsimogiannis D, Samiotaki M, Panayotou G, Oreopoulou V. Characteri- zation of flavonoid subgroups and hydroxy substitution by HPLC-MS/MS. Molecules. 2007; 12(3): 593-606.spa
dc.relation.referencesTunduguru R, Thurmond DC. promoting glucose transporter-4 vesicle trafficking along cytoskeletal tracks: PAK-ing them out. Front Endocrinol (Lausanne). 2017; 8: 329.spa
dc.relation.referencesUnger M. Capillary electrophoresis of natural products: Current applications and recent advances. Planta Med. 2009; 75(7), 735-45.spa
dc.relation.referencesValentová K, Vrba J, Bancířová M, Ulrichová J, Křen V. Isoquercitrin: Phar- macology, toxicology, and metabolism. Food Chem Toxicol. 2014; 68, 267-82. 22. Ikeda Y, Murakami A, Ohigashi H. Ursolic acid: An anti- and pro-inflam- matory triterpenoid. Mol Nutr Food Res. 2008; 52(1): 26-42.spa
dc.relation.referencesVanhoenacker G, Sandra, P. High temperature and temperature programmed HPLC: Possibilities and limitations. Anal Bioanal Chem. 2008; 390(1): 245-8. 16. Gomes SVF, Portugal LA, dos Anjos JP, de Jesus ON, de Oliveira EJ, David JP et al. Accelerated solvent extraction of phenolic compounds exploiting a Box-Behnken design and quantification of five flavonoids by HPLC-DAD in Passiflora species. Microchem J. 2017; 132: 28-35.spa
dc.relation.referencesVinatoru M. An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrason Sonochem. 2001; 8(3): 303-13.spa
dc.relation.referencesVoirin B, Sportouch M, Raymond O, Jay M, Bayet, C, Dangles, O et al. Separation of flavone C-glycosides and qualitative analysis of Passiflora incarnata L. by capillary zone electrophoresis. Phytochem Anal. 2000; 11(2): 90-8.spa
dc.relation.referencesWang S, Ye S, Cheng Y. Separation and on-line concentration of saponins from Panax notoginseng by micellar electrokinetic chromatography. J Chromatogr A. 2006; 1109(2): 279-84.spa
dc.relation.referencesWang X, Wu Q, Wu Y, Chen G, Yue W, Liang Q. Response surface optimized ultrasonic-assisted extraction of flavonoids from Sparganii rhizoma and eva- luation of their in vitro antioxidant activities. Molecules. 2012; 17(4): 6769-83. 14. Pingret D, Fabiano-Tixier AS, Farid C. Ultrasound-Assisted Extraction. En: Rostagno M, Prado J, editores. Natural product extraction: principles and applications. Cambridge: Royal Society of Chemistry; 2013; pp. 89-112.spa
dc.relation.referencesWatson DG. Pharmaceutical analysis: A textbook for pharmacy students and pharmaceutical chemists. 3.a ed. Edimburgo: Elsevier; 2012. 12. High-per- formance capillary electrophoresis; pp. 301-57.spa
dc.relation.referencesWosch L, dos Santos KC, Imig DC, Santos CAM. Comparative study of Passiflora taxa leaves: II. A chromatographic profile. Rev Bras Farmacogn. 2017; 27(1): 40-9.spa
dc.relation.referencesWu T, Yu C, Li R, Li J. Minireview: Recent advances in the determination of flavonoids by capillary electrophoresis. Instrum. Sci. Technol. 2018; 46(4): 364-86.spa
dc.relation.referencesXu X, Yu L, Chen G. Determination of flavonoids in Portulaca oleracea L. by capillary electrophoresis with electrochemical detection. J Pharm Biomed Anal. 2006; 41(2): 493-499.spa
dc.relation.referencesXu YC, Leung SW, Leung GP, Man RY. Kaempferol enhances endothe- lium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+)-activated K(+) channels. Br J Pharmacol. 2015; 172(12): 3003-14.spa
dc.relation.referencesYahya N, Attan N, Wahab R. An overview of cosmeceutically relevant plant extracts and strategies for extraction of plant-based bioactive compounds. Food Bioprod Process. 2018; 112: 69-85.spa
dc.relation.referencesYang SN, Berggren PO. The Role of voltage-gated calcium channels in pancreatic β-cell physiology and pathophysiology. Endocr Rev. 2006; 27(6): 621-76.spa
dc.relation.referencesYeh WJ, Hsia SM, Lee WH, Wu CH. Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings. J Food Drug Anal. 2017; 25(1): 84-92.spa
dc.relation.referencesYin Z, Zhang W, Feng F, Zhang Y, Kang W. α-Glucosidase inhibitors isolated from medicinal plants. Food Sci Hum Wellness. 2015; 3: 136-74.spa
dc.relation.referencesYolmeh M, Jafari SM. Applications of response surface methodology in the food industry processes. Food Bioprocess Technol. 2017; 10(3): 413-33. 35. Hemwimol S, Pavasant P, Shotipruk A. Ultrasound-assisted extraction of anthraquinones from roots of Morinda citrifolia. Ultrason Sonochem. 2006; 13(6): 543-8.spa
dc.relation.referencesYoon J, Baek S. Molecular targets of dietary polyphenols with anti-inflam- matory properties. Yonsei Med J. 2005; 46(5): 585-96.spa
dc.relation.referencesYuliana ND, Khatib A, Choi YH, Verpoorte R. Metabolomics for bioactivity assessment of natural products. Phyther Res. 2011; 25: 157-69.spa
dc.relation.referencesZhang Y, Liu D. Flavonol kaempferol improves chronic hyperglycemia-im- paired pancreatic beta-cell viability and insulin secretory function. Eur J Phar- macol. 2011; 670(1): 325-32.spa
dc.relation.referencesZucolotto SM, Fagundes C, Reginatto FH, Ramos FA, Castellanos L, Duque C et al. Analysis of C-glycosyl flavonoids from South American Passiflora species by HPLC-DAD and HPLC-MS. Phytochem Anal. 2012; 23(3): 232-9.spa
dc.rightsUniversidad Nacional de Colombia, 2021
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc580 - Plantas::581 - Temas específicos en historia natural de las plantasspa
dc.subject.lembPlantas medicinales
dc.subject.lembBotánica médica
dc.subject.lembAnálisis químico de las plantas
dc.titlePassiflora ligularis Juss. (granadilla): estudios químicos y farmacológicos de una planta con potencial terapéuticospa
dc.typeLibrospa
dc.type.coarhttp://purl.org/coar/resource_type/c_18cfspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/bookspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

Archivos

Bloque original

Mostrando 1 - 1 de 1
Miniatura
Nombre:
Passiflora_102021.pdf
Tamaño:
8.92 MB
Formato:
Adobe Portable Document Format
Descripción:
Libro Passiflora ligularis Juss
Descargar

Bloque de licencias

Mostrando 1 - 1 de 1
Miniatura
Nombre:
license.txt
Tamaño:
4.57 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Ciencia