Efectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistar

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dc.contributor.advisorDueñas Gomez, Zulma Janethspa
dc.contributor.advisorBetancurt Rendón, Jhonspa
dc.contributor.authorYepes Gómez, Heidy Vivianaspa
dc.contributor.researchgroupNeurobiología y Comportamientospa
dc.date.accessioned2024-05-08T20:44:26Z
dc.date.available2024-05-08T20:44:26Z
dc.date.issued2024-05
dc.descriptionilustraciones, diagramas, fotografíasspa
dc.description.abstractLa excreción de sodio a nivel renal en modelo murino, inducida por el CBD, está mediada por la unión del ligando en este caso el fitocannabinoide con los receptores para cannabis. Esta interacción modula el Endocannabinoidoma a nivel renal, específicamente en la reabsorción de sodio, modificando en cierta medida la tasa de filtración glomerular. En referencia a lo previamente explicado, este trabajo tuvo como objetivo identificar los efectos del fitocannabinoide cannabidiol a diferentes dosis, sobre la reabsorción de sodio a nivel renal. Metodología: Se están utilizaron 30 ratas macho Wistar, adultas (3 meses de edad), distribuidos en 4 grupos, grupo control, grupo vehículo, grupo al os que se les aplicó vía intraperitoneal CBD disuelto en acetite de oliva extra virgen a diferentes dosis (15, 30 y 50 mg/Kg) 48 horas previo a la toma de la muestra. El método utilizado para tomar la orina fue recolección directa puntual, que consiste en realizar un estímulo táctil sobre la espalda del animal, colocando un vaso precipitado de 5ml cerca de la zona perineal. Las muestras se almacenaron a -20°C, hasta su análisis por espectrometría de masas y análisis estadístico (ANOVA unifactorial; software spss, p=0.05). Resultados: los datos obtenidos indican que al aumentar la dosis de cannabidiol, 48 horas después de su aplicación, se evidencia un incremento de la excreción de sodio, Probablemente por una disminución de la actividad de la bomba Na+/K+ATPasa a nivel del túbulo proximal. Conclusión: Estos resultados apoyan la hipótesis que sugiere que el CBD es un antagonista de los receptores CB1 y agonista de los receptores TRPV1 a nivel renal, aumentando la excreción de sodio a nivel renal. (Texto tomado de la fuente).spa
dc.description.abstractThe excretion of sodium at the renal level in the murine model, induced by CBD, is mediated by binding of the ligand in this case the phytocannabinoid to the receptors for cannabis. This interaction modulates the Endocannabinoidome at the renal level, specifically in sodium reabsorption, modifying to some extent the glomerular filtration rate. In reference to the previously explained, this study aimed to identify the effects of the phytocannabinoid cannabidiol at different doses, on sodium reabsorption at the renal level. Methodology: Thirty adult male Wistar rats (3 months of age) were used, distributed in 4 groups, control group, vehicle group, to which were administered intraperitoneally CBD dissolved in extra virgin olive oil at different doses (15, 30 and 50 mg/Kg) 48 hours prior to sampling. The method used to collect urine was direct collection, which consists of performing a tactile stimulus on the back of the animal, placing a 5ml precipitated vessel near the perineal area. Samples were stored at -20°C until analysis by mass spectrometry and statistical analysis (single-factorial ANOVA; spss software, p=0. 05). Results: the data obtained indicate that when increasing the dose of cannabidiol, 48 hours after its application, there is evidence of an increase in sodium excretion, probably due to a decrease in the activity of the Na+/K+ATPase pump at the level of the proximal tubule. Conclusion: These results support the hypothesis that CBD is an antagonist of CB1 receptors and agonist of TRPV1 receptors at the renal level, increasing sodium excretion at the renal level.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Fisiologíaspa
dc.description.methodsPara llevar a cabo este trabajo, se realizó un estudio de tipo experimental completo, donde se utilizaron ratas Wistar a las que se les aplicó el fitocannabinoide cannabidiol (CBD) full espectrum (donado por la empresa ICAN de la Ciudad de México) a dosis de15- 50mg/Kg ; estas dosis se estandarizaron de esta manera de acuerdo con la metodología utilizada en el estudio de Hložek y colaboradores en el 2017 donde evaluaron el perfil farmacocinético de diferentes fitocannabinoides entre ellos el CBD administrados por vía subcutánea en ratas Wistar con el objetivo de determinar cambios comportamentales . Posteriormente, se midieron los niveles de excreción de sodio en orina, obteniendo esta, mediante el método de recolección directa puntual en vaso precipitado , 40 horas post administración del CBD. El estudio que se llevó a cabo es un estudio experimental con casos y controles.spa
dc.description.researchareaModelos animales; estrés y comportamiento; vínculo materno; neurobiología del estrésspa
dc.format.extentXIII, 74 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86056
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina - Maestría en Fisiologíaspa
dc.relation.indexedBiremespa
dc.relation.referencesFrancisca Medina Pontigo D, Daya Dra Sylvia Arrau Barra F, Marczuk Dyurich Flor Ortiz Rios Mish Castillo Vázquez M, Santisteban-Arenas RR, Andrés Cifuentes Sanabria Sara Lorena Rojas Jeidy Yuranny Valcárcel Peña C, EDITORIAL MVZ Cert Luis Fernando Martínez Cornejo D, et al. Estudio Preliminar De La Respuesta Clínica Al Tratamiento Con Extracto De Cannabis Sativa En Perros Con Epilepsia Refractaria Aosteoartritis Canina Y Analgesia Cannabinoide: Implementación Y Consideraciones. Remevet [Internet]. 2019;30–1. Available from: www.remevet.com,spa
dc.relation.referencesJhon J. Betancurt. Bases científicas del cannabis en Medicina Veterinaria. Remevet. 2020;spa
dc.relation.referencesHartsel JA, Boyar K, Pham A, Silver RJ, Makriyannis A. Cannabis in Veterinary Medicine: Cannabinoid Therapies for Animals. Nutraceuticals in Veterinary Medicine. 2019. 121–155 p.spa
dc.relation.referencesBatalla A, Bos J, Postma A, Bossong MG. The Impact of Cannabidiol on Human Brain Function: A Systematic Review. Vol. 11, Frontiers in Pharmacology. Frontiers Media S.A.; 2021.spa
dc.relation.referencesRusso EB, Burnett A, Hall B, Parker KK. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res. 2005 Aug;30(8):1037–43.spa
dc.relation.referencesMechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol. 1995 Jun 29;50(1):83–90.spa
dc.relation.referencesDevane WA, Hanuš L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (1979). 1992;258(5090):1946–9.spa
dc.relation.referencesRusso EB, Jiang HE, Li X, Sutton A, Carboni A, Del Bianco F, et al. Phytochemical and genetic analyses of ancient cannabis from Central Asia. J Exp Bot [Internet]. 2008;59(15):4171–82. Available from: http://jxb.oxfordjournals.org/open_access.htmlspa
dc.relation.referencesJaniak P, Poirier B, Bidouard JP, Cadrouvele C, Pierre F, Gouraud L, et al. Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats. Kidney Int. 2007;72(11):1345–57.spa
dc.relation.referencesRoca AJ. Cannabis Medicinal. Revista Medicina. 2014;36(4):293–7.spa
dc.relation.referencesFundacion-canna.es. El sistema endocannabinoide. In: Madrid, editor. El sistema endocannabinoide (sf) . 2023.spa
dc.relation.referencesSilver RJ. The Endocannabinoid System of Animals. Animals. 2019;9(9):686.spa
dc.relation.referencesMaccarrone M. Metabolism of the endocannabinoid anandamide: Open questions after 25 years. Front Mol Neurosci. 2017 May 29;10:110–350.spa
dc.relation.referencesBasavarajappa BS. Critical Enzymes Involved in Endocannabinoid Metabolism. Bentham Science. 2007;14(10.2174/092986607780090829):237–46.spa
dc.relation.referencesDi Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC, et al. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature. 1994;372(6507):686–91.spa
dc.relation.referencesDe Petrocellis L, Bisogno T, Maccarrone M, Davis JB, Finazzi-Agrò A, Di Marzo V. The Activity of Anandamide at Vanilloid VR1 Receptors Requires Facilitated Transport across the Cell Membrane and Is Limited by Intracellular Metabolism. Journal of Biological Chemistry [Internet]. 2001 Apr 20 [cited 2023 Apr 17];276(16):12856–63. Available from: http://www.jbc.org/article/S0021925819343959/fulltextspa
dc.relation.referencesFrancois H, Lecru L. The Role of Cannabinoid Receptors in Renal Diseases. Curr Med Chem. 2018 Mar 16;25(7):793–801.spa
dc.relation.referencesHonniball CI, Lucey PG, Li S, Shenoy S, Orlando TM, Hibbitts CA, et al. Molecular water detected on the sunlit Moon by SOFIA. Nat Astron. 2020;spa
dc.relation.referencesTsuboi K, Uyama T, Okamoto Y, Ueda N. Endocannabinoids and related N-acylethanolamines: Biological activities and metabolism Makoto Murakami. Inflamm Regen. 2018 Oct 1;38(1).spa
dc.relation.referencesHaspula D, Clark MA. Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory diseases. Int J Mol Sci. 2020 Oct 1;21(20):1–65.spa
dc.relation.referencesZhu Y, Wang DH. Segmental regulation of sodium and water excretion by TRPV1 activation in the kidney. J Cardiovasc Pharmacol. 2008;51(5):437–42.spa
dc.relation.referencesDawidowicz AL, Olszowy-Tomczyk M, Typek R. CBG, CBD, Δ9-THC, CBN, CBGA, CBDA and Δ9-THCA as antioxidant agents and their intervention abilities in antioxidant action. Fitoterapia. 2021 Jul 1;152:2–10.spa
dc.relation.referencesMarzo V Di, Wang J. The Endocannabinoidome The World of Endocannabinoids and Related Mediators [Internet]. 2015. Available from: www.elsevier.com/permissions.spa
dc.relation.referencesBen-Cnaan E, Tam J, Permyakova A, Azar S, Hirsch S, Baraghithy S, et al. The Metabolic Efficacy of a Cannabidiolic Acid (CBDA) Derivative in Treating Diet-and Genetic-Induced Obesity. Int J Mol Sci. 2022 May 1;23(10).spa
dc.relation.referencesde Almeida DL, Devi LA. Diversity of molecular targets and signaling pathways for CBD. Vol. 8, Pharmacology Research and Perspectives. Blackwell Publishing Ltd; 2020. p. 1–10.spa
dc.relation.referencesSampaio LS, Taveira Da Silva R, Lima D, Sampaio CLC, Iannotti FA, Mazzarella E, et al. The endocannabinoid system in renal cells: Regulation of Na + transport by CB1 receptors through distinct cell signalling pathways. Br J Pharmacol. 2015;172(19):4615–25.spa
dc.relation.referencesSampaio LS, Iannotti FA, Veneziani L, Borelli-Tôrres RT, De Maio F, Piscitelli F, et al. Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na + /K + ATPase expression and activity in kidney proximal tubule cells. Biochem Pharmacol [Internet]. 2018;154:482–91. Available from: https://doi.org/10.1016/j.bcp.2018.06.005spa
dc.relation.referencesChua JT, Argueta DA, Dipatrizio N V., Kovesdy CP, Vaziri ND, Kalantar-Zadeh K, et al. Endocannabinoid System and the Kidneys: From Renal Physiology to Injury and Disease. Cannabis Cannabinoid Res. 2019;4(1):10–20.spa
dc.relation.referencesMeneton P, Ichikawa I, Inagami T, Schnermann J. Renal physiology of the mouse. Am J Physiol Renal Physiol. 2000;278(3 47-3):339–51.spa
dc.relation.referencesAhmad A, Dempsey SK, Daneva Z, Li N, Poklis JL, Li PL, et al. Modulation of mean arterial pressure and diuresis by renomedullary infusion of a selective inhibitor of fatty acid amide hydrolase. Am J Physiol Renal Physiol. 2018;315(4):F967–76.spa
dc.relation.referencesRachel Cianciolo; Cathy Brown;Charles Mohr. Atlas of Renal Lesions in Proteinuric Dogs [Internet]. 2018. 1–337 p. Available from: file:///C:/Users/Heidy/Downloads/Atlas-of-Renal-Lesions-in-Proteinuric-Dogs-1572364976.pdfspa
dc.relation.referencesAnsary TM, Fujisawa Y, Rahman A, Nakano D, Hitomi H, Kobara H, et al. Responses of renal hemodynamics and tubular functions to acute sodium-glucose cotransporter 2 inhibitor administration in non-diabetic anesthetized rats /631/443/272/1684 /692/4022/272/1684 article. Sci Rep. 2017 Dec 1;7(1):1–9.spa
dc.relation.referencesJ Frey BA, Grisk O, Bandelow N, Wussow S, Bie P, Rettig R, et al. Sodium homeostasis in transplanted rats with a spontaneously hypertensive rat kidney. Am J Physiol Regulatory Integrative Comp Physiol [Internet]. 2000;1099–104. Available from: http://www.ajpregu.orgspa
dc.relation.referencesKawachi H, Suzuki K, Miyauchi N, Hashimoto T, Otaki Y, Shimizu F. Slit diaphragm dysfunction in proteinuric states: Identification of novel therapeutic targets for nephrotic syndrome. Vol. 13, Clinical and Experimental Nephrology. 2009. p. 275–80.spa
dc.relation.referencesZhang SY, Marlier A, Gribouval O, Gilbert T, Heidet L, Antignac C, et al. In vivo expression of podocyte slit diaphragm-associated proteins in nephrotic patients with NPHS2 mutation. Kidney Int. 2004;66(3):945–54.spa
dc.relation.referencesPatrakka J, Tryggvason K. Molecular make-up of the glomerular filtration barrier. Biochem Biophys Res Commun. 2010 May 21;396(1):164–9.spa
dc.relation.referencesKlein BG. Cunningham. Fisiología Veterinaria [Internet]. Cunningham. Fisiología Veterinaria. 2014. 0 p. Available from: http://evolve.elsevier.com/Klein/physiologyspa
dc.relation.referencesBartges Joe, Polzin DJames. Nephrology and urology of small animals. Wiley-Blackwell; 2011. 904 p.spa
dc.relation.referencesThomas Colville and Joanna M. Baassert. Clinical Anatomy and Physiology for Veterinary Technicians [Internet]. 2016. Available from: http://evolve.elsevier.com/Colville/APvettech/YOU’VEJUSTPURCHASEDspa
dc.relation.referencesHoward E. Evans P and A de LDP. Miller’s ANATOMY of the DOG fourth edition. Vol. FOURTH EDITION, Miller’s Anatomy of the Dog. 2012. 1–781 p.spa
dc.relation.referencesDelaney MA, Treuting PM. Urinary System Cap. 16 [Internet]. Comparative Anatomy and Histology. Elsevier Inc.; 2018. 275–300 p. Available from: http://dx.doi.org/10.1016/B978-0-12-802900-8.00016-6spa
dc.relation.referencesBulger RE, Cronin RE, Dobyan DC. Survey of the Morphology of the Dog Kidney. ANAT REC. 1979;194:41–66.spa
dc.relation.referencesGilbert EA, Barclay T, Schlieder JE, Quintana E V., Hord BJ, Kostov VB, et al. The First Habitable-zone Earth-sized Planet from TESS. I. Validation of the TOI-700 System. Astron J [Internet]. 2020 Aug 14;160(3):116. Available from: https://iopscience.iop.org/article/10.3847/1538-3881/aba4b2spa
dc.relation.referencesJr William J Bacha J and LMB. COLOR ATLAS OF VETERINARY HISTOLOGY Third Edition. New Jersey; 2017.spa
dc.relation.referencesEsquinas Castillo P. Estudio comparativo de glomerulopatías en caninos y en humanos: Una aproximación morfologica y moleculat [Internet]. [Bogotá]: Universidad Naciona de Colombia; 2020 [cited 2022 Sep 8]. Available from: https://repositorio.unal.edu.co/handle/unal/78368spa
dc.relation.referencesYasaman Pirahanchi; Rishita Jessu; Narothama R. Aeddula. Physiology, Sodium Potassium Pump. In: StatPearls Publishing. 2023.spa
dc.relation.referencesBoron WF, David PN, Myers I, Scarpa Chairman A, Boulpaep EL. Medical Physiology THIRD EDITION. Vol. 3. 2016. 1–3292 p.spa
dc.relation.referencesTaub M. Gene level regulation of Na,K-ATPase in the renal proximal tubule is controlled by two independent but interacting regulatory mechanisms involving salt inducible kinase 1 and CREB-regulated transcriptional coactivators. Vol. 19, International Journal of Molecular Sciences. MDPI AG; 2018. p. 2–20.spa
dc.relation.referencesEvaristo Mariela J, en Alberto Cedillo Cruz Omar Alberto Hernández Aguirre MC. DETERMINACIÓN DE URANIO Y TORIO EN ORINA POR ESPECTROMETRÍA DE MASA CON PLASMA ACOPLADO INDUCTIVAMENTE (ICP-MS). [Juarez Mexico]: UNIVERSIDAD POLITÉCNICA DEL VALLE DE TOLUCA; 2017.spa
dc.relation.referencesCrocq MA. History of cannabis and the endocannabinoid system. Dialogues Clin Neurosci. 2020 Sep 1;22(3):223–8.spa
dc.relation.referencesBaron EP, Lucas P, Eades J, Hogue O. Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. The Journal of Headache and Pain [Internet]. 2018;2–28. Available from: https://doi.org/10.1186/s10194-018-0862-2spa
dc.relation.referencesZou S, Kumar U. Molecular Sciences Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. 2018; Available from: www.mdpi.com/journal/ijmsspa
dc.relation.referencesJarvis S, Rassmussen S, Winters B. Role of the Endocannabinoid System and Medical Cannabis. Journal for Nurse Practitioners. 2017 Sep 1;13(8):525–31.spa
dc.relation.referencesPerdija Ž, Chingwaru W, Setinc M, Zeman S, Mater Europaea -Ecm A, Perdija SZ, et al. The biochemistry of the endocannabinoid system Neonatal neurology View project Quantifying the risk of transmission of diarrhoeal pathogens from farm to fork View project Silvija Zeman Polytechnic of Međimurje in Čakovec THE BIOCHEMISTRY OF THE ENDOCANNABINOID SYSTEM [Internet]. 2020 Sep. Available from: https://www.britannica.com/science/cell-membranespa
dc.relation.referencesRitter JK, Li G, Xia M, Boini K. Anandamide and its metabolites: What are their roles in the kidney? Frontiers in Bioscience - Scholar. 2016 Jun 1;8(2):264–77.spa
dc.relation.referencesArreaza G, Devane WA, Omeir RL, Sajnani G, Kunz J, Cravatt BF, et al. The cloned rat hydrolytic enzyme responsible for the breakdown of anandamide also catalyzes its formation via the condensation of arachidonic acid and ethanolamine. Neurosci Lett. 1997 Sep 26;234(1):59–62.spa
dc.relation.referencesPossomato-Vieira, José S. and Khalil RAK. Anandamide and its metabolites: what are their roles in the kidney? Physiol Behav. 2016;176(12):139–48.spa
dc.relation.referencesPirone A, Lenzi C, Coli A, Giannessi E, Stornelli MR, Miragliotta V. Preferential epithelial expression of type-1 cannabinoid receptor (CB1R) in the developing canine embryo. Springerplus. 2015 Dec 1;4(1):1–7.spa
dc.relation.referencesPark F, Potukuchi PK, Moradi H, Kovesdy CP. Cannabinoids and the kidney: Effects in health and disease. Am J Physiol Renal Physiol. 2017;313(5):F1124–32.spa
dc.relation.referencesSilva-Cardoso GK, Lazarini-Lopes W, Hallak JE, Crippa JA, Zuardi AW, Garcia-Cairasco N, et al. Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and TRPV1 receptors. Neuropharmacology. 2021 Oct 1;197.spa
dc.relation.referencesFreundt-Revilla J, Kegler K, Baumgärtner W, Tipold A. Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system. PLoS One. 2017;12(7):1–21.spa
dc.relation.referencesMartín Giménez VM, Noriega SE, Kassuha DE, Fuentes LB, Manucha W. Anandamide and endocannabinoid system: an attractive therapeutic approach for cardiovascular disease. Ther Adv Cardiovasc Dis. 2018;12(7):177–90.spa
dc.relation.referencesHill MN, McLaughlin RJ, Morrish AC, Viau V, Floresco SB, Hillard CJ, et al. Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. Neuropsychopharmacology [Internet]. 2009;34(13):2733–45. Available from: http://dx.doi.org/10.1038/npp.2009.114spa
dc.relation.referencesHinden L, Tam J. Do endocannabinoids regulate glucose reabsorption in the kidney? Nephron. 2019;143(1):24–7.spa
dc.relation.referencesTam J. The emerging role of the endocannabinoid system in the pathogenesis and treatment of kidney diseases. J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):267–76.spa
dc.relation.referencesSimon GM, Cravatt BF. Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. Journal of Biological Chemistry. 2008 Apr 4;283(14):9341–9.spa
dc.relation.referencesAl Banchaabouchi M, Marescau B, Possemiers I, D’Hooge R, Levillain O, De Deyn PP. N G,N G-Dimethylarginine and N G,N’G-dimethylarginine in renal insufficiency. Pflugers Arch. 2000 Mar;439(5):524–31.spa
dc.relation.referencesLim JC, Lim SK, Han HJ, Park SH. Cannabinoid receptor 1 mediates palmitic acid-induced apoptosis via endoplasmic reticulum stress in human renal proximal tubular cells. J Cell Physiol. 2010;225(3):654–63.spa
dc.relation.referencesWade CE, Morey-Holton E. Alteration of renal function of rats following spaceflight. Am J Physiol Regul Integr Comp Physiol. 1998;275(4 44-4):1058–65.spa
dc.relation.referencesBrooks DP, Nambi P, Laping NJ, Olson BA, Pullen M, Wade CE. Renal vasopressin receptor expression and function in rats following spaceflight. J Appl Physiol. 2000;88(4):1316–20.spa
dc.relation.referencesLarson G, Fuller DQ. The evolution of animal domestication. Annu Rev Ecol Evol Syst. 2014 Nov 23;45:115–36.spa
dc.relation.referencesUdi S, Hinden L, Earley B, Drori A, Reuveni N, Hadar R, et al. Proximal tubular cannabinoid-1 receptor regulates obesity-induced CKD. Journal of the American Society of Nephrology. 2017 Dec 1;28(12):3518–32.spa
dc.relation.referencesDrori A, Permyakova A, Hadar R, Udi S, Nemirovski A, Tam J. Cannabinoid-1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells. Diabetes Obes Metab. 2019 Jan 1;21(1):146–59.spa
dc.relation.referencesUdi S, Hinden L, Ahmad M, Drori A, Iyer MR, Cinar R, et al. Dual inhibition of cannabinoid CB1 receptor and inducible NOS attenuates obesity-induced chronic kidney disease. Br J Pharmacol. 2020 Jan 1;177(1):110–27.spa
dc.relation.referencesThomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG. Cannabidiol displays unexpectedly high potency as an antagonist of CB 1 and CB 2 receptor agonists in vitro. Br J Pharmacol. 2007 Mar;150(5):613–23.spa
dc.relation.referencesCelorrio M, Rojo-Bustamante E, Fernández-Suárez D, Sáez E, Estella-Hermoso de Mendoza A, Müller CE, et al. GPR55: A therapeutic target for Parkinson’s disease? Neuropharmacology. 2017 Oct 1;125:319–32.spa
dc.relation.referencesBisogno T, Hanuš L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, et al. Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001;134(4):845–52.spa
dc.relation.referencesEsposito G, Scuderi C, Valenza M, Togna GI, Latina V, de Filippis D, et al. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement. PLoS One. 2011 Dec 5;6(12).spa
dc.relation.referencesSeeman P. Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose. Transl Psychiatry. 2016;6(10):1–4.spa
dc.relation.referencesGonca E, Darici F. The Effect of Cannabidiol on ischemia/reperfusion-induced ventricular arrhythmias: The role of adenosine a1 receptors. J Cardiovasc Pharmacol Ther. 2015 Jan 12;20(1):76–83.spa
dc.relation.referencesKathmann M, Flau K, Redmer A, Tränkle C, Schlicker E. Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors. Naunyn Schmiedebergs Arch Pharmacol. 2006 Feb;372(5):354–61.spa
dc.relation.referencesGhovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Inhibitory effects of cannabidiol on voltage-dependent sodium currents. Journal of Biological Chemistry. 2019 Oct 26;293(43):16546–58.spa
dc.relation.referencesMalik S. Financial-integration thresholds for consumption risk-sharing. International Review of Economics and Finance. 2015 Jul 1;38:73–93.spa
dc.relation.referencesCastaño Bilbao I, Roblero FS, García-Fernández N. Estudios de función renal: función glomerular y tubular. Análisis de la orina. 2009.spa
dc.relation.referencesJaime Pérez Loredo CAL. TASA DE FILTRACION GLOMERULAR MEDIDA y ESTIMADA. NUMEROSOS MÉTODOS DE MEDICIÓN. nefrología diálisis y trasplante. 2015;35:153–64.spa
dc.relation.referencesFu Q, Colgan SP, Shelley CS. Hypoxia: The force that drives chronic Kidney disease. Vol. 14, Clinical Medicine and Research. Marshfield Clinic; 2016. p. 15–39.spa
dc.relation.referencesKeppler A, Gretz N, Schmidt R, Kloetzer HM, Groene HJ, Lelongt B, et al. Plasma creatinine determination in mice and rats: An enzymatic method compares favorably with a high-performance liquid chromatography assay. Kidney Int. 2007 Jan;71(1):74–8.spa
dc.relation.referencesStevens LA, Levey AS. Measurement of kidney function. Vol. 89, Medical Clinics of North America. W.B. Saunders; 2005. p. 457–73.spa
dc.relation.referencesMullens W, Damman K, Testani JM, Martens P, Mueller C, Lassus J, et al. Evaluation of kidney function throughout the heart failure trajectory-a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2020;22:584–603.spa
dc.relation.referencesDANUM – Instrumental Analysis. https://danum74.wordpress.com/2014/05/15/Espectroscopia-De-Masas-2/. 2014. ESPECTROMETRIA DE MASASspa
dc.relation.referencesGoldberg ME. A look at chronic pain in dogs. Veterinary Nursing Journal [Internet]. 2017;32(2):37–44. Available from: http://dx.doi.org/10.1080/17415349.2016.1262217spa
dc.relation.referencesZadik-Weiss L, Ritter S, Hermush V, Asher N, Avital A, Or R. Feline cognitive dysfunction as a model for Alzheimer’s disease in the research of CBD as a potential treatment—a narrative review. J Cannabis Res. 2020;2(1):0–5.spa
dc.relation.referencesFreundt-Revilla J, Heinrich F, Zoerner A, Gesell F, Beyerbach M, Shamir M, et al. The endocannabinoid system in canine steroid-responsive meningitis-arteritis and intraspinal spirocercosis. PLoS One. 2018 Feb 1;13(2).spa
dc.relation.referencesKogan LR, Hellyer PW, Silcox S, Schoenfeld-Tacher R. Canadian dog owners’ use and perceptions of cannabis products. Canadian Veterinary Journal. 2019;60(7):749–55.spa
dc.relation.referencesBarutta F, Bruno G, Mastrocola R, Bellini S, Gruden G. The role of cannabinoid signaling in acute and chronic kidney diseases. Kidney Int [Internet]. 2018;94(2):252–8. Available from: http://www.sciencedirect.com/science/article/pii/S0085253818301406spa
dc.relation.referencesBarutta F, Corbelli A, Mastrocola R, Gambino R, Marzo V Di, Pinach S, et al. Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy. Diabetes. 2010 Apr;59(4):1046–54.spa
dc.relation.referencesDao M, François H. Cannabinoid Receptor 1 Inhibition in Chronic Kidney Disease: A New Therapeutic Toolbox. Front Endocrinol (Lausanne). 2021 Jul 7;12:830.spa
dc.relation.referencesPeres LAB, Cunha Júnior AD Da, Schäfer AJ, Silva AL Da, Gaspar AD, Scarpari DF, et al. Renal biomarkers of male and female Wistar rats ( Rattus norvegicus ) undergoing renal. J Bras Nefrol [Internet]. 2013;35(3):277–88. Available from: http://www.gnresearch.org/doi/10.5935/01012800.20130001%5Cnhttp://www.ncbi.nlm.nih.gov/pubmed/24100743spa
dc.relation.referencesCorsetti S, Borruso S, Malandrucco L, Spallucci V, Maragliano L, Perino R, et al. Cannabis sativa L. may reduce aggressive behaviour towards humans in shelter dogs. Scientific Reports | [Internet]. 2021;11:2773. Available from: https://doi.org/10.1038/s41598-021-82439-2spa
dc.relation.referencesDel-Angel-Caraza J, Quijano-Hernández IA, Soriano-Vargas E, Barbosa-Mireles MA, Martínez-Castañeda JS. Urinary bladder worm (Pearsonema sp.) infection in domestic dogs and cats in Mexico at a high altitude. Parasitol Res. 2018 Jun 1;117(6):1979–83.spa
dc.relation.referencesD. Caroline Coile. Cannabis and CBD Science for Dogs: Natural Supplements to Support Healthy Living and Graceful Aging. ilustrada. 2013. 1–94 p.spa
dc.relation.referencesHložek T, Uttl L, Kadeřábek L, Balíková M, Lhotková E, Horsley RR, et al. Pharmacokinetic and behavioural profile of THC, CBD, and THC+CBD combination after pulmonary, oral, and subcutaneous administration in rats and confirmation of conversion in vivo of CBD to THC. European Neuropsychopharmacology. 2017 Dec 1;27(12):1223–37.spa
dc.relation.referencesKurien BT, Everds NE, Scofield & RH. Experimental animal urine collection: a review. Laboratory Animals Ltd. 2004;38:333–61.spa
dc.relation.referencesCharan J, Kantharia ND. How to calculate sample size in animal studies? J Pharmacol Pharmacother [Internet]. 2013 [cited 2022 Oct 26];4(4):303–303. Available from: http://www.3rs-reduction.co.uk/html/6__power_and_sample_size.html,http://www.acuc.berkeley.edu/,http://www.bu.edu/orccommittees/iacuc/policies-and-guidelines/sample-size-calculations/,http://www.ucd.ie/researchethics/etc.spa
dc.relation.referencesAcosta Murillo NR. Modelo murino comparativo pediátrico de injuria renal aguda isquémica y descripción histopatológica en tres grupos etarios. [Bogota]: Universidad Nacional de Colombia ; 2016.spa
dc.relation.referencesLarrinaga G, Varona A, Pérez I, Sanz B, Ugalde A, Cándenas ML, et al. Expression of cannabinoid receptors in human kidney. Histol Histopathol. 2010 Sep;25(9):1133–8.spa
dc.relation.referencesJenkin KA, McAinch AJ, Grinfeld E, Hryciw DH. Role for cannabinoid receptors in human proximal tubular hypertrophy. Cellular Physiology and Biochemistry. 2010;26(6):879–86.spa
dc.relation.referencesJasionek G, Drummond SE, Brett O, Lucking EF, Abdulla MA, O KD. Renal cortical oxygen tension is decreased following exposure to long-term but not short-term intermittent hypoxia in the rat. Am J Physiol Renal Physiol [Internet]. 2019;316:635–45. Available from: http://www.ajprenal.orgspa
dc.relation.referencesFilipiuc LE, Ştefănescu R, Solcan C, Ciorpac M, Szilagyi A, Cojocaru D, et al. Acute Toxicity and Pharmacokinetic Profile of an EU-GMP-Certified Cannabis sativa L. in Rodents. Pharmaceuticals. 2023 May 1;16(5):1–21.spa
dc.relation.referencesAmbrus L, Kelemen B, Szabó T, Bíró T, Tóth BI. Human podocytes express functional thermosensitive TRPV channels. Br J Pharmacol. 2017 Dec 1;174(23):4493–507.spa
dc.relation.referencesTaub M, Garamella S, Kim D, Rajkhowa T, Cutuli F. Renal proximal tubule Na,K-ATPase is controlled by CREB-regulated transcriptional coactivators as well as salt-inducible kinase 1. Cell Signal. 2015 Dec 1;27(12):2568–78.spa
dc.relation.referencesLi J, Wang DH. Role of TRPV1 channels in renal haemodynamics and function in Dahl salt-sensitive hypertensive rats. Exp Physiol. 2008;93(8):945–53.spa
dc.relation.referencesGolosova D, Levchenko V, Kravtsova O, Palygin O, Staruschenko A. Acute and long-term effects of cannabinoids on hypertension and kidney injury. Sci Rep. 2022 Dec 1;12(1):1–12.spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseReconocimiento 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/spa
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.ddc590 - Animales::599 - Mamíferosspa
dc.subject.decsCannabidiol/metabolismospa
dc.subject.decsCannabidiol/metabolismeng
dc.subject.decsUrinálisis/veterinariaspa
dc.subject.decsUrinalysis/veterinaryeng
dc.subject.decsReabsorción Renal/efectos de los fármacosspa
dc.subject.decsRenal Reabsorption/drug effectseng
dc.subject.proposalReabsorción de sodio a nivel renalspa
dc.subject.proposalEndocannabinoidomaspa
dc.subject.proposalFiltración glomerularspa
dc.subject.proposalReceptor CB1spa
dc.subject.proposalCBDspa
dc.subject.proposalRenal sodium reabsorptioneng
dc.subject.proposalEndocannabinoidomeeng
dc.subject.proposalGlomerular filtrationeng
dc.subject.proposalCB1 receptoreng
dc.subject.proposalCBDeng
dc.titleEfectos del fitocannabinoide cannabidiol sobre la excreción de sodio en ratas Wistarspa
dc.title.translatedEffects of the phytocannabinoid cannabidiol on sodium excretion in Wistar ratseng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentAdministradoresspa
dcterms.audience.professionaldevelopmentBibliotecariosspa
dcterms.audience.professionaldevelopmentConsejerosspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentGrupos comunitariosspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
dcterms.audience.professionaldevelopmentMedios de comunicaciónspa
dcterms.audience.professionaldevelopmentPadres y familiasspa
dcterms.audience.professionaldevelopmentPersonal de apoyo escolarspa
dcterms.audience.professionaldevelopmentProveedores de ayuda financiera para estudiantesspa
dcterms.audience.professionaldevelopmentPúblico generalspa
dcterms.audience.professionaldevelopmentReceptores de fondos federales y solicitantesspa
dcterms.audience.professionaldevelopmentResponsables políticosspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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