Uso del veneno de abeja en acupuntura, como terapia complementaria en el tratamiento de pacientes con osteoartritis y artritis reumatoide. Scoping review.

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dc.contributor.advisorMercado Pedroza, Manuel Esteban
dc.contributor.advisorJagua Gualdrón, Andrés
dc.contributor.authorSuárez Mora, Andrea Carolina
dc.contributor.researchgroupMedicina Tradicional China y Acupunturaspa
dc.coverage.temporalColombiaspa
dc.date.accessioned2025-09-05T16:41:12Z
dc.date.available2025-09-05T16:41:12Z
dc.date.issued2025
dc.descriptionilustraciones a color, diagramas, fotografíasspa
dc.description.abstractObjetivo: Determinar cuál es el estado actual en investigación del uso del veneno de abeja en acupuntura como terapia complementaria en el tratamiento de pacientes con osteoartritis y artritis reumatoide. Metodología: Revisión de alcance de publicaciones en ScienceDirect, Scopus, Cochrane Library, Biblioteca Virtual en Salud, PubMed y Scielo entre los años 2014 – 2024, en idiomas inglés y español. Resultados: De 807 artículos identificados y una tesis de repositorio, 11 artículos cumplieron con criterios de elegibilidad. La evidencia del uso del veneno de abeja en acupuntura en artritis reumatoide y osteoartritis se puede sustentar en los efectos reguladores en las citoquinas y en las vías de señalización inflamatorias, sin embargo, los estudios en humanos son limitados y carecen de información detallada del tratamiento farmacológico de base y el diagnóstico a través de la Medicina Tradicional China. Los efectos con esta terapia son dependientes de la dosis y el tiempo de administración, además de la hipersensibilidad del paciente. Conclusiones: La evidencia preclínica del tema muestra los potenciales beneficios en salud. Se necesita más investigación para evaluar su efectividad y seguridad en humanos (Texto tomado de la fuente).spa
dc.description.abstractObjective: Determine the current status of research on the use of bee venom in acupuncture as a complementary therapy in the treatment of patients with osteoarthritis and rheumatoid arthritis. Methodology: Scoping review of publications in ScienceDirect, Scopus, Cochrane Library, Biblioteca Virtual en Salud, PubMed and Scielo between the years 2014 – 2024, in English and Spanish languages. Results: Of 807 identified articles and one repository thesis, 11 articles met the eligibility criteria. The evidence for the use of bee venom in acupuncture in rheumatoid arthritis and osteoarthritis can be supported by the regulatory effects on cytokines and inflammatory signaling pathways, however, studies in humans are limited and lack detailed information on the basic pharmacological treatment and diagnosis through Traditional Chinese Medicine. The effects with this therapy are dependent on the dose and time of administration, in addition to the patient's hypersensitivity. Conclusions: Preclinical evidence on the topic shows potential health benefits. Further research is needed to evaluate its effectiveness and safety in humans.eng
dc.description.curricularareaMedicina.Sede Bogotáspa
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Medicina Alternativaspa
dc.description.methodsLa presente investigación se enmarca en una revisión de alcance de la literatura, en la cual se realizó un protocolo redactado conforme a la extensión PRISMA para revisiones de alcance (PRISMA – ScR)(66,67), aprobado por el Subcomité Asesor de la Maestría en Medicina Alternativa de la Facultad de Medicina de la Universidad Nacional de Colombia y evaluado posteriormente por evaluador experto quien califico como aprobado.spa
dc.description.researchareaMedicina Alternativaspa
dc.format.extent95 páginasspa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/88634
dc.language.isospa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.programBogotá - Medicina - Maestría en Medicina Alternativaspa
dc.relation.referencesCaliogna L, Berni M, Torriani C, Mancuso ME, Di Minno MND, Brancato AM, et al. Pathogenesis of osteoarthritis, rheumatoid arthritis, and hemophilic arthropathy: The role of angiogenesis. Vol. 30, Haemophilia. John Wiley and Sons Inc; 2024. p. 1256–64.
dc.relation.referencesSteinmetz JD, Culbreth GT, Haile LM, Rafferty Q, Lo J, Fukutaki KG, et al. Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023 Sep 1;5(9):e508–22.
dc.relation.referencesBlack RJ, Cross M, Haile LM, Culbreth GT, Steinmetz JD, Hagins H, et al. Global, regional, and national burden of rheumatoid arthritis, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023 Oct 1;5(10):e594–610.
dc.relation.referencesPark S, Son Y, Lee H, Lee H, Lee J, Kang J, et al. Sex-Specific Trends in the Prevalence of Osteoarthritis and Rheumatoid Arthritis From 2005 to 2021 in South Korea: Nationwide Cross-Sectional Study. JMIR Public Health Surveill. 2024 Nov 1;10:e57359.
dc.relation.referencesGomez F, Duque G, Curcio CL, Cano L, Osorio D, Rios S. Prevalence and burden of osteoarthritis amongst older people in Colombia: Results from national survey of health, wellbeing, and aging (SABE Colombia). Clin Epidemiol Glob Health. 2025 Jan 1;31.
dc.relation.referencesToro-Gutiérrez CE, Arbeláez-Cortés Á, Fernández-Aldana AR, Mejía-Romero RA, Méndez Patarroyo P, Quintana L. G, et al. Clinical practice guidelines for the early detection, diagnosis, treatment, and follow-up of patients with rheumatoid arthritis. Colombian Association of Rheumatology, 2022. Revista Colombiana de Reumatologia. 2024 Apr 1;31(2):205–22.
dc.relation.referencesCourties A, Kouki I, Soliman N, Mathieu S, Sellam J. Osteoarthritis year in review 2024: Epidemiology and therapy. Osteoarthritis Cartilage. 2024 Nov
dc.relation.referencesWang D, Liu W, Venkatesan JK, Madry H, Cucchiarini M. Therapeutic Controlled Release Strategies for Human Osteoarthritis. Advanced Healthcare Materials. John Wiley and Sons Inc; 2024.
dc.relation.referencesFeingold PG. Bi syndrome: treatment by acupuncture. Revista Internacional de Acupuntura. 2019 Jul 1;13(3):82–8.
dc.relation.referencesLee KH, Cho YY, Kim S, Sun SH. History of research on pharmacopuncture in Korea. J Pharmacopuncture [Internet]. 2016 Jun 1 [cited 2025 May 29];19(2):101–8. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4931294/
dc.relation.referencesLee JA, Son MJ, Choi J, Jun JH, Kim JI, Lee MS. Bee venom acupuncture for rheumatoid arthritis: a systematic review of randomised clinical trials. BMJ Open [Internet]. 2014 Nov 7 [cited 2025 May 29];4(11). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4225238/
dc.relation.referencesYue L, Berman J, Loeser RF. What Is Osteoarthritis [Internet]. Vol. 327, JAMA - Journal of the American Medical Association. American Medical Association; 2022 [cited 2025 May 29]. Available from: https://jamanetwork.com/journals/jama/fullarticle/2790632
dc.relation.referencesVincent TL, Alliston T, Kapoor M, Loeser RF, Troeberg L, Little CB. Osteoarthritis Pathophysiology: Therapeutic Target Discovery may Require a Multifaceted Approach. Clin Geriatr Med [Internet]. 2022 May [cited 2025 May 29];38(2):193–219. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9107912/
dc.relation.referencesPark YC, Goo BH, Park KJ, Kim JY, Baek YH. Traditional korean medicine as collaborating treatments with conventional treatments for knee osteoarthritis: A protocol for a systematic review and meta-analysis [Internet]. Vol. 14, Journal of Pain Research. Dove Medical Press Ltd; 2021 [cited 2025 May 29]. p. 1345–51. Available from: https://pubmed.ncbi.nlm.nih.gov/34054306/
dc.relation.referencesZhang AR, Cheng QH, Yang YZ, Yang X, Zhang ZZ, Guo HZ. Meta-analysis of outcomes after total knee arthroplasty in patients with rheumatoid arthritis and osteoarthritis [Internet]. Vol. 47, Asian Journal of Surgery. Elsevier (Singapore) Pte Ltd; 2024 [cited 2025 May 29]. p. 43–54. Available from: https://www.sciencedirect.com/science/article/pii/S101595842301432X?via%3Dihub
dc.relation.referencesFondo Colombiano de Enfermedades de Alto Costo. Situación de la artritis reumatoide en Colombia 2022 - Cuenta de Alto Costo. 2023 [cited 2024 May 30]; Available from: https://cuentadealtocosto.org/publicaciones/situacion-de-la-artritis-reumatoide-en-colombia-2022/
dc.relation.referencesCuervo FM, Santos AM, Londono J, Angarita JI, Rueda JC, Giraldo-Bustos R, et al. The burden of the most common rheumatic disease in Colombia. BMC Rheumatol [Internet]. 2022 Dec 1 [cited 2025 May 29];6(1). Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8772222/
dc.relation.referencesYang KR, Song HS. A Comparative study of Warm needling and Bee Venom Pharmacopuncture on Osteoarthritis of the Knee - a Randomized Controlled Trial -. Journal of Korean Institute of Herbal Acupuncture. 2008 Jun 30;11(2):21–31.
dc.relation.referencesLin TY, Hsieh CL. Clinical applications of bee venom acupoint injection [Internet]. Vol. 12, Toxins. MDPI; 2020 [cited 2025 May 29]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7601520/
dc.relation.referencesLee SH, Kwon GS, Kang MS, Yoon HM, Kim CH. Comparative Study on the Effects of Bee Venom Pharmacopuncture According to the Treatment Method for Knee Osteoarthritis. J Pharmacopuncture. 2012 Dec 31;15(4):7–14.
dc.relation.referencesKwon Y bae, Lee J dong, Lee H jung, Han H jae, Mar W chon, Kang S keel, et al. Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses. Pain [Internet]. 2001;90(3):271–80. Available from: https://www.sciencedirect.com/science/article/pii/S0304395900004127
dc.relation.referencesDuffy C, Sorolla A, Wang E, Golden E, Woodward E, Davern K, et al. Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer. NPJ Precis Oncol. 2020 Dec 1;4(1).
dc.relation.referencesSoo-Hyun Sung, Hee-Jung Lee, Ji-Eun Han, Angela Dong-Min Sung, Minjung Park. Bee Venom Acupuncture for Neck Pain: A Review of the Korean Literature. Toxins (Basel) [Internet]. 2023 [cited 2024 May 30];15(2). Available from: 10.3390/toxins15020129
dc.relation.referencesAufschnaiter A, Kohler V, Khalifa S, El-Wahed AA, Du M, El-Seedi H, et al. Apitoxin and Its Components against Cancer, Neurodegeneration and Rheumatoid Arthritis: Limitations and Possibilities. Vol. 12, Toxins. MDPI; 2020.
dc.relation.referencesLondoño J, Peláez Ballestas I, Cuervo F, Angarita I, Giraldo R, Rueda JC, et al. Prevalence of rheumatic disease in Colombia according to the Colombian Rheumatology Association (COPCORD) strategy. Prevalence study of rheumatic disease in Colombian population older than 18 years. Revista Colombiana de Reumatologia. 2018 Oct 1;25(4):245–56.
dc.relation.referencesSung WS, Kim JH, Lee DH, Kim EJ, Seo BK, Hong SU, et al. Effectiveness and safety of bee venom pharmacopuncture for rheumatoid arthritis: A systematic review protocol. Vol. 12, BMJ Open. BMJ Publishing Group; 2022.
dc.relation.referencesMinisterio de Salud y Protección Social-Departamento administrativo de ciencia tecnología e innovación C. Guía de Práctica Clínica para la detección temprana, diagnóstico y tratamiento de la artritis reumatoide [Internet]. Bogotá, Colombia; 2014 [cited 2024 May 30]. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/CA/gpc-tratamiento-artritis-reumatoide-profesionales.pdf
dc.relation.referencesChalem Choueka M, Arango Pilonieta CE, Díaz Cortés ME, Duperly Sánchez J, Forero Franco JP, Llinás Hernández PJ, et al. Recomendaciones sobre diagnóstico, prevención y tratamiento farmacológico y no farmacológico de la osteoartritis (OA) de rodilla. Revista Colombiana de Médicina Física y Rehabilitación [Internet]. 2017 Dec;27(2):160–84. Available from: http://www.revistacmfr.org/index.php/rcmfr/article/view/196
dc.relation.referencesInstituto de Evaluación Tecnológica en Salud - IETS y Ministerio de Salud y Protección Social. Posicionamiento terapéutico para el tratamiento farmacológico de la artritis reumatoide [Internet]. Colombia; 2022 [cited 2024 May 30]. Available from: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VP/RBC/ipt-artritis-reumatoide-resumen-2022.pdf
dc.relation.referencesQiao Y, Li F, Zhang L, Song X, Yu X, Zhang H, et al. A systematic review and meta-analysis comparing outcomes following total knee arthroplasty for rheumatoid arthritis versus for osteoarthritis. BMC Musculoskelet Disord. 2023 Dec 1;24(1).
dc.relation.referencesShen L, Ha Lee J, Cheon Joo J, Jung Park S, Sun Song Y. Bee Venom Acupuncture for Shoulder Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Available from: https://doi.org/10.3831/KPI.
dc.relation.referencesSung SH, Lee G. Bee venom acupuncture effects on pain and its mechanisms: An updated review. Vol. 13, Toxins. MDPI; 2021.
dc.relation.referencesOrganización Mundial de la Salud. Artritis reumatoide [Internet]. 2023 [cited 2024 May 30]. Available from: https://www.who.int/es/news-room/fact-sheets/detail/rheumatoid-arthritis
dc.relation.referencesCell Signaling Technology. Rheumatoid Arthritis Pathogenesis Signaling Pathw [Internet]. 2022 [cited 2024 May 30]. Available from: https://www.cellsignal.com/pathways/rheumatoid-arthritis
dc.relation.referencesJakobsson PJ, Robertson L, Welzel J, Zhang M, Zhihua Y, Kaixin G, et al. Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis [Internet]. Vol. 292, Journal of Internal Medicine. John Wiley and Sons Inc; 2022 [cited 2025 May 29]. p. 745–63. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9796271/
dc.relation.referencesOrganización Mundial de la Salud. Osteoartritis [Internet]. 2023 [cited 2024 May 30]. Available from: https://www.who.int/es/news-room/fact-sheets/detail/osteoarthritis
dc.relation.referencesMolnar V, Matišić V, Kodvanj I, Bjelica R, Jeleč Ž, Hudetz D, et al. Cytokines and Chemokines involved in osteoarthritis pathogenesis [Internet]. Vol. 22, International Journal of Molecular Sciences. MDPI; 2021 [cited 2025 May 29]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8431625/
dc.relation.referencesYunus MHM, Nordin A, Kamal H. Pathophysiological perspective of osteoarthritis [Internet]. Vol. 56, Medicina (Lithuania). MDPI AG; 2020 [cited 2025 May 29]. p. 1–13. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7696673/
dc.relation.referencesMaciocia Giovanni. La práctica de la medicina china. El tratamiento de enfermedades con acupuntura y fitoterapia china. Tercera. Elsevier España; 2022.
dc.relation.referencesMaciocia Giovanni. Los fundamentos de Medicina China. Segunda. Madrid: Gaia Ediciones; 2013.
dc.relation.referencesPing Li. El gran libro de la Medicina China. Segunda. Barcelona: Ediciones Martínez Roca ; 2002.
dc.relation.referencesNogueira A. Carlos. Acupuntura I. Fundamentos de Bioenergética. Quinta. C.E.M.E.T.C.S.L, editor. Madrid; 2001.
dc.relation.referencesGonzález González R, Dávila Hernández A, Santana Portillo JA, Liangxiao M, Xin N. Propuesta de análisis sinomédico de la célula. Vol. 10, Revista Internacional de Acupuntura. Ediciones Doyma, S.L.; 2016. p. 62–8.
dc.relation.referencesWan R, Fan Y, Zhao A, Xing Y, Huang X, Zhou L, et al. Comparison of Efficacy of Acupuncture-Related Therapy in the Treatment of Rheumatoid Arthritis: A Network Meta-Analysis of Randomized Controlled Trials. Vol. 13, Frontiers in Immunology. Frontiers Media S.A.; 2022.
dc.relation.referencesSun R, Wu L, Sun Y. Immunological studies on acupuncture and moxibustion treatment of rheumatoid arthritis: A review. Vol. 103, Medicine (United States). Lippincott Williams and Wilkins; 2024. p. E36875.
dc.relation.referencesAlmeida EAB, Bossert S, Danforth BN, Porto DS, Freitas F V., Davis CC, et al. The evolutionary history of bees in time and space. Current Biology. 2023 Aug 21;33(16):3409-3422.e6.
dc.relation.referencesIntegrated Taxonomic Information System. Apis mellifera [Internet]. 2025 [cited 2025 May 13]. Available from: https://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN&search_value=154396#null
dc.relation.referencesAamidor SE, Yagound B, Ronai I, Oldroyd BP. Sex mosaics in the honeybee: How haplodiploidy makes possible the evolution of novel forms of reproduction in social Hymenoptera. Biol Lett. 2018 Nov 1;14(11).
dc.relation.referencesRueppell O, Bachelier C, Kim Fondrk M, Page RE. Regulation of life history determines lifespan of worker honey bees (Apis mellifera L.) [Internet]. 2007 Oct [cited 2025 May 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/17689041/
dc.relation.referencesRoque Ramírez B. Apis mellifera y miRNAs: modelo natural de longevidad y una perspectiva hologenómica del envejecimiento. Revista del Centro de Investigación de la Universidad la Salle. 2021 Nov 10;14(56):113–22.
dc.relation.referencesCepeda Granados M, Bejarano Garavito DH, Vásquez Romero RE, Rodríguez García OA, Montes Campos WA. Buenas prácticas para la producción de reinas seleccionadas de abejas Apis mellifera [Internet]. Corporación Colombiana de Investigación Agropecuaria; 2024. Available from: https://editorial.agrosavia.co/index.php/publicaciones/catalog/book/412
dc.relation.referencesRamirez-Esquivel F, Ravi S. Functional anatomy of the worker honeybee stinger (Apis mellifera). iScience [Internet]. 2023 Jul 21;26(7):107103. Available from: https://doi.org/10.1016/j.isci.
dc.relation.referencesSerrinha V, Correia SD, Marques G. Productivity and Economic Analysis of a New Intensive Collector in the Portuguese Market with Implication of Open Innovation Perspective. Journal of Open Innovation: Technology, Market, and Complexity. 2019 Sep 1;5(3):71.
dc.relation.referencesGuatemal Adriana; Jáuregui Diego; Arteaga Vicente; Arciniegas Stalin. Determinación de las condiciones óptimas de un equipo extractor de apitoxina en abejas (Apis mellifera). REDVET Revista Electrónica de Veterinaria [Internet]. 2017 Dec 17 [cited 2025 May 17];18(12):1–11. Available from: https://www.redalyc.org/articulo.oa?id=63654640035
dc.relation.referencesSung SH, Kim JW, Han JE, Shin BC, Park JK, Lee G. Animal Venom for Medical Usage in Pharmacopuncture in Korean Medicine: Current Status and Clinical Implication. Toxins (Basel) [Internet]. 2021 Feb 1;13:105. Available from: https://doi.org/10.3390/toxins
dc.relation.referencesPineda Guerra Y, Betancur Echeverri J, Pedroza-Díaz J, Delgado-Trejos E, Rothlisberger S. Análisis proteómico del veneno de la abeja Africanizada: Comparación de métodos de extracción. Acta Biolo Colomb. 2016;21(3):619–26.
dc.relation.referencesUllah A, Aldakheel FM, Anjum SI, Raza G, Khan SA, Tlak Gajger I. Pharmacological properties and therapeutic potential of honey bee venom. Saudi Pharmaceutical Journal. 2023 Jan 1;31(1):96–109.
dc.relation.referencesIsidorov V, Zalewski A, Zambrowski G, Swiecicka I. Chemical Composition and Antimicrobial Properties of Honey Bee Venom. Molecules. 2023 May 1;28(10).
dc.relation.referencesAida A. Abd El-Wahed, Shaden A.M. Khalifa, Bassem Y. Sheikh, Mohamed A. Farag, Aamer Saeed, Fayaz A. Larik, et al. Bee Venom Composition: From Chemistry to Biological Activity. Studies in Natural Products Chemistry [Internet]. 2019 [cited 2024 May 30];60:459–84. Available from: https://doi.org/10.1016/B978-0-444-64181-6.00013-9.
dc.relation.referencesCarpena M, Nuñez-Estevez B, Soria-Lopez A, Simal-Gandara J. Bee venom: An updating review of its bioactive molecules and its health applications. Vol. 12, Nutrients. MDPI AG; 2020. p. 1–27.
dc.relation.referencesWehbe R, Frangieh J, Rima M, Obeid D El, Sabatier JM, Fajloun Z. Bee venom: Overview of main compounds and bioactivities for therapeutic interests. Vol. 24, Molecules. MDPI AG; 2019.
dc.relation.referencesKurek-Górecka A, Komosinska-Vassev K, Rzepecka-Stojko A, Olczyk P. Bee Venom in Wound Healing [Internet]. Vol. 26, Molecules. MDPI; 2021 [cited 2025 May 29]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7795515/
dc.relation.referencesYoo J, Lee G. Adverse Events Associated with the Clinical Use of Bee Venom: A Review [Internet]. Vol. 14, Toxins. MDPI; 2022 [cited 2025 May 29]. p. 562. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9415809/
dc.relation.referencesKhalil A, Elesawy BH, Ali TM, Ahmed OM. Bee venom: From venom to drug [Internet]. Vol. 26, Molecules. MDPI AG; 2021 [cited 2025 May 29]. p. 4941. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8400317/
dc.relation.referencesLee G, Bae H. Anti-inflammatory applications of melittin, a major component of bee venom: Detailed mechanism of action and adverse effects [Internet]. Vol. 21, Molecules. MDPI AG; 2016 [cited 2025 May 29]. p. 616. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6273919/
dc.relation.referencesMunn Z, Pollock D, Khalil H, Alexander L, McLnerney P, Godfrey CM, et al. What are scoping reviews? Providing a formal definition of scoping reviews as a type of evidence synthesis. Vol. 20, JBI Evidence Synthesis. Lippincott Williams and Wilkins; 2022. p. 950–2.
dc.relation.referencesTricco AC, Zarin W, Lillie E, Pham B, Straus SE. Utility of social media and crowd-sourced data for pharmacovigilance: A scoping review protocol. BMJ Open. 2017 Jan 1;7(1).
dc.relation.referencesBiblioteca Virtual en Salud PR de la B. Búsqueda DeCS/MeSH [Internet]. [cited 2024 May 30]. Available from: https://pesquisa.bvsalud.org/portal/decs-locator/?lang=es&mode=&tree_id=MT1.388.585.520
dc.relation.referencesJang S, Kim KH. Clinical Effectiveness and Adverse Events of Bee Venom Therapy: A Systematic Review of Randomized Controlled Trials. Vol. 12, Toxins. MDPI AG; 2020.
dc.relation.referencesLiu L, Deng D, Li C, Huang G, Zhang W, Liang T, et al. The combination of modified acupuncture needle and melittin hydrogel as a novel therapeutic approach for rheumatoid arthritis treatment. J Nanobiotechnology. 2024 Dec 1;22(1).
dc.relation.referencesSharaf SE, Alsanosi S, Alzahrani AR, Al-Ghamdi SS, Sharaf SE, Ayoub N. Knowledge, Attitude, and Practice of Bee Venom Acupuncture Therapy on Rheumatoid Arthritis Among Patients in Saudi Arabia. Int J Gen Med. 2022;15:1171–83.
dc.relation.referencesHuh JE, Seo BK, Lee JW, Kim C, Park YC, Lee JD, et al. Seo-Diluted BVA ALTERNATIVE THERAPIES, [E-PUB AHEAD OF PRINT] Analgesic Effects of Diluted Bee Venom Acupuncture Mediated by δ-Opioid and α 2-Adrenergic Receptors in Osteoarthritic Rats.
dc.relation.referencesConrad VJ, Hazan LL, Latorre AJ, Jakubowska A, Kim CMH. Efficacy and Safety of Honey Bee Venom (Apis mellifera) Dermal Injections to Treat Osteoarthritis Knee Pain and Physical Disability: A Randomized Controlled Trial. Journal of Alternative and Complementary Medicine. 2019 Aug 1;25(8):845–55.
dc.relation.referencesZhang S, Liu Y, Ye Y, Wang XR, Lin LT, Xiao LY, et al. Bee venom therapy: Potential mechanisms and therapeutic applications. Toxicon [Internet]. 2018 Jun 15 [cited 2025 May 29];148:64–73. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0041010118301454?via%3Dihub
dc.relation.referencesLiu F, Chen F, Yang L, Qiu F, Zhong G, Gao S, et al. Melittin acupoint injection in attenuating bone erosion in collageninduced arthritis mice via inhibition of the RANKL/NF-κB signaling pathway. Quant Imaging Med Surg. 2023 Sep 1;13(9):5996–6013.
dc.relation.referencesLee SH, Hong SJ, Kim SY. Randomized Controlled Double Blind Study of Bee Venom Therapy on Rheumatoid Arthritis. Korean Acupuncture & Moxibustion Medicine Society [Internet]. 2003 Dec 20 [cited 2025 May 20];20(6):80–8. Available from: https://203.250.218.22/article/JAKO200326662305853.page?&lang=en
dc.relation.referencesKwon YB, Kim JH, Yoon JH, Lee JD, Han HJ, Mar WC, et al. The analgesic efficacy of bee venom acupuncture for knee osteoarthritis: a comparative study with needle acupuncture. Am J Chin Med (Gard City N Y) [Internet]. 2001 Jan 1 [cited 2025 May 19];29(2):187–99. Available from: https://pubmed.ncbi.nlm.nih.gov/11527062/
dc.relation.referencesKwon YB, Lee HJ, Han HJ, Mar WC, Kang SK, Yoon OB, et al. The water-soluble fraction of bee venom produces antinociceptive and anti-inflammatory effects on rheumatoid arthritis in rats. Life Sci [Internet]. 2002 May 31 [cited 2025 May 20];71(71):191–204. Available from: https://doi.org/10.1016/S0024-3205(02)01617-X
dc.relation.referencesLee JD, Kim SY, Kim TW, Lee SH, Yang HI, Lee DI, et al. Anti-inflammatory effect of bee venom on type II collagen-induced arthritis. Am J Chin Med (Gard City N Y) [Internet]. 2004 [cited 2025 May 20];32(3):361–7. Available from: https://doi.org/10.1142/S0192415X04002016
dc.relation.referencesBaek YH, Huh JE, Lee JD, Choi DY, Park DS. Antinociceptive effect and the mechanism of bee venom acupuncture (Apipuncture) on inflammatory pain in the rat model of collagen-induced arthritis: Mediation by alpha2-Adrenoceptors. Brain Res [Internet]. 2006 Feb 16 [cited 2025 May 20];1073:305–10. Available from: 10.1016/j.brainres.2005.12.086
dc.relation.referencesSuh SJ, Kim KS, Kim MJ, Chang YC, Lee SD, Kim MS, et al. Effects of bee venom on protease activities and free radical damages in synovial fluid from type II collagen-induced rheumatoid arthritis rats. Toxicology in Vitro [Internet]. 2006 Dec [cited 2025 May 20];20(8):1465–71. Available from: https://doi.org/10.1016/j.tiv.2006.06.016
dc.relation.referencesLi J, Ke T, He C, Cao W, Wei M, Zhang L, et al. The anti-arthritic effects of synthetic melittin on the complete Freund’s adjuvant-induced rheumatoid arthritis model in rats. Am J Chin Med (Gard City N Y) [Internet]. 2010 [cited 2025 May 20];38(6):1039–49. Available from: 10.1142/S0192415X10008457
dc.relation.referencesDarwish SF, El-Bakly WM, Arafa HM, El-Demerdash E. Targeting TNF-α and NF-κB activation by bee venom: role in suppressing adjuvant induced arthritis and methotrexate hepatotoxicity in rats. PLoS One [Internet]. 2013 Nov 20 [cited 2025 May 20];8(11). Available from: 10.1371/journal.pone.0079284
dc.relation.referencesTian G, Zhao C, Zhang X, Mu W, Jiang Y, Wei X, et al. Evidence-based traditional Chinese medicine research: Two decades of development, its impact, and breakthrough. Journal of Evidence - Based Medicine [Internet]. 2021 Feb 1 [cited 2025 May 28];14(1):65–74. Available from: https://onlinelibrary.wiley.com/doi/epdf/10.1111/jebm.12420
dc.relation.referencesZeng L, Zhou G, Yang W, Liu J. Guidelines for the diagnosis and treatment of knee osteoarthritis with integrative medicine based on traditional Chinese medicine [Internet]. Vol. 10, Frontiers in Medicine. Frontiers Media SA; 2023 [cited 2025 May 28]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10617515/
dc.relation.referencesFocks C. Atlas de acupuntura. 2nd ed. Elsevier Masson, editor. Barcelona: Masson; 2009.
dc.relation.referencesWang M, Liu L, Zhang CS, Liao Z, Jing X, Fishers M, et al. Mechanism of traditional Chinese medicine in treating knee osteoarthritis [Internet]. Vol. 13, Journal of Pain Research. Dove Medical Press Ltd.; 2020 [cited 2025 Jun 10]. p. 1421–9. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7304682/
dc.relation.referencesZhang Q, Zhou M, Huo M, Si Y, Zhang Y, Fang Y, et al. Mechanisms of acupuncture–electroacupuncture on inflammatory pain [Internet]. Vol. 19, Molecular Pain. SAGE Publications Inc.; 2023 [cited 2025 Jun 9]. p. 1–22. Available from: https://pubmed.ncbi.nlm.nih.gov/37678839/
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseReconocimiento 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.decsTerapia por Acupunturaspa
dc.subject.decsAcupuncture Therapyeng
dc.subject.decsTerapias Complementariasspa
dc.subject.decsComplementary Therapieseng
dc.subject.decsApiterapiaspa
dc.subject.decsApitherapyeng
dc.subject.lembVeneno de insectosspa
dc.subject.lembInsect venomeng
dc.subject.proposalVenenos de abejaspa
dc.subject.proposalApaminaspa
dc.subject.proposalMelitinaspa
dc.subject.proposalOsteoartritisspa
dc.subject.proposalArtritis Reumatoidespa
dc.subject.proposalMedicina Tradicional Chinaspa
dc.subject.proposalTerapia por Acupunturaspa
dc.subject.proposalBee Venomseng
dc.subject.proposalApamineng
dc.subject.proposalMelittineng
dc.subject.proposalOsteoarthritiseng
dc.subject.proposalRheumatoid arthritiseng
dc.subject.proposalTraditional Chinese Medicineeng
dc.subject.proposalAcupuncture Therapyeng
dc.titleUso del veneno de abeja en acupuntura, como terapia complementaria en el tratamiento de pacientes con osteoartritis y artritis reumatoide. Scoping review.spa
dc.title.translatedUse of bee venom in acupuncture, as a complementary therapy in the treatment of patients with osteoarthritis and rheumatoid arthritis. Scoping review.eng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2

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Maestría en Medicina Alternativa