Conexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonales

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dc.contributor.advisorMontilla, María del Pilar
dc.contributor.advisorCrosby, Milton Josué
dc.contributor.authorCarreño Jiménez, Leidy Johanna
dc.date.accessioned2023-08-03T14:14:26Z
dc.date.available2023-08-03T14:14:26Z
dc.date.issued2023-04-24
dc.descriptionilustraciones, diagramasspa
dc.description.abstractDebido a al efecto pleiotrópico de algunas citocinas involucradas en el desarrollo de la respuesta inmune inflamatoria, el potencial efecto deletéreo en la fisiología celular inducido por la inflamación crónica y el moderado éxito de las terapias convencionales existentes (terapia alopática), la comprensión de los mecanismos inmunológicos en psoriasis y su efecto fisiopatológico se han convertido en la piedra angular para el desarrollo de nuevos y mejores medicamentos. Con la introducción de anticuerpos monoclonales y proteínas de fusión, sumado a las terapias químicas y físicas existentes, se ha incrementado el arsenal terapéutico disponible. Como consecuencia de la complejidad inmunológica de la enfermedad y su asociación con otras enfermedades ligadas a la respuesta inmune inflamatoria, surge la necesidad de ampliar el conocimiento acerca de la fisiopatología de la enfermedad y los mecanismos inmunológicos y moleculares de acción de los medicamentos empleados con el objeto de proporcionar la mejor asistencia a los pacientes. En la literatura se encuentra disponible abundante información respecto a datos clínicos de seguridad y eficacia de cada uno de los medicamentos utilizados en el tratamiento de la enfermedad, sin embargo, la información encontrada en la literatura respecto a las modificaciones en la expresión génica se encuentra fraccionada, situación que lleva a una pérdida de datos, que impide vislumbrar las implicaciones moleculares y bioquímicas de los diferentes tratamientos en el espectro de la enfermedad. Realizar una integración de esta información, permitirá una mejor comprensión de su rol en el manejo de la psoriasis y posibilitará el análisis de los aspectos diferenciales a nivel molecular de los múltiples mecanismos de acción de las terapias biológicas indicadas en esta patología. Objetivo Identificar las respuestas transcripcionales y de expresión proteica según los mecanismos de acción de los anticuerpos monoclonales que tienen como blanco directo e indirecto el eje IL-23/T17 en tratamiento de la psoriasis. (Texto tomado de la fuente)spa
dc.description.abstractDue to the pleiotropic effect of some cytokines involved in the development of the inflammatory immune response, the potential deleterious effect on cell physiology induced by chronic inflammation and the moderate success of existing conventional therapies (allopathic therapy), understanding the mechanisms Immunological agents in psoriasis and their pathophysiological effect have become the cornerstone for the development of new and better medicines. With the introduction of monoclonal antibodies and fusion proteins, added to existing chemical and physical therapies, the available therapeutic arsenal has increased. Because of the immunological complexity of the disease and its association with other diseases linked to the inflammatory immune response, there is a need to broaden the knowledge about the pathophysiology of the disease and the immunological and molecular mechanisms of action of the medicines used to provide the best care to patients. Abundant information is available in the literature regarding clinical data on safety and efficacy of each of the medicines used in the treatment of the disease, however, the information found in the literature regarding the modifications in gene expression is fragmented, a situation that leads to a loss of data, which prevents a glimpse of the molecular and biochemical implications of the different treatments in the spectrum of the disease. Carrying out an integration of this information will allow a better understanding of its role in the management of psoriasis and will enable the analysis of the differential aspects at the molecular level of the multiple mechanisms of action of the biological therapies indicated in this pathology.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagister en Inmunologíaspa
dc.description.methodsEl protocolo fue presentado y registrado en la plataforma de revisiones sistemáticas PROSPERO, con el registro: CRD42020222010. Se utilizaron las bases de datos de PUBMED/MEDLINE, Embase, LILACS y CENTRAL, para los idiomas español inglés, desde el 01/05/2005 hasta 20/08/2022. Se seleccionaron artículos originales observacionales de cohorte, casos y controles y ensayos clínicos con comparaciones antes y después, en los que se habían administrado anticuerpos monoclonales tipo anti-IL-23, anti-IL-17, anti-TNF- α y anti IL-12/23. Acorde con la metodología Cochrane, se sintetizaron los datos a través de descripciones cualitativas (narrativa) y cuantitativa a través de mapas de calor (Lasagna plot), forest plot y metaanálisis de efectos aleatorios debido a la heterogeneidad.spa
dc.description.technicalinfo*Revisión sistemática de la literaturaspa
dc.format.extentiv, 59 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/84429
dc.language.isospaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.programBogotá - Medicina - Maestría en Inmunologíaspa
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dc.relation.references120. Mehta H, Mashiko S, Angsana J, Rubio M, Hsieh YM, Maari C, et al. Differential Changes in Inflammatory Mononuclear Phagocyte and T-Cell Profiles within Psoriatic Skin during Treatment with Guselkumab vs. Secukinumab. J Invest Dermatol. 2021;141(7):1707-1718.e9.spa
dc.relation.references121. Eyerich K, Weisenseel P, Pinter A, Schäkel K, Asadullah K, Wegner S, et al. IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants with moderate-to severe plaque-type psoriasis (GUIDE). BMJ Open. 2021;11(9):e049822.spa
dc.relation.references122. Grabarek BO, Dąbala M, Kasela T, Gralewski M, Gładysz D. Changes in the Expression Pattern of DUSP1-7 and miRNA Regulating their Expression in the Keratinocytes Treated with LPS and Adalimumab. Curr Pharm Biotechnol. 2022;23(6):873-81.spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.ddc610 - Medicina y salud::616 - Enfermedadesspa
dc.subject.decsEtanercept
dc.subject.decsAdalimumab
dc.subject.decsAnticuerpos Monoclonales
dc.subject.decsAntibodies, Monoclonaleng
dc.subject.proposalPsoriasisspa
dc.subject.proposalAnticuerpo monoclonalspa
dc.subject.proposalExpresión génicaspa
dc.subject.proposalExpresión proteicaspa
dc.subject.proposalCorrelaciónspa
dc.subject.proposalRespondedoresspa
dc.subject.proposalNo respondedoresspa
dc.subject.proposalPsoriasiseng
dc.subject.proposalMonoclonal antibodyeng
dc.subject.proposalGene Expressioneng
dc.subject.proposalProtein expressioneng
dc.subject.proposalCorrelationeng
dc.subject.proposalResponderseng
dc.subject.proposalNon responderseng
dc.titleConexiones moleculares y su implicación en psoriasis: Variaciones en la expresión génica y proteica a nivel de los queratinocitos de pacientes con psoriasis de moderada a severa que fueron tratados con anticuerpos monoclonalesspa
dc.title.translatedMolecular Connections and their implication in Psoriasis: Variations in gene and protein expression at the level of the keratinocytes from patients with moderate to severe psoriasis who were treated with monoclonal antibodies.eng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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